|Institutional Source||Beutler Lab|
|Gene Name||aryl-hydrocarbon receptor repressor|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0165 (G1)|
|Chromosomal Location||74211118-74292331 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||G to A at 74283024 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000105268 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022059] [ENSMUST00000109640]|
|AlphaFold||no structure available at present|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||96% (81/84)|
FUNCTION: This gene encodes a protein that represses aryl hydrocarbon receptor-dependent signaling. The encoded protein competes with the aryl hydrocarbon receptor transcription factor for heterodimerization with the aryl hydrocarbon receptor nuclear translocator protein and binding to xenobiotic response element (XRE) sequence in many genes. This protein is implicated in the regulation of cell growth and differentiation as well as mediating dioxin toxicity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased susceptibility to chemically induced tumors. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ahrr||
(F):5'- GGGCACTTTCCACAGACAGAATGAC -3'
(R):5'- TGAGGGCCAATGGATCGTACTGAC -3'
(F):5'- CCACAGACAGAATGACTTATTGCTG -3'
(R):5'- AATGGATCGTACTGACCTTCTTG -3'