Incidental Mutation 'R7849:Krt6b'
ID 606843
Institutional Source Beutler Lab
Gene Symbol Krt6b
Ensembl Gene ENSMUSG00000023041
Gene Name keratin 6B
Synonyms mK6[b], Krt2-6b
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R7849 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 101584458-101588722 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 101587009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 254 (N254K)
Ref Sequence ENSEMBL: ENSMUSP00000023786 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023786]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000023786
AA Change: N254K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023786
Gene: ENSMUSG00000023041
AA Change: N254K

DomainStartEndE-ValueType
Pfam:Keratin_2_head 15 148 1.3e-36 PFAM
Filament 151 464 2.79e-175 SMART
low complexity region 483 537 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agap1 T C 1: 89,558,141 (GRCm39) V143A probably damaging Het
Agmo A G 12: 37,292,044 (GRCm39) R2G probably benign Het
Alms1 A T 6: 85,598,479 (GRCm39) I1102L possibly damaging Het
Ankrd13a T C 5: 114,929,343 (GRCm39) I140T possibly damaging Het
Arhgef10l T A 4: 140,311,245 (GRCm39) probably null Het
Atxn2l A T 7: 126,092,345 (GRCm39) H967Q possibly damaging Het
B3galnt2 A T 13: 14,169,077 (GRCm39) N370I probably benign Het
Bltp1 T A 3: 37,080,477 (GRCm39) I325N Het
Cacna1e C T 1: 154,509,464 (GRCm39) D264N probably damaging Het
Ccdc112 A T 18: 46,429,390 (GRCm39) Y103N probably benign Het
Ccdc68 A C 18: 70,080,246 (GRCm39) E197A probably damaging Het
Cdr1 AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC X: 60,228,130 (GRCm39) probably benign Het
Cntn3 T C 6: 102,242,392 (GRCm39) M418V probably benign Het
Cpne4 T A 9: 104,563,718 (GRCm39) C32S probably damaging Het
Csf2rb2 A T 15: 78,168,621 (GRCm39) S845T probably benign Het
Ctnnd2 T G 15: 31,027,733 (GRCm39) V1219G probably damaging Het
Cyp4f14 G A 17: 33,128,325 (GRCm39) A230V probably benign Het
Cyth1 TGGGCAA T 11: 118,074,749 (GRCm39) probably null Het
Dmxl1 T A 18: 50,094,214 (GRCm39) C2897S probably benign Het
Elavl2 T A 4: 91,260,280 (GRCm39) probably benign Het
Elp1 A T 4: 56,758,968 (GRCm39) S1191T possibly damaging Het
Fam135a T C 1: 24,083,331 (GRCm39) E298G probably damaging Het
Fbn1 A T 2: 125,151,405 (GRCm39) I2534N probably damaging Het
Fibin A G 2: 110,192,825 (GRCm39) S106P probably damaging Het
Fndc3a C T 14: 72,802,100 (GRCm39) V568M probably benign Het
Frem2 A G 3: 53,479,795 (GRCm39) F1966S probably damaging Het
Gata4 T G 14: 63,442,174 (GRCm39) E216A possibly damaging Het
Gmps T A 3: 63,922,984 (GRCm39) V649E probably benign Het
Golga4 A T 9: 118,388,379 (GRCm39) N1834Y possibly damaging Het
Gpr89 A T 3: 96,778,806 (GRCm39) Y422* probably null Het
Gzmc A T 14: 56,469,829 (GRCm39) F157Y probably benign Het
Hdhd2 A G 18: 77,052,962 (GRCm39) D204G probably damaging Het
Hspa4 T G 11: 53,171,530 (GRCm39) T225P possibly damaging Het
Klhl30 T A 1: 91,287,059 (GRCm39) D448E probably benign Het
Kptn A G 7: 15,853,966 (GRCm39) Y28C probably damaging Het
Krt10 A T 11: 99,278,432 (GRCm39) N242K probably damaging Het
Lama5 G T 2: 179,843,605 (GRCm39) D447E probably damaging Het
Lgr6 T C 1: 134,915,419 (GRCm39) Y720C probably damaging Het
Macf1 G C 4: 123,301,392 (GRCm39) P1037A probably benign Het
Map3k19 C T 1: 127,751,383 (GRCm39) G656D probably benign Het
Mroh7 A C 4: 106,578,287 (GRCm39) N130K probably benign Het
Muc16 T C 9: 18,551,801 (GRCm39) T4831A probably benign Het
Nfkb1 A T 3: 135,291,173 (GRCm39) L533H Het
Oaf G A 9: 43,134,077 (GRCm39) R215C probably damaging Het
Or4x11 A G 2: 89,867,626 (GRCm39) Y121C probably damaging Het
Or51k1 C A 7: 103,661,510 (GRCm39) R133L possibly damaging Het
Or5m3b G A 2: 85,871,949 (GRCm39) V97I probably benign Het
Or8a1 A G 9: 37,642,003 (GRCm39) I92T probably damaging Het
Or8g2b A G 9: 39,751,618 (GRCm39) D296G possibly damaging Het
Otub1 T C 19: 7,177,425 (GRCm39) D74G probably damaging Het
Oxct2b A G 4: 123,010,680 (GRCm39) E200G probably damaging Het
Pcdh1 T C 18: 38,322,662 (GRCm39) D1057G probably benign Het
Pkd1 T A 17: 24,805,174 (GRCm39) V3242E probably damaging Het
Pkd1l3 CCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACACAGGTGACATCAGACACACCTGCATCCAATAGCCCACCACAGGGGACATCAGACACACCTGGATTCAGCAGCCCAACACAGGTGACAACAGCCACACTTGTATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACATCTGCATCCATCAGCCCACCACAGGTAATATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACA CCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACACAGGTGACATCAGACACACCTGCATCCAATAGCCCACCACAGGGGACATCAGACACACCTGGATTCAGCAGCCCAACACAGGTGACAACAGCCACACTTGTATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGACACATCTGCATCCATCAGCCCACCACAGGTAATATCAGACACACCTGCATCCAGCAGCCCACCACAGGTGACATCAGAGACACCTGCATCCAGCAGCCCAACA 8: 110,350,420 (GRCm39) probably benign Het
Pla2g4e T A 2: 120,015,803 (GRCm39) D247V probably benign Het
Pole T A 5: 110,480,414 (GRCm39) M1995K probably benign Het
Ppargc1a T C 5: 51,705,855 (GRCm39) E76G probably benign Het
Pten G T 19: 32,777,396 (GRCm39) R130L probably damaging Het
Ptprj A T 2: 90,274,804 (GRCm39) V1186D probably damaging Het
Rab4a T A 8: 124,532,876 (GRCm39) M1K probably null Het
Rapgef3 C A 15: 97,656,271 (GRCm39) probably null Het
Rarb C A 14: 16,548,473 (GRCm38) V83F probably damaging Het
Rgs22 A T 15: 36,099,858 (GRCm39) F410I probably damaging Het
Rhpn2 A C 7: 35,080,912 (GRCm39) E459A probably benign Het
Rims4 A T 2: 163,705,974 (GRCm39) L220Q probably damaging Het
Robo2 T C 16: 73,770,132 (GRCm39) T531A possibly damaging Het
Sbf2 T C 7: 109,971,717 (GRCm39) H839R probably damaging Het
Setbp1 T C 18: 78,900,068 (GRCm39) R1200G probably benign Het
Slc12a8 C A 16: 33,444,930 (GRCm39) P275T probably damaging Het
Slc23a1 G T 18: 35,757,554 (GRCm39) T239N probably benign Het
Slc37a3 T A 6: 39,341,517 (GRCm39) T40S possibly damaging Het
Speer4c1 T C 5: 15,915,925 (GRCm39) probably null Het
Tet1 A T 10: 62,655,252 (GRCm39) H1556Q possibly damaging Het
Tfcp2l1 T A 1: 118,603,325 (GRCm39) D454E probably damaging Het
Timd6 T A 11: 46,468,058 (GRCm39) I44K not run Het
Tmem123 A T 9: 7,790,890 (GRCm39) M64L probably benign Het
Tmem62 A T 2: 120,814,853 (GRCm39) H172L probably benign Het
Trim15 T G 17: 37,177,764 (GRCm39) Y77S probably benign Het
Trim37 T A 11: 87,092,270 (GRCm39) V693E possibly damaging Het
Trim65 A G 11: 116,017,082 (GRCm39) L460S probably damaging Het
Ttc39a T C 4: 109,279,687 (GRCm39) V109A probably benign Het
Ttc7 A G 17: 87,600,374 (GRCm39) M163V probably null Het
Vps13b T C 15: 35,423,378 (GRCm39) S233P probably damaging Het
Vwf T C 6: 125,633,766 (GRCm39) L2084P Het
Wasl A G 6: 24,633,922 (GRCm39) V114A possibly damaging Het
Wdr5 A G 2: 27,409,463 (GRCm39) S62G probably damaging Het
Wfdc11 G T 2: 164,507,445 (GRCm39) S4* probably null Het
Wfikkn2 C A 11: 94,129,810 (GRCm39) M110I probably benign Het
Wiz T G 17: 32,576,760 (GRCm39) E588A probably benign Het
Xylt1 A G 7: 117,255,891 (GRCm39) H821R probably benign Het
Zbtb7c A T 18: 76,278,772 (GRCm39) H410L probably benign Het
Zc3h18 T A 8: 123,110,710 (GRCm39) D186E probably damaging Het
Zfp687 G T 3: 94,917,673 (GRCm39) L700I possibly damaging Het
Zmym2 T A 14: 57,184,020 (GRCm39) M994K probably benign Het
Other mutations in Krt6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00327:Krt6b APN 15 101,588,267 (GRCm39) missense probably benign 0.22
IGL01653:Krt6b APN 15 101,587,549 (GRCm39) missense probably damaging 1.00
IGL01900:Krt6b APN 15 101,585,981 (GRCm39) missense possibly damaging 0.45
IGL03187:Krt6b APN 15 101,588,392 (GRCm39) missense probably benign
R0511:Krt6b UTSW 15 101,586,042 (GRCm39) splice site probably benign
R0788:Krt6b UTSW 15 101,585,954 (GRCm39) missense probably damaging 0.96
R1370:Krt6b UTSW 15 101,585,987 (GRCm39) missense probably damaging 0.96
R1481:Krt6b UTSW 15 101,586,809 (GRCm39) missense probably benign 0.05
R2007:Krt6b UTSW 15 101,586,562 (GRCm39) missense probably damaging 1.00
R2112:Krt6b UTSW 15 101,586,999 (GRCm39) missense possibly damaging 0.48
R2166:Krt6b UTSW 15 101,587,050 (GRCm39) critical splice acceptor site probably null
R2227:Krt6b UTSW 15 101,587,557 (GRCm39) missense probably damaging 0.96
R2495:Krt6b UTSW 15 101,586,757 (GRCm39) missense probably damaging 1.00
R2496:Krt6b UTSW 15 101,588,216 (GRCm39) missense probably damaging 1.00
R4726:Krt6b UTSW 15 101,586,520 (GRCm39) missense probably damaging 0.98
R4969:Krt6b UTSW 15 101,588,460 (GRCm39) missense possibly damaging 0.71
R6301:Krt6b UTSW 15 101,587,386 (GRCm39) missense probably damaging 1.00
R6646:Krt6b UTSW 15 101,585,649 (GRCm39) missense probably damaging 0.98
R7232:Krt6b UTSW 15 101,586,577 (GRCm39) missense probably damaging 1.00
R7406:Krt6b UTSW 15 101,587,513 (GRCm39) missense probably benign 0.04
R7414:Krt6b UTSW 15 101,587,449 (GRCm39) missense probably benign 0.05
R8110:Krt6b UTSW 15 101,588,577 (GRCm39) missense probably damaging 0.96
R8348:Krt6b UTSW 15 101,586,455 (GRCm39) missense probably damaging 1.00
R8448:Krt6b UTSW 15 101,586,455 (GRCm39) missense probably damaging 1.00
R8736:Krt6b UTSW 15 101,587,047 (GRCm39) missense probably damaging 1.00
R9466:Krt6b UTSW 15 101,586,027 (GRCm39) missense probably damaging 1.00
R9633:Krt6b UTSW 15 101,586,996 (GRCm39) missense probably benign 0.00
R9720:Krt6b UTSW 15 101,588,226 (GRCm39) missense probably benign 0.40
Z1177:Krt6b UTSW 15 101,586,767 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCAGCATCTACATCCTGAG -3'
(R):5'- CCAAGGAGGGTCCAGGTTTATAG -3'

Sequencing Primer
(F):5'- GCATCTACATCCTGAGAAATCCATG -3'
(R):5'- TCCAGGTTTATAGGACATTAAGGG -3'
Posted On 2019-12-20