Incidental Mutation 'R7850:Or8s8'
ID 606895
Institutional Source Beutler Lab
Gene Symbol Or8s8
Ensembl Gene ENSMUSG00000032987
Gene Name olfactory receptor family 8 subfamily S member 8
Synonyms GA_x6K02T2NBG7-5275017-5274082, Olfr281, MOR160-5
MMRRC Submission 045903-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R7850 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 98354193-98355128 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 98354949 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 253 (G253R)
Ref Sequence ENSEMBL: ENSMUSP00000150530 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109163] [ENSMUST00000217517]
AlphaFold Q8VET6
Predicted Effect probably damaging
Transcript: ENSMUST00000109163
AA Change: G253R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104791
Gene: ENSMUSG00000032987
AA Change: G253R

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.8e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 277 2.2e-5 PFAM
Pfam:7tm_1 41 288 2.4e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217517
AA Change: G253R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630089N07Rik A T 16: 97,869,328 (GRCm39) D2E probably damaging Het
Abhd16b G A 2: 181,135,518 (GRCm39) R140H not run Het
Acad11 G T 9: 103,991,728 (GRCm39) G588C probably damaging Het
Baz2b C A 2: 59,767,060 (GRCm39) E107D probably damaging Het
Bcas1 A G 2: 170,190,023 (GRCm39) S625P probably damaging Het
Bdp1 T A 13: 100,228,832 (GRCm39) L265F probably damaging Het
Cacna1s A G 1: 135,998,786 (GRCm39) Y227C probably damaging Het
Cacna2d2 G A 9: 107,402,575 (GRCm39) A848T probably benign Het
Cep135 T C 5: 76,739,720 (GRCm39) probably null Het
Cyp2b9 G T 7: 25,886,111 (GRCm39) E93* probably null Het
Dcp2 C A 18: 44,533,415 (GRCm39) S122* probably null Het
Ecel1 A G 1: 87,079,745 (GRCm39) L456P probably damaging Het
Entpd8 T C 2: 24,975,028 (GRCm39) M453T probably damaging Het
Gcc2 T A 10: 58,114,703 (GRCm39) V1084D probably damaging Het
Grem1 A G 2: 113,580,178 (GRCm39) C108R probably damaging Het
Gtf2ird1 T C 5: 134,392,069 (GRCm39) E880G probably benign Het
Hacd2 T A 16: 34,922,477 (GRCm39) M222K probably damaging Het
Htr1b G T 9: 81,514,652 (GRCm39) probably null Het
Htt T G 5: 35,009,631 (GRCm39) probably null Het
Ifnab T G 4: 88,609,133 (GRCm39) D111A probably benign Het
Igsf10 A T 3: 59,227,053 (GRCm39) L2207I probably benign Het
Itln1 T C 1: 171,358,166 (GRCm39) Y194C probably damaging Het
Kmt5b T A 19: 3,865,043 (GRCm39) D702E probably damaging Het
Knop1 T C 7: 118,449,860 (GRCm39) E382G unknown Het
Lrit3 A C 3: 129,594,452 (GRCm39) L42V probably damaging Het
Mug2 A G 6: 122,052,170 (GRCm39) E976G probably damaging Het
Or5an10 T C 19: 12,275,996 (GRCm39) M167V probably benign Het
Or8g28 A T 9: 39,169,518 (GRCm39) I150N possibly damaging Het
Papln A T 12: 83,827,436 (GRCm39) E758V probably damaging Het
Pcnx3 A C 19: 5,728,960 (GRCm39) F967V possibly damaging Het
Pcnx4 G T 12: 72,602,842 (GRCm39) C368F probably benign Het
Pi15 T A 1: 17,673,105 (GRCm39) Y101* probably null Het
Ppp1r9a G A 6: 4,905,894 (GRCm39) V150M possibly damaging Het
Prrt4 A T 6: 29,176,900 (GRCm39) probably null Het
Ptgdr A G 14: 45,090,828 (GRCm39) V310A probably benign Het
Ric1 G A 19: 29,572,293 (GRCm39) S696N probably benign Het
Setx T A 2: 29,037,430 (GRCm39) V1305D probably damaging Het
Slk G A 19: 47,610,796 (GRCm39) R822H probably damaging Het
Tas2r135 T A 6: 42,383,072 (GRCm39) F204I probably benign Het
Tcaf3 A T 6: 42,571,140 (GRCm39) probably null Het
Tmtc2 A G 10: 105,409,568 (GRCm39) Y15H probably benign Het
Treml2 T C 17: 48,615,168 (GRCm39) S218P probably benign Het
Tubb2a T C 13: 34,258,554 (GRCm39) E412G probably damaging Het
Usp48 T G 4: 137,333,060 (GRCm39) probably null Het
Vmn2r25 A T 6: 123,805,431 (GRCm39) N475K probably damaging Het
Zscan4-ps1 G A 7: 10,799,735 (GRCm39) H385Y probably benign Het
Other mutations in Or8s8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Or8s8 APN 15 98,354,299 (GRCm39) missense possibly damaging 0.61
IGL01016:Or8s8 APN 15 98,354,186 (GRCm39) utr 5 prime probably benign
IGL02372:Or8s8 APN 15 98,354,709 (GRCm39) missense probably damaging 1.00
IGL02730:Or8s8 APN 15 98,354,317 (GRCm39) missense probably damaging 1.00
R0732:Or8s8 UTSW 15 98,354,959 (GRCm39) missense possibly damaging 0.94
R1714:Or8s8 UTSW 15 98,354,614 (GRCm39) missense probably damaging 1.00
R1959:Or8s8 UTSW 15 98,354,634 (GRCm39) missense probably damaging 1.00
R4169:Or8s8 UTSW 15 98,354,878 (GRCm39) missense probably benign 0.00
R4902:Or8s8 UTSW 15 98,354,796 (GRCm39) missense probably damaging 0.99
R5014:Or8s8 UTSW 15 98,354,857 (GRCm39) missense possibly damaging 0.80
R6082:Or8s8 UTSW 15 98,354,647 (GRCm39) missense probably damaging 0.97
R6378:Or8s8 UTSW 15 98,354,425 (GRCm39) missense probably benign 0.42
R7383:Or8s8 UTSW 15 98,354,578 (GRCm39) missense probably damaging 1.00
R7853:Or8s8 UTSW 15 98,354,866 (GRCm39) missense probably benign 0.42
R7912:Or8s8 UTSW 15 98,354,574 (GRCm39) missense probably benign 0.00
R8750:Or8s8 UTSW 15 98,354,929 (GRCm39) missense probably damaging 0.97
R9326:Or8s8 UTSW 15 98,354,935 (GRCm39) missense probably damaging 1.00
R9786:Or8s8 UTSW 15 98,354,713 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- CCACTACACGTGTGAGTTACC -3'
(R):5'- TCGCAGGCACTTCCCTAATG -3'

Sequencing Primer
(F):5'- GCTCAGATATCTCCATCAACGTGG -3'
(R):5'- AATGTCCTTCTCACAGCGG -3'
Posted On 2019-12-20