Incidental Mutation 'R7852:Fstl5'
ID 606973
Institutional Source Beutler Lab
Gene Symbol Fstl5
Ensembl Gene ENSMUSG00000034098
Gene Name follistatin-like 5
Synonyms 9130207J01Rik
MMRRC Submission 045905-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R7852 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 75981582-76617317 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 76615275 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 779 (I779V)
Ref Sequence ENSEMBL: ENSMUSP00000038506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038364] [ENSMUST00000160261] [ENSMUST00000162471]
AlphaFold Q8BFR2
Predicted Effect probably benign
Transcript: ENSMUST00000038364
AA Change: I779V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000038506
Gene: ENSMUSG00000034098
AA Change: I779V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160261
AA Change: I779V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000125393
Gene: ENSMUSG00000034098
AA Change: I779V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162471
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik GTGT GTGTTTGT 11: 43,478,253 (GRCm39) probably null Het
Aco1 A G 4: 40,180,263 (GRCm39) D388G probably benign Het
Adgrl1 T G 8: 84,662,187 (GRCm39) L1016R probably damaging Het
Agmo C T 12: 37,292,051 (GRCm39) P4L possibly damaging Het
Agrn A T 4: 156,253,514 (GRCm39) H1792Q probably benign Het
Arhgef40 C T 14: 52,229,254 (GRCm39) L615F unknown Het
Atp6v1b1 A T 6: 83,729,452 (GRCm39) M121L possibly damaging Het
Cd38 C A 5: 44,058,790 (GRCm39) L135M probably damaging Het
Cep152 A T 2: 125,432,033 (GRCm39) N622K possibly damaging Het
Cfhr1 A C 1: 139,484,165 (GRCm39) V117G probably damaging Het
Dnajb1 T A 8: 84,336,834 (GRCm39) D201E probably benign Het
Dpysl2 T C 14: 67,100,092 (GRCm39) N48S probably benign Het
Dsc2 A G 18: 20,179,342 (GRCm39) I242T possibly damaging Het
Eif1ad10 A C 12: 88,216,588 (GRCm39) Y95D probably damaging Het
Eif1ad3 G A 12: 87,843,742 (GRCm39) V130M unknown Het
Fam193a C A 5: 34,568,161 (GRCm39) D153E probably benign Het
Flnc G T 6: 29,440,897 (GRCm39) D332Y probably damaging Het
Gm29394 T C 15: 57,912,172 (GRCm39) I11V unknown Het
Gm36864 ATCAGAAGTTTC ATC 7: 43,886,361 (GRCm39) probably benign Het
Gnpnat1 G A 14: 45,622,110 (GRCm39) P28S probably damaging Het
Grk5 T C 19: 61,069,383 (GRCm39) probably null Het
Gys2 A T 6: 142,376,059 (GRCm39) F534L probably damaging Het
Igdcc4 G A 9: 65,027,540 (GRCm39) V201I probably benign Het
Khdc4 T A 3: 88,604,043 (GRCm39) S287T probably benign Het
Kif12 G C 4: 63,086,226 (GRCm39) P374A probably benign Het
Krt16 A T 11: 100,137,592 (GRCm39) I371N probably damaging Het
Lrfn2 G A 17: 49,376,972 (GRCm39) V18I possibly damaging Het
Masp2 G A 4: 148,687,189 (GRCm39) E24K probably benign Het
Mdga2 T C 12: 66,517,724 (GRCm39) N37D possibly damaging Het
Med12l T A 3: 59,155,332 (GRCm39) F1171I probably damaging Het
Med22 A T 2: 26,800,376 (GRCm39) Y18N probably damaging Het
Mfsd4b1 T C 10: 39,879,411 (GRCm39) N162S probably benign Het
Micu2 A T 14: 58,169,710 (GRCm39) N213K probably benign Het
Mpc1 C T 17: 8,515,740 (GRCm39) T86I probably damaging Het
Mto1 G T 9: 78,356,820 (GRCm39) V112L possibly damaging Het
Napepld C T 5: 21,888,171 (GRCm39) V93I probably benign Het
Nkx2-2 A T 2: 147,026,189 (GRCm39) M183K probably damaging Het
Nlrp10 A G 7: 108,524,281 (GRCm39) S400P probably damaging Het
Nynrin T C 14: 56,108,886 (GRCm39) L1331P probably damaging Het
Ofcc1 T A 13: 40,333,915 (GRCm39) D392V probably damaging Het
Or10q12 A G 19: 13,745,874 (GRCm39) H56R probably benign Het
Or11a4 T C 17: 37,536,163 (GRCm39) V49A probably benign Het
Or2ag16 A T 7: 106,351,845 (GRCm39) M250K probably damaging Het
Or6c38 T A 10: 128,929,385 (GRCm39) I153F probably benign Het
Patl2 C T 2: 122,009,590 (GRCm39) probably benign Het
Pde8b T G 13: 95,244,205 (GRCm39) D78A probably damaging Het
Pgls T A 8: 72,047,847 (GRCm39) probably null Het
Pik3c2a A G 7: 116,016,693 (GRCm39) S355P probably benign Het
Pole G A 5: 110,454,695 (GRCm39) R976Q probably damaging Het
Ppip5k2 A G 1: 97,668,896 (GRCm39) L511S probably damaging Het
Prcp A T 7: 92,577,900 (GRCm39) N390Y probably benign Het
Rpgrip1 T A 14: 52,383,337 (GRCm39) N752K probably benign Het
Rsl1d1 A G 16: 11,021,098 (GRCm39) S8P probably benign Het
S100a1 C A 3: 90,419,392 (GRCm39) A18S probably benign Het
Slc25a13 A G 6: 6,152,461 (GRCm39) F92S probably damaging Het
Slc35f3 T C 8: 127,121,219 (GRCm39) I360T probably damaging Het
Slc35f6 T C 5: 30,814,159 (GRCm39) Y202H possibly damaging Het
Sox6 A T 7: 115,400,839 (GRCm39) M1K probably null Het
Stx8 G A 11: 67,860,611 (GRCm39) D11N probably damaging Het
Vmn2r130 A G 17: 23,282,788 (GRCm39) N156S probably benign Het
Vmn2r52 T C 7: 9,892,895 (GRCm39) Y748C probably damaging Het
Vmn2r78 T A 7: 86,569,378 (GRCm39) Y90* probably null Het
Zc3h4 A G 7: 16,156,392 (GRCm39) S303G unknown Het
Other mutations in Fstl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01632:Fstl5 APN 3 76,615,135 (GRCm39) missense probably benign 0.30
IGL01658:Fstl5 APN 3 76,389,562 (GRCm39) missense possibly damaging 0.70
IGL01917:Fstl5 APN 3 76,615,153 (GRCm39) missense probably damaging 1.00
IGL02073:Fstl5 APN 3 76,566,959 (GRCm39) splice site probably benign
IGL02329:Fstl5 APN 3 76,496,302 (GRCm39) missense probably damaging 1.00
IGL02651:Fstl5 APN 3 76,500,841 (GRCm39) missense probably damaging 1.00
IGL02967:Fstl5 APN 3 76,229,498 (GRCm39) missense probably damaging 1.00
IGL03004:Fstl5 APN 3 76,555,738 (GRCm39) splice site probably benign
IGL03107:Fstl5 APN 3 76,443,618 (GRCm39) missense probably damaging 1.00
IGL03113:Fstl5 APN 3 76,337,099 (GRCm39) nonsense probably null
P0038:Fstl5 UTSW 3 76,052,369 (GRCm39) missense probably damaging 1.00
PIT4131001:Fstl5 UTSW 3 76,567,006 (GRCm39) missense probably damaging 0.99
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0078:Fstl5 UTSW 3 76,566,952 (GRCm39) splice site probably benign
R0137:Fstl5 UTSW 3 76,614,786 (GRCm39) missense probably damaging 1.00
R0183:Fstl5 UTSW 3 76,229,579 (GRCm39) missense possibly damaging 0.86
R0330:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R0427:Fstl5 UTSW 3 76,615,034 (GRCm39) nonsense probably null
R0687:Fstl5 UTSW 3 76,615,119 (GRCm39) missense possibly damaging 0.62
R1642:Fstl5 UTSW 3 76,317,929 (GRCm39) missense possibly damaging 0.80
R1765:Fstl5 UTSW 3 76,500,783 (GRCm39) missense possibly damaging 0.90
R1900:Fstl5 UTSW 3 76,615,467 (GRCm39) missense probably damaging 1.00
R1996:Fstl5 UTSW 3 76,615,141 (GRCm39) missense probably benign 0.19
R2157:Fstl5 UTSW 3 76,615,372 (GRCm39) missense possibly damaging 0.46
R2228:Fstl5 UTSW 3 76,389,659 (GRCm39) missense probably damaging 1.00
R2851:Fstl5 UTSW 3 76,337,045 (GRCm39) splice site probably benign
R4021:Fstl5 UTSW 3 76,536,282 (GRCm39) missense probably benign 0.00
R4086:Fstl5 UTSW 3 76,555,593 (GRCm39) missense probably damaging 1.00
R4777:Fstl5 UTSW 3 76,500,807 (GRCm39) missense probably damaging 1.00
R4829:Fstl5 UTSW 3 76,229,489 (GRCm39) missense probably damaging 1.00
R4934:Fstl5 UTSW 3 76,496,272 (GRCm39) missense probably damaging 1.00
R4955:Fstl5 UTSW 3 76,131,183 (GRCm39) critical splice donor site probably null
R4977:Fstl5 UTSW 3 76,317,801 (GRCm39) nonsense probably null
R5166:Fstl5 UTSW 3 76,536,267 (GRCm39) missense possibly damaging 0.86
R5232:Fstl5 UTSW 3 76,052,284 (GRCm39) missense possibly damaging 0.89
R5313:Fstl5 UTSW 3 76,500,812 (GRCm39) missense possibly damaging 0.90
R5584:Fstl5 UTSW 3 76,229,574 (GRCm39) missense probably damaging 1.00
R5647:Fstl5 UTSW 3 76,496,399 (GRCm39) missense probably damaging 1.00
R5842:Fstl5 UTSW 3 76,229,590 (GRCm39) missense possibly damaging 0.94
R5978:Fstl5 UTSW 3 76,052,392 (GRCm39) missense probably damaging 1.00
R6007:Fstl5 UTSW 3 76,317,899 (GRCm39) missense probably damaging 1.00
R6064:Fstl5 UTSW 3 76,229,605 (GRCm39) missense probably benign 0.13
R6327:Fstl5 UTSW 3 76,615,108 (GRCm39) missense probably benign 0.31
R6386:Fstl5 UTSW 3 76,229,373 (GRCm39) missense probably benign 0.13
R6523:Fstl5 UTSW 3 76,443,641 (GRCm39) missense probably benign 0.00
R6852:Fstl5 UTSW 3 76,615,162 (GRCm39) missense probably damaging 1.00
R6861:Fstl5 UTSW 3 76,229,523 (GRCm39) missense probably damaging 1.00
R6866:Fstl5 UTSW 3 76,229,532 (GRCm39) missense probably damaging 0.99
R7100:Fstl5 UTSW 3 76,443,600 (GRCm39) missense probably benign 0.11
R7341:Fstl5 UTSW 3 76,389,704 (GRCm39) splice site probably null
R7495:Fstl5 UTSW 3 76,615,099 (GRCm39) missense possibly damaging 0.85
R7558:Fstl5 UTSW 3 76,337,092 (GRCm39) missense possibly damaging 0.95
R7731:Fstl5 UTSW 3 76,569,069 (GRCm39) missense probably damaging 1.00
R7787:Fstl5 UTSW 3 76,337,131 (GRCm39) missense probably damaging 1.00
R7874:Fstl5 UTSW 3 76,569,093 (GRCm39) missense probably benign 0.10
R7881:Fstl5 UTSW 3 76,443,605 (GRCm39) missense probably damaging 1.00
R7986:Fstl5 UTSW 3 76,337,097 (GRCm39) missense probably damaging 0.98
R8039:Fstl5 UTSW 3 76,555,725 (GRCm39) missense possibly damaging 0.69
R8050:Fstl5 UTSW 3 76,614,810 (GRCm39) missense probably benign 0.00
R8844:Fstl5 UTSW 3 76,337,154 (GRCm39) missense possibly damaging 0.71
R8929:Fstl5 UTSW 3 76,615,138 (GRCm39) missense probably damaging 0.98
R9012:Fstl5 UTSW 3 76,567,027 (GRCm39) missense probably damaging 1.00
R9069:Fstl5 UTSW 3 76,615,416 (GRCm39) missense probably damaging 0.99
R9221:Fstl5 UTSW 3 76,569,114 (GRCm39) missense probably damaging 0.98
R9373:Fstl5 UTSW 3 76,555,669 (GRCm39) nonsense probably null
R9427:Fstl5 UTSW 3 76,229,583 (GRCm39) missense
R9490:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R9603:Fstl5 UTSW 3 76,496,260 (GRCm39) missense probably damaging 1.00
Z1176:Fstl5 UTSW 3 76,615,289 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCATCCGAGGAGAGATTCTG -3'
(R):5'- AATTAGGTAAGAGGGCTCCTTAGG -3'

Sequencing Primer
(F):5'- GGATGCTTTTGACATCCACAC -3'
(R):5'- GAGGGCTCCTTAGGCATCG -3'
Posted On 2019-12-20