Incidental Mutation 'R7852:Zc3h4'
ID 606990
Institutional Source Beutler Lab
Gene Symbol Zc3h4
Ensembl Gene ENSMUSG00000059273
Gene Name zinc finger CCCH-type containing 4
Synonyms Kiaa1064-hp, Bwq1, LOC330474
MMRRC Submission 045905-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7852 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 16134835-16171621 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 16156392 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 303 (S303G)
Ref Sequence ENSEMBL: ENSMUSP00000096386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098789] [ENSMUST00000209289]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000098789
AA Change: S303G
SMART Domains Protein: ENSMUSP00000096386
Gene: ENSMUSG00000059273
AA Change: S303G

DomainStartEndE-ValueType
low complexity region 2 22 N/A INTRINSIC
low complexity region 35 97 N/A INTRINSIC
low complexity region 144 170 N/A INTRINSIC
low complexity region 184 247 N/A INTRINSIC
low complexity region 264 324 N/A INTRINSIC
ZnF_C3H1 341 366 1.95e-3 SMART
ZnF_C3H1 370 395 6.17e-6 SMART
ZnF_C3H1 396 419 3.38e-1 SMART
low complexity region 433 451 N/A INTRINSIC
low complexity region 456 486 N/A INTRINSIC
low complexity region 489 505 N/A INTRINSIC
low complexity region 552 641 N/A INTRINSIC
low complexity region 705 720 N/A INTRINSIC
coiled coil region 729 760 N/A INTRINSIC
internal_repeat_2 767 822 3.38e-5 PROSPERO
low complexity region 837 850 N/A INTRINSIC
low complexity region 863 880 N/A INTRINSIC
low complexity region 881 892 N/A INTRINSIC
internal_repeat_2 986 1037 3.38e-5 PROSPERO
low complexity region 1049 1072 N/A INTRINSIC
low complexity region 1077 1097 N/A INTRINSIC
low complexity region 1175 1195 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000209289
AA Change: S311G
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik GTGT GTGTTTGT 11: 43,478,253 (GRCm39) probably null Het
Aco1 A G 4: 40,180,263 (GRCm39) D388G probably benign Het
Adgrl1 T G 8: 84,662,187 (GRCm39) L1016R probably damaging Het
Agmo C T 12: 37,292,051 (GRCm39) P4L possibly damaging Het
Agrn A T 4: 156,253,514 (GRCm39) H1792Q probably benign Het
Arhgef40 C T 14: 52,229,254 (GRCm39) L615F unknown Het
Atp6v1b1 A T 6: 83,729,452 (GRCm39) M121L possibly damaging Het
Cd38 C A 5: 44,058,790 (GRCm39) L135M probably damaging Het
Cep152 A T 2: 125,432,033 (GRCm39) N622K possibly damaging Het
Cfhr1 A C 1: 139,484,165 (GRCm39) V117G probably damaging Het
Dnajb1 T A 8: 84,336,834 (GRCm39) D201E probably benign Het
Dpysl2 T C 14: 67,100,092 (GRCm39) N48S probably benign Het
Dsc2 A G 18: 20,179,342 (GRCm39) I242T possibly damaging Het
Eif1ad10 A C 12: 88,216,588 (GRCm39) Y95D probably damaging Het
Eif1ad3 G A 12: 87,843,742 (GRCm39) V130M unknown Het
Fam193a C A 5: 34,568,161 (GRCm39) D153E probably benign Het
Flnc G T 6: 29,440,897 (GRCm39) D332Y probably damaging Het
Fstl5 A G 3: 76,615,275 (GRCm39) I779V probably benign Het
Gm29394 T C 15: 57,912,172 (GRCm39) I11V unknown Het
Gm36864 ATCAGAAGTTTC ATC 7: 43,886,361 (GRCm39) probably benign Het
Gnpnat1 G A 14: 45,622,110 (GRCm39) P28S probably damaging Het
Grk5 T C 19: 61,069,383 (GRCm39) probably null Het
Gys2 A T 6: 142,376,059 (GRCm39) F534L probably damaging Het
Igdcc4 G A 9: 65,027,540 (GRCm39) V201I probably benign Het
Khdc4 T A 3: 88,604,043 (GRCm39) S287T probably benign Het
Kif12 G C 4: 63,086,226 (GRCm39) P374A probably benign Het
Krt16 A T 11: 100,137,592 (GRCm39) I371N probably damaging Het
Lrfn2 G A 17: 49,376,972 (GRCm39) V18I possibly damaging Het
Masp2 G A 4: 148,687,189 (GRCm39) E24K probably benign Het
Mdga2 T C 12: 66,517,724 (GRCm39) N37D possibly damaging Het
Med12l T A 3: 59,155,332 (GRCm39) F1171I probably damaging Het
Med22 A T 2: 26,800,376 (GRCm39) Y18N probably damaging Het
Mfsd4b1 T C 10: 39,879,411 (GRCm39) N162S probably benign Het
Micu2 A T 14: 58,169,710 (GRCm39) N213K probably benign Het
Mpc1 C T 17: 8,515,740 (GRCm39) T86I probably damaging Het
Mto1 G T 9: 78,356,820 (GRCm39) V112L possibly damaging Het
Napepld C T 5: 21,888,171 (GRCm39) V93I probably benign Het
Nkx2-2 A T 2: 147,026,189 (GRCm39) M183K probably damaging Het
Nlrp10 A G 7: 108,524,281 (GRCm39) S400P probably damaging Het
Nynrin T C 14: 56,108,886 (GRCm39) L1331P probably damaging Het
Ofcc1 T A 13: 40,333,915 (GRCm39) D392V probably damaging Het
Or10q12 A G 19: 13,745,874 (GRCm39) H56R probably benign Het
Or11a4 T C 17: 37,536,163 (GRCm39) V49A probably benign Het
Or2ag16 A T 7: 106,351,845 (GRCm39) M250K probably damaging Het
Or6c38 T A 10: 128,929,385 (GRCm39) I153F probably benign Het
Patl2 C T 2: 122,009,590 (GRCm39) probably benign Het
Pde8b T G 13: 95,244,205 (GRCm39) D78A probably damaging Het
Pgls T A 8: 72,047,847 (GRCm39) probably null Het
Pik3c2a A G 7: 116,016,693 (GRCm39) S355P probably benign Het
Pole G A 5: 110,454,695 (GRCm39) R976Q probably damaging Het
Ppip5k2 A G 1: 97,668,896 (GRCm39) L511S probably damaging Het
Prcp A T 7: 92,577,900 (GRCm39) N390Y probably benign Het
Rpgrip1 T A 14: 52,383,337 (GRCm39) N752K probably benign Het
Rsl1d1 A G 16: 11,021,098 (GRCm39) S8P probably benign Het
S100a1 C A 3: 90,419,392 (GRCm39) A18S probably benign Het
Slc25a13 A G 6: 6,152,461 (GRCm39) F92S probably damaging Het
Slc35f3 T C 8: 127,121,219 (GRCm39) I360T probably damaging Het
Slc35f6 T C 5: 30,814,159 (GRCm39) Y202H possibly damaging Het
Sox6 A T 7: 115,400,839 (GRCm39) M1K probably null Het
Stx8 G A 11: 67,860,611 (GRCm39) D11N probably damaging Het
Vmn2r130 A G 17: 23,282,788 (GRCm39) N156S probably benign Het
Vmn2r52 T C 7: 9,892,895 (GRCm39) Y748C probably damaging Het
Vmn2r78 T A 7: 86,569,378 (GRCm39) Y90* probably null Het
Other mutations in Zc3h4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Zc3h4 APN 7 16,156,159 (GRCm39) missense unknown
IGL00923:Zc3h4 APN 7 16,163,617 (GRCm39) missense unknown
IGL01541:Zc3h4 APN 7 16,168,257 (GRCm39) missense unknown
IGL02115:Zc3h4 APN 7 16,159,708 (GRCm39) missense unknown
IGL02303:Zc3h4 APN 7 16,168,002 (GRCm39) missense unknown
IGL02336:Zc3h4 APN 7 16,159,702 (GRCm39) missense unknown
IGL02734:Zc3h4 APN 7 16,157,849 (GRCm39) missense unknown
IGL02736:Zc3h4 APN 7 16,151,308 (GRCm39) nonsense probably null
BB008:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
BB018:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
R0032:Zc3h4 UTSW 7 16,168,565 (GRCm39) missense unknown
R0032:Zc3h4 UTSW 7 16,168,565 (GRCm39) missense unknown
R0220:Zc3h4 UTSW 7 16,163,198 (GRCm39) missense unknown
R0336:Zc3h4 UTSW 7 16,169,103 (GRCm39) missense unknown
R0416:Zc3h4 UTSW 7 16,154,200 (GRCm39) missense probably damaging 1.00
R0666:Zc3h4 UTSW 7 16,168,697 (GRCm39) missense unknown
R0864:Zc3h4 UTSW 7 16,154,104 (GRCm39) missense probably damaging 0.99
R1068:Zc3h4 UTSW 7 16,163,161 (GRCm39) missense unknown
R1145:Zc3h4 UTSW 7 16,150,838 (GRCm39) missense possibly damaging 0.53
R1145:Zc3h4 UTSW 7 16,150,838 (GRCm39) missense possibly damaging 0.53
R1472:Zc3h4 UTSW 7 16,168,695 (GRCm39) missense unknown
R1665:Zc3h4 UTSW 7 16,163,505 (GRCm39) missense unknown
R2087:Zc3h4 UTSW 7 16,150,865 (GRCm39) missense possibly damaging 0.72
R2182:Zc3h4 UTSW 7 16,156,441 (GRCm39) missense unknown
R2508:Zc3h4 UTSW 7 16,168,264 (GRCm39) missense unknown
R3037:Zc3h4 UTSW 7 16,155,410 (GRCm39) missense unknown
R4439:Zc3h4 UTSW 7 16,163,036 (GRCm39) missense unknown
R4576:Zc3h4 UTSW 7 16,168,579 (GRCm39) missense unknown
R5030:Zc3h4 UTSW 7 16,156,155 (GRCm39) missense unknown
R5160:Zc3h4 UTSW 7 16,168,573 (GRCm39) missense unknown
R5270:Zc3h4 UTSW 7 16,168,440 (GRCm39) missense unknown
R5490:Zc3h4 UTSW 7 16,162,930 (GRCm39) missense unknown
R5519:Zc3h4 UTSW 7 16,169,157 (GRCm39) missense unknown
R5770:Zc3h4 UTSW 7 16,163,536 (GRCm39) missense unknown
R7067:Zc3h4 UTSW 7 16,162,976 (GRCm39) nonsense probably null
R7234:Zc3h4 UTSW 7 16,162,961 (GRCm39) missense unknown
R7316:Zc3h4 UTSW 7 16,169,260 (GRCm39) missense unknown
R7771:Zc3h4 UTSW 7 16,163,824 (GRCm39) missense unknown
R7922:Zc3h4 UTSW 7 16,159,647 (GRCm39) missense unknown
R7931:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
R7965:Zc3h4 UTSW 7 16,163,770 (GRCm39) missense unknown
R8827:Zc3h4 UTSW 7 16,163,123 (GRCm39) missense unknown
R8859:Zc3h4 UTSW 7 16,168,939 (GRCm39) missense unknown
R9457:Zc3h4 UTSW 7 16,168,675 (GRCm39) missense unknown
R9562:Zc3h4 UTSW 7 16,168,891 (GRCm39) missense unknown
R9609:Zc3h4 UTSW 7 16,150,751 (GRCm39) missense unknown
R9721:Zc3h4 UTSW 7 16,168,770 (GRCm39) missense unknown
RF001:Zc3h4 UTSW 7 16,163,612 (GRCm39) small insertion probably benign
RF039:Zc3h4 UTSW 7 16,163,543 (GRCm39) small deletion probably benign
X0064:Zc3h4 UTSW 7 16,156,441 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AAGGAGCTGAACCAGTACCG -3'
(R):5'- GGCCTGGAGAGATTGATCACTAG -3'

Sequencing Primer
(F):5'- TCCAAGGACAGCCGAGGTC -3'
(R):5'- CTGAATTCAAGGCCAGCTTG -3'
Posted On 2019-12-20