Incidental Mutation 'R7852:Igdcc4'
ID 607002
Institutional Source Beutler Lab
Gene Symbol Igdcc4
Ensembl Gene ENSMUSG00000032816
Gene Name immunoglobulin superfamily, DCC subclass, member 4
Synonyms WI-18508, Nope, 9330155G14Rik, WI-16786
MMRRC Submission 045905-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.294) question?
Stock # R7852 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 65008768-65045222 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 65027540 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 201 (V201I)
Ref Sequence ENSEMBL: ENSMUSP00000045387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035499] [ENSMUST00000077696] [ENSMUST00000166273] [ENSMUST00000213533]
AlphaFold Q9EQS9
Predicted Effect probably benign
Transcript: ENSMUST00000035499
AA Change: V201I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000045387
Gene: ENSMUSG00000032816
AA Change: V201I

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IG 40 139 5e0 SMART
IGc2 154 218 1.3e-11 SMART
IGc2 255 318 1.13e-11 SMART
low complexity region 322 335 N/A INTRINSIC
IGc2 346 411 1.34e-13 SMART
FN3 428 511 3.58e-12 SMART
FN3 526 610 9.54e-8 SMART
FN3 630 726 7.34e-9 SMART
FN3 750 832 1.05e-9 SMART
FN3 848 932 2.14e-10 SMART
low complexity region 958 978 N/A INTRINSIC
low complexity region 1085 1100 N/A INTRINSIC
low complexity region 1154 1168 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000077696
AA Change: V201I

PolyPhen 2 Score 0.837 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000076878
Gene: ENSMUSG00000032816
AA Change: V201I

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IG 40 139 5e0 SMART
IGc2 154 218 1.3e-11 SMART
IGc2 255 458 7.02e-8 SMART
FN3 475 558 3.58e-12 SMART
FN3 573 656 1.1e-7 SMART
FN3 676 772 7.34e-9 SMART
FN3 796 878 1.05e-9 SMART
FN3 894 978 2.14e-10 SMART
low complexity region 1004 1024 N/A INTRINSIC
low complexity region 1131 1146 N/A INTRINSIC
low complexity region 1200 1214 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166273
SMART Domains Protein: ENSMUSP00000132576
Gene: ENSMUSG00000032816

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Blast:IG 40 83 3e-22 BLAST
low complexity region 142 156 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213533
AA Change: V201I

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik GTGT GTGTTTGT 11: 43,478,253 (GRCm39) probably null Het
Aco1 A G 4: 40,180,263 (GRCm39) D388G probably benign Het
Adgrl1 T G 8: 84,662,187 (GRCm39) L1016R probably damaging Het
Agmo C T 12: 37,292,051 (GRCm39) P4L possibly damaging Het
Agrn A T 4: 156,253,514 (GRCm39) H1792Q probably benign Het
Arhgef40 C T 14: 52,229,254 (GRCm39) L615F unknown Het
Atp6v1b1 A T 6: 83,729,452 (GRCm39) M121L possibly damaging Het
Cd38 C A 5: 44,058,790 (GRCm39) L135M probably damaging Het
Cep152 A T 2: 125,432,033 (GRCm39) N622K possibly damaging Het
Cfhr1 A C 1: 139,484,165 (GRCm39) V117G probably damaging Het
Dnajb1 T A 8: 84,336,834 (GRCm39) D201E probably benign Het
Dpysl2 T C 14: 67,100,092 (GRCm39) N48S probably benign Het
Dsc2 A G 18: 20,179,342 (GRCm39) I242T possibly damaging Het
Eif1ad10 A C 12: 88,216,588 (GRCm39) Y95D probably damaging Het
Eif1ad3 G A 12: 87,843,742 (GRCm39) V130M unknown Het
Fam193a C A 5: 34,568,161 (GRCm39) D153E probably benign Het
Flnc G T 6: 29,440,897 (GRCm39) D332Y probably damaging Het
Fstl5 A G 3: 76,615,275 (GRCm39) I779V probably benign Het
Gm29394 T C 15: 57,912,172 (GRCm39) I11V unknown Het
Gm36864 ATCAGAAGTTTC ATC 7: 43,886,361 (GRCm39) probably benign Het
Gnpnat1 G A 14: 45,622,110 (GRCm39) P28S probably damaging Het
Grk5 T C 19: 61,069,383 (GRCm39) probably null Het
Gys2 A T 6: 142,376,059 (GRCm39) F534L probably damaging Het
Khdc4 T A 3: 88,604,043 (GRCm39) S287T probably benign Het
Kif12 G C 4: 63,086,226 (GRCm39) P374A probably benign Het
Krt16 A T 11: 100,137,592 (GRCm39) I371N probably damaging Het
Lrfn2 G A 17: 49,376,972 (GRCm39) V18I possibly damaging Het
Masp2 G A 4: 148,687,189 (GRCm39) E24K probably benign Het
Mdga2 T C 12: 66,517,724 (GRCm39) N37D possibly damaging Het
Med12l T A 3: 59,155,332 (GRCm39) F1171I probably damaging Het
Med22 A T 2: 26,800,376 (GRCm39) Y18N probably damaging Het
Mfsd4b1 T C 10: 39,879,411 (GRCm39) N162S probably benign Het
Micu2 A T 14: 58,169,710 (GRCm39) N213K probably benign Het
Mpc1 C T 17: 8,515,740 (GRCm39) T86I probably damaging Het
Mto1 G T 9: 78,356,820 (GRCm39) V112L possibly damaging Het
Napepld C T 5: 21,888,171 (GRCm39) V93I probably benign Het
Nkx2-2 A T 2: 147,026,189 (GRCm39) M183K probably damaging Het
Nlrp10 A G 7: 108,524,281 (GRCm39) S400P probably damaging Het
Nynrin T C 14: 56,108,886 (GRCm39) L1331P probably damaging Het
Ofcc1 T A 13: 40,333,915 (GRCm39) D392V probably damaging Het
Or10q12 A G 19: 13,745,874 (GRCm39) H56R probably benign Het
Or11a4 T C 17: 37,536,163 (GRCm39) V49A probably benign Het
Or2ag16 A T 7: 106,351,845 (GRCm39) M250K probably damaging Het
Or6c38 T A 10: 128,929,385 (GRCm39) I153F probably benign Het
Patl2 C T 2: 122,009,590 (GRCm39) probably benign Het
Pde8b T G 13: 95,244,205 (GRCm39) D78A probably damaging Het
Pgls T A 8: 72,047,847 (GRCm39) probably null Het
Pik3c2a A G 7: 116,016,693 (GRCm39) S355P probably benign Het
Pole G A 5: 110,454,695 (GRCm39) R976Q probably damaging Het
Ppip5k2 A G 1: 97,668,896 (GRCm39) L511S probably damaging Het
Prcp A T 7: 92,577,900 (GRCm39) N390Y probably benign Het
Rpgrip1 T A 14: 52,383,337 (GRCm39) N752K probably benign Het
Rsl1d1 A G 16: 11,021,098 (GRCm39) S8P probably benign Het
S100a1 C A 3: 90,419,392 (GRCm39) A18S probably benign Het
Slc25a13 A G 6: 6,152,461 (GRCm39) F92S probably damaging Het
Slc35f3 T C 8: 127,121,219 (GRCm39) I360T probably damaging Het
Slc35f6 T C 5: 30,814,159 (GRCm39) Y202H possibly damaging Het
Sox6 A T 7: 115,400,839 (GRCm39) M1K probably null Het
Stx8 G A 11: 67,860,611 (GRCm39) D11N probably damaging Het
Vmn2r130 A G 17: 23,282,788 (GRCm39) N156S probably benign Het
Vmn2r52 T C 7: 9,892,895 (GRCm39) Y748C probably damaging Het
Vmn2r78 T A 7: 86,569,378 (GRCm39) Y90* probably null Het
Zc3h4 A G 7: 16,156,392 (GRCm39) S303G unknown Het
Other mutations in Igdcc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Igdcc4 APN 9 65,042,446 (GRCm39) missense probably damaging 1.00
IGL01285:Igdcc4 APN 9 65,031,273 (GRCm39) missense probably damaging 1.00
IGL01412:Igdcc4 APN 9 65,021,731 (GRCm39) splice site probably benign
IGL01485:Igdcc4 APN 9 65,029,889 (GRCm39) missense probably benign 0.02
IGL01552:Igdcc4 APN 9 65,029,784 (GRCm39) intron probably benign
IGL01651:Igdcc4 APN 9 65,031,394 (GRCm39) missense possibly damaging 0.63
IGL01751:Igdcc4 APN 9 65,039,014 (GRCm39) missense probably damaging 1.00
IGL02164:Igdcc4 APN 9 65,032,064 (GRCm39) splice site probably benign
IGL02468:Igdcc4 APN 9 65,034,114 (GRCm39) missense probably damaging 1.00
IGL02616:Igdcc4 APN 9 65,040,360 (GRCm39) missense probably damaging 1.00
IGL02685:Igdcc4 APN 9 65,041,107 (GRCm39) missense possibly damaging 0.81
IGL02734:Igdcc4 APN 9 65,038,738 (GRCm39) missense possibly damaging 0.47
IGL02893:Igdcc4 APN 9 65,040,353 (GRCm39) missense probably damaging 1.00
R0006:Igdcc4 UTSW 9 65,042,382 (GRCm39) splice site probably benign
R0583:Igdcc4 UTSW 9 65,029,095 (GRCm39) missense possibly damaging 0.85
R0939:Igdcc4 UTSW 9 65,038,755 (GRCm39) critical splice donor site probably null
R1075:Igdcc4 UTSW 9 65,038,932 (GRCm39) missense possibly damaging 0.90
R1110:Igdcc4 UTSW 9 65,034,208 (GRCm39) missense possibly damaging 0.91
R1183:Igdcc4 UTSW 9 65,029,182 (GRCm39) missense possibly damaging 0.91
R1318:Igdcc4 UTSW 9 65,040,972 (GRCm39) missense probably damaging 1.00
R1507:Igdcc4 UTSW 9 65,041,026 (GRCm39) missense probably damaging 1.00
R1548:Igdcc4 UTSW 9 65,042,509 (GRCm39) missense probably benign 0.08
R1640:Igdcc4 UTSW 9 65,030,077 (GRCm39) missense probably damaging 1.00
R1681:Igdcc4 UTSW 9 65,036,077 (GRCm39) missense probably damaging 1.00
R1687:Igdcc4 UTSW 9 65,038,945 (GRCm39) missense probably damaging 1.00
R1716:Igdcc4 UTSW 9 65,034,179 (GRCm39) missense probably damaging 1.00
R1964:Igdcc4 UTSW 9 65,030,051 (GRCm39) missense probably benign
R1996:Igdcc4 UTSW 9 65,029,101 (GRCm39) missense probably damaging 1.00
R2150:Igdcc4 UTSW 9 65,032,617 (GRCm39) missense possibly damaging 0.92
R2278:Igdcc4 UTSW 9 65,038,025 (GRCm39) missense probably damaging 1.00
R3085:Igdcc4 UTSW 9 65,039,340 (GRCm39) missense probably damaging 1.00
R4011:Igdcc4 UTSW 9 65,042,761 (GRCm39) missense probably benign
R4077:Igdcc4 UTSW 9 65,039,047 (GRCm39) missense probably damaging 1.00
R4191:Igdcc4 UTSW 9 65,031,433 (GRCm39) missense probably benign 0.13
R4293:Igdcc4 UTSW 9 65,031,892 (GRCm39) critical splice acceptor site probably null
R4589:Igdcc4 UTSW 9 65,037,910 (GRCm39) missense probably damaging 1.00
R4931:Igdcc4 UTSW 9 65,031,297 (GRCm39) missense possibly damaging 0.66
R5093:Igdcc4 UTSW 9 65,030,039 (GRCm39) missense possibly damaging 0.51
R5106:Igdcc4 UTSW 9 65,031,983 (GRCm39) missense probably damaging 1.00
R5546:Igdcc4 UTSW 9 65,036,077 (GRCm39) missense probably damaging 1.00
R5634:Igdcc4 UTSW 9 65,041,828 (GRCm39) missense probably benign 0.18
R5810:Igdcc4 UTSW 9 65,035,977 (GRCm39) missense probably damaging 1.00
R6395:Igdcc4 UTSW 9 65,042,400 (GRCm39) missense probably damaging 1.00
R6475:Igdcc4 UTSW 9 65,027,603 (GRCm39) missense probably damaging 1.00
R6776:Igdcc4 UTSW 9 65,042,700 (GRCm39) missense probably benign 0.02
R6828:Igdcc4 UTSW 9 65,029,979 (GRCm39) missense probably benign
R6914:Igdcc4 UTSW 9 65,027,550 (GRCm39) missense probably benign 0.00
R6942:Igdcc4 UTSW 9 65,027,550 (GRCm39) missense probably benign 0.00
R7072:Igdcc4 UTSW 9 65,038,013 (GRCm39) missense probably damaging 1.00
R7234:Igdcc4 UTSW 9 65,042,750 (GRCm39) nonsense probably null
R7448:Igdcc4 UTSW 9 65,031,276 (GRCm39) missense possibly damaging 0.52
R7562:Igdcc4 UTSW 9 65,031,306 (GRCm39) missense probably damaging 1.00
R7607:Igdcc4 UTSW 9 65,041,040 (GRCm39) missense possibly damaging 0.85
R7734:Igdcc4 UTSW 9 65,039,035 (GRCm39) missense probably damaging 0.99
R7807:Igdcc4 UTSW 9 65,041,077 (GRCm39) missense probably benign 0.00
R7904:Igdcc4 UTSW 9 65,041,801 (GRCm39) missense probably benign 0.00
R8133:Igdcc4 UTSW 9 65,039,023 (GRCm39) missense possibly damaging 0.54
R8147:Igdcc4 UTSW 9 65,031,253 (GRCm39) missense probably benign 0.42
R8230:Igdcc4 UTSW 9 65,030,020 (GRCm39) missense probably damaging 1.00
R8822:Igdcc4 UTSW 9 65,031,298 (GRCm39) missense possibly damaging 0.50
R8846:Igdcc4 UTSW 9 65,037,898 (GRCm39) missense probably benign 0.12
R9250:Igdcc4 UTSW 9 65,038,932 (GRCm39) missense possibly damaging 0.90
R9613:Igdcc4 UTSW 9 65,027,522 (GRCm39) missense possibly damaging 0.87
R9681:Igdcc4 UTSW 9 65,041,858 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- AAAGAGCATGTCCTGGGTG -3'
(R):5'- ATCAGCTTTCCAAAGACCCG -3'

Sequencing Primer
(F):5'- GCTGGACAGATGTGCCTTC -3'
(R):5'- GACCCGGGTCTAGTCACTTTC -3'
Posted On 2019-12-20