Incidental Mutation 'R7853:Mllt6'
ID 607085
Institutional Source Beutler Lab
Gene Symbol Mllt6
Ensembl Gene ENSMUSG00000038437
Gene Name myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms Af17
MMRRC Submission 045906-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7853 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 97554240-97576289 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 97561142 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 277 (V277I)
Ref Sequence ENSEMBL: ENSMUSP00000045445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044730] [ENSMUST00000107586]
AlphaFold B1AR10
Predicted Effect probably benign
Transcript: ENSMUST00000044730
AA Change: V277I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000045445
Gene: ENSMUSG00000038437
AA Change: V277I

DomainStartEndE-ValueType
PHD 7 55 5.92e-7 SMART
PHD 119 178 5e-5 SMART
low complexity region 190 224 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 290 330 N/A INTRINSIC
low complexity region 358 380 N/A INTRINSIC
low complexity region 398 412 N/A INTRINSIC
low complexity region 487 498 N/A INTRINSIC
low complexity region 502 516 N/A INTRINSIC
low complexity region 520 536 N/A INTRINSIC
low complexity region 559 573 N/A INTRINSIC
low complexity region 579 601 N/A INTRINSIC
low complexity region 649 666 N/A INTRINSIC
coiled coil region 703 744 N/A INTRINSIC
low complexity region 746 756 N/A INTRINSIC
low complexity region 773 782 N/A INTRINSIC
low complexity region 802 848 N/A INTRINSIC
low complexity region 860 901 N/A INTRINSIC
coiled coil region 915 942 N/A INTRINSIC
low complexity region 995 1018 N/A INTRINSIC
low complexity region 1026 1037 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107586
AA Change: V277I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000103212
Gene: ENSMUSG00000038437
AA Change: V277I

DomainStartEndE-ValueType
PHD 7 55 5.92e-7 SMART
PHD 119 178 5e-5 SMART
low complexity region 190 224 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 290 330 N/A INTRINSIC
low complexity region 336 356 N/A INTRINSIC
low complexity region 388 410 N/A INTRINSIC
low complexity region 428 442 N/A INTRINSIC
low complexity region 517 528 N/A INTRINSIC
low complexity region 532 546 N/A INTRINSIC
low complexity region 550 566 N/A INTRINSIC
low complexity region 589 603 N/A INTRINSIC
low complexity region 609 631 N/A INTRINSIC
low complexity region 679 696 N/A INTRINSIC
coiled coil region 733 774 N/A INTRINSIC
low complexity region 776 786 N/A INTRINSIC
low complexity region 803 812 N/A INTRINSIC
low complexity region 832 878 N/A INTRINSIC
low complexity region 890 931 N/A INTRINSIC
coiled coil region 945 972 N/A INTRINSIC
low complexity region 1025 1048 N/A INTRINSIC
low complexity region 1056 1067 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik A G 2: 151,315,600 (GRCm39) I26T probably damaging Het
Aadacl4 G T 4: 144,344,592 (GRCm39) A123S probably benign Het
Adamts20 A C 15: 94,243,871 (GRCm39) C619G probably damaging Het
Ahcyl1 C A 3: 107,575,604 (GRCm39) V394L probably benign Het
Ankrd17 A C 5: 90,386,825 (GRCm39) L2378V possibly damaging Het
B3gnt3 T C 8: 72,145,357 (GRCm39) Y337C probably damaging Het
Bcl10 A G 3: 145,630,266 (GRCm39) K18R possibly damaging Het
Calcr G A 6: 3,707,499 (GRCm39) A267V probably benign Het
Ces1d C T 8: 93,901,695 (GRCm39) G425S probably benign Het
Col1a1 G T 11: 94,838,505 (GRCm39) R899L unknown Het
Commd1 C T 11: 22,906,532 (GRCm39) R168H possibly damaging Het
Cps1 T C 1: 67,213,640 (GRCm39) S791P possibly damaging Het
Ctsj T A 13: 61,151,884 (GRCm39) I58F probably damaging Het
Cyp2j5 T A 4: 96,529,656 (GRCm39) K238N probably benign Het
Dlgap4 A G 2: 156,547,802 (GRCm39) D423G probably benign Het
Eef1ece2 T A 16: 20,463,010 (GRCm39) probably null Het
Egln1 T C 8: 125,675,256 (GRCm39) N180D probably benign Het
Ehd1 T C 19: 6,327,225 (GRCm39) F74S probably damaging Het
Ext1 G A 15: 52,970,881 (GRCm39) A350V probably damaging Het
Fam186b T A 15: 99,178,628 (GRCm39) I233F probably damaging Het
Fam193a T G 5: 34,597,473 (GRCm39) N91K probably benign Het
Far1 T A 7: 113,153,355 (GRCm39) N329K probably damaging Het
Fhad1 A G 4: 141,637,134 (GRCm39) S1111P probably damaging Het
Fhl2 A G 1: 43,180,984 (GRCm39) S69P probably damaging Het
Flg2 C A 3: 93,128,054 (GRCm39) P2322Q unknown Het
Flvcr1 A G 1: 190,757,843 (GRCm39) Y108H probably damaging Het
Fos T A 12: 85,522,792 (GRCm39) S235T probably benign Het
Foxf1 T A 8: 121,811,438 (GRCm39) S101T probably damaging Het
Gfer C A 17: 24,913,259 (GRCm39) D198Y probably damaging Het
Ggps1 T C 13: 14,229,034 (GRCm39) I50V probably benign Het
Gkn2 A G 6: 87,355,255 (GRCm39) T155A probably benign Het
Gna12 C T 5: 140,746,449 (GRCm39) C332Y probably damaging Het
Hc T A 2: 34,900,045 (GRCm39) Y1096F probably damaging Het
Hoxa3 G A 6: 52,147,267 (GRCm39) probably benign Het
Hsd17b8 T G 17: 34,246,411 (GRCm39) D117A probably benign Het
Ifi206 A T 1: 173,299,100 (GRCm39) Y835* probably null Het
Ighv13-2 T G 12: 114,321,544 (GRCm39) E65A probably damaging Het
Kif5a A T 10: 127,071,537 (GRCm39) Y770* probably null Het
Lfng A G 5: 140,593,384 (GRCm39) S72G probably benign Het
Lipo2 C T 19: 33,737,344 (GRCm39) probably benign Het
Lnpep C T 17: 17,783,109 (GRCm39) S564N probably benign Het
Mfhas1 T A 8: 36,057,025 (GRCm39) L500* probably null Het
Mroh5 C T 15: 73,663,189 (GRCm39) D192N probably benign Het
Myo1f T A 17: 33,795,672 (GRCm39) V106D probably damaging Het
Mypn T A 10: 62,981,652 (GRCm39) I643F probably benign Het
Nup188 A G 2: 30,213,575 (GRCm39) N669D possibly damaging Het
Or14j5 C G 17: 38,161,714 (GRCm39) T77R probably damaging Het
Or2r11 A T 6: 42,437,573 (GRCm39) C127S probably damaging Het
Or5g26 T C 2: 85,494,689 (GRCm39) T30A probably benign Het
Or8s8 T C 15: 98,354,866 (GRCm39) V225A probably benign Het
Osbpl10 A G 9: 115,036,726 (GRCm39) T241A probably damaging Het
Peg3 C T 7: 6,711,839 (GRCm39) E1128K possibly damaging Het
Plch1 C A 3: 63,681,068 (GRCm39) M186I probably benign Het
Pon3 A C 6: 5,236,911 (GRCm39) L152R probably damaging Het
Prr36 G A 8: 4,263,905 (GRCm39) P587L unknown Het
Psma2 T A 13: 14,799,832 (GRCm39) I192N probably damaging Het
Rbm11 T C 16: 75,389,923 (GRCm39) F30L probably damaging Het
Rpap3 G A 15: 97,576,299 (GRCm39) A622V possibly damaging Het
Scgb2b11 T A 7: 31,908,807 (GRCm39) N98Y probably damaging Het
Siglec1 A G 2: 130,923,212 (GRCm39) L511P probably damaging Het
Sirpb1c C T 3: 15,887,156 (GRCm39) V228M probably damaging Het
Smpd4 T A 16: 17,460,605 (GRCm39) Y804N probably damaging Het
Sult6b2 T C 6: 142,747,524 (GRCm39) D75G not run Het
Sycp3 A C 10: 88,302,368 (GRCm39) K119N probably damaging Het
Syne2 T C 12: 76,078,278 (GRCm39) L4703P probably damaging Het
Tex12 C G 9: 50,470,523 (GRCm39) L20F possibly damaging Het
Them5 T A 3: 94,250,603 (GRCm39) Y55* probably null Het
Tmem43 A T 6: 91,458,968 (GRCm39) D213V probably benign Het
Tnfrsf10b A C 14: 70,005,239 (GRCm39) Q44P unknown Het
Trbv2 A T 6: 41,024,836 (GRCm39) Q84L probably benign Het
Trim2 C T 3: 84,212,537 (GRCm39) probably benign Het
Trim36 A G 18: 46,305,558 (GRCm39) V475A probably benign Het
Ttbk1 C A 17: 46,758,269 (GRCm39) E788D probably benign Het
Ttn T C 2: 76,543,626 (GRCm39) D33120G probably damaging Het
Ttn T A 2: 76,576,256 (GRCm39) N24879I probably damaging Het
Ube4a T A 9: 44,864,308 (GRCm39) Q76L probably benign Het
Vmn2r27 T A 6: 124,168,980 (GRCm39) I717F probably damaging Het
Vmn2r45 T C 7: 8,485,987 (GRCm39) K434E possibly damaging Het
Vta1 T C 10: 14,531,461 (GRCm39) T305A probably damaging Het
Zfp354c TCACACTCGGCACA TCACA 11: 50,706,067 (GRCm39) probably benign Het
Other mutations in Mllt6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01745:Mllt6 APN 11 97,567,754 (GRCm39) missense probably damaging 1.00
IGL01808:Mllt6 APN 11 97,563,310 (GRCm39) missense possibly damaging 0.88
IGL01967:Mllt6 APN 11 97,565,603 (GRCm39) missense probably damaging 0.98
IGL02247:Mllt6 APN 11 97,561,158 (GRCm39) missense probably benign 0.01
IGL03161:Mllt6 APN 11 97,557,977 (GRCm39) missense probably benign 0.03
R0284:Mllt6 UTSW 11 97,569,431 (GRCm39) missense probably benign 0.02
R0718:Mllt6 UTSW 11 97,567,185 (GRCm39) splice site probably benign
R0783:Mllt6 UTSW 11 97,556,571 (GRCm39) missense probably damaging 0.99
R0811:Mllt6 UTSW 11 97,569,387 (GRCm39) missense probably damaging 0.97
R0812:Mllt6 UTSW 11 97,569,387 (GRCm39) missense probably damaging 0.97
R0904:Mllt6 UTSW 11 97,555,824 (GRCm39) missense probably damaging 1.00
R0960:Mllt6 UTSW 11 97,555,772 (GRCm39) splice site probably benign
R1445:Mllt6 UTSW 11 97,563,277 (GRCm39) splice site probably benign
R1523:Mllt6 UTSW 11 97,555,849 (GRCm39) missense probably damaging 1.00
R1781:Mllt6 UTSW 11 97,563,395 (GRCm39) missense probably benign
R1952:Mllt6 UTSW 11 97,568,048 (GRCm39) missense probably damaging 0.99
R2258:Mllt6 UTSW 11 97,555,802 (GRCm39) missense probably damaging 1.00
R2259:Mllt6 UTSW 11 97,555,802 (GRCm39) missense probably damaging 1.00
R2927:Mllt6 UTSW 11 97,571,602 (GRCm39) missense probably damaging 0.98
R4866:Mllt6 UTSW 11 97,565,285 (GRCm39) missense probably damaging 1.00
R4938:Mllt6 UTSW 11 97,569,233 (GRCm39) missense probably benign
R5039:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5058:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5064:Mllt6 UTSW 11 97,564,775 (GRCm39) missense probably damaging 1.00
R5076:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5115:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5379:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5509:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5510:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5511:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5603:Mllt6 UTSW 11 97,564,331 (GRCm39) missense probably damaging 1.00
R5816:Mllt6 UTSW 11 97,563,400 (GRCm39) missense probably damaging 0.97
R6030:Mllt6 UTSW 11 97,568,051 (GRCm39) missense probably damaging 0.99
R6030:Mllt6 UTSW 11 97,568,051 (GRCm39) missense probably damaging 0.99
R6051:Mllt6 UTSW 11 97,571,569 (GRCm39) nonsense probably null
R6180:Mllt6 UTSW 11 97,569,362 (GRCm39) missense possibly damaging 0.85
R6277:Mllt6 UTSW 11 97,564,774 (GRCm39) missense probably damaging 1.00
R6667:Mllt6 UTSW 11 97,567,760 (GRCm39) missense probably damaging 1.00
R6754:Mllt6 UTSW 11 97,565,273 (GRCm39) missense probably damaging 1.00
R6791:Mllt6 UTSW 11 97,571,428 (GRCm39) missense probably damaging 0.98
R7049:Mllt6 UTSW 11 97,564,637 (GRCm39) missense probably damaging 1.00
R7194:Mllt6 UTSW 11 97,564,394 (GRCm39) missense probably benign 0.23
R7387:Mllt6 UTSW 11 97,565,426 (GRCm39) missense probably benign 0.04
R7484:Mllt6 UTSW 11 97,563,442 (GRCm39) missense probably benign 0.18
R7685:Mllt6 UTSW 11 97,567,790 (GRCm39) missense probably damaging 0.99
R7862:Mllt6 UTSW 11 97,556,631 (GRCm39) missense probably benign 0.03
R8004:Mllt6 UTSW 11 97,566,966 (GRCm39) missense possibly damaging 0.91
R8498:Mllt6 UTSW 11 97,567,688 (GRCm39) missense possibly damaging 0.86
R9044:Mllt6 UTSW 11 97,554,485 (GRCm39) missense probably damaging 1.00
R9297:Mllt6 UTSW 11 97,563,314 (GRCm39) missense probably damaging 0.96
R9457:Mllt6 UTSW 11 97,556,586 (GRCm39) missense probably benign 0.12
R9557:Mllt6 UTSW 11 97,564,310 (GRCm39) missense probably benign 0.04
Z1177:Mllt6 UTSW 11 97,567,251 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- TGAGCCCCATTTCTAAGAGGG -3'
(R):5'- CTCAAGAAGTGTTGAGGTTTGC -3'

Sequencing Primer
(F):5'- TAAGAGGGGTTCAGTTCTCCACAC -3'
(R):5'- AGACCCTCTGTGAGCTCAG -3'
Posted On 2019-12-20