Incidental Mutation 'IGL00332:Gpr75'
ID 6071
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr75
Ensembl Gene ENSMUSG00000043999
Gene Name G protein-coupled receptor 75
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL00332
Quality Score
Status
Chromosome 11
Chromosomal Location 30835358-30843729 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 30841590 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 165 (T165I)
Ref Sequence ENSEMBL: ENSMUSP00000105057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109430] [ENSMUST00000203878]
AlphaFold Q6X632
Predicted Effect probably damaging
Transcript: ENSMUST00000109430
AA Change: T165I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105057
Gene: ENSMUSG00000043999
AA Change: T165I

DomainStartEndE-ValueType
Pfam:7tm_1 59 376 1.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203878
SMART Domains Protein: ENSMUSP00000144900
Gene: ENSMUSG00000020305

DomainStartEndE-ValueType
low complexity region 20 36 N/A INTRINSIC
ANK 48 77 3.5e-2 SMART
ANK 81 110 8e-3 SMART
ANK 117 146 4.8e-5 SMART
ANK 150 179 1.7e-7 SMART
ANK 184 213 1.8e-4 SMART
ANK 217 246 1.8e-6 SMART
ANK 250 279 1.2e-7 SMART
ANK 285 315 1.1e0 SMART
ANK 318 347 1.2e-3 SMART
ANK 354 385 7.7e-1 SMART
SOCS 493 542 2.8e-4 SMART
SOCS_box 499 541 1.6e-17 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 T C 3: 97,083,737 (GRCm39) Y404H possibly damaging Het
Adgrv1 T A 13: 81,620,996 (GRCm39) probably benign Het
Akap13 A G 7: 75,378,667 (GRCm39) K2107E probably damaging Het
Ankrd42 A G 7: 92,233,662 (GRCm39) probably benign Het
Apba3 C T 10: 81,108,901 (GRCm39) P555S probably damaging Het
Aplnr A G 2: 84,967,985 (GRCm39) S337G probably benign Het
Arhgef40 A G 14: 52,226,417 (GRCm39) N154D probably damaging Het
Asb14 A G 14: 26,633,998 (GRCm39) K401R probably benign Het
Aspn C A 13: 49,719,968 (GRCm39) T328K probably benign Het
Barhl2 C T 5: 106,603,365 (GRCm39) A265T possibly damaging Het
Brca2 T A 5: 150,463,363 (GRCm39) H1042Q probably benign Het
C3 A G 17: 57,533,004 (GRCm39) L167P probably benign Het
Ccdc33 A G 9: 57,977,257 (GRCm39) probably benign Het
Cdk10 T A 8: 123,957,063 (GRCm39) M222K possibly damaging Het
Cfap45 C T 1: 172,362,912 (GRCm39) probably benign Het
Chil3 T A 3: 106,056,017 (GRCm39) N352I probably damaging Het
Chn2 G T 6: 54,272,907 (GRCm39) probably null Het
Cimip2b G A 4: 43,428,158 (GRCm39) R100W possibly damaging Het
Cpt1b T C 15: 89,305,066 (GRCm39) E394G probably benign Het
Fcgr2b T A 1: 170,788,799 (GRCm39) N273I possibly damaging Het
Fpr-rs7 G A 17: 20,333,480 (GRCm39) Q337* probably null Het
Fras1 T A 5: 96,887,217 (GRCm39) N2666K possibly damaging Het
Gfra3 C T 18: 34,824,601 (GRCm39) probably null Het
Gm4553 T C 7: 141,718,964 (GRCm39) S155G unknown Het
Gzmd A T 14: 56,367,737 (GRCm39) C179S probably damaging Het
Hand1 T G 11: 57,722,575 (GRCm39) H13P probably damaging Het
Irak3 C T 10: 120,013,972 (GRCm39) probably null Het
Isl2 T A 9: 55,452,253 (GRCm39) L275Q possibly damaging Het
Itgb2 T C 10: 77,393,240 (GRCm39) V367A probably damaging Het
Katna1 T C 10: 7,638,758 (GRCm39) probably benign Het
Myh6 A G 14: 55,184,450 (GRCm39) M1627T probably benign Het
Naprt A G 15: 75,765,164 (GRCm39) Y187H probably damaging Het
Nedd4 T A 9: 72,642,371 (GRCm39) V550E probably damaging Het
Nt5c2 A G 19: 46,884,954 (GRCm39) V252A possibly damaging Het
Or8k39 T C 2: 86,563,579 (GRCm39) I126V possibly damaging Het
Or9i16 C T 19: 13,864,945 (GRCm39) V210I probably benign Het
P2ry2 A G 7: 100,647,393 (GRCm39) V304A probably damaging Het
Pde4dip T C 3: 97,674,593 (GRCm39) N108D probably benign Het
Pdgfrl A G 8: 41,438,660 (GRCm39) T199A probably damaging Het
Plaa A G 4: 94,470,844 (GRCm39) Y431H probably benign Het
Pls1 A T 9: 95,664,472 (GRCm39) I177N possibly damaging Het
Plxna2 T C 1: 194,472,138 (GRCm39) F1035L probably damaging Het
Ppp6r3 A T 19: 3,564,729 (GRCm39) probably null Het
Prpf4b T C 13: 35,067,890 (GRCm39) S240P probably benign Het
Reg2 T A 6: 78,383,204 (GRCm39) Y50* probably null Het
Rev3l C T 10: 39,682,965 (GRCm39) T361I probably benign Het
Rps4l A G 6: 148,256,383 (GRCm39) probably benign Het
Scn11a A T 9: 119,598,982 (GRCm39) F1183I probably damaging Het
Sh2b2 T C 5: 136,253,273 (GRCm39) E327G probably damaging Het
Shank2 A G 7: 143,965,584 (GRCm39) K1057R probably damaging Het
Sim2 T A 16: 93,915,803 (GRCm39) Y255* probably null Het
Snx9 A G 17: 5,949,636 (GRCm39) N112S probably benign Het
Sphkap T A 1: 83,258,237 (GRCm39) I169F probably damaging Het
Spink5 A G 18: 44,100,111 (GRCm39) T43A probably benign Het
Stac2 C T 11: 97,932,005 (GRCm39) S265N probably benign Het
Tbx20 A G 9: 24,670,044 (GRCm39) V91A probably damaging Het
Tgfbr2 C T 9: 115,939,257 (GRCm39) R190H probably damaging Het
Ubr2 A G 17: 47,301,916 (GRCm39) probably null Het
Wdfy3 C T 5: 102,063,204 (GRCm39) probably null Het
Wdr82 T C 9: 106,061,449 (GRCm39) V166A probably benign Het
Zfhx4 C T 3: 5,307,401 (GRCm39) A209V probably damaging Het
Zfp518b T A 5: 38,831,109 (GRCm39) T299S possibly damaging Het
Other mutations in Gpr75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00787:Gpr75 APN 11 30,842,290 (GRCm39) missense probably benign 0.00
IGL01102:Gpr75 APN 11 30,841,755 (GRCm39) missense probably benign 0.41
IGL01790:Gpr75 APN 11 30,841,132 (GRCm39) missense probably damaging 0.97
IGL01975:Gpr75 APN 11 30,841,835 (GRCm39) missense probably benign 0.09
IGL02266:Gpr75 APN 11 30,841,977 (GRCm39) missense probably benign 0.01
IGL02338:Gpr75 APN 11 30,841,730 (GRCm39) missense probably benign 0.00
IGL02394:Gpr75 APN 11 30,842,190 (GRCm39) missense possibly damaging 0.92
IGL03208:Gpr75 APN 11 30,842,699 (GRCm39) missense probably damaging 1.00
Thinner UTSW 11 30,841,527 (GRCm39) missense probably damaging 1.00
R0053:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
R0053:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
R0449:Gpr75 UTSW 11 30,842,456 (GRCm39) missense probably damaging 0.99
R1289:Gpr75 UTSW 11 30,842,706 (GRCm39) missense probably benign 0.23
R1760:Gpr75 UTSW 11 30,841,527 (GRCm39) missense probably damaging 1.00
R3123:Gpr75 UTSW 11 30,841,709 (GRCm39) missense possibly damaging 0.82
R4669:Gpr75 UTSW 11 30,842,072 (GRCm39) missense probably damaging 1.00
R4704:Gpr75 UTSW 11 30,841,110 (GRCm39) missense probably benign
R4809:Gpr75 UTSW 11 30,842,154 (GRCm39) missense possibly damaging 0.74
R4913:Gpr75 UTSW 11 30,841,808 (GRCm39) missense possibly damaging 0.85
R4982:Gpr75 UTSW 11 30,841,463 (GRCm39) missense possibly damaging 0.96
R4982:Gpr75 UTSW 11 30,841,462 (GRCm39) missense probably damaging 1.00
R5071:Gpr75 UTSW 11 30,842,380 (GRCm39) missense probably damaging 1.00
R5318:Gpr75 UTSW 11 30,842,459 (GRCm39) missense probably benign 0.00
R6019:Gpr75 UTSW 11 30,841,640 (GRCm39) missense probably benign 0.39
R6199:Gpr75 UTSW 11 30,841,527 (GRCm39) missense probably damaging 1.00
R6455:Gpr75 UTSW 11 30,841,529 (GRCm39) missense probably damaging 1.00
R7188:Gpr75 UTSW 11 30,842,687 (GRCm39) missense probably damaging 1.00
R7826:Gpr75 UTSW 11 30,841,209 (GRCm39) missense probably damaging 0.99
R8053:Gpr75 UTSW 11 30,841,559 (GRCm39) missense probably benign 0.25
R8703:Gpr75 UTSW 11 30,841,890 (GRCm39) missense probably damaging 0.99
R8870:Gpr75 UTSW 11 30,841,860 (GRCm39) missense probably benign 0.00
R8930:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
R8932:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
Z1088:Gpr75 UTSW 11 30,841,139 (GRCm39) missense probably benign 0.11
Posted On 2012-04-20