Incidental Mutation 'R7853:Myo1f'
ID 607104
Institutional Source Beutler Lab
Gene Symbol Myo1f
Ensembl Gene ENSMUSG00000024300
Gene Name myosin IF
Synonyms C330006B10Rik
MMRRC Submission 045906-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # R7853 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 33774681-33826738 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 33795672 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 106 (V106D)
Ref Sequence ENSEMBL: ENSMUSP00000084887 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087605] [ENSMUST00000173372] [ENSMUST00000174695]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000087605
AA Change: V106D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000084887
Gene: ENSMUSG00000024300
AA Change: V106D

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 717 909 1.7e-51 PFAM
low complexity region 939 952 N/A INTRINSIC
low complexity region 973 987 N/A INTRINSIC
low complexity region 991 1001 N/A INTRINSIC
SH3 1044 1098 2.09e-19 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000173372
AA Change: V106D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134715
Gene: ENSMUSG00000024300
AA Change: V106D

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 716 780 6e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000174695
AA Change: V76D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134600
Gene: ENSMUSG00000024300
AA Change: V76D

DomainStartEndE-ValueType
Pfam:Myosin_head 47 98 1.3e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik A G 2: 151,315,600 (GRCm39) I26T probably damaging Het
Aadacl4 G T 4: 144,344,592 (GRCm39) A123S probably benign Het
Adamts20 A C 15: 94,243,871 (GRCm39) C619G probably damaging Het
Ahcyl1 C A 3: 107,575,604 (GRCm39) V394L probably benign Het
Ankrd17 A C 5: 90,386,825 (GRCm39) L2378V possibly damaging Het
B3gnt3 T C 8: 72,145,357 (GRCm39) Y337C probably damaging Het
Bcl10 A G 3: 145,630,266 (GRCm39) K18R possibly damaging Het
Calcr G A 6: 3,707,499 (GRCm39) A267V probably benign Het
Ces1d C T 8: 93,901,695 (GRCm39) G425S probably benign Het
Col1a1 G T 11: 94,838,505 (GRCm39) R899L unknown Het
Commd1 C T 11: 22,906,532 (GRCm39) R168H possibly damaging Het
Cps1 T C 1: 67,213,640 (GRCm39) S791P possibly damaging Het
Ctsj T A 13: 61,151,884 (GRCm39) I58F probably damaging Het
Cyp2j5 T A 4: 96,529,656 (GRCm39) K238N probably benign Het
Dlgap4 A G 2: 156,547,802 (GRCm39) D423G probably benign Het
Eef1ece2 T A 16: 20,463,010 (GRCm39) probably null Het
Egln1 T C 8: 125,675,256 (GRCm39) N180D probably benign Het
Ehd1 T C 19: 6,327,225 (GRCm39) F74S probably damaging Het
Ext1 G A 15: 52,970,881 (GRCm39) A350V probably damaging Het
Fam186b T A 15: 99,178,628 (GRCm39) I233F probably damaging Het
Fam193a T G 5: 34,597,473 (GRCm39) N91K probably benign Het
Far1 T A 7: 113,153,355 (GRCm39) N329K probably damaging Het
Fhad1 A G 4: 141,637,134 (GRCm39) S1111P probably damaging Het
Fhl2 A G 1: 43,180,984 (GRCm39) S69P probably damaging Het
Flg2 C A 3: 93,128,054 (GRCm39) P2322Q unknown Het
Flvcr1 A G 1: 190,757,843 (GRCm39) Y108H probably damaging Het
Fos T A 12: 85,522,792 (GRCm39) S235T probably benign Het
Foxf1 T A 8: 121,811,438 (GRCm39) S101T probably damaging Het
Gfer C A 17: 24,913,259 (GRCm39) D198Y probably damaging Het
Ggps1 T C 13: 14,229,034 (GRCm39) I50V probably benign Het
Gkn2 A G 6: 87,355,255 (GRCm39) T155A probably benign Het
Gna12 C T 5: 140,746,449 (GRCm39) C332Y probably damaging Het
Hc T A 2: 34,900,045 (GRCm39) Y1096F probably damaging Het
Hoxa3 G A 6: 52,147,267 (GRCm39) probably benign Het
Hsd17b8 T G 17: 34,246,411 (GRCm39) D117A probably benign Het
Ifi206 A T 1: 173,299,100 (GRCm39) Y835* probably null Het
Ighv13-2 T G 12: 114,321,544 (GRCm39) E65A probably damaging Het
Kif5a A T 10: 127,071,537 (GRCm39) Y770* probably null Het
Lfng A G 5: 140,593,384 (GRCm39) S72G probably benign Het
Lipo2 C T 19: 33,737,344 (GRCm39) probably benign Het
Lnpep C T 17: 17,783,109 (GRCm39) S564N probably benign Het
Mfhas1 T A 8: 36,057,025 (GRCm39) L500* probably null Het
Mllt6 G A 11: 97,561,142 (GRCm39) V277I probably benign Het
Mroh5 C T 15: 73,663,189 (GRCm39) D192N probably benign Het
Mypn T A 10: 62,981,652 (GRCm39) I643F probably benign Het
Nup188 A G 2: 30,213,575 (GRCm39) N669D possibly damaging Het
Or14j5 C G 17: 38,161,714 (GRCm39) T77R probably damaging Het
Or2r11 A T 6: 42,437,573 (GRCm39) C127S probably damaging Het
Or5g26 T C 2: 85,494,689 (GRCm39) T30A probably benign Het
Or8s8 T C 15: 98,354,866 (GRCm39) V225A probably benign Het
Osbpl10 A G 9: 115,036,726 (GRCm39) T241A probably damaging Het
Peg3 C T 7: 6,711,839 (GRCm39) E1128K possibly damaging Het
Plch1 C A 3: 63,681,068 (GRCm39) M186I probably benign Het
Pon3 A C 6: 5,236,911 (GRCm39) L152R probably damaging Het
Prr36 G A 8: 4,263,905 (GRCm39) P587L unknown Het
Psma2 T A 13: 14,799,832 (GRCm39) I192N probably damaging Het
Rbm11 T C 16: 75,389,923 (GRCm39) F30L probably damaging Het
Rpap3 G A 15: 97,576,299 (GRCm39) A622V possibly damaging Het
Scgb2b11 T A 7: 31,908,807 (GRCm39) N98Y probably damaging Het
Siglec1 A G 2: 130,923,212 (GRCm39) L511P probably damaging Het
Sirpb1c C T 3: 15,887,156 (GRCm39) V228M probably damaging Het
Smpd4 T A 16: 17,460,605 (GRCm39) Y804N probably damaging Het
Sult6b2 T C 6: 142,747,524 (GRCm39) D75G not run Het
Sycp3 A C 10: 88,302,368 (GRCm39) K119N probably damaging Het
Syne2 T C 12: 76,078,278 (GRCm39) L4703P probably damaging Het
Tex12 C G 9: 50,470,523 (GRCm39) L20F possibly damaging Het
Them5 T A 3: 94,250,603 (GRCm39) Y55* probably null Het
Tmem43 A T 6: 91,458,968 (GRCm39) D213V probably benign Het
Tnfrsf10b A C 14: 70,005,239 (GRCm39) Q44P unknown Het
Trbv2 A T 6: 41,024,836 (GRCm39) Q84L probably benign Het
Trim2 C T 3: 84,212,537 (GRCm39) probably benign Het
Trim36 A G 18: 46,305,558 (GRCm39) V475A probably benign Het
Ttbk1 C A 17: 46,758,269 (GRCm39) E788D probably benign Het
Ttn T C 2: 76,543,626 (GRCm39) D33120G probably damaging Het
Ttn T A 2: 76,576,256 (GRCm39) N24879I probably damaging Het
Ube4a T A 9: 44,864,308 (GRCm39) Q76L probably benign Het
Vmn2r27 T A 6: 124,168,980 (GRCm39) I717F probably damaging Het
Vmn2r45 T C 7: 8,485,987 (GRCm39) K434E possibly damaging Het
Vta1 T C 10: 14,531,461 (GRCm39) T305A probably damaging Het
Zfp354c TCACACTCGGCACA TCACA 11: 50,706,067 (GRCm39) probably benign Het
Other mutations in Myo1f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00851:Myo1f APN 17 33,800,938 (GRCm39) missense probably benign 0.01
IGL01019:Myo1f APN 17 33,811,977 (GRCm39) missense possibly damaging 0.93
IGL01524:Myo1f APN 17 33,798,857 (GRCm39) missense probably damaging 1.00
IGL01744:Myo1f APN 17 33,802,654 (GRCm39) splice site probably benign
IGL01951:Myo1f APN 17 33,816,991 (GRCm39) missense possibly damaging 0.64
IGL02132:Myo1f APN 17 33,798,945 (GRCm39) missense probably benign 0.10
IGL02170:Myo1f APN 17 33,797,246 (GRCm39) missense probably benign 0.14
IGL02173:Myo1f APN 17 33,826,318 (GRCm39) missense probably damaging 1.00
IGL02277:Myo1f APN 17 33,798,835 (GRCm39) splice site probably null
IGL02550:Myo1f APN 17 33,799,124 (GRCm39) unclassified probably benign
IGL02550:Myo1f APN 17 33,807,116 (GRCm39) missense probably damaging 1.00
IGL02615:Myo1f APN 17 33,823,630 (GRCm39) missense probably benign
IGL02801:Myo1f APN 17 33,797,111 (GRCm39) missense probably damaging 1.00
IGL02817:Myo1f APN 17 33,823,532 (GRCm39) missense probably benign 0.06
IGL02904:Myo1f APN 17 33,804,632 (GRCm39) nonsense probably null
IGL03056:Myo1f APN 17 33,804,574 (GRCm39) missense probably damaging 1.00
IGL03334:Myo1f APN 17 33,817,168 (GRCm39) missense probably damaging 1.00
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0321:Myo1f UTSW 17 33,811,986 (GRCm39) missense probably benign 0.31
R0375:Myo1f UTSW 17 33,820,930 (GRCm39) missense probably benign 0.27
R0487:Myo1f UTSW 17 33,797,258 (GRCm39) missense probably damaging 1.00
R0925:Myo1f UTSW 17 33,797,107 (GRCm39) missense probably damaging 0.96
R1394:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1395:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1474:Myo1f UTSW 17 33,813,001 (GRCm39) missense possibly damaging 0.77
R1760:Myo1f UTSW 17 33,805,172 (GRCm39) missense probably benign 0.03
R1965:Myo1f UTSW 17 33,817,146 (GRCm39) nonsense probably null
R2409:Myo1f UTSW 17 33,795,641 (GRCm39) missense probably damaging 1.00
R2432:Myo1f UTSW 17 33,794,823 (GRCm39) missense probably damaging 1.00
R4610:Myo1f UTSW 17 33,801,306 (GRCm39) missense probably damaging 1.00
R4785:Myo1f UTSW 17 33,817,165 (GRCm39) missense possibly damaging 0.95
R5239:Myo1f UTSW 17 33,820,709 (GRCm39) missense probably benign 0.00
R5881:Myo1f UTSW 17 33,799,259 (GRCm39) missense possibly damaging 0.46
R5881:Myo1f UTSW 17 33,795,627 (GRCm39) missense probably damaging 1.00
R6160:Myo1f UTSW 17 33,823,318 (GRCm39) missense probably benign
R6210:Myo1f UTSW 17 33,820,044 (GRCm39) missense probably damaging 1.00
R6365:Myo1f UTSW 17 33,805,090 (GRCm39) missense probably benign
R6464:Myo1f UTSW 17 33,795,621 (GRCm39) missense probably damaging 1.00
R6532:Myo1f UTSW 17 33,794,820 (GRCm39) missense probably damaging 1.00
R6678:Myo1f UTSW 17 33,794,819 (GRCm39) missense probably damaging 1.00
R7241:Myo1f UTSW 17 33,798,902 (GRCm39) missense probably damaging 0.99
R7266:Myo1f UTSW 17 33,820,668 (GRCm39) missense probably benign
R7513:Myo1f UTSW 17 33,794,788 (GRCm39) missense probably damaging 1.00
R7606:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R7779:Myo1f UTSW 17 33,797,247 (GRCm39) missense probably benign 0.27
R7884:Myo1f UTSW 17 33,817,270 (GRCm39) missense probably damaging 1.00
R8507:Myo1f UTSW 17 33,816,992 (GRCm39) missense probably benign 0.09
R8807:Myo1f UTSW 17 33,794,879 (GRCm39) missense probably damaging 1.00
R9009:Myo1f UTSW 17 33,823,662 (GRCm39) missense probably benign 0.12
R9083:Myo1f UTSW 17 33,813,036 (GRCm39) missense probably damaging 0.99
R9227:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9230:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9528:Myo1f UTSW 17 33,797,156 (GRCm39) critical splice donor site probably null
X0028:Myo1f UTSW 17 33,795,412 (GRCm39) missense possibly damaging 0.67
X0065:Myo1f UTSW 17 33,820,957 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AATCTCTGTAAACCCCTTCAAGCAG -3'
(R):5'- GAACAAATATACTGATTCAGGAGCC -3'

Sequencing Primer
(F):5'- TGACCGAGAAATTGACCTCTATCAG -3'
(R):5'- TATACTGATTCAGGAGCCAAGAG -3'
Posted On 2019-12-20