Mutagenetix > Incidental Mutation

Incidental Mutation 'R7855:Tenm4'

607186

Institutional Source

Beutler Lab

Gene Symbol

Tenm4

Ensembl Gene

ENSMUSG00000048078

Gene Name

teneurin transmembrane protein 4

Synonyms

Doc4, l7Rn3, Ten-m4, ELM2, l(7)-3Rn, Odz4

MMRRC Submission

045908-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7855 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

96171246-96911093 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 96873874 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 1541 (H1541R)

Ref Sequence

ENSEMBL: ENSMUSP00000102783 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107162] [ENSMUST00000107165] [ENSMUST00000107166]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000107162
AA Change: H1533R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000102780
Gene: ENSMUSG00000048078
AA Change: H1533R

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	410	5.6e-195	PFAM
transmembrane domain	411	433	N/A	INTRINSIC
EGF_like	637	665	3.43e1	SMART
EGF	668	696	2.29e1	SMART
EGF	701	730	1.88e-1	SMART
EGF	733	762	1.13e1	SMART
EGF	767	797	2.39e1	SMART
EGF	800	828	4.32e-1	SMART
EGF	831	859	6.02e0	SMART
EGF	862	894	9.93e-1	SMART
low complexity region	900	914	N/A	INTRINSIC
Pfam:RHS_repeat	2327	2380	5.5e-7	PFAM
Pfam:Tox-GHH	2740	2818	5.2e-34	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107165
AA Change: H1541R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000102783
Gene: ENSMUSG00000048078
AA Change: H1541R

Domain	Start	End	E-Value	Type
Pfam:Ten_N	36	402	1.1e-171	PFAM
transmembrane domain	403	425	N/A	INTRINSIC
EGF_like	629	657	3.43e1	SMART
EGF	660	688	2.29e1	SMART
EGF	693	722	1.88e-1	SMART
EGF	725	754	1.13e1	SMART
EGF	759	789	2.39e1	SMART
EGF	792	820	4.32e-1	SMART
EGF	823	851	6.02e0	SMART
EGF	863	895	9.93e-1	SMART
low complexity region	901	915	N/A	INTRINSIC
Pfam:RHS_repeat	2335	2368	1.6e-7	PFAM
Pfam:Tox-GHH	2749	2826	1.8e-32	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107166
AA Change: H1504R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000102784
Gene: ENSMUSG00000048078
AA Change: H1504R

Domain	Start	End	E-Value	Type
Pfam:Ten_N	35	193	1.4e-83	PFAM
Pfam:Ten_N	187	365	5e-78	PFAM
transmembrane domain	366	388	N/A	INTRINSIC
EGF_like	592	620	3.43e1	SMART
EGF	623	651	2.29e1	SMART
EGF	656	685	1.88e-1	SMART
EGF	688	717	1.13e1	SMART
EGF	722	752	2.39e1	SMART
EGF	755	783	4.32e-1	SMART
EGF	786	814	6.02e0	SMART
EGF	826	858	9.93e-1	SMART
low complexity region	864	878	N/A	INTRINSIC
Pfam:RHS_repeat	2298	2351	3.8e-7	PFAM
Pfam:Tox-GHH	2711	2789	3.9e-34	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700081O15Rik	T	A	19: 7,422,256	I456N	probably damaging	Het
Abca6	A	T	11: 110,191,628	V1173D	probably benign	Het
Ace	A	T	11: 105,972,379	M327L	probably benign	Het
Bcl2l2	C	T	14: 54,884,379		probably benign	Het
Bicdl2	C	T	17: 23,666,017	Q231*	probably null	Het
Brms1l	A	T	12: 55,866,053	D277V	possibly damaging	Het
Cd38	C	A	5: 43,901,448	L135M	probably damaging	Het
Col6a3	G	T	1: 90,810,621	P1059T	possibly damaging	Het
Coro1c	A	T	5: 113,848,597	M262K	probably benign	Het
Cpxm2	G	T	7: 132,057,695	P481Q	possibly damaging	Het
Dnah12	G	T	14: 26,829,329	V2543F	probably benign	Het
Dock2	A	C	11: 34,273,698	D1145E	probably damaging	Het
Elf3	G	A	1: 135,254,352	R364W	probably damaging	Het
Eln	AGGGACACCAGCACCAGCCCCAAATCCGGGGACACCAGCACCAGCCCCAAATCCGGGGACACCAGCACCAGCCCCAAATCCGGGGACACCAGCACCAGCCCCAAATCCAGGGACACCAGC	AGGGACACCAGCACCAGCCCCAAATCCGGGGACACCAGCACCAGCCCCAAATCCGGGGACACCAGCACCAGCCCCAAATCCAGGGACACCAGC	5: 134,711,081		probably benign	Het
Epha3	A	G	16: 63,773,560	I55T	probably damaging	Het
Fam69c	G	A	18: 84,730,046		probably benign	Het
Gfer	C	A	17: 24,694,285	D198Y	probably damaging	Het
Gm10436	A	T	12: 88,176,083	I450N	probably benign	Het
Gm11568	A	T	11: 99,858,184	T72S	unknown	Het
Gm21994	C	T	2: 150,255,146	R121Q	probably benign	Het
Gm5415	A	C	1: 32,546,033	I265M	probably damaging	Het
Igkv3-1	C	T	6: 70,704,069	A84V	probably benign	Het
Il1rl2	A	C	1: 40,343,119	Y197S	probably damaging	Het
Il2ra	T	C	2: 11,680,336	I161T	possibly damaging	Het
Itgb8	C	T	12: 119,166,772	R667H	probably benign	Het
Kcnh7	G	A	2: 62,837,194	Q334*	probably null	Het
Lctl	A	C	9: 64,133,216	R480S	possibly damaging	Het
Lrba	T	G	3: 86,315,430	I617S	possibly damaging	Het
Marf1	G	T	16: 14,114,201	H1651N	probably benign	Het
Mitf	T	A	6: 97,993,196	Y142N	probably damaging	Het
Olfr569	A	G	7: 102,887,628	V175A	probably benign	Het
Olfr620	T	A	7: 103,611,772	I194F	possibly damaging	Het
Pecam1	A	G	11: 106,671,750	V708A	probably benign	Het
Pinlyp	C	T	7: 24,542,440		probably null	Het
Polh	G	A	17: 46,175,248	R382W	probably damaging	Het
Prdm10	A	G	9: 31,327,474	I221V	probably benign	Het
Pskh1	G	T	8: 105,913,090	R134L	probably benign	Het
Ptpre	A	G	7: 135,651,995	N6D	probably benign	Het
Rasgrp4	C	T	7: 29,150,610	P58L	unknown	Het
Rhbdf2	G	T	11: 116,602,240	C393*	probably null	Het
Rlf	T	C	4: 121,182,691	I174M	possibly damaging	Het
Ryr2	T	A	13: 11,706,623	R2641*	probably null	Het
Simc1	A	G	13: 54,524,832	H331R	probably benign	Het
Skp2	A	G	15: 9,122,241	S256P	probably benign	Het
Smarcd2	T	C	11: 106,267,566	R10G	probably benign	Het
Spef2	A	G	15: 9,687,895	L480P	possibly damaging	Het
Top1	T	A	2: 160,714,088	L489Q	probably damaging	Het
Ttll13	C	T	7: 80,254,097	H258Y	probably damaging	Het
Unc80	A	G	1: 66,483,349	R237G	possibly damaging	Het
Vmn1r55	A	G	7: 5,146,624	F267L	probably benign	Het
Vmn2r96	T	A	17: 18,597,868	M761K	possibly damaging	Het
Vps33a	G	A	5: 123,570,979	H58Y	possibly damaging	Het
Zfp354c	TCACACTCGGCACA	TCACA	11: 50,815,240		probably benign	Het
Zfp467	T	C	6: 48,439,181	Q179R	probably damaging	Het
Zfp729a	A	T	13: 67,619,948	S721T	possibly damaging	Het

Other mutations in Tenm4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Tenm4	APN	7	96,868,009 (GRCm38)	missense	probably benign	0.00
IGL00468:Tenm4	APN	7	96,874,472 (GRCm38)	missense	probably damaging	0.98
IGL00519:Tenm4	APN	7	96,805,138 (GRCm38)	splice site	probably benign
IGL00979:Tenm4	APN	7	96,729,391 (GRCm38)	missense	probably damaging	0.96
IGL01401:Tenm4	APN	7	96,874,267 (GRCm38)	missense	probably damaging	1.00
IGL01459:Tenm4	APN	7	96,729,385 (GRCm38)	missense	probably damaging	1.00
IGL01519:Tenm4	APN	7	96,895,177 (GRCm38)	missense	probably damaging	1.00
IGL01545:Tenm4	APN	7	96,874,303 (GRCm38)	missense	probably benign	0.00
IGL01579:Tenm4	APN	7	96,863,502 (GRCm38)	missense	probably benign	0.00
IGL01587:Tenm4	APN	7	96,863,502 (GRCm38)	missense	probably benign	0.00
IGL01625:Tenm4	APN	7	96,885,358 (GRCm38)	missense	probably damaging	1.00
IGL01655:Tenm4	APN	7	96,553,724 (GRCm38)	missense	probably damaging	1.00
IGL01683:Tenm4	APN	7	96,885,404 (GRCm38)	missense	possibly damaging	0.84
IGL01728:Tenm4	APN	7	96,896,064 (GRCm38)	missense	probably damaging	1.00
IGL01732:Tenm4	APN	7	96,895,509 (GRCm38)	missense	probably damaging	1.00
IGL01924:Tenm4	APN	7	96,895,212 (GRCm38)	missense	probably damaging	1.00
IGL01966:Tenm4	APN	7	96,553,550 (GRCm38)	missense	probably damaging	1.00
IGL02177:Tenm4	APN	7	96,895,662 (GRCm38)	missense	probably benign	0.40
IGL02207:Tenm4	APN	7	96,874,116 (GRCm38)	missense	possibly damaging	0.85
IGL02269:Tenm4	APN	7	96,823,822 (GRCm38)	missense	probably damaging	1.00
IGL02274:Tenm4	APN	7	96,854,734 (GRCm38)	missense	probably damaging	1.00
IGL02375:Tenm4	APN	7	96,704,137 (GRCm38)	missense	possibly damaging	0.52
IGL02415:Tenm4	APN	7	96,874,074 (GRCm38)	missense	probably damaging	0.98
IGL02472:Tenm4	APN	7	96,774,176 (GRCm38)	unclassified	probably benign
IGL02656:Tenm4	APN	7	96,885,433 (GRCm38)	missense	probably damaging	1.00
IGL02678:Tenm4	APN	7	96,896,219 (GRCm38)	missense	probably damaging	1.00
IGL02829:Tenm4	APN	7	96,894,998 (GRCm38)	nonsense	probably null
IGL02863:Tenm4	APN	7	96,873,706 (GRCm38)	missense	probably damaging	1.00
IGL03145:Tenm4	APN	7	96,842,968 (GRCm38)	missense	probably damaging	0.98
IGL03153:Tenm4	APN	7	96,873,762 (GRCm38)	missense	probably damaging	1.00
principium	UTSW	7	96,797,481 (GRCm38)	missense	probably damaging	0.98
toccata	UTSW	7	96,902,989 (GRCm38)	critical splice donor site	probably null
P0026:Tenm4	UTSW	7	96,874,527 (GRCm38)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,892,926 (GRCm38)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,892,926 (GRCm38)	missense	probably damaging	1.00
R0140:Tenm4	UTSW	7	96,896,052 (GRCm38)	missense	possibly damaging	0.78
R0164:Tenm4	UTSW	7	96,729,340 (GRCm38)	splice site	probably benign
R0277:Tenm4	UTSW	7	96,694,950 (GRCm38)	missense	possibly damaging	0.54
R0323:Tenm4	UTSW	7	96,694,950 (GRCm38)	missense	possibly damaging	0.54
R0362:Tenm4	UTSW	7	96,772,035 (GRCm38)	nonsense	probably null
R0381:Tenm4	UTSW	7	96,905,881 (GRCm38)	missense	probably damaging	1.00
R0420:Tenm4	UTSW	7	96,873,766 (GRCm38)	missense	possibly damaging	0.85
R0426:Tenm4	UTSW	7	96,777,851 (GRCm38)	missense	probably damaging	1.00
R0513:Tenm4	UTSW	7	96,895,623 (GRCm38)	missense	probably benign	0.35
R0624:Tenm4	UTSW	7	96,774,020 (GRCm38)	missense	probably damaging	1.00
R0837:Tenm4	UTSW	7	96,896,275 (GRCm38)	splice site	probably benign
R1037:Tenm4	UTSW	7	96,797,481 (GRCm38)	missense	probably damaging	0.98
R1172:Tenm4	UTSW	7	96,848,044 (GRCm38)	missense	probably damaging	1.00
R1422:Tenm4	UTSW	7	96,550,051 (GRCm38)	missense	probably damaging	0.99
R1427:Tenm4	UTSW	7	96,843,048 (GRCm38)	missense	probably benign	0.42
R1462:Tenm4	UTSW	7	96,704,153 (GRCm38)	missense	probably damaging	1.00
R1462:Tenm4	UTSW	7	96,704,153 (GRCm38)	missense	probably damaging	1.00
R1597:Tenm4	UTSW	7	96,902,989 (GRCm38)	critical splice donor site	probably null
R1701:Tenm4	UTSW	7	96,902,889 (GRCm38)	missense	probably damaging	1.00
R1707:Tenm4	UTSW	7	96,888,685 (GRCm38)	missense	probably damaging	1.00
R1809:Tenm4	UTSW	7	96,873,780 (GRCm38)	missense	probably benign	0.17
R1812:Tenm4	UTSW	7	96,895,940 (GRCm38)	missense	probably damaging	1.00
R1895:Tenm4	UTSW	7	96,735,808 (GRCm38)	missense	probably damaging	1.00
R1933:Tenm4	UTSW	7	96,895,326 (GRCm38)	missense	probably damaging	1.00
R1946:Tenm4	UTSW	7	96,735,808 (GRCm38)	missense	probably damaging	1.00
R2108:Tenm4	UTSW	7	96,906,290 (GRCm38)	missense	probably damaging	1.00
R2151:Tenm4	UTSW	7	96,902,847 (GRCm38)	missense	probably damaging	1.00
R2247:Tenm4	UTSW	7	96,906,009 (GRCm38)	missense	probably benign	0.03
R2329:Tenm4	UTSW	7	96,895,862 (GRCm38)	missense	probably benign	0.00
R2893:Tenm4	UTSW	7	96,894,990 (GRCm38)	missense	probably damaging	1.00
R2990:Tenm4	UTSW	7	96,893,125 (GRCm38)	splice site	probably null
R3409:Tenm4	UTSW	7	96,895,160 (GRCm38)	missense	probably damaging	1.00
R3410:Tenm4	UTSW	7	96,852,530 (GRCm38)	missense	probably damaging	0.99
R3411:Tenm4	UTSW	7	96,852,530 (GRCm38)	missense	probably damaging	0.99
R3440:Tenm4	UTSW	7	96,553,516 (GRCm38)	missense	probably benign	0.00
R3441:Tenm4	UTSW	7	96,553,516 (GRCm38)	missense	probably benign	0.00
R3719:Tenm4	UTSW	7	96,863,563 (GRCm38)	missense	possibly damaging	0.92
R3772:Tenm4	UTSW	7	96,694,880 (GRCm38)	missense	probably damaging	1.00
R3773:Tenm4	UTSW	7	96,694,880 (GRCm38)	missense	probably damaging	1.00
R4093:Tenm4	UTSW	7	96,895,772 (GRCm38)	missense	probably damaging	1.00
R4439:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4441:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4510:Tenm4	UTSW	7	96,894,863 (GRCm38)	missense	probably benign
R4511:Tenm4	UTSW	7	96,894,863 (GRCm38)	missense	probably benign
R4543:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4645:Tenm4	UTSW	7	96,895,742 (GRCm38)	missense	probably damaging	1.00
R4701:Tenm4	UTSW	7	96,895,349 (GRCm38)	missense	probably damaging	1.00
R4707:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4714:Tenm4	UTSW	7	96,894,924 (GRCm38)	missense	probably damaging	1.00
R4742:Tenm4	UTSW	7	96,797,484 (GRCm38)	missense	probably damaging	0.99
R4784:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4785:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4801:Tenm4	UTSW	7	96,906,245 (GRCm38)	missense	probably damaging	0.97
R4802:Tenm4	UTSW	7	96,906,245 (GRCm38)	missense	probably damaging	0.97
R4880:Tenm4	UTSW	7	96,905,818 (GRCm38)	splice site	probably null
R5036:Tenm4	UTSW	7	96,852,561 (GRCm38)	missense	probably damaging	1.00
R5036:Tenm4	UTSW	7	96,694,790 (GRCm38)	missense	probably damaging	1.00
R5050:Tenm4	UTSW	7	96,895,788 (GRCm38)	missense	probably damaging	1.00
R5103:Tenm4	UTSW	7	96,842,957 (GRCm38)	missense	probably damaging	1.00
R5106:Tenm4	UTSW	7	96,843,149 (GRCm38)	missense	probably damaging	0.99
R5118:Tenm4	UTSW	7	96,893,086 (GRCm38)	missense	probably damaging	1.00
R5272:Tenm4	UTSW	7	96,874,203 (GRCm38)	missense	probably damaging	0.98
R5282:Tenm4	UTSW	7	96,837,331 (GRCm38)	missense	possibly damaging	0.90
R5403:Tenm4	UTSW	7	96,888,827 (GRCm38)	missense	probably damaging	1.00
R5404:Tenm4	UTSW	7	96,894,680 (GRCm38)	missense	probably damaging	1.00
R5567:Tenm4	UTSW	7	96,896,209 (GRCm38)	nonsense	probably null
R5590:Tenm4	UTSW	7	96,797,401 (GRCm38)	missense	possibly damaging	0.93
R5590:Tenm4	UTSW	7	96,797,400 (GRCm38)	missense	possibly damaging	0.73
R5597:Tenm4	UTSW	7	96,553,517 (GRCm38)	missense	probably benign	0.00
R5782:Tenm4	UTSW	7	96,893,039 (GRCm38)	missense	probably benign	0.00
R5861:Tenm4	UTSW	7	96,843,217 (GRCm38)	intron	probably benign
R5890:Tenm4	UTSW	7	96,902,860 (GRCm38)	missense	probably damaging	1.00
R5930:Tenm4	UTSW	7	96,854,719 (GRCm38)	missense	probably damaging	1.00
R5940:Tenm4	UTSW	7	96,845,895 (GRCm38)	missense	probably damaging	1.00
R6012:Tenm4	UTSW	7	96,522,433 (GRCm38)	intron	probably benign
R6060:Tenm4	UTSW	7	96,873,711 (GRCm38)	missense	probably damaging	1.00
R6104:Tenm4	UTSW	7	96,837,289 (GRCm38)	missense	probably damaging	0.97
R6283:Tenm4	UTSW	7	96,874,494 (GRCm38)	missense	probably benign	0.33
R6333:Tenm4	UTSW	7	96,774,124 (GRCm38)	missense	probably damaging	1.00
R6522:Tenm4	UTSW	7	96,843,044 (GRCm38)	missense	possibly damaging	0.88
R6616:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6746:Tenm4	UTSW	7	96,892,860 (GRCm38)	missense	probably damaging	1.00
R6751:Tenm4	UTSW	7	96,845,712 (GRCm38)	missense	possibly damaging	0.95
R6806:Tenm4	UTSW	7	96,811,959 (GRCm38)	missense	possibly damaging	0.95
R6807:Tenm4	UTSW	7	96,895,271 (GRCm38)	missense	probably damaging	1.00
R6807:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6809:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6810:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6811:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6853:Tenm4	UTSW	7	96,837,295 (GRCm38)	missense	possibly damaging	0.94
R6886:Tenm4	UTSW	7	96,797,392 (GRCm38)	missense	possibly damaging	0.85
R6920:Tenm4	UTSW	7	96,895,550 (GRCm38)	missense	probably damaging	1.00
R6937:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6939:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7011:Tenm4	UTSW	7	96,896,135 (GRCm38)	nonsense	probably null
R7033:Tenm4	UTSW	7	96,895,223 (GRCm38)	nonsense	probably null
R7040:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7083:Tenm4	UTSW	7	96,895,349 (GRCm38)	missense	probably damaging	1.00
R7238:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7239:Tenm4	UTSW	7	96,735,813 (GRCm38)	missense	possibly damaging	0.47
R7239:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7337:Tenm4	UTSW	7	96,874,126 (GRCm38)	missense	probably benign	0.44
R7400:Tenm4	UTSW	7	96,694,803 (GRCm38)	missense	probably damaging	0.97
R7407:Tenm4	UTSW	7	96,773,987 (GRCm38)	missense	possibly damaging	0.89
R7449:Tenm4	UTSW	7	96,874,213 (GRCm38)	missense	possibly damaging	0.65
R7473:Tenm4	UTSW	7	96,774,146 (GRCm38)	missense	probably damaging	1.00
R7477:Tenm4	UTSW	7	96,845,808 (GRCm38)	missense	probably damaging	0.99
R7489:Tenm4	UTSW	7	96,837,314 (GRCm38)	missense	possibly damaging	0.90
R7498:Tenm4	UTSW	7	96,848,017 (GRCm38)	missense	probably damaging	1.00
R7562:Tenm4	UTSW	7	96,888,814 (GRCm38)	missense	probably damaging	1.00
R7615:Tenm4	UTSW	7	96,845,926 (GRCm38)	missense	probably damaging	1.00
R7624:Tenm4	UTSW	7	96,895,985 (GRCm38)	missense	possibly damaging	0.95
R7626:Tenm4	UTSW	7	96,893,014 (GRCm38)	missense	probably damaging	1.00
R7690:Tenm4	UTSW	7	96,863,533 (GRCm38)	missense	probably benign	0.00
R7692:Tenm4	UTSW	7	96,895,403 (GRCm38)	missense	probably damaging	1.00
R7748:Tenm4	UTSW	7	96,894,702 (GRCm38)	missense	probably damaging	1.00
R7763:Tenm4	UTSW	7	96,895,692 (GRCm38)	missense	probably benign	0.38
R7792:Tenm4	UTSW	7	96,774,014 (GRCm38)	missense	possibly damaging	0.54
R7868:Tenm4	UTSW	7	96,906,380 (GRCm38)	missense	possibly damaging	0.79
R7878:Tenm4	UTSW	7	96,852,357 (GRCm38)	missense	probably damaging	1.00
R7997:Tenm4	UTSW	7	96,874,305 (GRCm38)	missense	probably benign	0.44
R8017:Tenm4	UTSW	7	96,704,041 (GRCm38)	missense	probably damaging	1.00
R8019:Tenm4	UTSW	7	96,704,041 (GRCm38)	missense	probably damaging	1.00
R8054:Tenm4	UTSW	7	96,729,346 (GRCm38)	splice site	probably benign
R8061:Tenm4	UTSW	7	96,852,456 (GRCm38)	missense	probably damaging	1.00
R8108:Tenm4	UTSW	7	96,854,728 (GRCm38)	missense	probably benign	0.39
R8140:Tenm4	UTSW	7	96,895,176 (GRCm38)	missense	probably damaging	1.00
R8214:Tenm4	UTSW	7	96,895,407 (GRCm38)	missense	probably damaging	1.00
R8258:Tenm4	UTSW	7	96,867,991 (GRCm38)	missense	probably damaging	1.00
R8259:Tenm4	UTSW	7	96,867,991 (GRCm38)	missense	probably damaging	1.00
R8364:Tenm4	UTSW	7	96,772,106 (GRCm38)	critical splice donor site	probably null
R8542:Tenm4	UTSW	7	96,811,932 (GRCm38)	missense	probably damaging	0.99
R8669:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8670:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8683:Tenm4	UTSW	7	96,902,857 (GRCm38)	missense	probably damaging	0.99
R8691:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8692:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8714:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8716:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8735:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8736:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8737:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8738:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8738:Tenm4	UTSW	7	96,873,840 (GRCm38)	missense	probably damaging	1.00
R8739:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8776:Tenm4	UTSW	7	96,895,032 (GRCm38)	missense	probably damaging	1.00
R8776-TAIL:Tenm4	UTSW	7	96,895,032 (GRCm38)	missense	probably damaging	1.00
R8777:Tenm4	UTSW	7	96,896,037 (GRCm38)	missense	probably damaging	1.00
R8777-TAIL:Tenm4	UTSW	7	96,896,037 (GRCm38)	missense	probably damaging	1.00
R8817:Tenm4	UTSW	7	96,874,128 (GRCm38)	missense	probably benign	0.01
R8851:Tenm4	UTSW	7	96,852,503 (GRCm38)	missense	probably damaging	1.00
R8913:Tenm4	UTSW	7	96,702,745 (GRCm38)	splice site	probably benign
R8977:Tenm4	UTSW	7	96,811,970 (GRCm38)	missense	probably damaging	1.00
R9100:Tenm4	UTSW	7	96,845,854 (GRCm38)	missense	probably damaging	1.00
R9136:Tenm4	UTSW	7	96,823,918 (GRCm38)	missense	possibly damaging	0.69
R9163:Tenm4	UTSW	7	96,823,873 (GRCm38)	missense	probably damaging	1.00
R9188:Tenm4	UTSW	7	96,772,027 (GRCm38)	missense	probably damaging	1.00
R9195:Tenm4	UTSW	7	96,892,919 (GRCm38)	missense	probably damaging	1.00
R9217:Tenm4	UTSW	7	96,885,439 (GRCm38)	missense	probably damaging	1.00
R9344:Tenm4	UTSW	7	96,896,145 (GRCm38)	missense	probably damaging	1.00
R9414:Tenm4	UTSW	7	96,896,160 (GRCm38)	missense	probably benign
R9466:Tenm4	UTSW	7	96,550,045 (GRCm38)	missense	possibly damaging	0.79
R9559:Tenm4	UTSW	7	96,823,849 (GRCm38)	missense	probably benign
R9626:Tenm4	UTSW	7	96,896,138 (GRCm38)	missense	probably damaging	1.00
R9673:Tenm4	UTSW	7	96,867,989 (GRCm38)	missense	probably damaging	1.00
R9676:Tenm4	UTSW	7	96,895,431 (GRCm38)	missense	probably damaging	1.00
R9678:Tenm4	UTSW	7	96,737,412 (GRCm38)	missense	possibly damaging	0.94
R9775:Tenm4	UTSW	7	96,906,554 (GRCm38)	missense	possibly damaging	0.92
R9790:Tenm4	UTSW	7	96,888,839 (GRCm38)	missense	probably damaging	1.00
R9791:Tenm4	UTSW	7	96,888,839 (GRCm38)	missense	probably damaging	1.00
R9803:Tenm4	UTSW	7	96,553,478 (GRCm38)	missense	probably damaging	1.00
X0021:Tenm4	UTSW	7	96,873,909 (GRCm38)	nonsense	probably null
X0026:Tenm4	UTSW	7	96,868,087 (GRCm38)	missense	probably damaging	0.98
X0066:Tenm4	UTSW	7	96,894,794 (GRCm38)	missense	probably damaging	1.00
X0066:Tenm4	UTSW	7	96,848,030 (GRCm38)	missense	probably damaging	1.00
Z1176:Tenm4	UTSW	7	96,905,914 (GRCm38)	missense	probably benign	0.00
Z1177:Tenm4	UTSW	7	96,863,585 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- GTCTCCATTGTCAGGTTCGC -3'
(R):5'- TTGCATCCTTGGCGTAACC -3'

Sequencing Primer
(F):5'- TGGAGTGGCCCACAGACTTAG -3'
(R):5'- TGGCGTAACCATCATCTCCAGAG -3'

Posted On

2019-12-20