Incidental Mutation 'R7856:Zfp937'
| ID |
607224 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp937
|
| Ensembl Gene |
ENSMUSG00000060336 |
| Gene Name |
zinc finger protein 937 |
| Synonyms |
Gm4979 |
| MMRRC Submission |
045909-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.096)
|
| Stock # |
R7856 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
150059993-150082645 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 150081467 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 499
(V499A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073454
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073782]
|
| AlphaFold |
A2ANU7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073782
AA Change: V499A
PolyPhen 2
Score 0.235 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000073454
Gene: ENSMUSG00000060336
AA Change: V499A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
8.19e-20 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
467 |
490 |
7.26e-3 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
100% (36/36) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cacna1h |
T |
C |
17: 25,608,451 (GRCm39) |
T819A |
probably damaging |
Het |
| Ccdc34 |
T |
A |
2: 109,874,572 (GRCm39) |
Y310* |
probably null |
Het |
| Ccdc63 |
A |
G |
5: 122,268,006 (GRCm39) |
W8R |
probably benign |
Het |
| Ces2g |
G |
A |
8: 105,693,014 (GRCm39) |
V351I |
not run |
Het |
| Ces3b |
A |
G |
8: 105,819,894 (GRCm39) |
*572W |
probably null |
Het |
| Dgka |
T |
C |
10: 128,572,533 (GRCm39) |
N40S |
probably benign |
Het |
| Dnajc13 |
C |
A |
9: 104,044,684 (GRCm39) |
R1835L |
possibly damaging |
Het |
| Dusp7 |
C |
A |
9: 106,246,067 (GRCm39) |
A24E |
unknown |
Het |
| Ep400 |
T |
A |
5: 110,814,450 (GRCm39) |
T2931S |
probably damaging |
Het |
| Gm4847 |
A |
T |
1: 166,462,395 (GRCm39) |
L365Q |
probably damaging |
Het |
| Gtse1 |
C |
T |
15: 85,748,342 (GRCm39) |
T249M |
probably benign |
Het |
| Hook3 |
T |
C |
8: 26,525,249 (GRCm39) |
D619G |
probably damaging |
Het |
| Itsn1 |
T |
A |
16: 91,705,375 (GRCm39) |
|
probably null |
Het |
| Kti12 |
A |
C |
4: 108,705,443 (GRCm39) |
E119A |
probably benign |
Het |
| Kti12 |
G |
T |
4: 108,705,444 (GRCm39) |
E119D |
probably benign |
Het |
| Mx1 |
A |
G |
16: 97,256,735 (GRCm39) |
I148T |
probably damaging |
Het |
| Or5m3 |
T |
A |
2: 85,838,640 (GRCm39) |
N173K |
probably damaging |
Het |
| Or6c1b |
A |
G |
10: 129,272,885 (GRCm39) |
E68G |
probably damaging |
Het |
| Orc3 |
T |
C |
4: 34,585,647 (GRCm39) |
I416V |
probably benign |
Het |
| Plcxd3 |
A |
T |
15: 4,546,581 (GRCm39) |
Y195F |
probably damaging |
Het |
| Ppp1r3a |
A |
T |
6: 14,718,025 (GRCm39) |
I963N |
probably benign |
Het |
| Ppp1r7 |
A |
G |
1: 93,278,068 (GRCm39) |
D69G |
possibly damaging |
Het |
| Rars1 |
A |
G |
11: 35,699,412 (GRCm39) |
V627A |
probably benign |
Het |
| Sash1 |
A |
G |
10: 8,605,472 (GRCm39) |
S973P |
probably benign |
Het |
| Slc22a28 |
T |
C |
19: 8,040,698 (GRCm39) |
T518A |
probably damaging |
Het |
| Slc4a9 |
C |
T |
18: 36,661,751 (GRCm39) |
H92Y |
probably benign |
Het |
| Son |
A |
G |
16: 91,456,146 (GRCm39) |
D1631G |
probably damaging |
Het |
| Stat5a |
T |
C |
11: 100,774,728 (GRCm39) |
W746R |
unknown |
Het |
| Thsd4 |
A |
T |
9: 59,910,144 (GRCm39) |
L508Q |
probably damaging |
Het |
| Tlx1 |
C |
T |
19: 45,144,427 (GRCm39) |
Q292* |
probably null |
Het |
| Ttc34 |
T |
C |
4: 154,945,743 (GRCm39) |
V259A |
probably benign |
Het |
| Xrn2 |
T |
G |
2: 146,910,393 (GRCm39) |
|
probably null |
Het |
| Yif1b |
A |
G |
7: 28,944,045 (GRCm39) |
D137G |
possibly damaging |
Het |
| Zfp850 |
A |
G |
7: 27,689,899 (GRCm39) |
I103T |
probably benign |
Het |
|
| Other mutations in Zfp937 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0350:Zfp937
|
UTSW |
2 |
150,081,222 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0449:Zfp937
|
UTSW |
2 |
150,081,466 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1403:Zfp937
|
UTSW |
2 |
150,080,868 (GRCm39) |
nonsense |
probably null |
|
|
R1403:Zfp937
|
UTSW |
2 |
150,080,868 (GRCm39) |
nonsense |
probably null |
|
|
R1465:Zfp937
|
UTSW |
2 |
150,080,967 (GRCm39) |
nonsense |
probably null |
|
|
R1465:Zfp937
|
UTSW |
2 |
150,080,967 (GRCm39) |
nonsense |
probably null |
|
|
R4510:Zfp937
|
UTSW |
2 |
150,080,431 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4511:Zfp937
|
UTSW |
2 |
150,080,431 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4689:Zfp937
|
UTSW |
2 |
150,078,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Zfp937
|
UTSW |
2 |
150,080,229 (GRCm39) |
nonsense |
probably null |
|
|
R6287:Zfp937
|
UTSW |
2 |
150,080,261 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6701:Zfp937
|
UTSW |
2 |
150,081,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6746:Zfp937
|
UTSW |
2 |
150,081,343 (GRCm39) |
nonsense |
probably null |
|
|
R6838:Zfp937
|
UTSW |
2 |
150,081,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7162:Zfp937
|
UTSW |
2 |
150,081,439 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7213:Zfp937
|
UTSW |
2 |
150,081,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7441:Zfp937
|
UTSW |
2 |
150,080,630 (GRCm39) |
frame shift |
probably null |
|
|
R7481:Zfp937
|
UTSW |
2 |
150,081,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7694:Zfp937
|
UTSW |
2 |
150,081,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7902:Zfp937
|
UTSW |
2 |
150,080,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7956:Zfp937
|
UTSW |
2 |
150,081,076 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8058:Zfp937
|
UTSW |
2 |
150,081,421 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8468:Zfp937
|
UTSW |
2 |
150,080,634 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9514:Zfp937
|
UTSW |
2 |
150,080,890 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9617:Zfp937
|
UTSW |
2 |
150,080,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Zfp937
|
UTSW |
2 |
150,060,081 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CATACTGGACAGAAAGCCTATGG -3'
(R):5'- GGCTTGTAAAATGTGAAAAGGCTTG -3'
Sequencing Primer
(F):5'- CCTATGGATGCAAGCAATGTGGC -3'
(R):5'- AAAGGCTTGATCTGATGTAGTGTAC -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation