Incidental Mutation 'R7857:Cdon'
ID 607285
Institutional Source Beutler Lab
Gene Symbol Cdon
Ensembl Gene ENSMUSG00000038119
Gene Name cell adhesion molecule-related/down-regulated by oncogenes
Synonyms CAM-related/down-regulated by oncogenes, CDO
MMRRC Submission 045910-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.351) question?
Stock # R7857 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 35332836-35418948 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 35367908 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 268 (R268G)
Ref Sequence ENSEMBL: ENSMUSP00000045547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129] [ENSMUST00000137200] [ENSMUST00000151682] [ENSMUST00000154652]
AlphaFold Q32MD9
Predicted Effect possibly damaging
Transcript: ENSMUST00000042842
AA Change: R268G

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: R268G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000119129
AA Change: R268G

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: R268G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127264
SMART Domains Protein: ENSMUSP00000115216
Gene: ENSMUSG00000038119

DomainStartEndE-ValueType
IGc2 1 51 6.26e-5 SMART
IG_like 18 62 1.06e2 SMART
IGc2 81 134 6.45e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000137200
Predicted Effect probably benign
Transcript: ENSMUST00000151682
SMART Domains Protein: ENSMUSP00000119206
Gene: ENSMUSG00000038119

DomainStartEndE-ValueType
IGc2 40 103 1.35e-9 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000154652
AA Change: R268G

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000117499
Gene: ENSMUSG00000038119
AA Change: R268G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b A T 12: 113,454,104 (GRCm39) N307I probably benign Het
Ahnak G A 19: 8,984,832 (GRCm39) V2039M probably damaging Het
Arhgef40 T A 14: 52,226,212 (GRCm39) H85Q probably damaging Het
Ash1l T A 3: 88,891,616 (GRCm39) L1165* probably null Het
Cck A G 9: 121,322,514 (GRCm39) W100R probably damaging Het
Cldn12 T C 5: 5,558,209 (GRCm39) T73A probably benign Het
Cnot1 ACG A 8: 96,472,275 (GRCm39) probably null Het
Ctnnd2 A T 15: 30,620,076 (GRCm39) T143S probably benign Het
Cyp2b13 T A 7: 25,788,153 (GRCm39) L427Q possibly damaging Het
Dnah3 A T 7: 119,550,927 (GRCm39) Y152N probably damaging Het
Dsg1b A T 18: 20,529,520 (GRCm39) M322L probably benign Het
Efhc1 T C 1: 21,045,226 (GRCm39) M414T probably benign Het
Elp3 G A 14: 65,800,759 (GRCm39) T302M probably benign Het
Entpd6 T C 2: 150,607,473 (GRCm39) probably null Het
Epb41l4a G T 18: 34,139,098 (GRCm39) C13* probably null Het
Ephb6 T C 6: 41,590,331 (GRCm39) S28P probably benign Het
Fbxo21 T C 5: 118,126,878 (GRCm39) S210P probably benign Het
Gapvd1 T A 2: 34,619,079 (GRCm39) E98V probably benign Het
Gcdh A G 8: 85,619,093 (GRCm39) V157A probably damaging Het
Gm10638 G T 8: 87,472,891 (GRCm39) R188L unknown Het
Grk3 T C 5: 113,109,427 (GRCm39) T177A unknown Het
Gsc T G 12: 104,438,424 (GRCm39) E148A probably damaging Het
Hacd4 C T 4: 88,355,702 (GRCm39) G61E probably damaging Het
Herc3 G A 6: 58,820,637 (GRCm39) W7* probably null Het
Il1rl2 T C 1: 40,366,642 (GRCm39) Y59H probably benign Het
Irag1 T A 7: 110,522,742 (GRCm39) K234* probably null Het
Kif1c A G 11: 70,619,103 (GRCm39) T913A probably benign Het
Lipg C T 18: 75,078,891 (GRCm39) G454R probably damaging Het
Lrrc74a A G 12: 86,788,485 (GRCm39) D155G probably benign Het
Ltf A T 9: 110,851,444 (GRCm39) I137F probably benign Het
Med19 T A 2: 84,515,969 (GRCm39) M166K probably damaging Het
Mei1 A T 15: 81,976,918 (GRCm39) Y167F not run Het
Ncaph A C 2: 126,946,165 (GRCm39) D724E probably damaging Het
Neb T A 2: 52,112,996 (GRCm39) D4266V probably damaging Het
Npffr1 G T 10: 61,449,765 (GRCm39) W13L probably benign Het
Or51b6 A T 7: 103,555,817 (GRCm39) H54L Het
Pcdha12 A T 18: 37,155,468 (GRCm39) D729V probably benign Het
Pcdha7 A T 18: 37,108,892 (GRCm39) E639V probably damaging Het
Pcdhb18 A T 18: 37,624,364 (GRCm39) M565L probably benign Het
Plcd3 A T 11: 102,968,760 (GRCm39) D310E probably benign Het
Pmm2 C G 16: 8,460,632 (GRCm39) Q29E probably benign Het
Poli T G 18: 70,642,225 (GRCm39) E658D probably benign Het
Prss22 G A 17: 24,212,853 (GRCm39) R295C probably damaging Het
Psg26 A G 7: 18,212,215 (GRCm39) I380T possibly damaging Het
Reep5 A T 18: 34,505,521 (GRCm39) V50E possibly damaging Het
Rfx7 A G 9: 72,500,605 (GRCm39) T122A possibly damaging Het
Robo1 A G 16: 72,767,099 (GRCm39) N424D probably damaging Het
Slc4a7 T C 14: 14,772,624 (GRCm38) V711A probably benign Het
Smc4 T C 3: 68,940,552 (GRCm39) V1162A possibly damaging Het
Snta1 A T 2: 154,225,817 (GRCm39) L189H probably benign Het
Tmem121 C T 12: 113,152,696 (GRCm39) R305C possibly damaging Het
Tmem68 A G 4: 3,551,825 (GRCm39) V271A probably damaging Het
Tmx4 T G 2: 134,481,582 (GRCm39) M114L probably benign Het
Trps1 T A 15: 50,524,401 (GRCm39) R1176S probably damaging Het
Usp21 A G 1: 171,114,335 (GRCm39) L63P probably benign Het
Vmn2r84 T A 10: 130,226,738 (GRCm39) M367L probably benign Het
Wbp2nl A G 15: 82,190,273 (GRCm39) N67S probably benign Het
Wdr35 T C 12: 9,058,113 (GRCm39) probably null Het
Zfp236 G A 18: 82,686,726 (GRCm39) Q271* probably null Het
Zfp831 T C 2: 174,547,035 (GRCm39) V1406A probably benign Het
Zfp934 G A 13: 62,665,361 (GRCm39) H459Y Het
Other mutations in Cdon
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Cdon APN 9 35,389,412 (GRCm39) missense probably damaging 1.00
IGL01307:Cdon APN 9 35,368,860 (GRCm39) missense probably benign 0.01
IGL01528:Cdon APN 9 35,381,403 (GRCm39) missense possibly damaging 0.95
IGL01663:Cdon APN 9 35,394,510 (GRCm39) missense possibly damaging 0.57
IGL01723:Cdon APN 9 35,414,634 (GRCm39) missense probably benign 0.05
IGL02200:Cdon APN 9 35,394,405 (GRCm39) missense probably benign 0.28
IGL02444:Cdon APN 9 35,384,744 (GRCm39) missense probably benign 0.09
IGL02547:Cdon APN 9 35,389,950 (GRCm39) missense probably damaging 1.00
IGL02620:Cdon APN 9 35,364,095 (GRCm39) missense probably benign 0.00
IGL02861:Cdon APN 9 35,398,253 (GRCm39) missense probably damaging 0.96
IGL02894:Cdon APN 9 35,366,722 (GRCm39) missense probably benign 0.01
IGL03153:Cdon APN 9 35,389,255 (GRCm39) missense probably damaging 1.00
IGL03206:Cdon APN 9 35,414,602 (GRCm39) missense probably benign
IGL03374:Cdon APN 9 35,389,299 (GRCm39) missense possibly damaging 0.46
corleone UTSW 9 35,398,252 (GRCm39) nonsense probably null
indentured UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
Molar UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
Servitude UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
PIT4280001:Cdon UTSW 9 35,398,231 (GRCm39) missense probably damaging 1.00
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0064:Cdon UTSW 9 35,400,523 (GRCm39) missense probably benign 0.03
R0396:Cdon UTSW 9 35,381,426 (GRCm39) missense probably damaging 1.00
R0403:Cdon UTSW 9 35,384,796 (GRCm39) missense probably benign 0.00
R0490:Cdon UTSW 9 35,363,978 (GRCm39) missense probably damaging 1.00
R0547:Cdon UTSW 9 35,368,794 (GRCm39) missense possibly damaging 0.88
R0609:Cdon UTSW 9 35,389,907 (GRCm39) missense probably damaging 1.00
R0645:Cdon UTSW 9 35,388,379 (GRCm39) splice site probably null
R0781:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1110:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1391:Cdon UTSW 9 35,415,485 (GRCm39) missense possibly damaging 0.51
R1574:Cdon UTSW 9 35,364,233 (GRCm39) splice site probably benign
R1851:Cdon UTSW 9 35,394,454 (GRCm39) missense probably damaging 1.00
R2031:Cdon UTSW 9 35,415,370 (GRCm39) missense probably damaging 0.96
R2230:Cdon UTSW 9 35,403,222 (GRCm39) critical splice donor site probably null
R3683:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3684:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3685:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3941:Cdon UTSW 9 35,375,467 (GRCm39) missense probably benign 0.09
R4030:Cdon UTSW 9 35,403,202 (GRCm39) missense probably damaging 1.00
R4084:Cdon UTSW 9 35,389,427 (GRCm39) missense probably damaging 0.98
R4462:Cdon UTSW 9 35,368,876 (GRCm39) missense probably damaging 0.97
R4569:Cdon UTSW 9 35,388,265 (GRCm39) missense probably damaging 1.00
R4677:Cdon UTSW 9 35,389,901 (GRCm39) missense probably damaging 1.00
R4869:Cdon UTSW 9 35,364,200 (GRCm39) missense possibly damaging 0.71
R5032:Cdon UTSW 9 35,400,330 (GRCm39) missense probably damaging 1.00
R5047:Cdon UTSW 9 35,389,935 (GRCm39) missense probably damaging 1.00
R5214:Cdon UTSW 9 35,394,504 (GRCm39) missense probably damaging 1.00
R5341:Cdon UTSW 9 35,381,431 (GRCm39) missense probably damaging 1.00
R5410:Cdon UTSW 9 35,381,331 (GRCm39) missense probably damaging 0.99
R5581:Cdon UTSW 9 35,415,377 (GRCm39) missense probably benign 0.01
R5696:Cdon UTSW 9 35,403,162 (GRCm39) missense possibly damaging 0.69
R5757:Cdon UTSW 9 35,364,068 (GRCm39) missense probably damaging 0.98
R5802:Cdon UTSW 9 35,365,716 (GRCm39) missense probably damaging 0.99
R5845:Cdon UTSW 9 35,368,762 (GRCm39) missense probably damaging 1.00
R5949:Cdon UTSW 9 35,398,247 (GRCm39) missense probably benign 0.32
R6106:Cdon UTSW 9 35,366,704 (GRCm39) nonsense probably null
R6245:Cdon UTSW 9 35,388,235 (GRCm39) missense probably damaging 1.00
R6845:Cdon UTSW 9 35,398,252 (GRCm39) nonsense probably null
R6896:Cdon UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
R7060:Cdon UTSW 9 35,398,205 (GRCm39) missense probably damaging 1.00
R7076:Cdon UTSW 9 35,415,446 (GRCm39) missense probably benign 0.00
R7184:Cdon UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
R7382:Cdon UTSW 9 35,389,944 (GRCm39) missense probably damaging 1.00
R7763:Cdon UTSW 9 35,365,711 (GRCm39) nonsense probably null
R7885:Cdon UTSW 9 35,367,818 (GRCm39) missense probably benign 0.01
R7894:Cdon UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
R7984:Cdon UTSW 9 35,414,598 (GRCm39) missense probably benign 0.00
R8287:Cdon UTSW 9 35,375,225 (GRCm39) missense probably benign
R8428:Cdon UTSW 9 35,403,163 (GRCm39) missense probably benign 0.21
R8519:Cdon UTSW 9 35,389,950 (GRCm39) missense probably damaging 1.00
R8698:Cdon UTSW 9 35,398,269 (GRCm39) critical splice donor site probably null
R8797:Cdon UTSW 9 35,389,931 (GRCm39) missense probably damaging 1.00
R8995:Cdon UTSW 9 35,398,093 (GRCm39) missense probably damaging 1.00
R9090:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9177:Cdon UTSW 9 35,381,230 (GRCm39) missense probably benign 0.00
R9200:Cdon UTSW 9 35,414,617 (GRCm39) missense probably benign 0.00
R9271:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9330:Cdon UTSW 9 35,400,275 (GRCm39) nonsense probably null
R9477:Cdon UTSW 9 35,403,201 (GRCm39) missense probably damaging 1.00
R9612:Cdon UTSW 9 35,398,201 (GRCm39) missense probably damaging 1.00
R9730:Cdon UTSW 9 35,398,263 (GRCm39) missense probably benign 0.00
Z1177:Cdon UTSW 9 35,403,196 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGTGGACACGAGTCATTTC -3'
(R):5'- ACCAGTTAGACTAGGAAAATGATGC -3'

Sequencing Primer
(F):5'- GTGGACACGAGTCATTTCTAATG -3'
(R):5'- TCACATCTCCGGACTTGT -3'
Posted On 2019-12-20