Incidental Mutation 'R0196:Gstp2'
ID 60763
Institutional Source Beutler Lab
Gene Symbol Gstp2
Ensembl Gene ENSMUSG00000038155
Gene Name glutathione S-transferase, pi 2
Synonyms Gst3, Gst p-2, GSTpiA, Gst-3
MMRRC Submission 038455-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.412) question?
Stock # R0196 (G1)
Quality Score 139
Status Not validated
Chromosome 19
Chromosomal Location 4090288-4092221 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 4090514 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000129565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042700] [ENSMUST00000169613]
AlphaFold P46425
PDB Structure GLUTATHIONE S-TRANSFERASE YFYF CYS 47-CARBOXYMETHYLATED CLASS PI, FREE ENZYME [X-RAY DIFFRACTION]
1.8 ANGSTROMS MOLECULAR STRUCTURE OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS [X-RAY DIFFRACTION]
1.8 ANGSTROMS MOLECULAR STRUCTURE OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS [X-RAY DIFFRACTION]
GLUTATHIONE S-TRANSFERASE YFYF, CLASS PI, COMPLEXED WITH GLUTATHIONE [X-RAY DIFFRACTION]
MODIFIED GLUTATHIONE S-TRANSFERASE (PI) COMPLEXED WITH S (P-NITROBENZYL)GLUTATHIONE [X-RAY DIFFRACTION]
MOLECULAR STRUCTURE AT 1.8 ANGSTROMS OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS [X-RAY DIFFRACTION]
Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-hexyl glutathione [X-RAY DIFFRACTION]
Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-(p-nitrobenzyl) Glutathione [X-RAY DIFFRACTION]
Structure of Glutathione-S-Transferase C169A Mutant [X-RAY DIFFRACTION]
1.8 Angstroms molecular structure of mouse liver glutathione S-transferase mutant C47A complexed with S-(P-nitrobenzyl)glutathione [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000042700
AA Change: L157Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038931
Gene: ENSMUSG00000038155
AA Change: L157Q

DomainStartEndE-ValueType
Pfam:GST_N 2 75 4.2e-8 PFAM
Pfam:GST_C 97 188 1.4e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000169613
SMART Domains Protein: ENSMUSP00000129565
Gene: ENSMUSG00000060803

DomainStartEndE-ValueType
Pfam:GST_N 4 75 2.3e-8 PFAM
Pfam:GST_C 97 188 1.5e-15 PFAM
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 93.8%
  • 20x: 81.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933409G03Rik A G 2: 68,446,591 (GRCm39) probably benign Het
Aass G A 6: 23,109,519 (GRCm39) P317L probably damaging Het
Abca12 T A 1: 71,298,972 (GRCm39) N2313I possibly damaging Het
Adamts12 T C 15: 11,071,594 (GRCm39) I46T probably benign Het
Adipoq T G 16: 22,965,393 (GRCm39) probably null Het
Amy1 A T 3: 113,363,070 (GRCm39) D92E probably benign Het
Asb15 G A 6: 24,564,392 (GRCm39) R282Q probably damaging Het
Bag6 G C 17: 35,363,239 (GRCm39) G693A probably damaging Het
Birc6 T C 17: 74,887,282 (GRCm39) I870T possibly damaging Het
Cand2 A G 6: 115,766,463 (GRCm39) K356R probably damaging Het
Cbfa2t3 T C 8: 123,360,076 (GRCm39) Q525R possibly damaging Het
Cd4 T C 6: 124,844,769 (GRCm39) R339G probably damaging Het
Cdh8 A G 8: 99,917,066 (GRCm39) S350P probably damaging Het
Cep295 A T 9: 15,249,509 (GRCm39) S469T probably damaging Het
Ckap2l A T 2: 129,127,342 (GRCm39) S279T probably benign Het
Clnk T A 5: 38,927,282 (GRCm39) N66Y probably damaging Het
Col27a1 A T 4: 63,142,503 (GRCm39) T64S probably benign Het
Crtc1 T C 8: 70,838,871 (GRCm39) D599G probably damaging Het
Cyp2c23 A C 19: 44,000,795 (GRCm39) I363S probably damaging Het
Dnah10 A T 5: 124,911,139 (GRCm39) I4519F possibly damaging Het
Dner T A 1: 84,348,553 (GRCm39) I716F probably damaging Het
Dsel T G 1: 111,789,333 (GRCm39) T401P possibly damaging Het
Egfr A G 11: 16,861,746 (GRCm39) D1175G probably benign Het
Ephb3 A T 16: 21,036,804 (GRCm39) N343I probably damaging Het
Fbxw10 T A 11: 62,768,070 (GRCm39) F974I probably benign Het
Gfi1b T C 2: 28,503,786 (GRCm39) Y138C probably damaging Het
Gm11168 T A 9: 3,005,175 (GRCm39) L6H probably benign Het
Grb10 A C 11: 11,895,583 (GRCm39) V247G probably damaging Het
Hars2 C T 18: 36,922,257 (GRCm39) Q291* probably null Het
Hyal4 G T 6: 24,756,220 (GRCm39) W146L probably damaging Het
Il22ra1 C T 4: 135,461,556 (GRCm39) T107I possibly damaging Het
Itga8 A G 2: 12,209,540 (GRCm39) probably null Het
Klhl25 T C 7: 75,515,450 (GRCm39) S119P probably damaging Het
Krt81 C A 15: 101,361,508 (GRCm39) R24L possibly damaging Het
Lrrc8c T C 5: 105,754,636 (GRCm39) V137A probably benign Het
Macrod2 A T 2: 142,018,545 (GRCm39) E226V probably damaging Het
Mcemp1 A T 8: 3,718,201 (GRCm39) Q165L probably benign Het
Mcpt9 T A 14: 56,265,453 (GRCm39) K82M probably benign Het
Mpzl3 A G 9: 44,973,458 (GRCm39) T66A probably damaging Het
Msh6 G A 17: 88,287,788 (GRCm39) V143I possibly damaging Het
Mug1 G A 6: 121,815,684 (GRCm39) probably null Het
Ncr1 G T 7: 4,343,972 (GRCm39) C153F probably damaging Het
Nf1 T A 11: 79,359,595 (GRCm39) M1411K possibly damaging Het
Nf1 T A 11: 79,469,098 (GRCm39) V786D probably damaging Het
Nisch T C 14: 30,925,351 (GRCm39) probably benign Het
Nwd2 T A 5: 63,963,694 (GRCm39) Y1093N probably benign Het
Oas3 G A 5: 120,894,210 (GRCm39) R39C probably damaging Het
Or1e32 A T 11: 73,705,731 (GRCm39) M59K probably damaging Het
Or7a36 C T 10: 78,820,023 (GRCm39) T133I possibly damaging Het
Oxa1l T C 14: 54,600,944 (GRCm39) I139T probably damaging Het
P3h3 T A 6: 124,822,235 (GRCm39) N583Y probably damaging Het
Pcdh18 A T 3: 49,711,147 (GRCm39) probably null Het
Pcnp C T 16: 55,844,896 (GRCm39) probably benign Het
Pdzd8 G T 19: 59,289,563 (GRCm39) D612E probably benign Het
Pi4kb T C 3: 94,906,261 (GRCm39) S8P probably damaging Het
Pikfyve T G 1: 65,295,231 (GRCm39) V1454G possibly damaging Het
Podn T C 4: 107,878,695 (GRCm39) N246D probably damaging Het
Prg4 T C 1: 150,330,243 (GRCm39) probably benign Het
R3hdm2 T C 10: 127,320,390 (GRCm39) Y523H probably damaging Het
Rpf1 T A 3: 146,213,904 (GRCm39) E231V possibly damaging Het
Slc16a10 C T 10: 39,932,611 (GRCm39) E317K probably benign Het
Slc34a1 A T 13: 55,560,078 (GRCm39) I435F probably damaging Het
Snx19 A G 9: 30,344,683 (GRCm39) D629G probably damaging Het
Tomm70a T C 16: 56,966,463 (GRCm39) I472T probably benign Het
Trp53 A G 11: 69,479,506 (GRCm39) Y202C probably damaging Het
Ttc14 T A 3: 33,863,403 (GRCm39) probably benign Het
Ugt1a1 C T 1: 88,140,277 (GRCm39) A185V possibly damaging Het
Usp28 A G 9: 48,939,578 (GRCm39) D655G probably damaging Het
Vmn1r215 C T 13: 23,260,254 (GRCm39) T98I probably damaging Het
Vmn2r121 G T X: 123,041,879 (GRCm39) T426N probably benign Het
Vmn2r99 A G 17: 19,614,835 (GRCm39) N852D probably benign Het
Xrn2 T A 2: 146,889,580 (GRCm39) D654E probably damaging Het
Yju2 C A 17: 56,271,653 (GRCm39) D191E probably damaging Het
Zfp335 C G 2: 164,738,065 (GRCm39) A849P possibly damaging Het
Zfp954 C T 7: 7,118,390 (GRCm39) V385M probably damaging Het
Zmynd15 A G 11: 70,355,052 (GRCm39) T350A probably damaging Het
Other mutations in Gstp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02387:Gstp2 APN 19 4,091,094 (GRCm39) unclassified probably benign
PIT4362001:Gstp2 UTSW 19 4,090,713 (GRCm39) missense possibly damaging 0.82
R0545:Gstp2 UTSW 19 4,091,633 (GRCm39) missense possibly damaging 0.88
R6324:Gstp2 UTSW 19 4,090,499 (GRCm39) missense probably benign 0.00
R6478:Gstp2 UTSW 19 4,090,499 (GRCm39) missense probably benign 0.00
R7318:Gstp2 UTSW 19 4,091,065 (GRCm39) missense probably benign 0.00
R8218:Gstp2 UTSW 19 4,091,668 (GRCm39) missense probably benign 0.00
R9799:Gstp2 UTSW 19 4,091,901 (GRCm39) critical splice donor site probably null
Z1177:Gstp2 UTSW 19 4,091,583 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TTTTCAACAGGAAACGGCACCAAAG -3'
(R):5'- TTTGAGACCCTGCTGTCCCAGAAC -3'

Sequencing Primer
(F):5'- ACAAGAAGCTCTTGTCTCTTCAG -3'
(R):5'- GTGACCAGGTGAGCATCTC -3'
Posted On 2013-07-24