Incidental Mutation 'R0197:Olfr272'
ID 60766
Institutional Source Beutler Lab
Gene Symbol Olfr272
Ensembl Gene ENSMUSG00000051593
Gene Name olfactory receptor 272
Synonyms GA_x6K02T2N78B-7084885-7085844, MOR262-7
MMRRC Submission 038456-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R0197 (G1)
Quality Score 196
Status Validated
Chromosome 4
Chromosomal Location 52910207-52919178 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 52910849 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 315 (T315M)
Ref Sequence ENSEMBL: ENSMUSP00000149339 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051600] [ENSMUST00000107667] [ENSMUST00000213989]
AlphaFold Q8VGA0
Predicted Effect probably benign
Transcript: ENSMUST00000051600
AA Change: T315M

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000055721
Gene: ENSMUSG00000051593
AA Change: T315M

Pfam:7tm_4 31 314 1.6e-54 PFAM
Pfam:7tm_1 41 296 9.5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107667
AA Change: T315M

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000103294
Gene: ENSMUSG00000051593
AA Change: T315M

Pfam:7tm_1 39 294 9.5e-33 PFAM
Pfam:7tm_4 138 287 3.3e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213989
AA Change: T315M

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217085
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.3%
  • 10x: 92.5%
  • 20x: 75.9%
Validation Efficiency 97% (121/125)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 138,069,871 (GRCm38) L1607P probably damaging Het
1700016H13Rik T C 5: 103,648,821 (GRCm38) *118W probably null Het
1700061G19Rik A T 17: 56,883,835 (GRCm38) N468Y probably benign Het
2610507B11Rik A C 11: 78,269,704 (GRCm38) probably benign Het
4930452B06Rik C T 14: 8,518,695 (GRCm38) G254R probably damaging Het
Abcc2 A T 19: 43,826,614 (GRCm38) R1147* probably null Het
Agap2 A G 10: 127,091,702 (GRCm38) T1131A possibly damaging Het
Aldh9a1 A G 1: 167,361,847 (GRCm38) D388G probably damaging Het
Ap3d1 G T 10: 80,730,042 (GRCm38) A97E probably damaging Het
Arhgef10 T A 8: 14,962,636 (GRCm38) V320E probably damaging Het
Baiap2l1 C A 5: 144,266,010 (GRCm38) V498L probably damaging Het
Ccdc189 T C 7: 127,584,862 (GRCm38) E261G probably damaging Het
Cdh2 T C 18: 16,629,576 (GRCm38) N437S probably benign Het
Chd1 C A 17: 15,725,431 (GRCm38) N72K probably benign Het
Col4a3bp T A 13: 96,549,287 (GRCm38) Y63N probably benign Het
Cstf2t A T 19: 31,084,626 (GRCm38) M521L probably benign Het
Dlx5 T C 6: 6,881,619 (GRCm38) K90E possibly damaging Het
Dmp1 A G 5: 104,207,630 (GRCm38) E32G possibly damaging Het
Espnl T G 1: 91,344,489 (GRCm38) Y524D probably damaging Het
Fam20c T C 5: 138,755,724 (GRCm38) L30P probably damaging Het
Fat1 G T 8: 45,026,553 (GRCm38) A2879S probably benign Het
Gabrg1 A T 5: 70,774,389 (GRCm38) V337D probably damaging Het
Gart C A 16: 91,623,403 (GRCm38) D851Y possibly damaging Het
Gcc1 T C 6: 28,420,616 (GRCm38) H234R probably damaging Het
Gemin6 T A 17: 80,228,095 (GRCm38) H161Q probably damaging Het
Glt6d1 A G 2: 25,794,070 (GRCm38) I308T probably benign Het
Gm10320 T C 13: 98,491,983 (GRCm38) T7A probably benign Het
Gm10912 T C 2: 104,066,530 (GRCm38) S5P probably benign Het
Gm13088 C T 4: 143,656,440 (GRCm38) E70K possibly damaging Het
Gmpr2 T A 14: 55,672,735 (GRCm38) D7E possibly damaging Het
Hc A G 2: 34,984,750 (GRCm38) Y1620H probably damaging Het
Hoxa3 T C 6: 52,170,143 (GRCm38) probably benign Het
Ift140 A G 17: 25,090,933 (GRCm38) T1105A probably benign Het
Kdr G T 5: 75,968,422 (GRCm38) T188N possibly damaging Het
Lepr A T 4: 101,752,152 (GRCm38) D312V possibly damaging Het
Mcm3 A G 1: 20,810,105 (GRCm38) V501A probably damaging Het
Mcur1 T C 13: 43,545,740 (GRCm38) Y267C probably damaging Het
Med13 T A 11: 86,307,038 (GRCm38) T736S probably benign Het
Med13l T C 5: 118,671,002 (GRCm38) probably benign Het
Mroh2a G C 1: 88,246,042 (GRCm38) A871P probably damaging Het
Ndrg2 T A 14: 51,907,003 (GRCm38) probably benign Het
Oas3 G A 5: 120,756,145 (GRCm38) R39C probably damaging Het
Olfr1258 A G 2: 89,930,201 (GRCm38) T131A probably benign Het
Olfr1298 C T 2: 111,645,791 (GRCm38) V69I probably benign Het
Olfr558 T A 7: 102,709,995 (GRCm38) H245Q probably damaging Het
Onecut2 T A 18: 64,341,472 (GRCm38) S365T possibly damaging Het
Pds5b C A 5: 150,754,431 (GRCm38) Q505K probably benign Het
Rfx2 T C 17: 56,803,722 (GRCm38) Y88C probably damaging Het
Rpl6 T C 5: 121,208,478 (GRCm38) V214A probably benign Het
Samd3 T A 10: 26,271,854 (GRCm38) C476S possibly damaging Het
Sfi1 TCGC TC 11: 3,146,254 (GRCm38) probably null Het
Shank1 C T 7: 44,352,294 (GRCm38) R1146W unknown Het
Smcr8 T C 11: 60,778,115 (GRCm38) Y30H probably damaging Het
Smpd4 T A 16: 17,641,597 (GRCm38) probably null Het
Strip1 C A 3: 107,614,613 (GRCm38) D750Y probably damaging Het
Svep1 T C 4: 58,070,851 (GRCm38) K2312E possibly damaging Het
Taf1c A T 8: 119,599,983 (GRCm38) I438N probably damaging Het
Tnfaip1 A T 11: 78,530,014 (GRCm38) probably benign Het
Unc45b T A 11: 82,940,205 (GRCm38) L797Q possibly damaging Het
Usp24 T A 4: 106,407,133 (GRCm38) W1754R probably damaging Het
Utp20 G A 10: 88,777,516 (GRCm38) P1301L probably benign Het
Vmn2r115 T A 17: 23,359,781 (GRCm38) S743T probably damaging Het
Vps41 T G 13: 18,854,663 (GRCm38) probably null Het
Vps72 G T 3: 95,122,583 (GRCm38) L304F probably damaging Het
Wiz A T 17: 32,356,441 (GRCm38) I907N probably damaging Het
Zfp521 T C 18: 13,845,062 (GRCm38) T765A probably benign Het
Zfp616 A T 11: 74,085,674 (GRCm38) H923L probably damaging Het
Zp2 A T 7: 120,143,576 (GRCm38) probably benign Het
Other mutations in Olfr272
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Olfr272 APN 4 52,911,618 (GRCm38) missense possibly damaging 0.95
IGL02224:Olfr272 APN 4 52,911,392 (GRCm38) missense probably damaging 0.97
IGL03293:Olfr272 APN 4 52,910,835 (GRCm38) makesense probably null
K3955:Olfr272 UTSW 4 52,911,081 (GRCm38) missense probably damaging 1.00
R0195:Olfr272 UTSW 4 52,910,849 (GRCm38) missense probably benign 0.00
R0445:Olfr272 UTSW 4 52,910,849 (GRCm38) missense probably benign 0.00
R1517:Olfr272 UTSW 4 52,911,502 (GRCm38) nonsense probably null
R1536:Olfr272 UTSW 4 52,911,260 (GRCm38) missense probably benign 0.43
R1540:Olfr272 UTSW 4 52,910,996 (GRCm38) missense probably benign 0.00
R1551:Olfr272 UTSW 4 52,911,397 (GRCm38) nonsense probably null
R1612:Olfr272 UTSW 4 52,911,501 (GRCm38) missense probably benign
R1920:Olfr272 UTSW 4 52,910,849 (GRCm38) missense probably benign
R2181:Olfr272 UTSW 4 52,911,524 (GRCm38) missense probably damaging 1.00
R5410:Olfr272 UTSW 4 52,910,991 (GRCm38) missense probably benign 0.01
R6331:Olfr272 UTSW 4 52,911,399 (GRCm38) missense probably damaging 1.00
R6336:Olfr272 UTSW 4 52,911,459 (GRCm38) missense probably damaging 1.00
R7085:Olfr272 UTSW 4 52,910,961 (GRCm38) missense probably benign 0.02
R7541:Olfr272 UTSW 4 52,911,376 (GRCm38) missense probably benign 0.04
R7727:Olfr272 UTSW 4 52,911,368 (GRCm38) missense possibly damaging 0.89
R7891:Olfr272 UTSW 4 52,911,663 (GRCm38) missense probably benign 0.01
R8782:Olfr272 UTSW 4 52,911,693 (GRCm38) missense probably benign 0.16
R9321:Olfr272 UTSW 4 52,911,314 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2013-07-24