Mutagenetix > Incidental Mutation

Incidental Mutation 'R7866:Or8g21'

607783

Institutional Source

Beutler Lab

Gene Symbol

Or8g21

Ensembl Gene

ENSMUSG00000059595

Gene Name

olfactory receptor family 8 subfamily G member 21

Synonyms

MOR171-11, GA_x6K02T2PVTD-32691280-32690354, Olfr935

MMRRC Submission

045918-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

R7866 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

38905803-38906729 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 38906027 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 235 (S235T)

Ref Sequence

ENSEMBL: ENSMUSP00000149193 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000214157]

AlphaFold

Q8VG16

Predicted Effect

not run
Transcript: ENSMUST00000214157
AA Change: S235T

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg1	C	T	17: 31,317,269 (GRCm39)	R194*	probably null	Het
Actl6a	A	G	3: 32,766,262 (GRCm39)	T39A	possibly damaging	Het
Adamts6	T	A	13: 104,550,257 (GRCm39)	C624*	probably null	Het
Adgrl1	T	C	8: 84,664,564 (GRCm39)		probably null	Het
Ap3m2	A	G	8: 23,289,674 (GRCm39)	V143A	probably benign	Het
Ap5m1	T	C	14: 49,311,218 (GRCm39)	V96A	probably damaging	Het
Aqp5	T	A	15: 99,489,424 (GRCm39)	V91E	probably damaging	Het
Atp6v0b	A	T	4: 117,742,350 (GRCm39)	I181N	probably damaging	Het
Ccp110	T	A	7: 118,322,241 (GRCm39)	M632K	probably benign	Het
Cd44	A	T	2: 102,672,604 (GRCm39)		probably null	Het
Cidea	G	A	18: 67,491,854 (GRCm39)	R38Q	probably damaging	Het
Cnn3	T	C	3: 121,245,042 (GRCm39)	I86T	probably benign	Het
Col14a1	C	A	15: 55,252,016 (GRCm39)	D557E	unknown	Het
Col6a6	T	C	9: 105,566,760 (GRCm39)	Y2245C	probably damaging	Het
Dhrs4	A	T	14: 55,725,092 (GRCm39)	N196Y	probably damaging	Het
Dnah8	T	C	17: 31,093,901 (GRCm39)	V4665A	possibly damaging	Het
Dpep2	T	C	8: 106,716,113 (GRCm39)	T267A		Het
Dtx3l	T	A	16: 35,759,120 (GRCm39)	Q43L	probably benign	Het
Ednrb	A	G	14: 104,080,738 (GRCm39)	S59P	probably benign	Het
Eml4	A	G	17: 83,758,126 (GRCm39)	T435A	probably benign	Het
Fam135b	A	T	15: 71,333,925 (GRCm39)	F1090I	probably benign	Het
Filip1	A	G	9: 79,726,225 (GRCm39)	V798A	probably benign	Het
Fnip1	T	G	11: 54,356,228 (GRCm39)		probably benign	Het
Gabrb2	C	T	11: 42,378,050 (GRCm39)	Q89*	probably null	Het
Gtf2ird1	A	T	5: 134,392,063 (GRCm39)	V882E	probably benign	Het
Gucy1a2	T	A	9: 3,532,804 (GRCm39)	M1K	probably null	Het
Ift70b	A	G	2: 75,766,963 (GRCm39)	S597P	possibly damaging	Het
Igkv10-96	T	A	6: 68,609,025 (GRCm39)	D90V	possibly damaging	Het
Igkv4-54	G	A	6: 69,608,740 (GRCm39)	R60C	probably benign	Het
Igkv7-33	G	T	6: 70,035,847 (GRCm39)	A45D	probably damaging	Het
Klk1b22	A	T	7: 43,762,168 (GRCm39)	I15F	possibly damaging	Het
Lamp3	T	A	16: 19,518,490 (GRCm39)	D249V	probably benign	Het
Lrrfip2	T	C	9: 111,022,149 (GRCm39)	V125A	possibly damaging	Het
Mprip	G	A	11: 59,643,756 (GRCm39)	R638H	possibly damaging	Het
Muc5ac	A	G	7: 141,349,589 (GRCm39)	M501V	probably benign	Het
Myo5a	C	T	9: 75,111,034 (GRCm39)	P1509S	probably damaging	Het
Ngdn	A	G	14: 55,258,554 (GRCm39)	Y63C	probably damaging	Het
Oit3	A	G	10: 59,259,852 (GRCm39)	V517A	probably benign	Het
Pcdhb18	T	A	18: 37,623,512 (GRCm39)	F281I	probably damaging	Het
Pkd1	C	A	17: 24,809,881 (GRCm39)	Q3520K	probably benign	Het
Plxnb1	T	A	9: 108,929,525 (GRCm39)	I127N	probably damaging	Het
Ppfia2	A	T	10: 106,655,390 (GRCm39)	N319I	probably damaging	Het
Pxn	T	C	5: 115,686,665 (GRCm39)	S386P	possibly damaging	Het
Ralgps2	C	T	1: 156,714,738 (GRCm39)	V104I	probably benign	Het
Rp1	C	T	1: 4,417,924 (GRCm39)	V1063I	probably benign	Het
Slc10a5	A	T	3: 10,399,532 (GRCm39)	F376Y	probably damaging	Het
Snd1	T	A	6: 28,527,724 (GRCm39)	I277N	probably damaging	Het
Spc25	A	G	2: 69,036,406 (GRCm39)		probably null	Het
Tex29	A	G	8: 11,894,055 (GRCm39)	N6D	unknown	Het
Top6bl	T	A	19: 4,748,514 (GRCm39)	R61S	unknown	Het
Ttc6	G	A	12: 57,721,435 (GRCm39)	A975T	probably damaging	Het
Uba6	T	C	5: 86,320,560 (GRCm39)	E13G	probably damaging	Het
Ugcg	T	G	4: 59,211,927 (GRCm39)	C98G	possibly damaging	Het
Ugt2b36	T	A	5: 87,240,190 (GRCm39)	D65V	probably damaging	Het
Unc93b1	A	T	19: 3,985,243 (GRCm39)	D17V	not run	Het
Usf1	G	T	1: 171,245,462 (GRCm39)	W291C	unknown	Het
Vps29	T	C	5: 122,500,180 (GRCm39)	W97R	possibly damaging	Het
Zbtb6	T	C	2: 37,319,577 (GRCm39)	E117G	probably damaging	Het
Zfp735	A	C	11: 73,601,629 (GRCm39)	D191A	probably benign	Het

Other mutations in Or8g21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01522:Or8g21	APN	9	38,906,396 (GRCm39)	missense	probably benign	0.08
IGL01671:Or8g21	APN	9	38,906,149 (GRCm39)	missense	probably benign	0.05
IGL02331:Or8g21	APN	9	38,906,402 (GRCm39)	missense	probably damaging	0.99
IGL03069:Or8g21	APN	9	38,906,728 (GRCm39)	start codon destroyed	probably null	0.98
IGL03143:Or8g21	APN	9	38,906,732 (GRCm39)	utr 5 prime	probably benign
R0149:Or8g21	UTSW	9	38,905,880 (GRCm39)	missense	probably benign	0.05
R0400:Or8g21	UTSW	9	38,906,494 (GRCm39)	missense	probably damaging	1.00
R1818:Or8g21	UTSW	9	38,905,902 (GRCm39)	missense	possibly damaging	0.61
R2092:Or8g21	UTSW	9	38,906,485 (GRCm39)	missense	probably damaging	1.00
R2151:Or8g21	UTSW	9	38,906,012 (GRCm39)	missense	probably damaging	1.00
R2166:Or8g21	UTSW	9	38,906,513 (GRCm39)	nonsense	probably null
R2347:Or8g21	UTSW	9	38,905,805 (GRCm39)	makesense	probably null
R4404:Or8g21	UTSW	9	38,905,865 (GRCm39)	missense	possibly damaging	0.77
R4406:Or8g21	UTSW	9	38,905,865 (GRCm39)	missense	possibly damaging	0.77
R5152:Or8g21	UTSW	9	38,906,473 (GRCm39)	missense	possibly damaging	0.88
R5467:Or8g21	UTSW	9	38,906,200 (GRCm39)	missense	probably benign	0.14
R5509:Or8g21	UTSW	9	38,905,924 (GRCm39)	missense	probably benign	0.03
R5954:Or8g21	UTSW	9	38,906,711 (GRCm39)	missense	probably damaging	1.00
R6647:Or8g21	UTSW	9	38,906,210 (GRCm39)	missense	possibly damaging	0.55
R6680:Or8g21	UTSW	9	38,905,954 (GRCm39)	missense	probably damaging	1.00
R6928:Or8g21	UTSW	9	38,905,928 (GRCm39)	missense	probably benign	0.03
R7242:Or8g21	UTSW	9	38,906,437 (GRCm39)	missense	probably benign	0.31
R7271:Or8g21	UTSW	9	38,905,953 (GRCm39)	nonsense	probably null
R7309:Or8g21	UTSW	9	38,906,576 (GRCm39)	missense	probably damaging	1.00
R7775:Or8g21	UTSW	9	38,906,203 (GRCm39)	missense	probably damaging	1.00
R7778:Or8g21	UTSW	9	38,906,203 (GRCm39)	missense	probably damaging	1.00
R8280:Or8g21	UTSW	9	38,906,075 (GRCm39)	missense	probably benign
R8334:Or8g21	UTSW	9	38,905,889 (GRCm39)	missense	probably benign	0.00
R8841:Or8g21	UTSW	9	38,905,879 (GRCm39)	missense	possibly damaging	0.95
R9161:Or8g21	UTSW	9	38,905,816 (GRCm39)	missense	possibly damaging	0.70
R9169:Or8g21	UTSW	9	38,906,573 (GRCm39)	missense	probably benign	0.23
R9659:Or8g21	UTSW	9	38,906,296 (GRCm39)	missense	possibly damaging	0.64
R9739:Or8g21	UTSW	9	38,906,302 (GRCm39)	nonsense	probably null
R9788:Or8g21	UTSW	9	38,906,296 (GRCm39)	missense	possibly damaging	0.64

Predicted Primers

Posted On

2019-12-20