Incidental Mutation 'R7867:Vmn2r59'
| ID |
607839 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r59
|
| Ensembl Gene |
ENSMUSG00000092032 |
| Gene Name |
vomeronasal 2, receptor 59 |
| Synonyms |
EG628444 |
| MMRRC Submission |
045919-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R7867 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 41661707 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 703
(I703F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
| AlphaFold |
E9PUT5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168489
AA Change: I703F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: I703F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
A |
11: 9,212,139 (GRCm39) |
|
probably null |
Het |
| Abcf1 |
C |
A |
17: 36,272,890 (GRCm39) |
K252N |
probably damaging |
Het |
| Abi3 |
C |
T |
11: 95,724,851 (GRCm39) |
A211T |
possibly damaging |
Het |
| Acaca |
A |
T |
11: 84,140,350 (GRCm39) |
D608V |
possibly damaging |
Het |
| Akap10 |
A |
G |
11: 61,791,272 (GRCm39) |
Y396H |
probably damaging |
Het |
| Ap3b1 |
C |
G |
13: 94,619,771 (GRCm39) |
S778W |
unknown |
Het |
| Arb2a |
T |
C |
13: 78,050,837 (GRCm39) |
M165T |
probably benign |
Het |
| Baat |
G |
A |
4: 49,502,925 (GRCm39) |
L66F |
probably benign |
Het |
| Cachd1 |
A |
G |
4: 100,845,759 (GRCm39) |
N981S |
probably damaging |
Het |
| Cacna1c |
C |
T |
6: 118,753,407 (GRCm39) |
R243H |
|
Het |
| Cdh23 |
T |
A |
10: 60,150,390 (GRCm39) |
I2527F |
probably damaging |
Het |
| Cinp |
A |
G |
12: 110,840,557 (GRCm39) |
V198A |
probably benign |
Het |
| Clec4d |
T |
C |
6: 123,244,123 (GRCm39) |
|
probably null |
Het |
| Cnn3 |
A |
G |
3: 121,248,704 (GRCm39) |
I204V |
probably benign |
Het |
| Cpxm2 |
C |
A |
7: 131,650,800 (GRCm39) |
G620V |
probably damaging |
Het |
| Ctrl |
A |
C |
8: 106,659,497 (GRCm39) |
S93A |
probably benign |
Het |
| Cyp2d34 |
A |
G |
15: 82,501,425 (GRCm39) |
V301A |
possibly damaging |
Het |
| Dnaaf5 |
G |
T |
5: 139,147,565 (GRCm39) |
K376N |
probably damaging |
Het |
| Eno2 |
C |
T |
6: 124,740,137 (GRCm39) |
D300N |
probably damaging |
Het |
| Entrep3 |
T |
A |
3: 89,093,083 (GRCm39) |
Y280* |
probably null |
Het |
| Fam117b |
T |
A |
1: 60,014,046 (GRCm39) |
N440K |
probably damaging |
Het |
| Fam131a |
A |
G |
16: 20,514,584 (GRCm39) |
S62G |
probably benign |
Het |
| Fancm |
T |
A |
12: 65,163,240 (GRCm39) |
|
probably null |
Het |
| Fancm |
A |
G |
12: 65,165,173 (GRCm39) |
D1506G |
probably benign |
Het |
| Fhad1 |
C |
A |
4: 141,632,902 (GRCm39) |
V1201L |
probably benign |
Het |
| Gdpd4 |
T |
A |
7: 97,623,185 (GRCm39) |
C265* |
probably null |
Het |
| Gm3127 |
A |
T |
14: 15,425,888 (GRCm39) |
T98S |
probably null |
Het |
| Gpsm1 |
A |
T |
2: 26,230,448 (GRCm39) |
D466V |
probably benign |
Het |
| Gramd1a |
T |
G |
7: 30,842,992 (GRCm39) |
K76Q |
probably damaging |
Het |
| Gstp3 |
T |
C |
19: 4,108,808 (GRCm39) |
D24G |
probably damaging |
Het |
| Kalrn |
G |
A |
16: 33,810,161 (GRCm39) |
T2531I |
possibly damaging |
Het |
| Klk7 |
C |
A |
7: 43,462,333 (GRCm39) |
D108E |
probably damaging |
Het |
| Klkb1 |
A |
G |
8: 45,740,002 (GRCm39) |
S97P |
probably damaging |
Het |
| Krt13 |
T |
C |
11: 100,012,008 (GRCm39) |
D105G |
probably damaging |
Het |
| Lingo2 |
T |
A |
4: 35,709,302 (GRCm39) |
H226L |
probably benign |
Het |
| Lrba |
T |
C |
3: 86,275,896 (GRCm39) |
S1755P |
probably damaging |
Het |
| Marf1 |
A |
G |
16: 13,946,470 (GRCm39) |
V1217A |
probably damaging |
Het |
| Mtss1 |
A |
T |
15: 58,842,858 (GRCm39) |
V118E |
possibly damaging |
Het |
| Mug1 |
T |
A |
6: 121,850,593 (GRCm39) |
D696E |
probably benign |
Het |
| Ndufa3 |
C |
T |
7: 3,623,003 (GRCm39) |
P56L |
probably damaging |
Het |
| Nop56 |
T |
A |
2: 130,120,205 (GRCm39) |
C471S |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 58,891,652 (GRCm39) |
H6960L |
unknown |
Het |
| Or13a22 |
C |
T |
7: 140,073,049 (GRCm39) |
T166I |
probably benign |
Het |
| Pcdhb10 |
A |
C |
18: 37,546,619 (GRCm39) |
Q565P |
probably benign |
Het |
| Pde6g |
T |
A |
11: 120,338,953 (GRCm39) |
H79L |
possibly damaging |
Het |
| Phrf1 |
G |
T |
7: 140,836,524 (GRCm39) |
M265I |
unknown |
Het |
| Pkd2 |
T |
C |
5: 104,630,986 (GRCm39) |
F470S |
probably damaging |
Het |
| Plekhm1 |
T |
A |
11: 103,271,153 (GRCm39) |
D446V |
probably damaging |
Het |
| Prkaca |
A |
T |
8: 84,721,963 (GRCm39) |
T325S |
probably benign |
Het |
| Proz |
A |
T |
8: 13,111,027 (GRCm39) |
|
probably benign |
Het |
| Pten |
T |
C |
19: 32,792,894 (GRCm39) |
F238L |
probably benign |
Het |
| Ptpn21 |
G |
A |
12: 98,671,435 (GRCm39) |
L198F |
probably damaging |
Het |
| Rbm5 |
A |
T |
9: 107,628,930 (GRCm39) |
S394T |
probably benign |
Het |
| Scaf8 |
T |
G |
17: 3,227,994 (GRCm39) |
S408A |
unknown |
Het |
| Slc41a3 |
T |
A |
6: 90,617,909 (GRCm39) |
F312I |
probably damaging |
Het |
| Soat2 |
T |
A |
15: 102,059,598 (GRCm39) |
|
probably null |
Het |
| Sorcs1 |
C |
A |
19: 50,218,698 (GRCm39) |
G595* |
probably null |
Het |
| Spopfm1 |
G |
C |
3: 94,173,154 (GRCm39) |
S50T |
probably benign |
Het |
| Stox1 |
G |
T |
10: 62,500,723 (GRCm39) |
D612E |
probably benign |
Het |
| Suco |
T |
C |
1: 161,665,365 (GRCm39) |
I530M |
possibly damaging |
Het |
| Syne2 |
A |
G |
12: 76,030,501 (GRCm39) |
|
probably null |
Het |
| Thbd |
G |
A |
2: 148,249,664 (GRCm39) |
A68V |
probably damaging |
Het |
| Tmem109 |
A |
T |
19: 10,855,466 (GRCm39) |
M4K |
unknown |
Het |
| Tmub1 |
G |
C |
5: 24,651,664 (GRCm39) |
P85R |
possibly damaging |
Het |
| Tnk2 |
A |
C |
16: 32,500,053 (GRCm39) |
Q1039H |
probably damaging |
Het |
| Tpm3 |
T |
C |
3: 89,993,775 (GRCm39) |
L89S |
probably damaging |
Het |
| Unc13b |
C |
T |
4: 43,232,573 (GRCm39) |
R432* |
probably null |
Het |
| Xylt1 |
T |
A |
7: 117,074,749 (GRCm39) |
I122N |
probably benign |
Het |
| Zc3h12c |
T |
C |
9: 52,055,248 (GRCm39) |
E187G |
probably damaging |
Het |
|
| Other mutations in Vmn2r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01432:Vmn2r59
|
APN |
7 |
41,661,983 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0632:Vmn2r59
|
UTSW |
7 |
41,708,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
|
R1387:Vmn2r59
|
UTSW |
7 |
41,695,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5982:Vmn2r59
|
UTSW |
7 |
41,695,491 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
|
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Vmn2r59
|
UTSW |
7 |
41,695,196 (GRCm39) |
nonsense |
probably null |
|
|
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
|
R9432:Vmn2r59
|
UTSW |
7 |
41,696,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9433:Vmn2r59
|
UTSW |
7 |
41,695,590 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGCTCCCAAGTGCTAAGGAG -3'
(R):5'- AGCTACATCCTGCTATTGACAC -3'
Sequencing Primer
(F):5'- AGCAGAGGTATCCCAGGAC -3'
(R):5'- AGTTCCTTGCTCTTTATTGGCCAG -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation