Incidental Mutation 'R7868:Or10x1'
ID 607887
Institutional Source Beutler Lab
Gene Symbol Or10x1
Ensembl Gene ENSMUSG00000066672
Gene Name olfactory receptor family 10 subfamily X member 1
Synonyms Olfr417, MOR267-11, GA_x6K02T2P20D-20787051-20786119
MMRRC Submission 045920-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R7868 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 174196485-174197414 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 174196551 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 23 (T23A)
Ref Sequence ENSEMBL: ENSMUSP00000151782 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085862] [ENSMUST00000217962] [ENSMUST00000220394]
AlphaFold F8VQB1
Predicted Effect probably benign
Transcript: ENSMUST00000085862
AA Change: T23A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000083024
Gene: ENSMUSG00000066672
AA Change: T23A

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 5.7e-46 PFAM
Pfam:7tm_1 39 303 6.6e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217962
AA Change: T23A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000220394
AA Change: T23A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT 11: 43,478,257 (GRCm39) probably null Het
Acacb A G 5: 114,386,288 (GRCm39) E2274G probably benign Het
Adam7 A G 14: 68,770,090 (GRCm39) I21T possibly damaging Het
Aldh3b3 C T 19: 4,018,492 (GRCm39) R57* probably null Het
Arhgap22 T C 14: 33,086,473 (GRCm39) probably benign Het
B4galt5 G T 2: 167,143,340 (GRCm39) Y361* probably null Het
BC005537 C T 13: 24,987,382 (GRCm39) R7W possibly damaging Het
Bsn G T 9: 107,992,098 (GRCm39) A1218D possibly damaging Het
Ccdc141 T C 2: 76,938,756 (GRCm39) D283G probably damaging Het
Ccdc33 T A 9: 57,976,374 (GRCm39) I547F probably benign Het
Chdh A G 14: 29,753,288 (GRCm39) N66D probably benign Het
Ckap2l T A 2: 129,127,209 (GRCm39) Q323L probably damaging Het
Cpvl T A 6: 53,951,745 (GRCm39) I13F possibly damaging Het
Creb3l2 G A 6: 37,312,804 (GRCm39) P410L probably damaging Het
Dna2 T C 10: 62,805,643 (GRCm39) V960A probably benign Het
Dop1a G A 9: 86,384,037 (GRCm39) probably null Het
Dpysl5 A T 5: 30,902,760 (GRCm39) D64V probably damaging Het
Dysf A G 6: 84,091,081 (GRCm39) Q1041R probably benign Het
Efcab7 T C 4: 99,746,154 (GRCm39) V242A probably benign Het
Ehbp1 G A 11: 22,096,542 (GRCm39) R341* probably null Het
Eif1ad8 G T 12: 87,563,388 (GRCm39) probably benign Het
Fbxo32 A T 15: 58,077,986 (GRCm39) W8R probably damaging Het
Fpgs T C 2: 32,573,472 (GRCm39) N455D probably damaging Het
Fsip1 G A 2: 117,966,967 (GRCm39) Q453* probably null Het
Gm8257 T A 14: 44,894,754 (GRCm39) E12V probably damaging Het
Kdm3a A T 6: 71,572,473 (GRCm39) D1029E probably benign Het
Lipo4 T G 19: 33,488,968 (GRCm39) Q205P possibly damaging Het
Lpar6 A T 14: 73,476,435 (GRCm39) N132I probably damaging Het
Lrp1b C T 2: 41,339,246 (GRCm39) G866S Het
Man2c1 T C 9: 57,045,270 (GRCm39) F460L probably damaging Het
Map3k7cl T C 16: 87,378,100 (GRCm39) V72A probably damaging Het
Map4k1 A T 7: 28,699,387 (GRCm39) probably null Het
Matn1 A G 4: 130,682,311 (GRCm39) E496G probably damaging Het
Mfsd2a A T 4: 122,850,648 (GRCm39) V76E possibly damaging Het
Mmut C T 17: 41,257,934 (GRCm39) R367C probably damaging Het
Mtpap A G 18: 4,380,673 (GRCm39) E117G probably damaging Het
Muc17 T A 5: 137,175,625 (GRCm39) N15I Het
Ndufa10 A G 1: 92,388,169 (GRCm39) Y275H probably damaging Het
Nlrc4 A T 17: 74,755,047 (GRCm39) H56Q possibly damaging Het
Nrde2 G A 12: 100,097,446 (GRCm39) R785C possibly damaging Het
Nsun4 C A 4: 115,891,329 (GRCm39) C350F probably benign Het
Or51f23b A G 7: 102,402,812 (GRCm39) L108P possibly damaging Het
Or8g2 T A 9: 39,821,282 (GRCm39) F61Y probably benign Het
Or9s14 G A 1: 92,536,237 (GRCm39) G226D possibly damaging Het
Pdcd7 T A 9: 65,254,261 (GRCm39) C280S probably damaging Het
Peak1 G T 9: 56,167,754 (GRCm39) T58K probably damaging Het
Phactr2 T C 10: 13,108,353 (GRCm39) E573G probably damaging Het
Pramel27 A G 4: 143,578,154 (GRCm39) H138R possibly damaging Het
Ptprz1 G A 6: 23,000,963 (GRCm39) A1018T not run Het
Ralgapa1 G T 12: 55,659,423 (GRCm39) D2032E probably benign Het
Rapgef4 T A 2: 72,031,481 (GRCm39) N488K probably benign Het
Slc1a2 A G 2: 102,591,530 (GRCm39) D420G probably benign Het
Smyd5 T A 6: 85,421,297 (GRCm39) L337Q probably damaging Het
Tenm4 G A 7: 96,555,587 (GRCm39) R2764H possibly damaging Het
Tex35 A T 1: 156,926,908 (GRCm39) Y195* probably null Het
Tln2 T C 9: 67,255,508 (GRCm39) K690E probably damaging Het
Trpc4 A G 3: 54,209,707 (GRCm39) T691A probably benign Het
Tsr1 T A 11: 74,791,158 (GRCm39) F246I possibly damaging Het
Ttn ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG 2: 76,746,150 (GRCm39) probably benign Het
Ubr4 A T 4: 139,187,344 (GRCm39) Y669F unknown Het
Uox A C 3: 146,316,029 (GRCm39) D12A probably benign Het
Wdr17 A G 8: 55,149,302 (GRCm39) probably null Het
Other mutations in Or10x1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01885:Or10x1 APN 1 174,196,967 (GRCm39) missense probably damaging 0.99
PIT4366001:Or10x1 UTSW 1 174,196,656 (GRCm39) missense probably damaging 1.00
R0131:Or10x1 UTSW 1 174,197,152 (GRCm39) missense probably damaging 0.99
R0131:Or10x1 UTSW 1 174,197,152 (GRCm39) missense probably damaging 0.99
R0132:Or10x1 UTSW 1 174,197,152 (GRCm39) missense probably damaging 0.99
R1623:Or10x1 UTSW 1 174,196,515 (GRCm39) missense probably benign 0.43
R1862:Or10x1 UTSW 1 174,197,018 (GRCm39) missense probably damaging 0.97
R1901:Or10x1 UTSW 1 174,196,734 (GRCm39) missense probably benign
R1972:Or10x1 UTSW 1 174,197,136 (GRCm39) missense probably benign 0.05
R2180:Or10x1 UTSW 1 174,196,967 (GRCm39) missense probably damaging 0.99
R4413:Or10x1 UTSW 1 174,197,040 (GRCm39) missense probably damaging 0.98
R4528:Or10x1 UTSW 1 174,196,822 (GRCm39) missense probably damaging 1.00
R4750:Or10x1 UTSW 1 174,196,488 (GRCm39) missense probably benign 0.02
R4849:Or10x1 UTSW 1 174,196,966 (GRCm39) missense probably damaging 0.97
R4851:Or10x1 UTSW 1 174,196,562 (GRCm39) missense probably benign 0.44
R5394:Or10x1 UTSW 1 174,196,836 (GRCm39) missense probably damaging 1.00
R5916:Or10x1 UTSW 1 174,196,698 (GRCm39) missense probably damaging 1.00
R6248:Or10x1 UTSW 1 174,197,236 (GRCm39) missense probably benign
R7311:Or10x1 UTSW 1 174,196,759 (GRCm39) missense probably benign 0.30
Z1088:Or10x1 UTSW 1 174,197,310 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGAAATCACATCCTCTACATACATG -3'
(R):5'- AGATCCACCAGCATCTTGGG -3'

Sequencing Primer
(F):5'- TGCTAAACTGGATGAAAAATTGAGTG -3'
(R):5'- GGATGATAGTCAGGGTGTAGC -3'
Posted On 2019-12-20