Incidental Mutation 'R7869:Or4p8'
ID 607953
Institutional Source Beutler Lab
Gene Symbol Or4p8
Ensembl Gene ENSMUSG00000075114
Gene Name olfactory receptor family 4 subfamily P member 8
Synonyms MOR225-4, Olfr1208, GA_x6K02T2Q125-50372411-50371485
MMRRC Submission 045921-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R7869 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 88726918-88727992 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88727408 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 178 (I178V)
Ref Sequence ENSEMBL: ENSMUSP00000149280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099810] [ENSMUST00000214121] [ENSMUST00000214297]
AlphaFold Q8VG47
Predicted Effect probably benign
Transcript: ENSMUST00000099810
AA Change: I178V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000097398
Gene: ENSMUSG00000075114
AA Change: I178V

DomainStartEndE-ValueType
Pfam:7tm_4 28 302 1.9e-48 PFAM
Pfam:7tm_1 38 284 2.6e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214121
AA Change: I178V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000214297
AA Change: I178V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik G A 5: 113,332,001 (GRCm39) R738C possibly damaging Het
Acot12 G A 13: 91,919,844 (GRCm39) V260M probably benign Het
Alkbh8 A T 9: 3,359,503 (GRCm39) H264L probably damaging Het
Arfgef2 C T 2: 166,715,623 (GRCm39) T1356I probably damaging Het
Arhgap27 A T 11: 103,251,130 (GRCm39) N199K probably damaging Het
Asic2 T C 11: 81,858,824 (GRCm39) R63G probably damaging Het
Aspa T A 11: 73,204,378 (GRCm39) M197L probably benign Het
BC005537 C T 13: 24,987,382 (GRCm39) R7W possibly damaging Het
Brdt A T 5: 107,518,045 (GRCm39) I723L probably benign Het
C2cd3 T A 7: 100,118,698 (GRCm39) F2312Y probably damaging Het
Cd19 T C 7: 126,009,698 (GRCm39) N456S probably damaging Het
Ceacam1 G T 7: 25,175,954 (GRCm39) A80E probably damaging Het
Cep135 T C 5: 76,788,803 (GRCm39) V1132A probably benign Het
Cep85 A G 4: 133,859,609 (GRCm39) C687R probably damaging Het
Cln5 A G 14: 103,313,501 (GRCm39) Y251C probably damaging Het
Crygc A G 1: 65,111,014 (GRCm39) M91T possibly damaging Het
Ddt T C 10: 75,609,060 (GRCm39) K33R probably damaging Het
Dhfr G A 13: 92,494,471 (GRCm39) W58* probably null Het
Dhx40 T C 11: 86,688,532 (GRCm39) E297G probably benign Het
Dner T C 1: 84,361,602 (GRCm39) Y669C probably benign Het
Dpys G T 15: 39,656,782 (GRCm39) F428L probably damaging Het
Dspp A C 5: 104,323,531 (GRCm39) T225P probably damaging Het
Elac2 A G 11: 64,890,213 (GRCm39) K656E probably damaging Het
Ern1 T A 11: 106,349,845 (GRCm39) R24* probably null Het
F2rl2 T C 13: 95,837,519 (GRCm39) I188T probably damaging Het
Fam83b C T 9: 76,399,426 (GRCm39) C559Y possibly damaging Het
Fat1 T G 8: 45,504,259 (GRCm39) F4584C probably benign Het
Gabra6 G A 11: 42,207,322 (GRCm39) T254I possibly damaging Het
Garem1 T C 18: 21,432,757 (GRCm39) D24G probably damaging Het
Gas2l2 A T 11: 83,312,816 (GRCm39) L832* probably null Het
Gpr68 C T 12: 100,845,497 (GRCm39) D16N probably benign Het
Il17b T C 18: 61,825,480 (GRCm39) I172T probably damaging Het
Ildr2 T G 1: 166,136,861 (GRCm39) S567A probably benign Het
Kalrn A G 16: 33,809,217 (GRCm39) V2557A probably damaging Het
Kif1b A G 4: 149,268,833 (GRCm39) S1627P probably benign Het
Kif5a G A 10: 127,079,343 (GRCm39) T285M probably damaging Het
Lrif1 G A 3: 106,640,459 (GRCm39) probably null Het
Lrrn2 C T 1: 132,867,116 (GRCm39) T727I unknown Het
Lsg1 T C 16: 30,383,540 (GRCm39) E560G probably benign Het
Map4k4 C A 1: 40,013,204 (GRCm39) Q100K unknown Het
Mipep A T 14: 61,040,385 (GRCm39) R302W probably damaging Het
Morf4l1 G T 9: 89,975,844 (GRCm39) T316K probably damaging Het
Mov10 A T 3: 104,711,994 (GRCm39) V126E probably damaging Het
Muc2 T A 7: 141,303,471 (GRCm39) C559S Het
Myh7 A G 14: 55,226,530 (GRCm39) Y410H probably damaging Het
Nf1 T A 11: 79,309,414 (GRCm39) Y433N probably damaging Het
Nmd3 T C 3: 69,633,750 (GRCm39) L79P probably damaging Het
Nol10 G T 12: 17,408,239 (GRCm39) S155I probably null Het
Or2n1 T C 17: 38,486,830 (GRCm39) L285P possibly damaging Het
Or52n2c T A 7: 104,574,311 (GRCm39) Y220F probably damaging Het
Or5b12 A G 19: 12,896,911 (GRCm39) I254T probably benign Het
Pde3b T C 7: 114,093,922 (GRCm39) S389P probably benign Het
Polr1c C T 17: 46,555,817 (GRCm39) G188D probably benign Het
Prpf31 A G 7: 3,633,859 (GRCm39) M65V probably benign Het
Pum2 A G 12: 8,763,595 (GRCm39) T251A probably benign Het
Rabgap1 G A 2: 37,377,142 (GRCm39) V325I probably benign Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Rpl15 G T 14: 18,269,017 (GRCm38) Y203* probably null Het
Sac3d1 G A 19: 6,168,456 (GRCm39) P54L possibly damaging Het
Serpina3g A G 12: 104,206,510 (GRCm39) I104V probably benign Het
Setd2 C T 9: 110,379,082 (GRCm39) Q966* probably null Het
Simc1 G T 13: 54,651,713 (GRCm39) D9Y unknown Het
Slc5a8 T C 10: 88,757,567 (GRCm39) L519S probably benign Het
Srcap C A 7: 127,138,366 (GRCm39) Q1179K possibly damaging Het
Srd5a3 T C 5: 76,295,583 (GRCm39) L91P probably damaging Het
Stab1 T C 14: 30,876,429 (GRCm39) T887A probably benign Het
Sult2a6 A G 7: 13,988,737 (GRCm39) F8L not run Het
Thsd7a A T 6: 12,471,123 (GRCm39) C498* probably null Het
Timp4 T C 6: 115,227,355 (GRCm39) I75V probably benign Het
Tspyl4 T A 10: 34,174,096 (GRCm39) M196K probably damaging Het
Ubr2 T C 17: 47,301,934 (GRCm39) E172G probably benign Het
Ubr5 G A 15: 37,980,076 (GRCm39) A2434V probably null Het
Unc13c T G 9: 73,602,159 (GRCm39) L1362F probably damaging Het
Vmn2r11 A G 5: 109,199,986 (GRCm39) V489A probably damaging Het
Vps39 T C 2: 120,169,875 (GRCm39) T226A possibly damaging Het
Zan C T 5: 137,471,863 (GRCm39) E185K probably damaging Het
Other mutations in Or4p8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01340:Or4p8 APN 2 88,727,321 (GRCm39) missense probably damaging 1.00
IGL02132:Or4p8 APN 2 88,727,503 (GRCm39) missense probably benign
IGL02374:Or4p8 APN 2 88,727,803 (GRCm39) missense probably damaging 1.00
R1378:Or4p8 UTSW 2 88,727,370 (GRCm39) missense probably benign 0.01
R1570:Or4p8 UTSW 2 88,727,290 (GRCm39) missense probably damaging 1.00
R2056:Or4p8 UTSW 2 88,727,105 (GRCm39) missense probably damaging 1.00
R2092:Or4p8 UTSW 2 88,727,611 (GRCm39) missense probably damaging 0.99
R2185:Or4p8 UTSW 2 88,727,047 (GRCm39) missense probably damaging 0.99
R5223:Or4p8 UTSW 2 88,727,678 (GRCm39) missense probably benign 0.03
R5479:Or4p8 UTSW 2 88,727,035 (GRCm39) missense probably benign 0.13
R6463:Or4p8 UTSW 2 88,727,462 (GRCm39) missense probably benign 0.00
R6859:Or4p8 UTSW 2 88,727,278 (GRCm39) missense probably benign
R7347:Or4p8 UTSW 2 88,727,615 (GRCm39) missense possibly damaging 0.51
R7352:Or4p8 UTSW 2 88,727,062 (GRCm39) missense probably damaging 1.00
R7544:Or4p8 UTSW 2 88,727,705 (GRCm39) missense probably damaging 1.00
R7713:Or4p8 UTSW 2 88,728,122 (GRCm39) start gained probably benign
R7842:Or4p8 UTSW 2 88,727,305 (GRCm39) missense possibly damaging 0.89
R8137:Or4p8 UTSW 2 88,727,013 (GRCm39) makesense probably null
R8168:Or4p8 UTSW 2 88,727,120 (GRCm39) missense probably benign 0.09
R8556:Or4p8 UTSW 2 88,727,382 (GRCm39) nonsense probably null
R8967:Or4p8 UTSW 2 88,727,844 (GRCm39) nonsense probably null
R9092:Or4p8 UTSW 2 88,727,321 (GRCm39) missense probably damaging 1.00
R9221:Or4p8 UTSW 2 88,727,255 (GRCm39) missense probably benign
Z1176:Or4p8 UTSW 2 88,727,405 (GRCm39) missense probably damaging 1.00
Z1177:Or4p8 UTSW 2 88,727,144 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTAGAAAGAGCTTTGCGGCG -3'
(R):5'- TCTTTGGTGCCACTGAGATATTC -3'

Sequencing Primer
(F):5'- GGCTCTCTGATGACCTGGTC -3'
(R):5'- TGCCACTGAGATATTCATCTTGG -3'
Posted On 2019-12-20