Incidental Mutation 'R0144:Or5b105'
ID 60803
Institutional Source Beutler Lab
Gene Symbol Or5b105
Ensembl Gene ENSMUSG00000062844
Gene Name olfactory receptor family 5 subfamily B member 105
Synonyms GA_x6K02T2RE5P-3430689-3429787, Olfr1458, MOR202-24, EG667271
MMRRC Submission 038429-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R0144 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13079743-13080669 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13080642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 3 (R3C)
Ref Sequence ENSEMBL: ENSMUSP00000076019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076729] [ENSMUST00000207340] [ENSMUST00000215160]
AlphaFold A0A1L1SSD5
Predicted Effect possibly damaging
Transcript: ENSMUST00000076729
AA Change: R3C

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000076019
Gene: ENSMUSG00000062844
AA Change: R3C

DomainStartEndE-ValueType
Pfam:7tm_4 23 300 7.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 27 297 1.2e-6 PFAM
Pfam:7tm_1 33 282 5.8e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207340
AA Change: R9C
Predicted Effect probably benign
Transcript: ENSMUST00000215160
AA Change: R9C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.0%
  • 20x: 87.0%
Validation Efficiency 100% (90/90)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2010]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd4 T A 12: 84,652,739 (GRCm39) probably null Het
Acp6 T A 3: 97,073,145 (GRCm39) probably benign Het
AI661453 A T 17: 47,780,224 (GRCm39) probably benign Het
Aox1 A G 1: 58,109,233 (GRCm39) I674V probably benign Het
Armc2 A T 10: 41,823,883 (GRCm39) probably benign Het
Atp8b1 G C 18: 64,704,445 (GRCm39) probably benign Het
Baz2b A T 2: 59,737,839 (GRCm39) N1823K probably damaging Het
Bbx C T 16: 50,100,755 (GRCm39) E47K probably benign Het
Brca1 A T 11: 101,416,947 (GRCm39) S396T probably damaging Het
Btnl6 G T 17: 34,732,994 (GRCm39) R290S probably benign Het
Casp8ap2 A G 4: 32,643,797 (GRCm39) R957G possibly damaging Het
Ccdc13 A G 9: 121,656,417 (GRCm39) L132P probably damaging Het
Ccdc187 A G 2: 26,166,215 (GRCm39) I738T probably damaging Het
Ceacam15 G T 7: 16,407,116 (GRCm39) H134N probably benign Het
Cep170 T C 1: 176,620,161 (GRCm39) I46V probably benign Het
Cfap57 T C 4: 118,441,902 (GRCm39) D722G probably damaging Het
Col11a1 A T 3: 113,907,243 (GRCm39) D628V unknown Het
Csmd1 A T 8: 16,441,838 (GRCm39) V342E probably benign Het
Dennd1a A G 2: 38,016,652 (GRCm39) V64A probably damaging Het
Dlec1 G T 9: 118,971,934 (GRCm39) G1345V probably benign Het
Dnah1 G A 14: 30,989,831 (GRCm39) probably benign Het
Dock5 C T 14: 68,023,735 (GRCm39) G1142D probably benign Het
Etv2 C A 7: 30,334,308 (GRCm39) A142S probably benign Het
Fam110c C A 12: 31,124,500 (GRCm39) T154K unknown Het
Fbxo17 C G 7: 28,434,765 (GRCm39) D183E probably damaging Het
Fbxo30 T A 10: 11,170,964 (GRCm39) W681R probably damaging Het
Fig4 A G 10: 41,134,045 (GRCm39) Y413H probably damaging Het
Gab1 A G 8: 81,511,830 (GRCm39) probably benign Het
Gabarapl1 T C 6: 129,510,411 (GRCm39) M1T probably null Het
H2-M10.6 G A 17: 37,123,133 (GRCm39) C22Y probably damaging Het
Igfn1 T C 1: 135,889,751 (GRCm39) D2432G probably damaging Het
Il13 T C 11: 53,524,003 (GRCm39) D60G possibly damaging Het
Iqgap1 A G 7: 80,401,668 (GRCm39) L479P probably damaging Het
Itpr2 T A 6: 146,228,653 (GRCm39) Q1314L probably damaging Het
Jrk C T 15: 74,578,005 (GRCm39) G427S probably benign Het
Kcnb1 T G 2: 166,946,467 (GRCm39) N794H probably damaging Het
Klhl8 A T 5: 104,015,804 (GRCm39) S361R probably benign Het
Krt87 T C 15: 101,336,542 (GRCm39) Y37C probably benign Het
Lbp A T 2: 158,161,630 (GRCm39) S231C probably damaging Het
Lpin2 A G 17: 71,532,071 (GRCm39) E142G probably damaging Het
Lrch4 G A 5: 137,636,805 (GRCm39) probably null Het
Lypd11 A G 7: 24,423,015 (GRCm39) V101A possibly damaging Het
Manea A G 4: 26,340,719 (GRCm39) M81T probably benign Het
Mcm3ap A G 10: 76,316,849 (GRCm39) T618A probably benign Het
Me3 A G 7: 89,389,080 (GRCm39) D128G probably damaging Het
Mix23 A T 16: 35,905,484 (GRCm39) N92I possibly damaging Het
Mug2 A G 6: 122,047,970 (GRCm39) probably benign Het
Myo9b A T 8: 71,798,687 (GRCm39) Q901L probably damaging Het
Nalcn T C 14: 123,608,948 (GRCm39) R640G probably damaging Het
Nalcn C T 14: 123,647,251 (GRCm39) probably benign Het
Ncor1 T C 11: 62,283,421 (GRCm39) N422S probably damaging Het
Nf1 T A 11: 79,437,953 (GRCm39) Y88N probably damaging Het
Nrxn3 G A 12: 89,315,162 (GRCm39) A358T probably damaging Het
Or52s1 A T 7: 102,861,747 (GRCm39) I216F probably damaging Het
Or5p62 T C 7: 107,771,178 (GRCm39) I258V probably benign Het
Phlpp2 C T 8: 110,634,145 (GRCm39) R242W probably damaging Het
Pld5 T C 1: 175,798,107 (GRCm39) N431D probably benign Het
Prss28 G A 17: 25,528,424 (GRCm39) V16M probably damaging Het
Psmd2 T A 16: 20,480,975 (GRCm39) probably null Het
Ptpn21 A T 12: 98,654,868 (GRCm39) S700T probably benign Het
Rasa2 A T 9: 96,474,072 (GRCm39) V152D probably damaging Het
Reln G T 5: 22,153,447 (GRCm39) R2286S probably damaging Het
Rflnb G T 11: 75,915,789 (GRCm39) P102Q probably damaging Het
Rin2 G A 2: 145,718,559 (GRCm39) V680I probably damaging Het
Rnf213 A T 11: 119,370,426 (GRCm39) K4742* probably null Het
Rpp40 A T 13: 36,085,352 (GRCm39) S143T probably benign Het
Rps12 A G 10: 23,662,689 (GRCm39) I51T probably benign Het
Rsf1 T A 7: 97,285,614 (GRCm39) W109R probably damaging Het
Sipa1l2 C T 8: 126,176,615 (GRCm39) probably null Het
Tspan5 G T 3: 138,604,109 (GRCm39) V165L probably damaging Het
Uts2r T A 11: 121,052,291 (GRCm39) V385E probably benign Het
Vma21-ps T A 4: 52,497,231 (GRCm39) D5V possibly damaging Het
Vmn2r62 T A 7: 42,438,440 (GRCm39) N132I probably damaging Het
Zfp622 T C 15: 25,991,665 (GRCm39) probably benign Het
Zmiz1 A G 14: 25,655,671 (GRCm39) K766R probably damaging Het
Other mutations in Or5b105
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01684:Or5b105 APN 19 13,080,353 (GRCm39) missense possibly damaging 0.93
IGL02319:Or5b105 APN 19 13,080,026 (GRCm39) missense probably benign 0.14
IGL02926:Or5b105 APN 19 13,080,187 (GRCm39) missense possibly damaging 0.74
IGL03107:Or5b105 APN 19 13,080,401 (GRCm39) missense probably benign
IGL03304:Or5b105 APN 19 13,080,105 (GRCm39) missense probably damaging 1.00
R0046:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0049:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0099:Or5b105 UTSW 19 13,080,504 (GRCm39) missense probably benign 0.07
R0103:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0189:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0206:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0207:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0208:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0212:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0344:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0426:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0506:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0507:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0607:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0661:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0734:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R1347:Or5b105 UTSW 19 13,080,054 (GRCm39) missense probably benign 0.03
R1347:Or5b105 UTSW 19 13,080,054 (GRCm39) missense probably benign 0.03
R1443:Or5b105 UTSW 19 13,080,568 (GRCm39) nonsense probably null
R1446:Or5b105 UTSW 19 13,080,380 (GRCm39) missense possibly damaging 0.59
R1567:Or5b105 UTSW 19 13,080,006 (GRCm39) missense probably benign 0.00
R2190:Or5b105 UTSW 19 13,079,857 (GRCm39) missense probably damaging 1.00
R2438:Or5b105 UTSW 19 13,079,785 (GRCm39) missense probably benign 0.00
R4020:Or5b105 UTSW 19 13,079,790 (GRCm39) missense probably damaging 0.99
R4406:Or5b105 UTSW 19 13,079,958 (GRCm39) missense possibly damaging 0.70
R4631:Or5b105 UTSW 19 13,080,636 (GRCm39) missense probably benign 0.07
R4847:Or5b105 UTSW 19 13,079,898 (GRCm39) missense probably damaging 1.00
R4979:Or5b105 UTSW 19 13,080,053 (GRCm39) missense probably damaging 0.97
R6086:Or5b105 UTSW 19 13,079,745 (GRCm39) makesense probably null
R6480:Or5b105 UTSW 19 13,079,838 (GRCm39) missense probably benign 0.34
R6484:Or5b105 UTSW 19 13,080,431 (GRCm39) missense probably benign 0.34
R6786:Or5b105 UTSW 19 13,080,567 (GRCm39) missense probably benign 0.09
R7121:Or5b105 UTSW 19 13,080,537 (GRCm39) missense probably benign 0.03
R7547:Or5b105 UTSW 19 13,080,407 (GRCm39) missense not run
R7822:Or5b105 UTSW 19 13,080,417 (GRCm39) missense probably benign 0.00
R7949:Or5b105 UTSW 19 13,080,610 (GRCm39) splice site probably null
R8219:Or5b105 UTSW 19 13,080,284 (GRCm39) missense probably damaging 1.00
R8441:Or5b105 UTSW 19 13,080,020 (GRCm39) missense probably damaging 0.98
R8458:Or5b105 UTSW 19 13,079,840 (GRCm39) missense probably damaging 1.00
R9283:Or5b105 UTSW 19 13,079,821 (GRCm39) missense probably damaging 0.99
R9330:Or5b105 UTSW 19 13,080,588 (GRCm39) missense probably benign 0.10
R9592:Or5b105 UTSW 19 13,079,906 (GRCm39) missense probably benign 0.13
R9677:Or5b105 UTSW 19 13,080,518 (GRCm39) missense probably damaging 0.99
R9725:Or5b105 UTSW 19 13,080,272 (GRCm39) missense possibly damaging 0.74
X0024:Or5b105 UTSW 19 13,080,573 (GRCm39) missense probably benign 0.22
X0027:Or5b105 UTSW 19 13,080,588 (GRCm39) missense probably benign 0.10
Predicted Primers
Posted On 2013-07-24