Incidental Mutation 'R7872:Vmn1r57'
ID 608177
Institutional Source Beutler Lab
Gene Symbol Vmn1r57
Ensembl Gene ENSMUSG00000091652
Gene Name vomeronasal 1 receptor 57
Synonyms Gm7519
MMRRC Submission 045924-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R7872 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 5223477-5224409 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 5223613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 46 (I46N)
Ref Sequence ENSEMBL: ENSMUSP00000131917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170780] [ENSMUST00000227798] [ENSMUST00000228062]
AlphaFold K7N731
Predicted Effect possibly damaging
Transcript: ENSMUST00000170780
AA Change: I46N

PolyPhen 2 Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000131917
Gene: ENSMUSG00000091652
AA Change: I46N

DomainStartEndE-ValueType
Pfam:TAS2R 1 290 1.7e-12 PFAM
Pfam:7tm_1 20 279 1.8e-6 PFAM
Pfam:V1R 32 289 1.1e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000227798
AA Change: I46N

PolyPhen 2 Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228062
AA Change: I46N

PolyPhen 2 Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acta2 C T 19: 34,220,839 (GRCm39) D290N probably damaging Het
Adam18 T C 8: 25,101,116 (GRCm39) D682G probably benign Het
Ankrd46 A G 15: 36,485,989 (GRCm39) V88A possibly damaging Het
Ankub1 T A 3: 57,572,807 (GRCm39) K305I probably damaging Het
Atrn T A 2: 130,812,147 (GRCm39) probably null Het
Bambi A T 18: 3,511,406 (GRCm39) T76S probably benign Het
Cacna1a T A 8: 85,310,283 (GRCm39) V1447E probably damaging Het
Calcoco2 GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,808 (GRCm39) probably benign Het
Clcn2 A G 16: 20,527,210 (GRCm39) M629T probably damaging Het
Clcn4 T C 7: 7,290,780 (GRCm39) N673S probably benign Het
Col20a1 T C 2: 180,628,371 (GRCm39) F15S probably benign Het
Col2a1 G A 15: 97,898,458 (GRCm39) Q39* probably null Het
Creb3 A G 4: 43,563,332 (GRCm39) E119G probably benign Het
Dnah5 A C 15: 28,245,830 (GRCm39) D556A probably damaging Het
Edar C T 10: 58,446,348 (GRCm39) M192I possibly damaging Het
Fam91a1 A G 15: 58,320,209 (GRCm39) M634V probably benign Het
Fbxo10 C T 4: 45,051,699 (GRCm39) V471I not run Het
Fer1l5 T C 1: 36,460,967 (GRCm39) F2032L probably benign Het
Gm5150 A C 3: 16,060,485 (GRCm39) M1R probably null Het
Grin1 T C 2: 25,188,202 (GRCm39) E509G probably benign Het
Igkv10-94 C T 6: 68,681,913 (GRCm39) probably benign Het
Il18bp A G 7: 101,666,002 (GRCm39) Y59H possibly damaging Het
Ints8 A T 4: 11,254,062 (GRCm39) C17S probably benign Het
Kcnmb1 T C 11: 33,916,275 (GRCm39) Y74H probably damaging Het
Kpna1 T C 16: 35,843,565 (GRCm39) V313A probably benign Het
Lrp4 C T 2: 91,321,061 (GRCm39) T1029I possibly damaging Het
Lrrc7 A T 3: 158,059,099 (GRCm39) C3S probably damaging Het
Lyst C A 13: 13,810,450 (GRCm39) H707N probably benign Het
Map3k20 A G 2: 72,202,098 (GRCm39) K148R probably damaging Het
Mcidas G A 13: 113,135,521 (GRCm39) G315S probably damaging Het
Miip C T 4: 147,947,375 (GRCm39) G236S probably benign Het
Mocs1 T A 17: 49,746,561 (GRCm39) I177N probably damaging Het
Muc5b A G 7: 141,399,850 (GRCm39) D441G unknown Het
Ncoa1 T C 12: 4,328,186 (GRCm39) N884S probably benign Het
Or12j4 A G 7: 140,046,696 (GRCm39) N194S probably damaging Het
Or51a39 A G 7: 102,363,389 (GRCm39) V77A probably benign Het
Padi6 A T 4: 140,455,073 (GRCm39) F621L probably damaging Het
Pde8b C A 13: 95,223,347 (GRCm39) M197I possibly damaging Het
Pear1 T A 3: 87,659,522 (GRCm39) I771L probably benign Het
Poli A G 18: 70,655,891 (GRCm39) L281P probably damaging Het
Prdm12 T C 2: 31,530,231 (GRCm39) W41R probably damaging Het
Prkdc T G 16: 15,532,870 (GRCm39) S1500A probably benign Het
Prune2 T A 19: 17,096,798 (GRCm39) H767Q probably benign Het
Rasgef1b G A 5: 99,382,403 (GRCm39) Q196* probably null Het
Rnpc3 A T 3: 113,416,096 (GRCm39) L121* probably null Het
Rpp14 A G 14: 8,083,724 (GRCm38) M1V probably null Het
Ryr2 T A 13: 11,610,610 (GRCm39) D4072V probably damaging Het
Sgms1 T C 19: 32,102,765 (GRCm39) H314R probably damaging Het
Six4 CT C 12: 73,151,013 (GRCm39) probably benign Het
Slc37a3 A T 6: 39,324,244 (GRCm39) Y335N probably damaging Het
Tcp11l1 A T 2: 104,536,837 (GRCm39) H9Q probably benign Het
Tnrc6a T A 7: 122,779,057 (GRCm39) M1256K probably damaging Het
Trpc6 A G 9: 8,609,910 (GRCm39) N126S probably damaging Het
Tut4 T G 4: 108,374,715 (GRCm39) C933G probably damaging Het
Ubr4 T C 4: 139,120,373 (GRCm39) F266S possibly damaging Het
Uimc1 A G 13: 55,217,550 (GRCm39) V424A possibly damaging Het
Utrn T C 10: 12,573,873 (GRCm39) I1066V probably benign Het
Vmn1r204 A G 13: 22,740,404 (GRCm39) T12A probably benign Het
Vmn1r91 T C 7: 19,835,839 (GRCm39) Y253H probably benign Het
Vmn2r14 T A 5: 109,369,219 (GRCm39) H118L probably benign Het
Zfp775 A G 6: 48,597,404 (GRCm39) K426R probably benign Het
Other mutations in Vmn1r57
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01770:Vmn1r57 APN 7 5,223,667 (GRCm39) missense possibly damaging 0.61
IGL03124:Vmn1r57 APN 7 5,224,021 (GRCm39) missense possibly damaging 0.91
R1779:Vmn1r57 UTSW 7 5,223,576 (GRCm39) missense possibly damaging 0.89
R3025:Vmn1r57 UTSW 7 5,223,714 (GRCm39) nonsense probably null
R3917:Vmn1r57 UTSW 7 5,223,630 (GRCm39) missense probably damaging 1.00
R4093:Vmn1r57 UTSW 7 5,223,856 (GRCm39) missense possibly damaging 0.80
R4552:Vmn1r57 UTSW 7 5,223,667 (GRCm39) missense possibly damaging 0.61
R4628:Vmn1r57 UTSW 7 5,223,972 (GRCm39) missense probably damaging 1.00
R5186:Vmn1r57 UTSW 7 5,224,107 (GRCm39) missense probably benign 0.08
R5290:Vmn1r57 UTSW 7 5,224,319 (GRCm39) missense probably damaging 1.00
R5559:Vmn1r57 UTSW 7 5,223,898 (GRCm39) missense probably damaging 1.00
R6372:Vmn1r57 UTSW 7 5,223,826 (GRCm39) missense possibly damaging 0.61
R7105:Vmn1r57 UTSW 7 5,223,499 (GRCm39) missense probably damaging 1.00
R7220:Vmn1r57 UTSW 7 5,223,559 (GRCm39) missense probably null 1.00
R7835:Vmn1r57 UTSW 7 5,224,138 (GRCm39) missense probably benign 0.44
R8310:Vmn1r57 UTSW 7 5,224,024 (GRCm39) missense probably damaging 1.00
R9679:Vmn1r57 UTSW 7 5,224,230 (GRCm39) missense probably benign 0.09
R9681:Vmn1r57 UTSW 7 5,224,069 (GRCm39) missense probably damaging 0.99
X0064:Vmn1r57 UTSW 7 5,223,760 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACCACTGTCCTATGAAGC -3'
(R):5'- TAGCCCAGTTACCAGGAACAAG -3'

Sequencing Primer
(F):5'- ATGAAGCCATCTCCATGTTGTCTTAG -3'
(R):5'- TGACAAACTGGTAGGTGCTG -3'
Posted On 2019-12-20