Incidental Mutation 'R7873:Slco1a7'
ID 608245
Institutional Source Beutler Lab
Gene Symbol Slco1a7
Ensembl Gene ENSMUSG00000084927
Gene Name solute carrier organic anion transporter family, member 1a7
Synonyms Gm5724
MMRRC Submission 045925-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R7873 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 141653844-141719536 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 141673448 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 363 (L363F)
Ref Sequence ENSEMBL: ENSMUSP00000117177 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000148411]
AlphaFold L7N264
Predicted Effect probably benign
Transcript: ENSMUST00000148411
AA Change: L363F

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000117177
Gene: ENSMUSG00000084927
AA Change: L363F

DomainStartEndE-ValueType
Pfam:MFS_1 22 405 3.4e-26 PFAM
KAZAL 438 484 1.71e0 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik A T 16: 4,684,091 (GRCm39) I229F probably benign Het
Abca14 T C 7: 119,888,792 (GRCm39) L1246S probably benign Het
Abtb3 T C 10: 85,466,989 (GRCm39) V685A possibly damaging Het
Acacb A C 5: 114,361,339 (GRCm39) S1340R possibly damaging Het
Ankrd6 A T 4: 32,806,499 (GRCm39) S585T possibly damaging Het
Ark2c T C 18: 77,554,449 (GRCm39) D248G possibly damaging Het
Ccdc54 A G 16: 50,410,672 (GRCm39) V198A probably benign Het
Cnga4 A G 7: 105,056,249 (GRCm39) I387V probably damaging Het
Creg1 G T 1: 165,597,448 (GRCm39) D141Y probably damaging Het
Cxcr2 T C 1: 74,198,166 (GRCm39) L220P probably benign Het
Dennd5a T A 7: 109,526,141 (GRCm39) I344F probably damaging Het
Dysf A G 6: 84,060,747 (GRCm39) N448S probably benign Het
Efcab6 A G 15: 83,902,826 (GRCm39) probably null Het
Elf2 C A 3: 51,164,099 (GRCm39) V489F probably damaging Het
Elmod2 G T 8: 84,057,848 (GRCm39) H12N probably benign Het
Eln C T 5: 134,740,041 (GRCm39) G618E unknown Het
Fbxo33 G T 12: 59,265,807 (GRCm39) S153R possibly damaging Het
Fbxw7 A T 3: 84,833,071 (GRCm39) I38F possibly damaging Het
Flnc G A 6: 29,456,990 (GRCm39) V2329I possibly damaging Het
Fsip2 C T 2: 82,779,856 (GRCm39) R201C probably damaging Het
Gpr155 T C 2: 73,173,934 (GRCm39) E825G possibly damaging Het
Grk3 A T 5: 113,077,552 (GRCm39) M405K probably benign Het
H2bc7 A T 13: 23,758,244 (GRCm39) Y41N probably damaging Het
Hace1 T C 10: 45,548,883 (GRCm39) V597A possibly damaging Het
Ido1 A G 8: 25,074,758 (GRCm39) F295S probably damaging Het
Ighe T A 12: 113,234,942 (GRCm39) E406V Het
Ighv1-31 G T 12: 114,793,274 (GRCm39) A15E probably benign Het
Ighv1-75 A T 12: 115,797,988 (GRCm39) L10H probably damaging Het
Inpp5e T A 2: 26,297,957 (GRCm39) K215* probably null Het
Iqcn A G 8: 71,163,989 (GRCm39) M1061V probably benign Het
Krt18 C T 15: 101,939,391 (GRCm39) T288I probably benign Het
Lrwd1 A T 5: 136,152,792 (GRCm39) I490N probably benign Het
Macf1 T A 4: 123,398,344 (GRCm39) probably null Het
Mapk8ip3 A G 17: 25,125,146 (GRCm39) V482A probably benign Het
Mcidas G A 13: 113,135,521 (GRCm39) G315S probably damaging Het
Mdk A G 2: 91,761,773 (GRCm39) F7S probably benign Het
Mycbp2 G A 14: 103,393,582 (GRCm39) P2993L probably damaging Het
Niban3 A T 8: 72,054,892 (GRCm39) I193F probably damaging Het
Nme4 A T 17: 26,312,862 (GRCm39) Y99N probably damaging Het
Nr1d2 G A 14: 18,216,656 (GRCm38) R171* probably null Het
Or10h28 A G 17: 33,488,348 (GRCm39) I217V probably benign Het
Osgep G T 14: 51,153,347 (GRCm39) T326K probably damaging Het
Pdgfd C T 9: 6,337,271 (GRCm39) T201M probably benign Het
Pdk4 T C 6: 5,487,086 (GRCm39) D320G probably benign Het
Pelp1 A T 11: 70,285,552 (GRCm39) V772D probably damaging Het
Pkdrej T A 15: 85,700,724 (GRCm39) R1737S probably benign Het
Ppp1r13b A T 12: 111,801,320 (GRCm39) Y578N probably damaging Het
Ppp1r3b A C 8: 35,851,329 (GRCm39) K56T probably benign Het
Prdm11 G T 2: 92,819,628 (GRCm39) H261N probably benign Het
Preb T A 5: 31,116,109 (GRCm39) N166I probably benign Het
Psd3 T C 8: 68,335,634 (GRCm39) K681R possibly damaging Het
Ptgs1 G A 2: 36,141,292 (GRCm39) V580I probably damaging Het
Ptpro T A 6: 137,407,737 (GRCm39) S949T probably benign Het
Pum2 A G 12: 8,798,802 (GRCm39) E973G possibly damaging Het
Rdh1 A G 10: 127,595,892 (GRCm39) D29G probably benign Het
Rel A G 11: 23,692,957 (GRCm39) S359P probably benign Het
Ryr3 T A 2: 112,560,773 (GRCm39) H2996L probably benign Het
Scarb1 C T 5: 125,371,103 (GRCm39) C323Y probably damaging Het
Scn5a C T 9: 119,327,193 (GRCm39) R1309H probably damaging Het
Serpinb12 T A 1: 106,881,469 (GRCm39) V202E probably damaging Het
Shh A G 5: 28,663,298 (GRCm39) L290P possibly damaging Het
Six4 CT C 12: 73,151,013 (GRCm39) probably benign Het
Slc34a2 G A 5: 53,215,714 (GRCm39) G42R probably benign Het
Slc41a1 A G 1: 131,758,561 (GRCm39) N68D possibly damaging Het
Slc7a6os A G 8: 106,937,356 (GRCm39) S64P probably damaging Het
Smc1b A G 15: 84,994,851 (GRCm39) probably null Het
Snx9 T C 17: 5,968,751 (GRCm39) V349A possibly damaging Het
Sstr1 G T 12: 58,260,313 (GRCm39) G312V probably damaging Het
Tnfsf10 A G 3: 27,389,808 (GRCm39) I290V probably benign Het
Trio A G 15: 27,805,770 (GRCm39) C1717R possibly damaging Het
Ttbk1 T G 17: 46,757,494 (GRCm39) S1047R probably damaging Het
Ttn T C 2: 76,746,877 (GRCm39) D4724G probably benign Het
Uba1y T A Y: 825,542 (GRCm39) N301K probably benign Het
Unc5c A G 3: 141,533,310 (GRCm39) T853A probably benign Het
Vmn2r45 T A 7: 8,486,074 (GRCm39) I405L probably benign Het
Wdr37 A T 13: 8,855,969 (GRCm39) M458K probably damaging Het
Zdhhc14 A T 17: 5,762,729 (GRCm39) Y211F probably benign Het
Zfp108 G A 7: 23,960,758 (GRCm39) V450I probably benign Het
Zfp212 A T 6: 47,907,860 (GRCm39) R280* probably null Het
Zfp940 A T 7: 29,535,042 (GRCm39) V108E unknown Het
Other mutations in Slco1a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01023:Slco1a7 APN 6 141,700,155 (GRCm39) missense probably benign 0.14
IGL01347:Slco1a7 APN 6 141,700,192 (GRCm39) nonsense probably null
IGL01539:Slco1a7 APN 6 141,673,333 (GRCm39) missense possibly damaging 0.88
IGL01613:Slco1a7 APN 6 141,658,940 (GRCm39) missense possibly damaging 0.67
IGL02060:Slco1a7 APN 6 141,700,134 (GRCm39) missense probably benign 0.00
IGL02063:Slco1a7 APN 6 141,684,615 (GRCm39) missense probably benign 0.01
IGL02126:Slco1a7 APN 6 141,684,739 (GRCm39) missense probably benign 0.29
IGL02214:Slco1a7 APN 6 141,668,911 (GRCm39) missense possibly damaging 0.50
IGL02630:Slco1a7 APN 6 141,668,836 (GRCm39) missense probably damaging 1.00
R0966:Slco1a7 UTSW 6 141,673,299 (GRCm39) missense probably benign 0.00
R1082:Slco1a7 UTSW 6 141,657,859 (GRCm39) missense probably damaging 1.00
R1433:Slco1a7 UTSW 6 141,711,429 (GRCm39) missense probably benign 0.00
R1571:Slco1a7 UTSW 6 141,700,135 (GRCm39) nonsense probably null
R1765:Slco1a7 UTSW 6 141,700,084 (GRCm39) splice site probably benign
R2055:Slco1a7 UTSW 6 141,671,181 (GRCm39) missense probably benign 0.33
R2174:Slco1a7 UTSW 6 141,673,319 (GRCm39) nonsense probably null
R2495:Slco1a7 UTSW 6 141,711,503 (GRCm39) missense probably benign 0.02
R2857:Slco1a7 UTSW 6 141,690,264 (GRCm39) missense probably benign 0.35
R3551:Slco1a7 UTSW 6 141,654,322 (GRCm39) missense probably benign 0.20
R3824:Slco1a7 UTSW 6 141,700,100 (GRCm39) missense possibly damaging 0.50
R3912:Slco1a7 UTSW 6 141,673,362 (GRCm39) missense probably damaging 0.97
R3942:Slco1a7 UTSW 6 141,673,440 (GRCm39) missense probably damaging 0.98
R4161:Slco1a7 UTSW 6 141,654,322 (GRCm39) missense probably benign 0.20
R4168:Slco1a7 UTSW 6 141,684,673 (GRCm39) missense probably benign 0.03
R4395:Slco1a7 UTSW 6 141,657,844 (GRCm39) missense probably benign 0.02
R4720:Slco1a7 UTSW 6 141,668,948 (GRCm39) missense probably damaging 1.00
R4732:Slco1a7 UTSW 6 141,668,905 (GRCm39) missense probably benign 0.01
R4733:Slco1a7 UTSW 6 141,668,905 (GRCm39) missense probably benign 0.01
R4794:Slco1a7 UTSW 6 141,713,288 (GRCm39) missense probably benign 0.11
R5062:Slco1a7 UTSW 6 141,713,180 (GRCm39) missense possibly damaging 0.46
R5389:Slco1a7 UTSW 6 141,686,193 (GRCm39) missense probably benign 0.12
R5419:Slco1a7 UTSW 6 141,681,826 (GRCm39) splice site probably null
R5423:Slco1a7 UTSW 6 141,690,188 (GRCm39) missense probably damaging 1.00
R5704:Slco1a7 UTSW 6 141,658,980 (GRCm39) missense probably benign 0.00
R5973:Slco1a7 UTSW 6 141,700,182 (GRCm39) missense probably benign 0.01
R6041:Slco1a7 UTSW 6 141,684,764 (GRCm39) missense probably benign 0.11
R6284:Slco1a7 UTSW 6 141,671,119 (GRCm39) missense probably damaging 1.00
R6395:Slco1a7 UTSW 6 141,668,818 (GRCm39) splice site probably null
R6993:Slco1a7 UTSW 6 141,711,468 (GRCm39) missense possibly damaging 0.94
R7149:Slco1a7 UTSW 6 141,690,178 (GRCm39) missense probably damaging 1.00
R7159:Slco1a7 UTSW 6 141,719,504 (GRCm39) start codon destroyed probably damaging 1.00
R7627:Slco1a7 UTSW 6 141,690,271 (GRCm39) missense probably damaging 1.00
R7784:Slco1a7 UTSW 6 141,658,919 (GRCm39) critical splice donor site probably null
R8670:Slco1a7 UTSW 6 141,711,468 (GRCm39) missense possibly damaging 0.94
R8720:Slco1a7 UTSW 6 141,668,852 (GRCm39) missense probably benign 0.01
R9124:Slco1a7 UTSW 6 141,668,830 (GRCm39) missense possibly damaging 0.81
R9238:Slco1a7 UTSW 6 141,686,153 (GRCm39) missense probably damaging 0.98
R9381:Slco1a7 UTSW 6 141,711,490 (GRCm39) missense probably benign 0.00
X0020:Slco1a7 UTSW 6 141,700,091 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGTTAAGCCAGCAACTTGG -3'
(R):5'- GCTGAGTCAAATTCCCAATATACC -3'

Sequencing Primer
(F):5'- TTAAGCCAGCAACTTGGAAACTGTC -3'
(R):5'- GAATTGATAGGCATTTGAAAACCTCC -3'
Posted On 2019-12-20