Incidental Mutation 'R7874:Vmn2r5'
| ID |
608304 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r5
|
| Ensembl Gene |
ENSMUSG00000068999 |
| Gene Name |
vomeronasal 2, receptor 5 |
| Synonyms |
EG667060 |
| MMRRC Submission |
045926-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.145)
|
| Stock # |
R7874 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
64398242-64417156 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 64398453 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 842
(V842E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135592
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170270]
[ENSMUST00000177184]
|
| AlphaFold |
K7N788 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170270
AA Change: V755E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000131925
Gene: ENSMUSG00000068999
AA Change: V755E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
416 |
9.9e-78 |
PFAM |
|
Pfam:NCD3G
|
458 |
511 |
8.5e-18 |
PFAM |
|
Pfam:7tm_3
|
542 |
779 |
2.3e-74 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177184
AA Change: V842E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135592
Gene: ENSMUSG00000068999
AA Change: V842E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
86 |
503 |
1.8e-80 |
PFAM |
|
Pfam:NCD3G
|
545 |
598 |
1e-14 |
PFAM |
|
Pfam:7tm_3
|
631 |
865 |
1.4e-45 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
98% (57/58) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700008P02Rik |
C |
A |
3: 6,685,201 (GRCm39) |
K84N |
probably damaging |
Het |
| Aacs |
T |
C |
5: 125,583,271 (GRCm39) |
F276L |
possibly damaging |
Het |
| Aicda |
T |
A |
6: 122,538,908 (GRCm39) |
I179N |
probably damaging |
Het |
| Anks6 |
T |
A |
4: 47,049,275 (GRCm39) |
H210L |
unknown |
Het |
| Ano1 |
G |
A |
7: 144,175,461 (GRCm39) |
R486W |
probably damaging |
Het |
| Aoc1l3 |
A |
G |
6: 48,965,600 (GRCm39) |
N536S |
possibly damaging |
Het |
| Atp8b1 |
A |
G |
18: 64,704,095 (GRCm39) |
V341A |
probably benign |
Het |
| Btn1a1 |
T |
C |
13: 23,643,385 (GRCm39) |
T355A |
possibly damaging |
Het |
| Ccng2 |
C |
G |
5: 93,421,202 (GRCm39) |
S237R |
probably benign |
Het |
| Cd300ld2 |
CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG |
CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG |
11: 114,903,257 (GRCm39) |
|
probably benign |
Het |
| Ceacam19 |
A |
T |
7: 19,620,363 (GRCm39) |
D89E |
probably damaging |
Het |
| Cerkl |
T |
A |
2: 79,168,981 (GRCm39) |
R407S |
probably damaging |
Het |
| Chl1 |
A |
G |
6: 103,667,224 (GRCm39) |
T389A |
probably benign |
Het |
| Dcn |
A |
G |
10: 97,346,056 (GRCm39) |
|
probably null |
Het |
| Defa39 |
C |
A |
8: 22,192,812 (GRCm39) |
R61S |
possibly damaging |
Het |
| Dhtkd1 |
T |
C |
2: 5,922,485 (GRCm39) |
Q558R |
possibly damaging |
Het |
| Dhx36 |
C |
A |
3: 62,396,052 (GRCm39) |
V452L |
probably benign |
Het |
| Dlg5 |
A |
G |
14: 24,185,687 (GRCm39) |
V1906A |
probably damaging |
Het |
| Emc4 |
T |
C |
2: 112,194,178 (GRCm39) |
T159A |
probably damaging |
Het |
| Fstl5 |
C |
A |
3: 76,569,093 (GRCm39) |
P582Q |
probably benign |
Het |
| Izumo1r |
T |
A |
9: 14,811,875 (GRCm39) |
Y171F |
probably benign |
Het |
| Jag2 |
C |
T |
12: 112,879,566 (GRCm39) |
V401M |
probably damaging |
Het |
| Jph2 |
C |
T |
2: 163,217,762 (GRCm39) |
G305S |
probably damaging |
Het |
| Kbtbd13 |
C |
A |
9: 65,297,584 (GRCm39) |
V451L |
probably benign |
Het |
| Map3k12 |
T |
C |
15: 102,409,077 (GRCm39) |
T813A |
possibly damaging |
Het |
| Mast4 |
A |
G |
13: 102,875,783 (GRCm39) |
L1295P |
probably damaging |
Het |
| Mia2 |
T |
A |
12: 59,155,374 (GRCm39) |
D362E |
probably damaging |
Het |
| Mospd3 |
T |
C |
5: 137,598,290 (GRCm39) |
Y77C |
probably damaging |
Het |
| Muc5ac |
G |
C |
7: 141,363,040 (GRCm39) |
G2117A |
unknown |
Het |
| Mup8 |
T |
A |
4: 60,222,420 (GRCm39) |
H17L |
probably damaging |
Het |
| Naip2 |
C |
T |
13: 100,291,459 (GRCm39) |
D1160N |
probably benign |
Het |
| Naip2 |
T |
C |
13: 100,291,468 (GRCm39) |
S1157G |
probably benign |
Het |
| Ndnf |
A |
T |
6: 65,680,413 (GRCm39) |
M231L |
probably benign |
Het |
| Obscn |
T |
G |
11: 59,024,102 (GRCm39) |
T523P |
probably damaging |
Het |
| Or2t46 |
T |
C |
11: 58,472,573 (GRCm39) |
V301A |
possibly damaging |
Het |
| P4htm |
G |
T |
9: 108,474,148 (GRCm39) |
A130E |
probably benign |
Het |
| Phc3 |
A |
T |
3: 30,990,863 (GRCm39) |
D439E |
probably benign |
Het |
| Phlpp1 |
A |
G |
1: 106,317,603 (GRCm39) |
I1275V |
probably benign |
Het |
| Poln |
A |
T |
5: 34,181,694 (GRCm39) |
I719N |
probably damaging |
Het |
| Ptch2 |
T |
A |
4: 116,963,161 (GRCm39) |
L216Q |
possibly damaging |
Het |
| Rarres2 |
T |
A |
6: 48,549,079 (GRCm39) |
K41N |
probably benign |
Het |
| Rasal3 |
C |
T |
17: 32,615,681 (GRCm39) |
E386K |
possibly damaging |
Het |
| Rev3l |
T |
C |
10: 39,698,491 (GRCm39) |
I996T |
possibly damaging |
Het |
| Rreb1 |
A |
G |
13: 38,131,100 (GRCm39) |
N36S |
probably damaging |
Het |
| Serpinb9d |
T |
A |
13: 33,386,654 (GRCm39) |
|
probably null |
Het |
| Slc14a2 |
A |
G |
18: 78,203,983 (GRCm39) |
V526A |
probably benign |
Het |
| Slc45a4 |
T |
C |
15: 73,456,184 (GRCm39) |
|
probably null |
Het |
| Srrm2 |
G |
A |
17: 24,034,652 (GRCm39) |
R432H |
unknown |
Het |
| Th |
G |
A |
7: 142,449,308 (GRCm39) |
R266* |
probably null |
Het |
| Tln1 |
T |
C |
4: 43,538,041 (GRCm39) |
Y1853C |
probably damaging |
Het |
| Tln1 |
A |
T |
4: 43,555,606 (GRCm39) |
D169E |
probably damaging |
Het |
| Tmcc3 |
G |
A |
10: 94,386,889 (GRCm39) |
|
probably null |
Het |
| Tnxb |
A |
G |
17: 34,930,417 (GRCm39) |
E2034G |
probably damaging |
Het |
| Top6bl |
C |
T |
19: 4,708,451 (GRCm39) |
C347Y |
probably damaging |
Het |
| Ttc4 |
T |
C |
4: 106,522,881 (GRCm39) |
T346A |
probably benign |
Het |
| Vmn2r82 |
T |
G |
10: 79,232,345 (GRCm39) |
N781K |
probably damaging |
Het |
| Zdhhc17 |
A |
T |
10: 110,817,978 (GRCm39) |
Y67N |
possibly damaging |
Het |
| Zfp273 |
A |
G |
13: 67,973,558 (GRCm39) |
T229A |
probably benign |
Het |
| Zkscan5 |
A |
C |
5: 145,157,676 (GRCm39) |
H726P |
probably damaging |
Het |
| Zswim8 |
A |
G |
14: 20,773,217 (GRCm39) |
H1769R |
probably damaging |
Het |
| Zzef1 |
T |
C |
11: 72,750,479 (GRCm39) |
V929A |
probably benign |
Het |
|
| Other mutations in Vmn2r5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00742:Vmn2r5
|
APN |
3 |
64,398,834 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01139:Vmn2r5
|
APN |
3 |
64,398,826 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL03293:Vmn2r5
|
APN |
3 |
64,398,747 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4581001:Vmn2r5
|
UTSW |
3 |
64,411,348 (GRCm39) |
nonsense |
probably null |
|
|
R0063:Vmn2r5
|
UTSW |
3 |
64,411,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0142:Vmn2r5
|
UTSW |
3 |
64,400,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Vmn2r5
|
UTSW |
3 |
64,398,951 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0219:Vmn2r5
|
UTSW |
3 |
64,411,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0313:Vmn2r5
|
UTSW |
3 |
64,411,248 (GRCm39) |
missense |
probably benign |
|
|
R0620:Vmn2r5
|
UTSW |
3 |
64,411,235 (GRCm39) |
nonsense |
probably null |
|
|
R0726:Vmn2r5
|
UTSW |
3 |
64,411,186 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1073:Vmn2r5
|
UTSW |
3 |
64,398,726 (GRCm39) |
nonsense |
probably null |
|
|
R1549:Vmn2r5
|
UTSW |
3 |
64,411,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1581:Vmn2r5
|
UTSW |
3 |
64,398,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1624:Vmn2r5
|
UTSW |
3 |
64,417,116 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1973:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1975:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1977:Vmn2r5
|
UTSW |
3 |
64,411,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2189:Vmn2r5
|
UTSW |
3 |
64,417,014 (GRCm39) |
missense |
probably benign |
0.27 |
|
R2484:Vmn2r5
|
UTSW |
3 |
64,411,392 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4573:Vmn2r5
|
UTSW |
3 |
64,411,339 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5243:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5384:Vmn2r5
|
UTSW |
3 |
64,416,931 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5385:Vmn2r5
|
UTSW |
3 |
64,416,931 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5587:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5589:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5590:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5739:Vmn2r5
|
UTSW |
3 |
64,411,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6113:Vmn2r5
|
UTSW |
3 |
64,398,820 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6739:Vmn2r5
|
UTSW |
3 |
64,398,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7106:Vmn2r5
|
UTSW |
3 |
64,399,104 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7304:Vmn2r5
|
UTSW |
3 |
64,411,671 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7402:Vmn2r5
|
UTSW |
3 |
64,403,176 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7477:Vmn2r5
|
UTSW |
3 |
64,399,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r5
|
UTSW |
3 |
64,411,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7678:Vmn2r5
|
UTSW |
3 |
64,416,943 (GRCm39) |
missense |
probably benign |
|
|
R8110:Vmn2r5
|
UTSW |
3 |
64,398,709 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8223:Vmn2r5
|
UTSW |
3 |
64,398,726 (GRCm39) |
nonsense |
probably null |
|
|
R8767:Vmn2r5
|
UTSW |
3 |
64,415,103 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8896:Vmn2r5
|
UTSW |
3 |
64,411,203 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8948:Vmn2r5
|
UTSW |
3 |
64,398,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r5
|
UTSW |
3 |
64,398,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8962:Vmn2r5
|
UTSW |
3 |
64,398,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9012:Vmn2r5
|
UTSW |
3 |
64,411,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9109:Vmn2r5
|
UTSW |
3 |
64,411,411 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9126:Vmn2r5
|
UTSW |
3 |
64,399,159 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9192:Vmn2r5
|
UTSW |
3 |
64,398,938 (GRCm39) |
nonsense |
probably null |
|
|
R9221:Vmn2r5
|
UTSW |
3 |
64,411,721 (GRCm39) |
nonsense |
probably null |
|
|
R9375:Vmn2r5
|
UTSW |
3 |
64,411,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9529:Vmn2r5
|
UTSW |
3 |
64,400,018 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1088:Vmn2r5
|
UTSW |
3 |
64,416,963 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Vmn2r5
|
UTSW |
3 |
64,398,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCTACTCATCCAGAACAGTGG -3'
(R):5'- TACTTGGTGTTGGAGCCTCC -3'
Sequencing Primer
(F):5'- TGGATGCTCCTGTCAACA -3'
(R):5'- CATCTTTGAATGCAGTGAAGGTTC -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation