Mutagenetix > Incidental Mutation

Incidental Mutation 'R7878:Tenm4'

608575

Institutional Source

Beutler Lab

Gene Symbol

Tenm4

Ensembl Gene

ENSMUSG00000048078

Gene Name

teneurin transmembrane protein 4

Synonyms

Doc4, l7Rn3, Ten-m4, ELM2, l(7)-3Rn, Odz4

MMRRC Submission

045930-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7878 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

96171246-96911093 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 96852357 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 1256 (E1256G)

Ref Sequence

ENSEMBL: ENSMUSP00000102783 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107162] [ENSMUST00000107165] [ENSMUST00000107166]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000107162
AA Change: E1255G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102780
Gene: ENSMUSG00000048078
AA Change: E1255G

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	410	5.6e-195	PFAM
transmembrane domain	411	433	N/A	INTRINSIC
EGF_like	637	665	3.43e1	SMART
EGF	668	696	2.29e1	SMART
EGF	701	730	1.88e-1	SMART
EGF	733	762	1.13e1	SMART
EGF	767	797	2.39e1	SMART
EGF	800	828	4.32e-1	SMART
EGF	831	859	6.02e0	SMART
EGF	862	894	9.93e-1	SMART
low complexity region	900	914	N/A	INTRINSIC
Pfam:RHS_repeat	2327	2380	5.5e-7	PFAM
Pfam:Tox-GHH	2740	2818	5.2e-34	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107165
AA Change: E1256G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102783
Gene: ENSMUSG00000048078
AA Change: E1256G

Domain	Start	End	E-Value	Type
Pfam:Ten_N	36	402	1.1e-171	PFAM
transmembrane domain	403	425	N/A	INTRINSIC
EGF_like	629	657	3.43e1	SMART
EGF	660	688	2.29e1	SMART
EGF	693	722	1.88e-1	SMART
EGF	725	754	1.13e1	SMART
EGF	759	789	2.39e1	SMART
EGF	792	820	4.32e-1	SMART
EGF	823	851	6.02e0	SMART
EGF	863	895	9.93e-1	SMART
low complexity region	901	915	N/A	INTRINSIC
Pfam:RHS_repeat	2335	2368	1.6e-7	PFAM
Pfam:Tox-GHH	2749	2826	1.8e-32	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107166
AA Change: E1219G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102784
Gene: ENSMUSG00000048078
AA Change: E1219G

Domain	Start	End	E-Value	Type
Pfam:Ten_N	35	193	1.4e-83	PFAM
Pfam:Ten_N	187	365	5e-78	PFAM
transmembrane domain	366	388	N/A	INTRINSIC
EGF_like	592	620	3.43e1	SMART
EGF	623	651	2.29e1	SMART
EGF	656	685	1.88e-1	SMART
EGF	688	717	1.13e1	SMART
EGF	722	752	2.39e1	SMART
EGF	755	783	4.32e-1	SMART
EGF	786	814	6.02e0	SMART
EGF	826	858	9.93e-1	SMART
low complexity region	864	878	N/A	INTRINSIC
Pfam:RHS_repeat	2298	2351	3.8e-7	PFAM
Pfam:Tox-GHH	2711	2789	3.9e-34	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahi1	G	A	10: 20,981,431 (GRCm38)		probably null	Het
Ak7	T	A	12: 105,766,749 (GRCm38)	I584N	probably damaging	Het
Akip1	A	T	7: 109,707,402 (GRCm38)	Y102F	probably damaging	Het
Alg9	T	C	9: 50,842,783 (GRCm38)	Y588H	probably benign	Het
Arid1a	A	T	4: 133,687,271 (GRCm38)	N831K	unknown	Het
Bcl2l11	T	A	2: 128,128,688 (GRCm38)	L19*	probably null	Het
Btn1a1	T	C	13: 23,459,044 (GRCm38)	T412A	possibly damaging	Het
Ccbe1	T	C	18: 66,076,391 (GRCm38)	N193D	possibly damaging	Het
Ccdc168	T	C	1: 44,056,014 (GRCm38)	S1975G	probably benign	Het
Cd96	A	G	16: 46,117,776 (GRCm38)	S109P	probably damaging	Het
Cdh23	A	C	10: 60,314,200 (GRCm38)	I2622S	possibly damaging	Het
Cmya5	G	T	13: 93,089,757 (GRCm38)	T2941K	probably damaging	Het
Cntn1	T	C	15: 92,295,053 (GRCm38)	Y679H	probably damaging	Het
Cpsf1	A	G	15: 76,600,500 (GRCm38)	V619A	probably damaging	Het
Elp5	T	A	11: 69,970,599 (GRCm38)	I185F	probably damaging	Het
Frem1	A	G	4: 83,020,680 (GRCm38)	V55A	probably benign	Het
Kif1b	A	T	4: 149,214,997 (GRCm38)	Y985N	probably damaging	Het
Lao1	A	G	4: 118,967,422 (GRCm38)	N234D	probably benign	Het
Lima1	C	T	15: 99,819,550 (GRCm38)	V192I	probably benign	Het
Lrp2	T	G	2: 69,507,809 (GRCm38)	D1209A	probably damaging	Het
Lrp2	C	A	2: 69,507,810 (GRCm38)	D1209Y	probably damaging	Het
Luzp1	A	G	4: 136,541,852 (GRCm38)	H462R	probably benign	Het
Mab21l1	A	T	3: 55,784,017 (GRCm38)	T342S	probably benign	Het
Mst1	T	C	9: 108,084,613 (GRCm38)	V657A	probably benign	Het
Mtmr11	A	G	3: 96,169,199 (GRCm38)	K490R	probably benign	Het
Myh3	A	G	11: 67,087,251 (GRCm38)	D383G	probably damaging	Het
Nectin1	G	A	9: 43,803,901 (GRCm38)	G478D	probably benign	Het
Nrip1	A	G	16: 76,294,666 (GRCm38)	M1T	probably null	Het
Odad1	A	G	7: 45,924,560 (GRCm38)	E17G	possibly damaging	Het
Odad2	G	T	18: 7,217,801 (GRCm38)	H638N	probably benign	Het
Olfr625-ps1	A	T	7: 103,683,264 (GRCm38)	H182L	probably damaging	Het
Or1j10	A	G	2: 36,377,133 (GRCm38)	D119G	probably damaging	Het
Pnisr	C	A	4: 21,874,370 (GRCm38)	F704L	unknown	Het
Ptpn21	T	A	12: 98,715,128 (GRCm38)	K82N	probably damaging	Het
Pyroxd2	T	G	19: 42,742,665 (GRCm38)		probably null	Het
Pzp	A	G	6: 128,512,311 (GRCm38)	S446P	possibly damaging	Het
Rbck1	T	A	2: 152,318,410 (GRCm38)	I450F	probably damaging	Het
Rnase4	T	A	14: 51,104,876 (GRCm38)	L19Q	probably damaging	Het
Rrp9	A	G	9: 106,481,317 (GRCm38)	E118G	probably damaging	Het
Sec22a	A	G	16: 35,347,635 (GRCm38)	S169P	probably benign	Het
Sema5b	G	A	16: 35,661,626 (GRCm38)	S957N	probably benign	Het
Serpina3g	A	T	12: 104,238,102 (GRCm38)		probably benign	Het
Skint2	A	T	4: 112,649,745 (GRCm38)	I322F	possibly damaging	Het
Spata31h1	G	A	10: 82,284,022 (GRCm38)	R4385W	probably benign	Het
Sspo	G	A	6: 48,492,526 (GRCm38)	C4471Y	probably damaging	Het
Stk16	T	A	1: 75,212,945 (GRCm38)	L167*	probably null	Het
Tanc2	G	A	11: 105,913,415 (GRCm38)	R245H		Het
Tdpoz1	G	A	3: 93,671,124 (GRCm38)	Q118*	probably null	Het
Tekt3	C	T	11: 63,070,451 (GRCm38)	R149*	probably null	Het
Tie1	G	A	4: 118,478,424 (GRCm38)	R791C	probably damaging	Het
Tpr	T	A	1: 150,423,660 (GRCm38)	S1204T	possibly damaging	Het
Trim28	G	T	7: 13,024,362 (GRCm38)		probably benign	Het
Ucp1	A	G	8: 83,297,892 (GRCm38)	N282S	probably benign	Het
Unc80	T	A	1: 66,601,141 (GRCm38)	D1402E	possibly damaging	Het
Vmn1r69	T	A	7: 10,580,790 (GRCm38)	T5S	probably benign	Het
Zfyve28	T	A	5: 34,199,655 (GRCm38)	K733M	probably damaging	Het

Other mutations in Tenm4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Tenm4	APN	7	96,868,009 (GRCm38)	missense	probably benign	0.00
IGL00468:Tenm4	APN	7	96,874,472 (GRCm38)	missense	probably damaging	0.98
IGL00519:Tenm4	APN	7	96,805,138 (GRCm38)	splice site	probably benign
IGL00979:Tenm4	APN	7	96,729,391 (GRCm38)	missense	probably damaging	0.96
IGL01401:Tenm4	APN	7	96,874,267 (GRCm38)	missense	probably damaging	1.00
IGL01459:Tenm4	APN	7	96,729,385 (GRCm38)	missense	probably damaging	1.00
IGL01519:Tenm4	APN	7	96,895,177 (GRCm38)	missense	probably damaging	1.00
IGL01545:Tenm4	APN	7	96,874,303 (GRCm38)	missense	probably benign	0.00
IGL01579:Tenm4	APN	7	96,863,502 (GRCm38)	missense	probably benign	0.00
IGL01587:Tenm4	APN	7	96,863,502 (GRCm38)	missense	probably benign	0.00
IGL01625:Tenm4	APN	7	96,885,358 (GRCm38)	missense	probably damaging	1.00
IGL01655:Tenm4	APN	7	96,553,724 (GRCm38)	missense	probably damaging	1.00
IGL01683:Tenm4	APN	7	96,885,404 (GRCm38)	missense	possibly damaging	0.84
IGL01728:Tenm4	APN	7	96,896,064 (GRCm38)	missense	probably damaging	1.00
IGL01732:Tenm4	APN	7	96,895,509 (GRCm38)	missense	probably damaging	1.00
IGL01924:Tenm4	APN	7	96,895,212 (GRCm38)	missense	probably damaging	1.00
IGL01966:Tenm4	APN	7	96,553,550 (GRCm38)	missense	probably damaging	1.00
IGL02177:Tenm4	APN	7	96,895,662 (GRCm38)	missense	probably benign	0.40
IGL02207:Tenm4	APN	7	96,874,116 (GRCm38)	missense	possibly damaging	0.85
IGL02269:Tenm4	APN	7	96,823,822 (GRCm38)	missense	probably damaging	1.00
IGL02274:Tenm4	APN	7	96,854,734 (GRCm38)	missense	probably damaging	1.00
IGL02375:Tenm4	APN	7	96,704,137 (GRCm38)	missense	possibly damaging	0.52
IGL02415:Tenm4	APN	7	96,874,074 (GRCm38)	missense	probably damaging	0.98
IGL02472:Tenm4	APN	7	96,774,176 (GRCm38)	unclassified	probably benign
IGL02656:Tenm4	APN	7	96,885,433 (GRCm38)	missense	probably damaging	1.00
IGL02678:Tenm4	APN	7	96,896,219 (GRCm38)	missense	probably damaging	1.00
IGL02829:Tenm4	APN	7	96,894,998 (GRCm38)	nonsense	probably null
IGL02863:Tenm4	APN	7	96,873,706 (GRCm38)	missense	probably damaging	1.00
IGL03145:Tenm4	APN	7	96,842,968 (GRCm38)	missense	probably damaging	0.98
IGL03153:Tenm4	APN	7	96,873,762 (GRCm38)	missense	probably damaging	1.00
principium	UTSW	7	96,797,481 (GRCm38)	missense	probably damaging	0.98
toccata	UTSW	7	96,902,989 (GRCm38)	critical splice donor site	probably null
P0026:Tenm4	UTSW	7	96,874,527 (GRCm38)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,892,926 (GRCm38)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,892,926 (GRCm38)	missense	probably damaging	1.00
R0140:Tenm4	UTSW	7	96,896,052 (GRCm38)	missense	possibly damaging	0.78
R0164:Tenm4	UTSW	7	96,729,340 (GRCm38)	splice site	probably benign
R0277:Tenm4	UTSW	7	96,694,950 (GRCm38)	missense	possibly damaging	0.54
R0323:Tenm4	UTSW	7	96,694,950 (GRCm38)	missense	possibly damaging	0.54
R0362:Tenm4	UTSW	7	96,772,035 (GRCm38)	nonsense	probably null
R0381:Tenm4	UTSW	7	96,905,881 (GRCm38)	missense	probably damaging	1.00
R0420:Tenm4	UTSW	7	96,873,766 (GRCm38)	missense	possibly damaging	0.85
R0426:Tenm4	UTSW	7	96,777,851 (GRCm38)	missense	probably damaging	1.00
R0513:Tenm4	UTSW	7	96,895,623 (GRCm38)	missense	probably benign	0.35
R0624:Tenm4	UTSW	7	96,774,020 (GRCm38)	missense	probably damaging	1.00
R0837:Tenm4	UTSW	7	96,896,275 (GRCm38)	splice site	probably benign
R1037:Tenm4	UTSW	7	96,797,481 (GRCm38)	missense	probably damaging	0.98
R1172:Tenm4	UTSW	7	96,848,044 (GRCm38)	missense	probably damaging	1.00
R1422:Tenm4	UTSW	7	96,550,051 (GRCm38)	missense	probably damaging	0.99
R1427:Tenm4	UTSW	7	96,843,048 (GRCm38)	missense	probably benign	0.42
R1462:Tenm4	UTSW	7	96,704,153 (GRCm38)	missense	probably damaging	1.00
R1462:Tenm4	UTSW	7	96,704,153 (GRCm38)	missense	probably damaging	1.00
R1597:Tenm4	UTSW	7	96,902,989 (GRCm38)	critical splice donor site	probably null
R1701:Tenm4	UTSW	7	96,902,889 (GRCm38)	missense	probably damaging	1.00
R1707:Tenm4	UTSW	7	96,888,685 (GRCm38)	missense	probably damaging	1.00
R1809:Tenm4	UTSW	7	96,873,780 (GRCm38)	missense	probably benign	0.17
R1812:Tenm4	UTSW	7	96,895,940 (GRCm38)	missense	probably damaging	1.00
R1895:Tenm4	UTSW	7	96,735,808 (GRCm38)	missense	probably damaging	1.00
R1933:Tenm4	UTSW	7	96,895,326 (GRCm38)	missense	probably damaging	1.00
R1946:Tenm4	UTSW	7	96,735,808 (GRCm38)	missense	probably damaging	1.00
R2108:Tenm4	UTSW	7	96,906,290 (GRCm38)	missense	probably damaging	1.00
R2151:Tenm4	UTSW	7	96,902,847 (GRCm38)	missense	probably damaging	1.00
R2247:Tenm4	UTSW	7	96,906,009 (GRCm38)	missense	probably benign	0.03
R2329:Tenm4	UTSW	7	96,895,862 (GRCm38)	missense	probably benign	0.00
R2893:Tenm4	UTSW	7	96,894,990 (GRCm38)	missense	probably damaging	1.00
R2990:Tenm4	UTSW	7	96,893,125 (GRCm38)	splice site	probably null
R3409:Tenm4	UTSW	7	96,895,160 (GRCm38)	missense	probably damaging	1.00
R3410:Tenm4	UTSW	7	96,852,530 (GRCm38)	missense	probably damaging	0.99
R3411:Tenm4	UTSW	7	96,852,530 (GRCm38)	missense	probably damaging	0.99
R3440:Tenm4	UTSW	7	96,553,516 (GRCm38)	missense	probably benign	0.00
R3441:Tenm4	UTSW	7	96,553,516 (GRCm38)	missense	probably benign	0.00
R3719:Tenm4	UTSW	7	96,863,563 (GRCm38)	missense	possibly damaging	0.92
R3772:Tenm4	UTSW	7	96,694,880 (GRCm38)	missense	probably damaging	1.00
R3773:Tenm4	UTSW	7	96,694,880 (GRCm38)	missense	probably damaging	1.00
R4093:Tenm4	UTSW	7	96,895,772 (GRCm38)	missense	probably damaging	1.00
R4439:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4441:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4510:Tenm4	UTSW	7	96,894,863 (GRCm38)	missense	probably benign
R4511:Tenm4	UTSW	7	96,894,863 (GRCm38)	missense	probably benign
R4543:Tenm4	UTSW	7	96,895,815 (GRCm38)	missense	probably benign	0.01
R4645:Tenm4	UTSW	7	96,895,742 (GRCm38)	missense	probably damaging	1.00
R4701:Tenm4	UTSW	7	96,895,349 (GRCm38)	missense	probably damaging	1.00
R4707:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4714:Tenm4	UTSW	7	96,894,924 (GRCm38)	missense	probably damaging	1.00
R4742:Tenm4	UTSW	7	96,797,484 (GRCm38)	missense	probably damaging	0.99
R4784:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4785:Tenm4	UTSW	7	96,774,046 (GRCm38)	missense	probably damaging	0.99
R4801:Tenm4	UTSW	7	96,906,245 (GRCm38)	missense	probably damaging	0.97
R4802:Tenm4	UTSW	7	96,906,245 (GRCm38)	missense	probably damaging	0.97
R4880:Tenm4	UTSW	7	96,905,818 (GRCm38)	splice site	probably null
R5036:Tenm4	UTSW	7	96,852,561 (GRCm38)	missense	probably damaging	1.00
R5036:Tenm4	UTSW	7	96,694,790 (GRCm38)	missense	probably damaging	1.00
R5050:Tenm4	UTSW	7	96,895,788 (GRCm38)	missense	probably damaging	1.00
R5103:Tenm4	UTSW	7	96,842,957 (GRCm38)	missense	probably damaging	1.00
R5106:Tenm4	UTSW	7	96,843,149 (GRCm38)	missense	probably damaging	0.99
R5118:Tenm4	UTSW	7	96,893,086 (GRCm38)	missense	probably damaging	1.00
R5272:Tenm4	UTSW	7	96,874,203 (GRCm38)	missense	probably damaging	0.98
R5282:Tenm4	UTSW	7	96,837,331 (GRCm38)	missense	possibly damaging	0.90
R5403:Tenm4	UTSW	7	96,888,827 (GRCm38)	missense	probably damaging	1.00
R5404:Tenm4	UTSW	7	96,894,680 (GRCm38)	missense	probably damaging	1.00
R5567:Tenm4	UTSW	7	96,896,209 (GRCm38)	nonsense	probably null
R5590:Tenm4	UTSW	7	96,797,401 (GRCm38)	missense	possibly damaging	0.93
R5590:Tenm4	UTSW	7	96,797,400 (GRCm38)	missense	possibly damaging	0.73
R5597:Tenm4	UTSW	7	96,553,517 (GRCm38)	missense	probably benign	0.00
R5782:Tenm4	UTSW	7	96,893,039 (GRCm38)	missense	probably benign	0.00
R5861:Tenm4	UTSW	7	96,843,217 (GRCm38)	intron	probably benign
R5890:Tenm4	UTSW	7	96,902,860 (GRCm38)	missense	probably damaging	1.00
R5930:Tenm4	UTSW	7	96,854,719 (GRCm38)	missense	probably damaging	1.00
R5940:Tenm4	UTSW	7	96,845,895 (GRCm38)	missense	probably damaging	1.00
R6012:Tenm4	UTSW	7	96,522,433 (GRCm38)	intron	probably benign
R6060:Tenm4	UTSW	7	96,873,711 (GRCm38)	missense	probably damaging	1.00
R6104:Tenm4	UTSW	7	96,837,289 (GRCm38)	missense	probably damaging	0.97
R6283:Tenm4	UTSW	7	96,874,494 (GRCm38)	missense	probably benign	0.33
R6333:Tenm4	UTSW	7	96,774,124 (GRCm38)	missense	probably damaging	1.00
R6522:Tenm4	UTSW	7	96,843,044 (GRCm38)	missense	possibly damaging	0.88
R6616:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6746:Tenm4	UTSW	7	96,892,860 (GRCm38)	missense	probably damaging	1.00
R6751:Tenm4	UTSW	7	96,845,712 (GRCm38)	missense	possibly damaging	0.95
R6806:Tenm4	UTSW	7	96,811,959 (GRCm38)	missense	possibly damaging	0.95
R6807:Tenm4	UTSW	7	96,895,271 (GRCm38)	missense	probably damaging	1.00
R6807:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6809:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6810:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6811:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6853:Tenm4	UTSW	7	96,837,295 (GRCm38)	missense	possibly damaging	0.94
R6886:Tenm4	UTSW	7	96,797,392 (GRCm38)	missense	possibly damaging	0.85
R6920:Tenm4	UTSW	7	96,895,550 (GRCm38)	missense	probably damaging	1.00
R6937:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R6939:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7011:Tenm4	UTSW	7	96,896,135 (GRCm38)	nonsense	probably null
R7033:Tenm4	UTSW	7	96,895,223 (GRCm38)	nonsense	probably null
R7040:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7083:Tenm4	UTSW	7	96,895,349 (GRCm38)	missense	probably damaging	1.00
R7238:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7239:Tenm4	UTSW	7	96,735,813 (GRCm38)	missense	possibly damaging	0.47
R7239:Tenm4	UTSW	7	96,553,496 (GRCm38)	missense	probably benign	0.01
R7337:Tenm4	UTSW	7	96,874,126 (GRCm38)	missense	probably benign	0.44
R7400:Tenm4	UTSW	7	96,694,803 (GRCm38)	missense	probably damaging	0.97
R7407:Tenm4	UTSW	7	96,773,987 (GRCm38)	missense	possibly damaging	0.89
R7449:Tenm4	UTSW	7	96,874,213 (GRCm38)	missense	possibly damaging	0.65
R7473:Tenm4	UTSW	7	96,774,146 (GRCm38)	missense	probably damaging	1.00
R7477:Tenm4	UTSW	7	96,845,808 (GRCm38)	missense	probably damaging	0.99
R7489:Tenm4	UTSW	7	96,837,314 (GRCm38)	missense	possibly damaging	0.90
R7498:Tenm4	UTSW	7	96,848,017 (GRCm38)	missense	probably damaging	1.00
R7562:Tenm4	UTSW	7	96,888,814 (GRCm38)	missense	probably damaging	1.00
R7615:Tenm4	UTSW	7	96,845,926 (GRCm38)	missense	probably damaging	1.00
R7624:Tenm4	UTSW	7	96,895,985 (GRCm38)	missense	possibly damaging	0.95
R7626:Tenm4	UTSW	7	96,893,014 (GRCm38)	missense	probably damaging	1.00
R7690:Tenm4	UTSW	7	96,863,533 (GRCm38)	missense	probably benign	0.00
R7692:Tenm4	UTSW	7	96,895,403 (GRCm38)	missense	probably damaging	1.00
R7748:Tenm4	UTSW	7	96,894,702 (GRCm38)	missense	probably damaging	1.00
R7763:Tenm4	UTSW	7	96,895,692 (GRCm38)	missense	probably benign	0.38
R7792:Tenm4	UTSW	7	96,774,014 (GRCm38)	missense	possibly damaging	0.54
R7855:Tenm4	UTSW	7	96,873,874 (GRCm38)	missense	probably damaging	1.00
R7868:Tenm4	UTSW	7	96,906,380 (GRCm38)	missense	possibly damaging	0.79
R7997:Tenm4	UTSW	7	96,874,305 (GRCm38)	missense	probably benign	0.44
R8017:Tenm4	UTSW	7	96,704,041 (GRCm38)	missense	probably damaging	1.00
R8019:Tenm4	UTSW	7	96,704,041 (GRCm38)	missense	probably damaging	1.00
R8054:Tenm4	UTSW	7	96,729,346 (GRCm38)	splice site	probably benign
R8061:Tenm4	UTSW	7	96,852,456 (GRCm38)	missense	probably damaging	1.00
R8108:Tenm4	UTSW	7	96,854,728 (GRCm38)	missense	probably benign	0.39
R8140:Tenm4	UTSW	7	96,895,176 (GRCm38)	missense	probably damaging	1.00
R8214:Tenm4	UTSW	7	96,895,407 (GRCm38)	missense	probably damaging	1.00
R8258:Tenm4	UTSW	7	96,867,991 (GRCm38)	missense	probably damaging	1.00
R8259:Tenm4	UTSW	7	96,867,991 (GRCm38)	missense	probably damaging	1.00
R8364:Tenm4	UTSW	7	96,772,106 (GRCm38)	critical splice donor site	probably null
R8542:Tenm4	UTSW	7	96,811,932 (GRCm38)	missense	probably damaging	0.99
R8669:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8670:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8683:Tenm4	UTSW	7	96,902,857 (GRCm38)	missense	probably damaging	0.99
R8691:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8692:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8714:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8716:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8735:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8736:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8737:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8738:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8738:Tenm4	UTSW	7	96,873,840 (GRCm38)	missense	probably damaging	1.00
R8739:Tenm4	UTSW	7	96,905,941 (GRCm38)	missense	probably benign
R8776:Tenm4	UTSW	7	96,895,032 (GRCm38)	missense	probably damaging	1.00
R8776-TAIL:Tenm4	UTSW	7	96,895,032 (GRCm38)	missense	probably damaging	1.00
R8777:Tenm4	UTSW	7	96,896,037 (GRCm38)	missense	probably damaging	1.00
R8777-TAIL:Tenm4	UTSW	7	96,896,037 (GRCm38)	missense	probably damaging	1.00
R8817:Tenm4	UTSW	7	96,874,128 (GRCm38)	missense	probably benign	0.01
R8851:Tenm4	UTSW	7	96,852,503 (GRCm38)	missense	probably damaging	1.00
R8913:Tenm4	UTSW	7	96,702,745 (GRCm38)	splice site	probably benign
R8977:Tenm4	UTSW	7	96,811,970 (GRCm38)	missense	probably damaging	1.00
R9100:Tenm4	UTSW	7	96,845,854 (GRCm38)	missense	probably damaging	1.00
R9136:Tenm4	UTSW	7	96,823,918 (GRCm38)	missense	possibly damaging	0.69
R9163:Tenm4	UTSW	7	96,823,873 (GRCm38)	missense	probably damaging	1.00
R9188:Tenm4	UTSW	7	96,772,027 (GRCm38)	missense	probably damaging	1.00
R9195:Tenm4	UTSW	7	96,892,919 (GRCm38)	missense	probably damaging	1.00
R9217:Tenm4	UTSW	7	96,885,439 (GRCm38)	missense	probably damaging	1.00
R9344:Tenm4	UTSW	7	96,896,145 (GRCm38)	missense	probably damaging	1.00
R9414:Tenm4	UTSW	7	96,896,160 (GRCm38)	missense	probably benign
R9466:Tenm4	UTSW	7	96,550,045 (GRCm38)	missense	possibly damaging	0.79
R9559:Tenm4	UTSW	7	96,823,849 (GRCm38)	missense	probably benign
R9626:Tenm4	UTSW	7	96,896,138 (GRCm38)	missense	probably damaging	1.00
R9673:Tenm4	UTSW	7	96,867,989 (GRCm38)	missense	probably damaging	1.00
R9676:Tenm4	UTSW	7	96,895,431 (GRCm38)	missense	probably damaging	1.00
R9678:Tenm4	UTSW	7	96,737,412 (GRCm38)	missense	possibly damaging	0.94
R9775:Tenm4	UTSW	7	96,906,554 (GRCm38)	missense	possibly damaging	0.92
R9790:Tenm4	UTSW	7	96,888,839 (GRCm38)	missense	probably damaging	1.00
R9791:Tenm4	UTSW	7	96,888,839 (GRCm38)	missense	probably damaging	1.00
R9803:Tenm4	UTSW	7	96,553,478 (GRCm38)	missense	probably damaging	1.00
X0021:Tenm4	UTSW	7	96,873,909 (GRCm38)	nonsense	probably null
X0026:Tenm4	UTSW	7	96,868,087 (GRCm38)	missense	probably damaging	0.98
X0066:Tenm4	UTSW	7	96,894,794 (GRCm38)	missense	probably damaging	1.00
X0066:Tenm4	UTSW	7	96,848,030 (GRCm38)	missense	probably damaging	1.00
Z1176:Tenm4	UTSW	7	96,905,914 (GRCm38)	missense	probably benign	0.00
Z1177:Tenm4	UTSW	7	96,863,585 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- AACCCTGGGTTTCACTGTG -3'
(R):5'- GGAAGAGATCCCCTTACATACCTC -3'

Sequencing Primer
(F):5'- CACTGTGGTAGGACAAGTCTC -3'
(R):5'- CATCTCCAGGATGTTGGTGAC -3'

Posted On

2019-12-20