Mutagenetix > Incidental Mutation

Incidental Mutation 'R7879:Dnah11'

608660

Institutional Source

Beutler Lab

Gene Symbol

Dnah11

Ensembl Gene

ENSMUSG00000018581

Gene Name

dynein, axonemal, heavy chain 11

Synonyms

b2b598Clo, b2b1289Clo, b2b1203Clo, Dnahc11, avc4, b2b1279Clo, b2b1727Clo, lrd

MMRRC Submission

045931-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.603) question?

Stock #

R7879 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

117841717-118162778 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 118004744 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 2192 (D2192E)

Ref Sequence

ENSEMBL: ENSMUSP00000081867 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084806]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000084806
AA Change: D2192E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000081867
Gene: ENSMUSG00000018581
AA Change: D2192E

Domain	Start	End	E-Value	Type
low complexity region	18	28	N/A	INTRINSIC
Pfam:DHC_N1	218	794	1.6e-162	PFAM
low complexity region	1266	1282	N/A	INTRINSIC
Pfam:DHC_N2	1297	1705	1e-130	PFAM
low complexity region	1757	1773	N/A	INTRINSIC
AAA	1869	1963	1.51e0	SMART
Pfam:AAA_5	2150	2286	1.6e-12	PFAM
AAA	2474	2619	1.48e-1	SMART
AAA	2819	2931	4.57e-1	SMART
Pfam:MT	3069	3413	3.2e-162	PFAM
Pfam:AAA_9	3434	3656	2.9e-88	PFAM
Pfam:Dynein_heavy	3790	4486	7.1e-235	PFAM

Predicted Effect

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
PHENOTYPE: Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930449I24Rik	T	C	5: 146,439,662 (GRCm39)	I81T	probably benign	Het
Acnat2	G	A	4: 49,383,299 (GRCm39)	P85S	probably damaging	Het
Akr1c19	G	A	13: 4,286,223 (GRCm39)	V74M	probably damaging	Het
Alb	C	A	5: 90,620,507 (GRCm39)	T539K	probably benign	Het
B4galnt2	G	A	11: 95,760,223 (GRCm39)	T268I	possibly damaging	Het
Bcl7b	G	A	5: 135,205,986 (GRCm39)	E58K	possibly damaging	Het
Calr3	C	T	8: 73,178,487 (GRCm39)	S372N	unknown	Het
Cdcp3	T	A	7: 130,844,871 (GRCm39)	V588E	probably damaging	Het
Cdh20	A	T	1: 104,875,047 (GRCm39)		probably null	Het
Cdh20	A	C	1: 109,976,677 (GRCm39)	E114A	probably benign	Het
Cep70	A	G	9: 99,144,686 (GRCm39)	R74G	possibly damaging	Het
Chrna6	A	G	8: 27,897,109 (GRCm39)	F256S	probably damaging	Het
Cic	A	G	7: 24,984,551 (GRCm39)	T996A	probably benign	Het
Clstn2	A	G	9: 97,351,817 (GRCm39)	V536A	possibly damaging	Het
Csmd1	A	T	8: 16,441,820 (GRCm39)	M348K	probably benign	Het
Dnhd1	A	G	7: 105,352,646 (GRCm39)	I2600V	probably benign	Het
Dock3	A	C	9: 106,785,700 (GRCm39)	S185A	probably benign	Het
Dock4	A	T	12: 40,780,083 (GRCm39)	D628V	possibly damaging	Het
Dzank1	A	T	2: 144,333,718 (GRCm39)	S371T	probably benign	Het
Fam83b	A	T	9: 76,399,737 (GRCm39)	N455K	possibly damaging	Het
Fcrlb	T	C	1: 170,736,365 (GRCm39)	Y137C	probably damaging	Het
Gtf2i	G	A	5: 134,295,471 (GRCm39)	T327M	possibly damaging	Het
Hspa5	T	A	2: 34,665,941 (GRCm39)	M595K	probably benign	Het
Htt	C	T	5: 34,981,252 (GRCm39)	A875V	probably benign	Het
Hvcn1	G	A	5: 122,376,701 (GRCm39)		probably null	Het
Igsf10	A	G	3: 59,238,145 (GRCm39)	S679P	probably damaging	Het
Itsn2	A	G	12: 4,751,265 (GRCm39)	H1285R	probably benign	Het
Kcnq4	T	C	4: 120,559,632 (GRCm39)	T523A	probably benign	Het
Kif6	T	A	17: 50,139,214 (GRCm39)	I562N	probably benign	Het
Klhl9	C	A	4: 88,638,575 (GRCm39)	W555C	probably damaging	Het
Krt78	T	C	15: 101,856,624 (GRCm39)	T423A	probably benign	Het
Mapk10	C	T	5: 103,111,362 (GRCm39)	V391I	probably benign	Het
Noa1	T	C	5: 77,445,044 (GRCm39)	M592V	probably benign	Het
Npy5r	A	G	8: 67,133,968 (GRCm39)	M275T	possibly damaging	Het
Nuak2	T	A	1: 132,259,695 (GRCm39)	V499E	probably benign	Het
Or4x6	A	T	2: 89,949,185 (GRCm39)	C252*	probably null	Het
Or6c213	T	C	10: 129,574,559 (GRCm39)	I76V	probably benign	Het
Otogl	T	C	10: 107,612,970 (GRCm39)	E2052G	probably benign	Het
Pard3b	T	A	1: 62,198,670 (GRCm39)	C253S	possibly damaging	Het
Pclo	T	C	5: 14,727,228 (GRCm39)	S2029P	unknown	Het
Plekhg3	A	G	12: 76,612,343 (GRCm39)	I401M	probably damaging	Het
Polg	A	T	7: 79,100,392 (GRCm39)	C1140S	probably benign	Het
Prl7c1	A	T	13: 27,962,817 (GRCm39)	L62H	probably damaging	Het
Psmf1	T	A	2: 151,576,163 (GRCm39)	E115V	probably benign	Het
Ptpn9	A	T	9: 56,964,010 (GRCm39)	N381I	possibly damaging	Het
Pzp	A	G	6: 128,465,979 (GRCm39)	S1234P	probably benign	Het
Qrich1	A	G	9: 108,436,485 (GRCm39)	T728A	possibly damaging	Het
Ralgps2	C	A	1: 156,656,636 (GRCm39)	A323S	probably benign	Het
Rimbp3	T	C	16: 17,028,910 (GRCm39)	V778A	possibly damaging	Het
Scn1a	A	T	2: 66,116,349 (GRCm39)	L430*	probably null	Het
Sema7a	A	T	9: 57,862,363 (GRCm39)	I189F	probably damaging	Het
Slc22a8	T	C	19: 8,571,386 (GRCm39)	I39T	probably benign	Het
Stap2	T	C	17: 56,309,023 (GRCm39)	T115A	probably benign	Het
Stmn4	A	G	14: 66,595,388 (GRCm39)	I138V	probably benign	Het
Suds3	C	T	5: 117,236,335 (GRCm39)		probably null	Het
Taf4	G	A	2: 179,573,822 (GRCm39)	T682M	probably damaging	Het
Tet1	A	C	10: 62,714,825 (GRCm39)	D323E	probably benign	Het
Tia1	A	G	6: 86,401,347 (GRCm39)	D140G	probably damaging	Het
Trio	C	T	15: 27,852,010 (GRCm39)	R827H	possibly damaging	Het
Ttn	A	G	2: 76,625,397 (GRCm39)		probably null	Het
Unc80	T	C	1: 66,549,866 (GRCm39)	V708A	probably benign	Het
Vmn1r194	A	T	13: 22,428,772 (GRCm39)	T130S	probably benign	Het
Wfikkn2	A	G	11: 94,129,755 (GRCm39)	C129R	probably damaging	Het
Zkscan5	A	C	5: 145,157,676 (GRCm39)	H726P	probably damaging	Het

Other mutations in Dnah11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Dnah11	APN	12	118,162,480 (GRCm39)	missense	probably benign	0.28
IGL00422:Dnah11	APN	12	118,031,831 (GRCm39)	missense	probably damaging	1.00
IGL00436:Dnah11	APN	12	118,000,194 (GRCm39)	missense	possibly damaging	0.56
IGL00540:Dnah11	APN	12	118,150,657 (GRCm39)	missense	probably benign	0.01
IGL00687:Dnah11	APN	12	117,885,739 (GRCm39)	splice site	probably benign
IGL00833:Dnah11	APN	12	118,143,315 (GRCm39)	missense	probably damaging	1.00
IGL00906:Dnah11	APN	12	117,874,937 (GRCm39)	missense	probably damaging	1.00
IGL00952:Dnah11	APN	12	118,160,386 (GRCm39)	missense	possibly damaging	0.56
IGL01111:Dnah11	APN	12	118,106,669 (GRCm39)	splice site	probably benign
IGL01121:Dnah11	APN	12	118,014,430 (GRCm39)	missense	probably benign	0.02
IGL01143:Dnah11	APN	12	117,976,475 (GRCm39)	missense	probably damaging	1.00
IGL01359:Dnah11	APN	12	117,946,734 (GRCm39)	missense	probably damaging	0.99
IGL01372:Dnah11	APN	12	118,156,134 (GRCm39)	missense	probably damaging	1.00
IGL01410:Dnah11	APN	12	118,010,991 (GRCm39)	nonsense	probably null
IGL01418:Dnah11	APN	12	117,951,217 (GRCm39)	nonsense	probably null
IGL01444:Dnah11	APN	12	117,983,967 (GRCm39)	missense	possibly damaging	0.91
IGL01606:Dnah11	APN	12	117,946,767 (GRCm39)	missense	probably benign	0.15
IGL01645:Dnah11	APN	12	118,150,733 (GRCm39)	missense	possibly damaging	0.90
IGL01932:Dnah11	APN	12	118,156,005 (GRCm39)	splice site	probably benign
IGL02104:Dnah11	APN	12	118,156,125 (GRCm39)	missense	probably benign
IGL02151:Dnah11	APN	12	118,023,623 (GRCm39)	splice site	probably benign
IGL02189:Dnah11	APN	12	118,046,314 (GRCm39)	missense	probably benign	0.00
IGL02417:Dnah11	APN	12	118,020,915 (GRCm39)	missense	probably damaging	1.00
IGL02421:Dnah11	APN	12	118,150,637 (GRCm39)	missense	probably damaging	1.00
IGL02444:Dnah11	APN	12	117,939,608 (GRCm39)	splice site	probably benign
IGL02474:Dnah11	APN	12	117,991,180 (GRCm39)	splice site	probably null
IGL02526:Dnah11	APN	12	118,143,353 (GRCm39)	missense	possibly damaging	0.70
IGL02887:Dnah11	APN	12	117,874,775 (GRCm39)	missense	probably damaging	1.00
IGL03011:Dnah11	APN	12	117,976,112 (GRCm39)	missense	probably benign	0.08
IGL03061:Dnah11	APN	12	117,866,856 (GRCm39)	missense	probably damaging	1.00
IGL03182:Dnah11	APN	12	117,994,026 (GRCm39)	missense	probably damaging	0.99
IGL03220:Dnah11	APN	12	118,069,720 (GRCm39)	missense	probably benign
IGL03238:Dnah11	APN	12	118,073,633 (GRCm39)	missense	probably damaging	1.00
IGL03493:Dnah11	APN	12	117,976,533 (GRCm39)	missense	probably benign	0.00
P0045:Dnah11	UTSW	12	117,994,062 (GRCm39)	missense	probably benign
R0009:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R0066:Dnah11	UTSW	12	118,090,621 (GRCm39)	missense	probably benign	0.05
R0172:Dnah11	UTSW	12	117,951,188 (GRCm39)	missense	probably damaging	1.00
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0208:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0230:Dnah11	UTSW	12	117,946,791 (GRCm39)	nonsense	probably null
R0270:Dnah11	UTSW	12	118,004,748 (GRCm39)	missense	probably damaging	1.00
R0311:Dnah11	UTSW	12	118,090,868 (GRCm39)	missense	probably benign	0.03
R0325:Dnah11	UTSW	12	117,976,074 (GRCm39)	missense	probably benign
R0370:Dnah11	UTSW	12	117,958,962 (GRCm39)	missense	probably benign
R0416:Dnah11	UTSW	12	117,874,793 (GRCm39)	missense	probably damaging	1.00
R0505:Dnah11	UTSW	12	118,070,245 (GRCm39)	missense	probably damaging	1.00
R0540:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0554:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably benign	0.01
R0607:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0620:Dnah11	UTSW	12	117,951,204 (GRCm39)	missense	probably damaging	1.00
R0635:Dnah11	UTSW	12	117,971,731 (GRCm39)	missense	probably damaging	1.00
R0755:Dnah11	UTSW	12	118,162,360 (GRCm39)	missense	probably benign	0.17
R0755:Dnah11	UTSW	12	117,918,564 (GRCm39)	missense	possibly damaging	0.95
R0789:Dnah11	UTSW	12	117,874,967 (GRCm39)	missense	probably damaging	1.00
R0833:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0835:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R0836:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0846:Dnah11	UTSW	12	117,897,585 (GRCm39)	missense	probably damaging	0.97
R0865:Dnah11	UTSW	12	118,154,579 (GRCm39)	nonsense	probably null
R0928:Dnah11	UTSW	12	118,009,297 (GRCm39)	missense	probably damaging	1.00
R0939:Dnah11	UTSW	12	118,024,142 (GRCm39)	missense	probably damaging	1.00
R1203:Dnah11	UTSW	12	117,897,547 (GRCm39)	missense	possibly damaging	0.81
R1394:Dnah11	UTSW	12	117,936,099 (GRCm39)	missense	possibly damaging	0.75
R1398:Dnah11	UTSW	12	118,020,841 (GRCm39)	nonsense	probably null
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1500:Dnah11	UTSW	12	117,976,564 (GRCm39)	splice site	probably null
R1535:Dnah11	UTSW	12	117,982,465 (GRCm39)	missense	probably damaging	1.00
R1539:Dnah11	UTSW	12	117,894,991 (GRCm39)	missense	probably benign	0.01
R1554:Dnah11	UTSW	12	118,046,234 (GRCm39)	missense	possibly damaging	0.92
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1615:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R1618:Dnah11	UTSW	12	117,979,200 (GRCm39)	missense	probably damaging	0.98
R1638:Dnah11	UTSW	12	117,979,154 (GRCm39)	missense	possibly damaging	0.81
R1659:Dnah11	UTSW	12	118,084,459 (GRCm39)	missense	possibly damaging	0.94
R1671:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1678:Dnah11	UTSW	12	117,897,580 (GRCm39)	missense	possibly damaging	0.50
R1699:Dnah11	UTSW	12	118,154,603 (GRCm39)	missense	probably damaging	1.00
R1712:Dnah11	UTSW	12	118,160,379 (GRCm39)	missense	probably benign	0.32
R1728:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1729:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1764:Dnah11	UTSW	12	118,154,560 (GRCm39)	missense	probably benign	0.31
R1780:Dnah11	UTSW	12	117,991,293 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah11	UTSW	12	118,002,515 (GRCm39)	missense	probably damaging	0.99
R1800:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1863:Dnah11	UTSW	12	118,027,587 (GRCm39)	missense	possibly damaging	0.92
R1892:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R1907:Dnah11	UTSW	12	118,091,291 (GRCm39)	missense	possibly damaging	0.66
R1964:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R1967:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1997:Dnah11	UTSW	12	118,046,203 (GRCm39)	missense	possibly damaging	0.64
R2086:Dnah11	UTSW	12	118,077,606 (GRCm39)	missense	possibly damaging	0.82
R2092:Dnah11	UTSW	12	117,976,451 (GRCm39)	missense	possibly damaging	0.50
R2108:Dnah11	UTSW	12	117,984,088 (GRCm39)	missense	probably damaging	1.00
R2140:Dnah11	UTSW	12	117,972,545 (GRCm39)	missense	probably benign	0.01
R2261:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2261:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2262:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2262:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2328:Dnah11	UTSW	12	117,850,421 (GRCm39)	missense	probably damaging	0.98
R2352:Dnah11	UTSW	12	117,892,065 (GRCm39)	missense	probably damaging	1.00
R2410:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R2885:Dnah11	UTSW	12	117,951,162 (GRCm39)	nonsense	probably null
R3499:Dnah11	UTSW	12	117,874,758 (GRCm39)	missense	probably damaging	1.00
R3741:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3742:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3779:Dnah11	UTSW	12	118,094,448 (GRCm39)	splice site	probably benign
R3785:Dnah11	UTSW	12	117,981,337 (GRCm39)	missense	probably damaging	1.00
R3883:Dnah11	UTSW	12	117,942,188 (GRCm39)	splice site	probably benign
R4014:Dnah11	UTSW	12	117,938,649 (GRCm39)	missense	probably benign	0.16
R4043:Dnah11	UTSW	12	117,843,678 (GRCm39)	missense	probably damaging	1.00
R4072:Dnah11	UTSW	12	118,070,227 (GRCm39)	missense	probably damaging	1.00
R4073:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4074:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4076:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4201:Dnah11	UTSW	12	117,930,394 (GRCm39)	missense	possibly damaging	0.63
R4224:Dnah11	UTSW	12	118,094,627 (GRCm39)	missense	probably benign	0.06
R4233:Dnah11	UTSW	12	117,880,526 (GRCm39)	missense	probably damaging	1.00
R4358:Dnah11	UTSW	12	118,089,578 (GRCm39)	nonsense	probably null
R4430:Dnah11	UTSW	12	117,946,746 (GRCm39)	missense	probably benign	0.26
R4465:Dnah11	UTSW	12	117,951,186 (GRCm39)	missense	probably benign	0.09
R4489:Dnah11	UTSW	12	117,880,631 (GRCm39)	missense	probably benign	0.31
R4572:Dnah11	UTSW	12	117,973,860 (GRCm39)	missense	probably benign	0.00
R4574:Dnah11	UTSW	12	117,975,990 (GRCm39)	critical splice donor site	probably null
R4657:Dnah11	UTSW	12	118,156,162 (GRCm39)	missense	probably benign	0.02
R4709:Dnah11	UTSW	12	117,982,495 (GRCm39)	missense	probably benign	0.26
R4740:Dnah11	UTSW	12	118,084,279 (GRCm39)	missense	probably benign	0.28
R4803:Dnah11	UTSW	12	118,091,343 (GRCm39)	missense	possibly damaging	0.50
R4896:Dnah11	UTSW	12	117,958,935 (GRCm39)	missense	probably damaging	1.00
R4908:Dnah11	UTSW	12	118,090,618 (GRCm39)	missense	probably benign	0.37
R5018:Dnah11	UTSW	12	118,094,463 (GRCm39)	missense	probably benign	0.00
R5071:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5074:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5080:Dnah11	UTSW	12	118,162,565 (GRCm39)	start codon destroyed	probably null	0.01
R5097:Dnah11	UTSW	12	117,981,435 (GRCm39)	missense	probably damaging	1.00
R5131:Dnah11	UTSW	12	117,918,486 (GRCm39)	missense	probably damaging	1.00
R5215:Dnah11	UTSW	12	118,121,096 (GRCm39)	missense	probably benign	0.09
R5252:Dnah11	UTSW	12	118,089,676 (GRCm39)	missense	probably damaging	1.00
R5296:Dnah11	UTSW	12	117,847,151 (GRCm39)	missense	probably damaging	1.00
R5308:Dnah11	UTSW	12	118,049,415 (GRCm39)	missense	possibly damaging	0.60
R5368:Dnah11	UTSW	12	117,918,628 (GRCm39)	missense	probably damaging	1.00
R5383:Dnah11	UTSW	12	118,049,432 (GRCm39)	missense	probably damaging	0.99
R5499:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R5503:Dnah11	UTSW	12	117,844,186 (GRCm39)	critical splice donor site	probably null
R5546:Dnah11	UTSW	12	117,939,583 (GRCm39)	missense	possibly damaging	0.83
R5578:Dnah11	UTSW	12	117,982,537 (GRCm39)	missense	probably damaging	0.99
R5657:Dnah11	UTSW	12	117,847,352 (GRCm39)	missense	probably damaging	1.00
R5702:Dnah11	UTSW	12	118,077,642 (GRCm39)	missense	probably benign	0.04
R5706:Dnah11	UTSW	12	117,987,670 (GRCm39)	missense	probably damaging	1.00
R5727:Dnah11	UTSW	12	118,090,841 (GRCm39)	missense	probably damaging	1.00
R5737:Dnah11	UTSW	12	118,156,125 (GRCm39)	missense	probably benign
R5884:Dnah11	UTSW	12	118,141,269 (GRCm39)	missense	probably benign	0.00
R5900:Dnah11	UTSW	12	118,046,166 (GRCm39)	splice site	probably null
R5905:Dnah11	UTSW	12	117,918,659 (GRCm39)	missense	probably damaging	1.00
R5928:Dnah11	UTSW	12	117,878,371 (GRCm39)	splice site	probably null
R5973:Dnah11	UTSW	12	118,074,687 (GRCm39)	missense	probably benign	0.02
R6024:Dnah11	UTSW	12	117,994,007 (GRCm39)	missense	probably benign	0.34
R6056:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign	0.03
R6075:Dnah11	UTSW	12	118,068,586 (GRCm39)	missense	probably damaging	1.00
R6092:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign
R6191:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R6197:Dnah11	UTSW	12	118,143,482 (GRCm39)	missense	probably benign	0.03
R6262:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably damaging	0.98
R6321:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R6454:Dnah11	UTSW	12	117,880,590 (GRCm39)	missense	probably benign	0.01
R6614:Dnah11	UTSW	12	117,850,411 (GRCm39)	missense	possibly damaging	0.72
R6694:Dnah11	UTSW	12	118,150,617 (GRCm39)	splice site	probably null
R6712:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R6720:Dnah11	UTSW	12	118,009,381 (GRCm39)	missense	probably damaging	1.00
R6742:Dnah11	UTSW	12	118,077,629 (GRCm39)	missense	possibly damaging	0.82
R6806:Dnah11	UTSW	12	117,951,411 (GRCm39)	splice site	probably null
R6895:Dnah11	UTSW	12	117,958,926 (GRCm39)	missense	probably damaging	0.99
R6939:Dnah11	UTSW	12	118,070,297 (GRCm39)	missense	probably damaging	1.00
R6940:Dnah11	UTSW	12	118,162,503 (GRCm39)	missense	probably benign
R6945:Dnah11	UTSW	12	118,024,045 (GRCm39)	missense	probably damaging	1.00
R6958:Dnah11	UTSW	12	117,897,544 (GRCm39)	missense	probably damaging	1.00
R6970:Dnah11	UTSW	12	118,072,679 (GRCm39)	missense	probably benign	0.00
R6976:Dnah11	UTSW	12	118,162,378 (GRCm39)	missense	probably benign	0.16
R7000:Dnah11	UTSW	12	117,981,396 (GRCm39)	missense	probably damaging	1.00
R7011:Dnah11	UTSW	12	117,885,753 (GRCm39)	frame shift	probably null
R7101:Dnah11	UTSW	12	118,031,880 (GRCm39)	missense	probably benign
R7106:Dnah11	UTSW	12	117,924,884 (GRCm39)	missense	probably benign	0.15
R7203:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R7219:Dnah11	UTSW	12	118,090,624 (GRCm39)	missense	probably benign	0.00
R7219:Dnah11	UTSW	12	118,004,830 (GRCm39)	missense	possibly damaging	0.95
R7308:Dnah11	UTSW	12	117,959,010 (GRCm39)	missense	probably damaging	1.00
R7361:Dnah11	UTSW	12	117,982,477 (GRCm39)	missense	probably damaging	1.00
R7367:Dnah11	UTSW	12	117,951,177 (GRCm39)	missense	possibly damaging	0.59
R7399:Dnah11	UTSW	12	118,089,520 (GRCm39)	missense	probably damaging	1.00
R7399:Dnah11	UTSW	12	117,991,212 (GRCm39)	missense	probably benign	0.00
R7404:Dnah11	UTSW	12	118,068,543 (GRCm39)	missense	probably benign	0.36
R7473:Dnah11	UTSW	12	117,866,911 (GRCm39)	missense	probably benign	0.19
R7545:Dnah11	UTSW	12	117,894,939 (GRCm39)	missense	probably damaging	1.00
R7608:Dnah11	UTSW	12	118,104,505 (GRCm39)	splice site	probably null
R7625:Dnah11	UTSW	12	118,160,377 (GRCm39)	missense	probably benign
R7761:Dnah11	UTSW	12	117,987,648 (GRCm39)	missense	probably damaging	1.00
R7881:Dnah11	UTSW	12	117,951,237 (GRCm39)	missense	probably benign	0.04
R7904:Dnah11	UTSW	12	117,867,003 (GRCm39)	missense	possibly damaging	0.72
R8100:Dnah11	UTSW	12	117,930,368 (GRCm39)	missense	probably damaging	0.99
R8179:Dnah11	UTSW	12	117,842,284 (GRCm39)	missense	possibly damaging	0.90
R8192:Dnah11	UTSW	12	117,976,181 (GRCm39)	missense	probably benign
R8254:Dnah11	UTSW	12	117,842,259 (GRCm39)	missense	possibly damaging	0.89
R8268:Dnah11	UTSW	12	117,991,243 (GRCm39)	nonsense	probably null
R8272:Dnah11	UTSW	12	118,074,752 (GRCm39)	missense	probably benign	0.01
R8344:Dnah11	UTSW	12	118,049,466 (GRCm39)	missense	probably benign	0.00
R8515:Dnah11	UTSW	12	117,939,533 (GRCm39)	missense	probably damaging	1.00
R8528:Dnah11	UTSW	12	117,972,538 (GRCm39)	missense	probably damaging	0.96
R8557:Dnah11	UTSW	12	117,842,247 (GRCm39)	missense	probably benign
R8676:Dnah11	UTSW	12	118,154,539 (GRCm39)	missense	probably damaging	1.00
R8738:Dnah11	UTSW	12	118,049,384 (GRCm39)	critical splice donor site	probably null
R8773:Dnah11	UTSW	12	117,958,950 (GRCm39)	missense	possibly damaging	0.94
R8818:Dnah11	UTSW	12	117,874,764 (GRCm39)	missense	probably damaging	1.00
R8855:Dnah11	UTSW	12	118,156,107 (GRCm39)	missense	probably benign	0.03
R8866:Dnah11	UTSW	12	118,156,107 (GRCm39)	missense	probably benign	0.03
R8881:Dnah11	UTSW	12	118,090,550 (GRCm39)	missense	probably benign	0.05
R8881:Dnah11	UTSW	12	118,077,647 (GRCm39)	missense	probably benign	0.00
R8920:Dnah11	UTSW	12	118,077,674 (GRCm39)	missense	probably damaging	0.99
R8944:Dnah11	UTSW	12	118,091,381 (GRCm39)	missense	possibly damaging	0.63
R8945:Dnah11	UTSW	12	117,987,718 (GRCm39)	missense	probably benign	0.36
R8962:Dnah11	UTSW	12	117,918,630 (GRCm39)	missense	probably damaging	1.00
R8962:Dnah11	UTSW	12	117,916,273 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah11	UTSW	12	118,094,578 (GRCm39)	missense	probably benign	0.00
R9155:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9162:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9164:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9171:Dnah11	UTSW	12	117,894,918 (GRCm39)	missense	probably damaging	0.99
R9186:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R9205:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9208:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9234:Dnah11	UTSW	12	117,951,095 (GRCm39)	missense	probably damaging	1.00
R9264:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R9290:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9291:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9315:Dnah11	UTSW	12	118,143,341 (GRCm39)	missense	probably benign	0.11
R9353:Dnah11	UTSW	12	118,143,434 (GRCm39)	missense	probably benign	0.00
R9375:Dnah11	UTSW	12	117,884,703 (GRCm39)	missense	possibly damaging	0.67
R9392:Dnah11	UTSW	12	118,141,290 (GRCm39)	missense	probably benign	0.00
R9392:Dnah11	UTSW	12	118,011,055 (GRCm39)	nonsense	probably null
R9433:Dnah11	UTSW	12	117,976,007 (GRCm39)	missense	probably damaging	1.00
R9511:Dnah11	UTSW	12	117,878,352 (GRCm39)	missense	probably damaging	1.00
R9526:Dnah11	UTSW	12	118,150,711 (GRCm39)	missense	probably damaging	0.98
R9566:Dnah11	UTSW	12	117,938,728 (GRCm39)	missense	possibly damaging	0.69
R9673:Dnah11	UTSW	12	117,982,513 (GRCm39)	missense	possibly damaging	0.91
R9705:Dnah11	UTSW	12	118,094,770 (GRCm39)	missense	probably damaging	1.00
R9716:Dnah11	UTSW	12	118,024,148 (GRCm39)	missense	probably damaging	0.99
R9746:Dnah11	UTSW	12	117,842,311 (GRCm39)	nonsense	probably null
R9764:Dnah11	UTSW	12	117,884,704 (GRCm39)	missense	probably benign	0.05
RF023:Dnah11	UTSW	12	117,918,585 (GRCm39)	missense	probably damaging	1.00
RF047:Dnah11	UTSW	12	117,973,818 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,858,747 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,946,704 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah11	UTSW	12	118,094,534 (GRCm39)	missense	probably damaging	0.97
Z1176:Dnah11	UTSW	12	118,090,854 (GRCm39)	missense	probably benign	0.00
Z1176:Dnah11	UTSW	12	117,894,912 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- TAGCACTTCCCAAACCTTGC -3'
(R):5'- TACGGGATATCCAGGAGCAC -3'

Sequencing Primer
(F):5'- CAGGTCATTATCATCATAGCACGCTG -3'
(R):5'- TATCCAGGAGCACATGATAGGTTAG -3'

Posted On

2019-12-20