Incidental Mutation 'R7880:Or5ak22'
ID 608675
Institutional Source Beutler Lab
Gene Symbol Or5ak22
Ensembl Gene ENSMUSG00000075221
Gene Name olfactory receptor family 5 subfamily AK member 22
Synonyms MOR203-1, Olfr992, GA_x6K02T2Q125-46877170-46876241
MMRRC Submission 045932-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R7880 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 85229946-85230875 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 85230379 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Tyrosine at position 166 (S166Y)
Ref Sequence ENSEMBL: ENSMUSP00000149333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099927] [ENSMUST00000213749] [ENSMUST00000214895] [ENSMUST00000215617]
AlphaFold Q8VGC6
Predicted Effect possibly damaging
Transcript: ENSMUST00000099927
AA Change: S166Y

PolyPhen 2 Score 0.708 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097511
Gene: ENSMUSG00000075221
AA Change: S166Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 285 3.3e-6 PFAM
Pfam:7tm_1 41 290 7.1e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213749
AA Change: S166Y

PolyPhen 2 Score 0.708 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214895
AA Change: S166Y

PolyPhen 2 Score 0.708 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect probably benign
Transcript: ENSMUST00000215617
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam12 T A 7: 133,511,691 (GRCm39) D703V possibly damaging Het
Adamts1 G A 16: 85,594,940 (GRCm39) R340* probably null Het
Akap13 A G 7: 75,235,964 (GRCm39) T180A probably damaging Het
Arhgap31 G A 16: 38,423,087 (GRCm39) A993V probably benign Het
Asxl3 C T 18: 22,655,208 (GRCm39) P1073S possibly damaging Het
Bmp3 T G 5: 99,020,434 (GRCm39) S286A probably damaging Het
Cacna2d4 C T 6: 119,326,116 (GRCm39) S1078F probably damaging Het
Cd101 A G 3: 100,915,182 (GRCm39) L799P probably benign Het
Chst13 C T 6: 90,302,062 (GRCm39) R28H possibly damaging Het
CN725425 T A 15: 91,130,308 (GRCm39) C390* probably null Het
Crabp1 C A 9: 54,672,942 (GRCm39) C82* probably null Het
Cyp2b23 A C 7: 26,372,559 (GRCm39) V352G probably damaging Het
Dmrta1 T A 4: 89,577,081 (GRCm39) V179E possibly damaging Het
Ect2l T C 10: 18,012,702 (GRCm39) D839G possibly damaging Het
Espnl A T 1: 91,272,488 (GRCm39) E616V possibly damaging Het
Fam50b C A 13: 34,930,802 (GRCm39) Q93K probably benign Het
Focad C T 4: 88,319,407 (GRCm39) R1539C unknown Het
Gm14443 T A 2: 175,011,163 (GRCm39) I428L probably benign Het
Gm21886 ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG 18: 80,133,040 (GRCm39) probably benign Het
Gramd1c C G 16: 43,812,439 (GRCm39) A193P probably benign Het
Gsn A G 2: 35,173,939 (GRCm39) H54R probably damaging Het
Gucy2g T A 19: 55,194,712 (GRCm39) I902F probably damaging Het
H2-T9 T A 17: 36,438,761 (GRCm39) H210L possibly damaging Het
Heg1 T C 16: 33,539,879 (GRCm39) S280P possibly damaging Het
Herc1 G T 9: 66,415,506 (GRCm39) R4827L probably damaging Het
Igsf21 A G 4: 139,884,819 (GRCm39) C46R probably damaging Het
Kansl1 G T 11: 104,314,979 (GRCm39) A353D probably damaging Het
Kcnab3 A G 11: 69,222,290 (GRCm39) Y311C probably damaging Het
Kctd18 A G 1: 58,006,778 (GRCm39) I24T possibly damaging Het
Lpcat4 C A 2: 112,070,376 (GRCm39) H30N probably benign Het
Lrrc4c A G 2: 97,461,143 (GRCm39) I590V probably benign Het
Lrrc69 T C 4: 14,703,946 (GRCm39) I291M possibly damaging Het
Nsun6 A C 2: 15,001,190 (GRCm39) C455W probably damaging Het
Or12e1 T A 2: 87,022,434 (GRCm39) C134* probably null Het
Or4c3 A T 2: 89,852,381 (GRCm39) F10I probably damaging Het
Or7g19 T G 9: 18,856,024 (GRCm39) L27V probably benign Het
Orc6 T C 8: 86,031,873 (GRCm39) I162T probably benign Het
Pex13 A T 11: 23,599,369 (GRCm39) S381T probably benign Het
Ppil1 G A 17: 29,480,762 (GRCm39) H54Y probably damaging Het
Prrt4 T C 6: 29,170,155 (GRCm39) I766V probably benign Het
Rab32 C T 10: 10,422,159 (GRCm39) V187M probably damaging Het
Sema5a T A 15: 32,686,954 (GRCm39) I1022N probably damaging Het
Sipa1l2 T C 8: 126,191,132 (GRCm39) T953A probably damaging Het
Snapc3 T C 4: 83,353,431 (GRCm39) S157P probably damaging Het
Spink5 A G 18: 44,119,393 (GRCm39) R235G probably benign Het
Stx5a G A 19: 8,719,692 (GRCm39) G19D probably damaging Het
Taf4 G A 2: 179,573,822 (GRCm39) T682M probably damaging Het
Taf4 G A 2: 179,577,726 (GRCm39) R532* probably null Het
Tmpo T A 10: 91,001,892 (GRCm39) K106* probably null Het
Trnt1 T C 6: 106,746,517 (GRCm39) probably null Het
Vmn1r228 A T 17: 20,996,672 (GRCm39) I282N probably damaging Het
Vps13d A T 4: 144,907,684 (GRCm39) probably null Het
Zfp703 A G 8: 27,468,718 (GRCm39) I51V unknown Het
Zfp787 A G 7: 6,135,190 (GRCm39) F354L probably benign Het
Znrf2 T C 6: 54,794,332 (GRCm39) V111A probably benign Het
Zwint G T 10: 72,492,924 (GRCm39) R182L probably benign Het
Other mutations in Or5ak22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01613:Or5ak22 APN 2 85,230,515 (GRCm39) missense probably damaging 1.00
IGL02538:Or5ak22 APN 2 85,230,647 (GRCm39) missense probably damaging 1.00
IGL02550:Or5ak22 APN 2 85,230,166 (GRCm39) missense probably damaging 0.99
R0128:Or5ak22 UTSW 2 85,230,305 (GRCm39) missense probably damaging 0.99
R0130:Or5ak22 UTSW 2 85,230,305 (GRCm39) missense probably damaging 0.99
R0345:Or5ak22 UTSW 2 85,230,685 (GRCm39) missense possibly damaging 0.60
R0413:Or5ak22 UTSW 2 85,230,019 (GRCm39) missense probably damaging 1.00
R0535:Or5ak22 UTSW 2 85,230,439 (GRCm39) missense possibly damaging 0.71
R1243:Or5ak22 UTSW 2 85,230,617 (GRCm39) missense probably benign
R1255:Or5ak22 UTSW 2 85,230,647 (GRCm39) missense probably damaging 1.00
R1293:Or5ak22 UTSW 2 85,230,697 (GRCm39) splice site probably null
R1840:Or5ak22 UTSW 2 85,230,512 (GRCm39) missense probably benign 0.42
R1847:Or5ak22 UTSW 2 85,230,785 (GRCm39) missense probably damaging 0.99
R2300:Or5ak22 UTSW 2 85,230,476 (GRCm39) missense probably benign
R4574:Or5ak22 UTSW 2 85,230,370 (GRCm39) missense probably damaging 1.00
R4872:Or5ak22 UTSW 2 85,230,772 (GRCm39) missense probably damaging 1.00
R5435:Or5ak22 UTSW 2 85,230,814 (GRCm39) missense probably benign 0.05
R6846:Or5ak22 UTSW 2 85,230,861 (GRCm39) missense probably damaging 1.00
R7075:Or5ak22 UTSW 2 85,230,544 (GRCm39) missense probably damaging 1.00
R7253:Or5ak22 UTSW 2 85,229,983 (GRCm39) missense probably benign 0.00
R7454:Or5ak22 UTSW 2 85,229,955 (GRCm39) missense probably damaging 0.99
R9098:Or5ak22 UTSW 2 85,229,995 (GRCm39) missense probably damaging 1.00
R9345:Or5ak22 UTSW 2 85,230,097 (GRCm39) missense probably benign 0.27
R9756:Or5ak22 UTSW 2 85,230,682 (GRCm39) missense probably damaging 1.00
RF007:Or5ak22 UTSW 2 85,230,137 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTTAGGATGGCAGCCAAG -3'
(R):5'- ACAGGATGCTTGGCTCAATTACTG -3'

Sequencing Primer
(F):5'- CCTTAGGATGGCAGCCAAGATAAATG -3'
(R):5'- GTATCTTTGTAACCAGTGACTGC -3'
Posted On 2019-12-20