Incidental Mutation 'R7880:Gm21886'
ID608725
Institutional Source Beutler Lab
Gene Symbol Gm21886
Ensembl Gene ENSMUSG00000096597
Gene Namepredicted gene, 21886
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #R7880 (G1)
Quality Score124.458
Status Not validated
Chromosome18
Chromosomal Location80089297-80089962 bp(-) (GRCm38)
Type of Mutationsmall deletion (9 aa in frame mutation)
DNA Base Change (assembly) ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG to ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG at 80089825 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070219] [ENSMUST00000178391]
Predicted Effect probably benign
Transcript: ENSMUST00000070219
SMART Domains Protein: ENSMUSP00000069182
Gene: ENSMUSG00000056214

DomainStartEndE-ValueType
PB1 18 98 1.16e-16 SMART
PDZ 168 251 8.6e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178391
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam12 T A 7: 133,909,962 D703V possibly damaging Het
Adamts1 G A 16: 85,798,052 R340* probably null Het
Akap13 A G 7: 75,586,216 T180A probably damaging Het
Arhgap31 G A 16: 38,602,725 A993V probably benign Het
Asxl3 C T 18: 22,522,151 P1073S possibly damaging Het
Bmp3 T G 5: 98,872,575 S286A probably damaging Het
Cacna2d4 C T 6: 119,349,155 S1078F probably damaging Het
Cd101 A G 3: 101,007,866 L799P probably benign Het
Chst13 C T 6: 90,325,080 R28H possibly damaging Het
CN725425 T A 15: 91,246,105 C390* probably null Het
Crabp1 C A 9: 54,765,658 C82* probably null Het
Cyp2b23 A C 7: 26,673,134 V352G probably damaging Het
Dmrta1 T A 4: 89,688,844 V179E possibly damaging Het
Ect2l T C 10: 18,136,954 D839G possibly damaging Het
Espnl A T 1: 91,344,766 E616V possibly damaging Het
Fam50b C A 13: 34,746,819 Q93K probably benign Het
Focad C T 4: 88,401,170 R1539C unknown Het
Gm14443 T A 2: 175,169,370 I428L probably benign Het
Gm7030 T A 17: 36,127,869 H210L possibly damaging Het
Gramd1c C G 16: 43,992,076 A193P probably benign Het
Gsn A G 2: 35,283,927 H54R probably damaging Het
Gucy2g T A 19: 55,206,280 I902F probably damaging Het
Heg1 T C 16: 33,719,509 S280P possibly damaging Het
Herc1 G T 9: 66,508,224 R4827L probably damaging Het
Igsf21 A G 4: 140,157,508 C46R probably damaging Het
Kansl1 G T 11: 104,424,153 A353D probably damaging Het
Kcnab3 A G 11: 69,331,464 Y311C probably damaging Het
Kctd18 A G 1: 57,967,619 I24T possibly damaging Het
Lpcat4 C A 2: 112,240,031 H30N probably benign Het
Lrrc4c A G 2: 97,630,798 I590V probably benign Het
Lrrc69 T C 4: 14,703,946 I291M possibly damaging Het
Nsun6 A C 2: 14,996,379 C455W probably damaging Het
Olfr1112 T A 2: 87,192,090 C134* probably null Het
Olfr1264 A T 2: 90,022,037 F10I probably damaging Het
Olfr832 T G 9: 18,944,728 L27V probably benign Het
Olfr992 G T 2: 85,400,035 S166Y possibly damaging Het
Orc6 T C 8: 85,305,244 I162T probably benign Het
Pex13 A T 11: 23,649,369 S381T probably benign Het
Ppil1 G A 17: 29,261,788 H54Y probably damaging Het
Prrt4 T C 6: 29,170,156 I766V probably benign Het
Rab32 C T 10: 10,546,415 V187M probably damaging Het
Sema5a T A 15: 32,686,808 I1022N probably damaging Het
Sipa1l2 T C 8: 125,464,393 T953A probably damaging Het
Snapc3 T C 4: 83,435,194 S157P probably damaging Het
Spink5 A G 18: 43,986,326 R235G probably benign Het
Stx5a G A 19: 8,742,328 G19D probably damaging Het
Taf4 G A 2: 179,932,029 T682M probably damaging Het
Taf4 G A 2: 179,935,933 R532* probably null Het
Tmpo T A 10: 91,166,030 K106* probably null Het
Trnt1 T C 6: 106,769,556 probably null Het
Vmn1r228 A T 17: 20,776,410 I282N probably damaging Het
Vps13d A T 4: 145,181,114 probably null Het
Zfp703 A G 8: 26,978,690 I51V unknown Het
Zfp787 A G 7: 6,132,191 F354L probably benign Het
Znrf2 T C 6: 54,817,347 V111A probably benign Het
Zwint G T 10: 72,657,092 R182L probably benign Het
Other mutations in Gm21886
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1679:Gm21886 UTSW 18 80089739 missense probably damaging 1.00
R1902:Gm21886 UTSW 18 80089418 missense probably damaging 1.00
R3779:Gm21886 UTSW 18 80089434 missense possibly damaging 0.94
R7146:Gm21886 UTSW 18 80089482 small deletion probably benign
R7254:Gm21886 UTSW 18 80089735 nonsense probably null
R7405:Gm21886 UTSW 18 80089825 small deletion probably benign
R7412:Gm21886 UTSW 18 80089752 small deletion probably benign
R7427:Gm21886 UTSW 18 80089652 missense probably damaging 1.00
R7428:Gm21886 UTSW 18 80089652 missense probably damaging 1.00
R7526:Gm21886 UTSW 18 80089825 small deletion probably benign
R7756:Gm21886 UTSW 18 80089825 small deletion probably benign
R7891:Gm21886 UTSW 18 80089757 missense probably null 0.17
R8026:Gm21886 UTSW 18 80089746 missense probably damaging 1.00
R8295:Gm21886 UTSW 18 80089825 small deletion probably benign
Z1176:Gm21886 UTSW 18 80089387 nonsense probably null
Z1176:Gm21886 UTSW 18 80089923 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCCTGTAAATAGTAGGTGC -3'
(R):5'- TGGGACAGATGAGCTTCTCTTC -3'

Sequencing Primer
(F):5'- TGCTCACTGAGACCTGTAGACAG -3'
(R):5'- GACAGATGAGCTTCTCTTCAGAGC -3'
Posted On2019-12-20