Mutagenetix > Incidental Mutation

Incidental Mutation 'R7881:Fer1l5'

608731

Institutional Source

Beutler Lab

Gene Symbol

Fer1l5

Ensembl Gene

ENSMUSG00000037432

Gene Name

fer-1 like family member 5

Synonyms

4930533C12Rik

MMRRC Submission

045933-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

R7881 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

36411372-36461191 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 36446117 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 876 (T876M)

Ref Sequence

ENSEMBL: ENSMUSP00000142130 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179162]

AlphaFold

P0DM40

Predicted Effect

not run
Transcript: ENSMUST00000179162
AA Change: T876M

SMART Domains

Protein: ENSMUSP00000142130
Gene: ENSMUSG00000037432
AA Change: T876M

Domain	Start	End	E-Value	Type
C2	1	98	2.74e-4	SMART
C2	168	264	4.29e-6	SMART
FerI	250	323	1.59e-19	SMART
C2	325	422	1.06e-5	SMART
FerA	602	669	6.26e-18	SMART
FerB	691	764	1.38e-37	SMART
internal_repeat_1	781	836	1.77e-5	PROSPERO
internal_repeat_1	852	904	1.77e-5	PROSPERO
DysFC	913	951	1.61e-3	SMART
DysFC	981	1013	4.81e-2	SMART
C2	1078	1222	1.56e0	SMART
Pfam:C2	1248	1329	1e-1	PFAM
low complexity region	1376	1387	N/A	INTRINSIC
low complexity region	1459	1470	N/A	INTRINSIC
C2	1487	1586	2.21e-8	SMART
C2	1659	1851	5.32e-2	SMART
transmembrane domain	1964	1986	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

97% (63/65)

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	A	G	13: 77,471,685 (GRCm39)	N1030S	possibly damaging	Het
4930507D05Rik	A	G	10: 62,285,303 (GRCm39)	H9R	unknown	Het
Anks1b	T	A	10: 90,802,880 (GRCm39)	S398T	probably benign	Het
Bbox1	T	A	2: 110,122,871 (GRCm39)	K139N	probably benign	Het
Birc6	C	A	17: 74,948,666 (GRCm39)	H3047N	probably damaging	Het
C1ra	G	A	6: 124,494,684 (GRCm39)	E316K	probably benign	Het
Camta1	G	A	4: 151,920,333 (GRCm39)	S18F	probably damaging	Het
Ccnb1ip1	T	C	14: 51,031,277 (GRCm39)	Y12C	possibly damaging	Het
Celsr3	G	A	9: 108,705,271 (GRCm39)	A585T	probably benign	Het
Col6a4	T	C	9: 105,957,497 (GRCm39)	N109S	probably benign	Het
Crisp4	A	T	1: 18,198,893 (GRCm39)	D180E	probably benign	Het
Dmxl1	T	A	18: 49,997,450 (GRCm39)	M546K	probably damaging	Het
Dnah11	C	T	12: 117,951,237 (GRCm39)	V3024I	probably benign	Het
Dnah2	T	C	11: 69,322,064 (GRCm39)	D3752G	probably damaging	Het
Dram1	G	T	10: 88,160,609 (GRCm39)	D237E	probably benign	Het
Ehbp1l1	T	C	19: 5,769,426 (GRCm39)	N626D	probably benign	Het
Elavl1	T	G	8: 4,361,763 (GRCm39)	N3T	probably damaging	Het
Fam184a	A	G	10: 53,574,589 (GRCm39)	V340A	probably benign	Het
Foxp2	T	A	6: 15,409,888 (GRCm39)	V471E	unknown	Het
Fstl5	G	A	3: 76,443,605 (GRCm39)	G317R	probably damaging	Het
Gm32742	T	C	9: 51,060,414 (GRCm39)	E963G	possibly damaging	Het
Gpbp1	A	T	13: 111,575,733 (GRCm39)	S257T	possibly damaging	Het
Gsdmc4	C	T	15: 63,769,568 (GRCm39)	C218Y	possibly damaging	Het
Hmg20b	T	C	10: 81,182,442 (GRCm39)	H298R	probably damaging	Het
Igf2r	A	T	17: 12,967,591 (GRCm39)	C72S	probably benign	Het
Kcnip1	A	G	11: 33,583,206 (GRCm39)	M193T	probably damaging	Het
Khdc1c	G	T	1: 21,439,899 (GRCm39)	C150F	probably benign	Het
Kmt2b	A	G	7: 30,279,208 (GRCm39)	S1485P	probably damaging	Het
Lnpep	A	G	17: 17,787,001 (GRCm39)	S533P	probably benign	Het
Megf8	T	A	7: 25,040,060 (GRCm39)	V997E	possibly damaging	Het
Mob2	T	C	7: 141,563,177 (GRCm39)	Y94C	probably damaging	Het
Muc5ac	G	C	7: 141,363,040 (GRCm39)	G2117A	unknown	Het
Npepl1	A	G	2: 173,962,387 (GRCm39)	D351G	probably damaging	Het
Nrg1	G	A	8: 32,328,352 (GRCm39)	Q213*	probably null	Het
Nrp2	A	G	1: 62,810,990 (GRCm39)	D677G	probably benign	Het
Or11h7	A	G	14: 50,890,904 (GRCm39)	E70G	probably damaging	Het
Or2b4	G	T	17: 38,116,320 (GRCm39)	G95C	probably damaging	Het
Or56a3	G	T	7: 104,735,780 (GRCm39)	V286F	probably damaging	Het
Or5aq7	G	T	2: 86,938,401 (GRCm39)	T110K	probably damaging	Het
Or5m3b	C	A	2: 85,871,814 (GRCm39)	Q52K	probably benign	Het
Or8c8	T	A	9: 38,165,406 (GRCm39)	M228K	probably benign	Het
Peg10	ACATCAGGATCC	ACATCAGGATCCCCATCAGGATCC	6: 4,756,454 (GRCm39)		probably benign	Het
Phaf1	C	A	8: 105,976,084 (GRCm39)	T347N	probably benign	Het
Prune2	G	A	19: 17,100,393 (GRCm39)	V1966I	possibly damaging	Het
Ptch2	A	G	4: 116,967,585 (GRCm39)	H751R	probably benign	Het
Ptges2	T	A	2: 32,292,243 (GRCm39)	M353K	probably damaging	Het
Pum3	G	A	19: 27,373,728 (GRCm39)	Q564*	probably null	Het
Qtrt1	A	G	9: 21,330,637 (GRCm39)	D279G	probably damaging	Het
Rftn1	C	T	17: 50,354,463 (GRCm39)	V300I	probably benign	Het
Robo2	T	C	16: 73,717,585 (GRCm39)	T1172A	probably benign	Het
Sdc3	A	G	4: 130,544,244 (GRCm39)	D74G	unknown	Het
Setd1b	A	G	5: 123,290,336 (GRCm39)	M768V	unknown	Het
Shld2	A	T	14: 33,989,724 (GRCm39)	M394K	possibly damaging	Het
Siglech	A	T	7: 55,422,289 (GRCm39)	H298L	probably benign	Het
Sipa1	A	T	19: 5,701,704 (GRCm39)	L977Q	probably damaging	Het
Slc9c1	G	A	16: 45,403,332 (GRCm39)	V800I	probably benign	Het
Spata31e1	A	G	13: 49,943,547 (GRCm39)	S44P	possibly damaging	Het
Spata31f1a	C	T	4: 42,851,586 (GRCm39)	C190Y	probably benign	Het
Tbc1d8	C	T	1: 39,425,104 (GRCm39)	R582Q	probably damaging	Het
Tmem247	T	A	17: 87,229,728 (GRCm39)	F190I	probably damaging	Het
Trim42	C	A	9: 97,245,070 (GRCm39)	A577S	possibly damaging	Het
Ubiad1	G	A	4: 148,528,726 (GRCm39)	T61I	probably benign	Het
Usp40	G	A	1: 87,923,435 (GRCm39)	Q279*	probably null	Het
Usp48	A	G	4: 137,360,766 (GRCm39)	N733S	probably benign	Het
Vmn2r83	A	T	10: 79,314,261 (GRCm39)	I170F	probably benign	Het
Xkr4	G	A	1: 3,286,487 (GRCm39)	P568S	probably damaging	Het
Zc3h7b	T	C	15: 81,664,679 (GRCm39)	W513R	probably damaging	Het
Zfp40	T	C	17: 23,410,440 (GRCm39)		probably benign	Het
Zfp652	T	A	11: 95,640,935 (GRCm39)	S287T	possibly damaging	Het
Znrf3	G	A	11: 5,394,533 (GRCm39)	A49V	unknown	Het

Other mutations in Fer1l5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4151001:Fer1l5	UTSW	1	36,450,728 (GRCm39)	missense	probably benign	0.27
R5580:Fer1l5	UTSW	1	36,424,539 (GRCm39)	nonsense	probably null
R5848:Fer1l5	UTSW	1	36,428,016 (GRCm39)	missense	probably benign	0.39
R5930:Fer1l5	UTSW	1	36,424,254 (GRCm39)	nonsense	probably null
R6193:Fer1l5	UTSW	1	36,448,517 (GRCm39)	missense	probably benign	0.20
R6195:Fer1l5	UTSW	1	36,414,367 (GRCm39)	splice site	probably null
R6207:Fer1l5	UTSW	1	36,424,241 (GRCm39)	missense	probably damaging	1.00
R6233:Fer1l5	UTSW	1	36,414,367 (GRCm39)	splice site	probably null
R6349:Fer1l5	UTSW	1	36,450,355 (GRCm39)	missense	probably damaging	0.96
R6478:Fer1l5	UTSW	1	36,441,612 (GRCm39)	missense	probably damaging	1.00
R6514:Fer1l5	UTSW	1	36,442,697 (GRCm39)	missense	probably benign	0.01
R6611:Fer1l5	UTSW	1	36,445,735 (GRCm39)	missense	probably benign	0.01
R6634:Fer1l5	UTSW	1	36,450,466 (GRCm39)	missense	probably damaging	0.99
R6733:Fer1l5	UTSW	1	36,447,753 (GRCm39)	critical splice donor site	probably null
R6816:Fer1l5	UTSW	1	36,445,591 (GRCm39)	missense	possibly damaging	0.60
R7225:Fer1l5	UTSW	1	36,460,033 (GRCm39)	missense	possibly damaging	0.90
R7316:Fer1l5	UTSW	1	36,457,197 (GRCm39)	missense	probably benign	0.41
R7455:Fer1l5	UTSW	1	36,428,064 (GRCm39)	missense	probably benign	0.00
R7473:Fer1l5	UTSW	1	36,460,689 (GRCm39)	missense	possibly damaging	0.53
R7702:Fer1l5	UTSW	1	36,459,775 (GRCm39)	nonsense	probably null
R7714:Fer1l5	UTSW	1	36,440,558 (GRCm39)	missense	probably damaging	1.00
R7872:Fer1l5	UTSW	1	36,460,967 (GRCm39)	missense	probably benign	0.00
R7984:Fer1l5	UTSW	1	36,447,702 (GRCm39)	missense	possibly damaging	0.68
R8326:Fer1l5	UTSW	1	36,415,841 (GRCm39)	missense	probably benign	0.04
R8523:Fer1l5	UTSW	1	36,426,271 (GRCm39)	missense	probably benign	0.27
R8528:Fer1l5	UTSW	1	36,456,855 (GRCm39)	missense	possibly damaging	0.91
R8975:Fer1l5	UTSW	1	36,456,897 (GRCm39)	missense	probably benign	0.13
R9011:Fer1l5	UTSW	1	36,441,601 (GRCm39)	missense	probably damaging	0.96
R9084:Fer1l5	UTSW	1	36,429,619 (GRCm39)	missense	probably benign	0.00
R9140:Fer1l5	UTSW	1	36,460,047 (GRCm39)	intron	probably benign
R9180:Fer1l5	UTSW	1	36,449,999 (GRCm39)	missense	probably null	1.00
R9312:Fer1l5	UTSW	1	36,460,248 (GRCm39)	missense	probably damaging	1.00
R9510:Fer1l5	UTSW	1	36,442,662 (GRCm39)	missense	probably damaging	0.97
R9655:Fer1l5	UTSW	1	36,460,696 (GRCm39)	missense	probably benign	0.40
Z1176:Fer1l5	UTSW	1	36,429,644 (GRCm39)	nonsense	probably null
Z1177:Fer1l5	UTSW	1	36,448,275 (GRCm39)	missense	probably benign	0.03

Predicted Primers

Posted On

2019-12-20