Incidental Mutation 'R7881:Or5m3b'
ID 608736
Institutional Source Beutler Lab
Gene Symbol Or5m3b
Ensembl Gene ENSMUSG00000045392
Gene Name olfactory receptor family 5 subfamily M member 3B
Synonyms GA_x6K02T2Q125-47516301-47517233, Olfr1033, MOR199-2
MMRRC Submission 045933-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R7881 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85850984-85875152 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 85871814 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 52 (Q52K)
Ref Sequence ENSEMBL: ENSMUSP00000149818 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000213496] [ENSMUST00000213774] [ENSMUST00000213865] [ENSMUST00000214546] [ENSMUST00000215682] [ENSMUST00000218397]
AlphaFold Q8VFK5
Predicted Effect probably benign
Transcript: ENSMUST00000213496
Predicted Effect probably benign
Transcript: ENSMUST00000213774
Predicted Effect probably benign
Transcript: ENSMUST00000213865
AA Change: Q52K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000214546
AA Change: Q52K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000215682
AA Change: Q52K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000218397
AA Change: Q52K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (63/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A G 13: 77,471,685 (GRCm39) N1030S possibly damaging Het
4930507D05Rik A G 10: 62,285,303 (GRCm39) H9R unknown Het
Anks1b T A 10: 90,802,880 (GRCm39) S398T probably benign Het
Bbox1 T A 2: 110,122,871 (GRCm39) K139N probably benign Het
Birc6 C A 17: 74,948,666 (GRCm39) H3047N probably damaging Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Camta1 G A 4: 151,920,333 (GRCm39) S18F probably damaging Het
Ccnb1ip1 T C 14: 51,031,277 (GRCm39) Y12C possibly damaging Het
Celsr3 G A 9: 108,705,271 (GRCm39) A585T probably benign Het
Col6a4 T C 9: 105,957,497 (GRCm39) N109S probably benign Het
Crisp4 A T 1: 18,198,893 (GRCm39) D180E probably benign Het
Dmxl1 T A 18: 49,997,450 (GRCm39) M546K probably damaging Het
Dnah11 C T 12: 117,951,237 (GRCm39) V3024I probably benign Het
Dnah2 T C 11: 69,322,064 (GRCm39) D3752G probably damaging Het
Dram1 G T 10: 88,160,609 (GRCm39) D237E probably benign Het
Ehbp1l1 T C 19: 5,769,426 (GRCm39) N626D probably benign Het
Elavl1 T G 8: 4,361,763 (GRCm39) N3T probably damaging Het
Fam184a A G 10: 53,574,589 (GRCm39) V340A probably benign Het
Fer1l5 C T 1: 36,446,117 (GRCm39) T876M not run Het
Foxp2 T A 6: 15,409,888 (GRCm39) V471E unknown Het
Fstl5 G A 3: 76,443,605 (GRCm39) G317R probably damaging Het
Gm32742 T C 9: 51,060,414 (GRCm39) E963G possibly damaging Het
Gpbp1 A T 13: 111,575,733 (GRCm39) S257T possibly damaging Het
Gsdmc4 C T 15: 63,769,568 (GRCm39) C218Y possibly damaging Het
Hmg20b T C 10: 81,182,442 (GRCm39) H298R probably damaging Het
Igf2r A T 17: 12,967,591 (GRCm39) C72S probably benign Het
Kcnip1 A G 11: 33,583,206 (GRCm39) M193T probably damaging Het
Khdc1c G T 1: 21,439,899 (GRCm39) C150F probably benign Het
Kmt2b A G 7: 30,279,208 (GRCm39) S1485P probably damaging Het
Lnpep A G 17: 17,787,001 (GRCm39) S533P probably benign Het
Megf8 T A 7: 25,040,060 (GRCm39) V997E possibly damaging Het
Mob2 T C 7: 141,563,177 (GRCm39) Y94C probably damaging Het
Muc5ac G C 7: 141,363,040 (GRCm39) G2117A unknown Het
Npepl1 A G 2: 173,962,387 (GRCm39) D351G probably damaging Het
Nrg1 G A 8: 32,328,352 (GRCm39) Q213* probably null Het
Nrp2 A G 1: 62,810,990 (GRCm39) D677G probably benign Het
Or11h7 A G 14: 50,890,904 (GRCm39) E70G probably damaging Het
Or2b4 G T 17: 38,116,320 (GRCm39) G95C probably damaging Het
Or56a3 G T 7: 104,735,780 (GRCm39) V286F probably damaging Het
Or5aq7 G T 2: 86,938,401 (GRCm39) T110K probably damaging Het
Or8c8 T A 9: 38,165,406 (GRCm39) M228K probably benign Het
Peg10 ACATCAGGATCC ACATCAGGATCCCCATCAGGATCC 6: 4,756,454 (GRCm39) probably benign Het
Phaf1 C A 8: 105,976,084 (GRCm39) T347N probably benign Het
Prune2 G A 19: 17,100,393 (GRCm39) V1966I possibly damaging Het
Ptch2 A G 4: 116,967,585 (GRCm39) H751R probably benign Het
Ptges2 T A 2: 32,292,243 (GRCm39) M353K probably damaging Het
Pum3 G A 19: 27,373,728 (GRCm39) Q564* probably null Het
Qtrt1 A G 9: 21,330,637 (GRCm39) D279G probably damaging Het
Rftn1 C T 17: 50,354,463 (GRCm39) V300I probably benign Het
Robo2 T C 16: 73,717,585 (GRCm39) T1172A probably benign Het
Sdc3 A G 4: 130,544,244 (GRCm39) D74G unknown Het
Setd1b A G 5: 123,290,336 (GRCm39) M768V unknown Het
Shld2 A T 14: 33,989,724 (GRCm39) M394K possibly damaging Het
Siglech A T 7: 55,422,289 (GRCm39) H298L probably benign Het
Sipa1 A T 19: 5,701,704 (GRCm39) L977Q probably damaging Het
Slc9c1 G A 16: 45,403,332 (GRCm39) V800I probably benign Het
Spata31e1 A G 13: 49,943,547 (GRCm39) S44P possibly damaging Het
Spata31f1a C T 4: 42,851,586 (GRCm39) C190Y probably benign Het
Tbc1d8 C T 1: 39,425,104 (GRCm39) R582Q probably damaging Het
Tmem247 T A 17: 87,229,728 (GRCm39) F190I probably damaging Het
Trim42 C A 9: 97,245,070 (GRCm39) A577S possibly damaging Het
Ubiad1 G A 4: 148,528,726 (GRCm39) T61I probably benign Het
Usp40 G A 1: 87,923,435 (GRCm39) Q279* probably null Het
Usp48 A G 4: 137,360,766 (GRCm39) N733S probably benign Het
Vmn2r83 A T 10: 79,314,261 (GRCm39) I170F probably benign Het
Xkr4 G A 1: 3,286,487 (GRCm39) P568S probably damaging Het
Zc3h7b T C 15: 81,664,679 (GRCm39) W513R probably damaging Het
Zfp40 T C 17: 23,410,440 (GRCm39) probably benign Het
Zfp652 T A 11: 95,640,935 (GRCm39) S287T possibly damaging Het
Znrf3 G A 11: 5,394,533 (GRCm39) A49V unknown Het
Other mutations in Or5m3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:Or5m3b APN 2 85,872,441 (GRCm39) missense probably damaging 1.00
IGL01745:Or5m3b APN 2 85,872,381 (GRCm39) missense possibly damaging 0.74
IGL02317:Or5m3b APN 2 85,871,913 (GRCm39) missense probably damaging 0.99
IGL02400:Or5m3b APN 2 85,872,420 (GRCm39) missense probably benign 0.00
R0692:Or5m3b UTSW 2 85,872,516 (GRCm39) missense probably benign 0.00
R1629:Or5m3b UTSW 2 85,871,766 (GRCm39) missense probably damaging 0.99
R2105:Or5m3b UTSW 2 85,871,674 (GRCm39) missense probably damaging 0.97
R2288:Or5m3b UTSW 2 85,872,377 (GRCm39) nonsense probably null
R4451:Or5m3b UTSW 2 85,872,303 (GRCm39) missense probably damaging 1.00
R4512:Or5m3b UTSW 2 85,871,913 (GRCm39) missense probably damaging 0.99
R4878:Or5m3b UTSW 2 85,871,799 (GRCm39) missense probably benign 0.08
R5442:Or5m3b UTSW 2 85,872,295 (GRCm39) missense probably benign 0.29
R5867:Or5m3b UTSW 2 85,871,795 (GRCm39) missense probably benign 0.01
R7849:Or5m3b UTSW 2 85,871,949 (GRCm39) missense probably benign 0.00
Z1088:Or5m3b UTSW 2 85,872,063 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCGCTAATATAAGGAATGTTCTG -3'
(R):5'- CCACATGAACAAGGGCAATG -3'

Sequencing Primer
(F):5'- CAGAAGTGAGAAGATGCTCA -3'
(R):5'- TGAAGAAGAAGCACTGTACTAAGC -3'
Posted On 2019-12-20