Incidental Mutation 'R0148:Or7e177'
ID 60881
Institutional Source Beutler Lab
Gene Symbol Or7e177
Ensembl Gene ENSMUSG00000049028
Gene Name olfactory receptor family 7 subfamily E member 177
Synonyms Olfr873, GA_x6K02T2PVTD-14040245-14041204, MOR145-2
MMRRC Submission 038432-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R0148 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 20211507-20212466 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 20212387 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 297 (M297R)
Ref Sequence ENSEMBL: ENSMUSP00000153816 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053919] [ENSMUST00000075717] [ENSMUST00000215540]
AlphaFold E9PX82
Predicted Effect probably damaging
Transcript: ENSMUST00000053919
AA Change: M294R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000054778
Gene: ENSMUSG00000049028
AA Change: M294R

DomainStartEndE-ValueType
Pfam:7tm_4 41 317 1.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 45 315 1.6e-8 PFAM
Pfam:7tm_1 51 300 3e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000075717
AA Change: M298R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000075135
Gene: ENSMUSG00000049028
AA Change: M298R

DomainStartEndE-ValueType
Pfam:7tm_4 45 321 6.2e-43 PFAM
Pfam:7TM_GPCR_Srsx 49 309 3e-8 PFAM
Pfam:7tm_1 55 304 1.5e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213057
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213445
Predicted Effect probably damaging
Transcript: ENSMUST00000215540
AA Change: M297R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216567
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217193
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 96.0%
  • 20x: 91.8%
Validation Efficiency 86% (30/35)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,639,405 (GRCm39) probably null Het
Agtr1a T C 13: 30,565,927 (GRCm39) S331P probably benign Het
Ank1 T A 8: 23,613,993 (GRCm39) N1545K probably damaging Het
Bahcc1 A T 11: 120,159,230 (GRCm39) Q152H probably damaging Het
Bend3 T A 10: 43,387,946 (GRCm39) Y780N probably damaging Het
Bod1l G T 5: 41,976,040 (GRCm39) A1758E possibly damaging Het
Ctcfl T C 2: 172,960,340 (GRCm39) D81G possibly damaging Het
Ddx39a C T 8: 84,449,105 (GRCm39) R298C possibly damaging Het
Dock8 T C 19: 25,096,823 (GRCm39) L577P probably benign Het
Drc1 A T 5: 30,486,487 (GRCm39) N13I possibly damaging Het
Efl1 T C 7: 82,320,878 (GRCm39) S104P probably damaging Het
Eml4 T A 17: 83,729,081 (GRCm39) N85K probably damaging Het
Epb41l4a T C 18: 33,931,853 (GRCm39) T581A probably damaging Het
Epha3 T C 16: 63,433,307 (GRCm39) D446G possibly damaging Het
Fam209 G T 2: 172,315,900 (GRCm39) G92C probably damaging Het
Fbln1 G A 15: 85,115,027 (GRCm39) R193H probably damaging Het
Fbxw21 A G 9: 108,977,085 (GRCm39) probably null Het
Fgf17 C T 14: 70,876,313 (GRCm39) R49Q probably damaging Het
Flnb T C 14: 7,939,077 (GRCm38) S2307P probably benign Het
Galr1 A G 18: 82,423,695 (GRCm39) L194P probably benign Het
Gar1 T C 3: 129,623,122 (GRCm39) H89R probably damaging Het
Gbp4 T A 5: 105,267,362 (GRCm39) Y519F probably benign Het
Git1 A G 11: 77,396,554 (GRCm39) T601A probably benign Het
Gm10722 T "C,A" 9: 3,001,405 (GRCm39) probably null Het
Gm5142 C T 14: 59,416,119 (GRCm39) R13H possibly damaging Het
Gria2 A C 3: 80,615,038 (GRCm39) W481G probably damaging Het
Homer2 T C 7: 81,274,026 (GRCm39) T57A probably benign Het
Hpse2 A C 19: 42,920,099 (GRCm39) probably null Het
Hspb7 T C 4: 141,151,302 (GRCm39) I148T probably damaging Het
Htr1d C A 4: 136,170,788 (GRCm39) T339K probably damaging Het
Il4ra T A 7: 125,174,709 (GRCm39) C306S probably damaging Het
Kansl3 A T 1: 36,392,897 (GRCm39) C225S probably damaging Het
Lama3 G A 18: 12,581,329 (GRCm39) C596Y probably damaging Het
Lama5 T C 2: 179,832,199 (GRCm39) H1714R probably benign Het
Marchf6 C T 15: 31,490,758 (GRCm39) V293M probably damaging Het
Med12l A G 3: 58,945,075 (GRCm39) D100G probably damaging Het
Mettl14 G A 3: 123,165,043 (GRCm39) T316I probably damaging Het
Mmp15 A T 8: 96,098,945 (GRCm39) N591Y probably benign Het
Mrpl53 T C 6: 83,086,518 (GRCm39) L74P probably damaging Het
Mvp C T 7: 126,589,037 (GRCm39) V577M probably damaging Het
Neb T C 2: 52,139,388 (GRCm39) K140E probably damaging Het
Nfya A G 17: 48,706,026 (GRCm39) V48A possibly damaging Het
Ngf G T 3: 102,417,119 (GRCm39) probably benign Het
Nipsnap3b C T 4: 53,017,088 (GRCm39) A104V possibly damaging Het
Nlrp14 A G 7: 106,781,928 (GRCm39) Y375C probably benign Het
Nod1 A G 6: 54,915,202 (GRCm39) Y764H probably damaging Het
Or13d1 A T 4: 52,971,232 (GRCm39) I204F probably benign Het
Or2w25 G A 11: 59,504,320 (GRCm39) V177M probably damaging Het
Pcdhb19 A T 18: 37,630,235 (GRCm39) Q10L probably benign Het
Pdcl T C 2: 37,242,142 (GRCm39) I203V probably benign Het
Peg10 C A 6: 4,755,711 (GRCm39) R96S possibly damaging Het
Pknox1 T A 17: 31,823,764 (GRCm39) N379K probably benign Het
Prodh T G 16: 17,895,677 (GRCm39) Q360P probably damaging Het
Raf1 C T 6: 115,609,934 (GRCm39) G202S probably benign Het
Rgs11 T A 17: 26,426,433 (GRCm39) probably null Het
Rilp A T 11: 75,401,059 (GRCm39) H29L probably damaging Het
Rtel1 T C 2: 180,962,839 (GRCm39) C31R probably damaging Het
Rubcnl T A 14: 75,279,898 (GRCm39) I427K probably damaging Het
Ryr1 C A 7: 28,751,460 (GRCm39) R3706L probably damaging Het
Ryr2 T C 13: 11,729,434 (GRCm39) D2396G probably damaging Het
Slc45a2 T C 15: 11,025,954 (GRCm39) S435P probably damaging Het
Spata17 A G 1: 186,844,798 (GRCm39) V111A probably damaging Het
Svep1 C T 4: 58,116,608 (GRCm39) D881N possibly damaging Het
Sypl2 T A 3: 108,126,411 (GRCm39) N67I possibly damaging Het
Tenm3 T C 8: 48,689,755 (GRCm39) Y1944C probably damaging Het
Tep1 A T 14: 51,062,246 (GRCm39) D2535E possibly damaging Het
Tkt T A 14: 30,294,177 (GRCm39) I529N probably damaging Het
Trp53i11 T G 2: 93,028,080 (GRCm39) V39G probably damaging Het
Trpm2 C T 10: 77,761,659 (GRCm39) G997D probably damaging Het
Usp3 A G 9: 66,447,449 (GRCm39) V219A possibly damaging Het
Usp4 T A 9: 108,268,870 (GRCm39) probably null Het
Wdfy3 A G 5: 102,065,277 (GRCm39) V1297A probably benign Het
Wdr46 T A 17: 34,159,997 (GRCm39) F70I probably benign Het
Xkr6 T C 14: 64,056,998 (GRCm39) V303A unknown Het
Zdbf2 C T 1: 63,343,165 (GRCm39) Q515* probably null Het
Zfhx2 A G 14: 55,310,354 (GRCm39) Y731H possibly damaging Het
Other mutations in Or7e177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Or7e177 APN 9 20,211,880 (GRCm39) missense probably damaging 1.00
IGL02268:Or7e177 APN 9 20,211,588 (GRCm39) missense probably damaging 1.00
IGL02416:Or7e177 APN 9 20,211,541 (GRCm39) missense probably benign 0.01
IGL03124:Or7e177 APN 9 20,212,459 (GRCm39) missense probably benign 0.00
R0147:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0266:Or7e177 UTSW 9 20,212,454 (GRCm39) missense probably benign 0.01
R0831:Or7e177 UTSW 9 20,211,861 (GRCm39) missense probably benign 0.20
R1456:Or7e177 UTSW 9 20,212,134 (GRCm39) missense probably benign 0.35
R1894:Or7e177 UTSW 9 20,211,633 (GRCm39) missense probably benign 0.23
R1928:Or7e177 UTSW 9 20,212,354 (GRCm39) missense probably benign 0.12
R2135:Or7e177 UTSW 9 20,211,593 (GRCm39) missense probably benign 0.00
R2379:Or7e177 UTSW 9 20,211,963 (GRCm39) missense possibly damaging 0.87
R2911:Or7e177 UTSW 9 20,211,775 (GRCm39) missense possibly damaging 0.60
R3788:Or7e177 UTSW 9 20,211,666 (GRCm39) missense probably benign 0.13
R4657:Or7e177 UTSW 9 20,211,919 (GRCm39) missense probably damaging 1.00
R5754:Or7e177 UTSW 9 20,212,390 (GRCm39) missense probably damaging 1.00
R6291:Or7e177 UTSW 9 20,211,899 (GRCm39) missense probably damaging 1.00
R6410:Or7e177 UTSW 9 20,211,748 (GRCm39) missense probably damaging 1.00
R7014:Or7e177 UTSW 9 20,211,959 (GRCm39) nonsense probably null
R7521:Or7e177 UTSW 9 20,212,036 (GRCm39) missense probably benign 0.00
R8201:Or7e177 UTSW 9 20,212,317 (GRCm39) missense probably damaging 1.00
R8355:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8455:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8523:Or7e177 UTSW 9 20,212,093 (GRCm39) missense probably benign 0.10
R8874:Or7e177 UTSW 9 20,212,069 (GRCm39) missense possibly damaging 0.95
R9283:Or7e177 UTSW 9 20,212,419 (GRCm39) missense possibly damaging 0.61
R9397:Or7e177 UTSW 9 20,211,748 (GRCm39) missense possibly damaging 0.50
R9595:Or7e177 UTSW 9 20,211,661 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGGAGGTATAAAGCCTTCTCTACCTG -3'
(R):5'- TCATGACGTTGCAGTCATAAGCACC -3'

Sequencing Primer
(F):5'- CTGTGGGTCTCATCTGTCAG -3'
(R):5'- cttctttcagccttccctaattc -3'
Posted On 2013-07-24