Incidental Mutation 'R7882:Vmn2r45'
ID 608820
Institutional Source Beutler Lab
Gene Symbol Vmn2r45
Ensembl Gene ENSMUSG00000090662
Gene Name vomeronasal 2, receptor 45
Synonyms
MMRRC Submission 045934-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R7882 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 8474468-8491958 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 8486409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 293 (L293S)
Ref Sequence ENSEMBL: ENSMUSP00000129466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164845]
AlphaFold L7N2B5
Predicted Effect possibly damaging
Transcript: ENSMUST00000164845
AA Change: L293S

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: L293S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 154 469 4.5e-26 PFAM
Pfam:NCD3G 512 565 6.4e-21 PFAM
Pfam:7tm_3 598 833 2.1e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (48/48)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadm C A 3: 153,644,250 (GRCm39) E110* probably null Het
Adad1 G T 3: 37,133,951 (GRCm39) V289F probably damaging Het
Adgra2 A G 8: 27,607,440 (GRCm39) D717G probably benign Het
Arid3b T C 9: 57,703,780 (GRCm39) I389M possibly damaging Het
Axdnd1 A G 1: 156,225,023 (GRCm39) V47A Het
Cachd1 T A 4: 100,824,244 (GRCm39) L562M probably benign Het
Cadm2 A T 16: 66,528,357 (GRCm39) I326N probably benign Het
Ccpg1 T C 9: 72,922,787 (GRCm39) F799S probably damaging Het
Ces1c T C 8: 93,833,231 (GRCm39) I411M probably benign Het
Cgn T G 3: 94,669,941 (GRCm39) K1066N probably damaging Het
Cntn4 A G 6: 106,330,684 (GRCm39) I101V probably benign Het
Cntrl A G 2: 35,060,592 (GRCm39) E1928G probably benign Het
Cxcl12 A G 6: 117,148,464 (GRCm39) Y28C probably damaging Het
Cyp2r1 A T 7: 114,153,824 (GRCm39) probably null Het
D430041D05Rik C T 2: 104,087,974 (GRCm39) W334* probably null Het
Dsp G A 13: 38,367,994 (GRCm39) R671Q possibly damaging Het
Fancm A G 12: 65,173,568 (GRCm39) K1960R probably benign Het
Fgd5 T A 6: 92,045,459 (GRCm39) Y1331N probably damaging Het
Ina G A 19: 47,004,100 (GRCm39) E303K Het
Kctd3 C A 1: 188,715,243 (GRCm39) V369F possibly damaging Het
Kif14 T C 1: 136,399,314 (GRCm39) probably null Het
Kif14 T C 1: 136,443,763 (GRCm39) V1312A probably benign Het
Krt84 T C 15: 101,436,826 (GRCm39) I403V probably benign Het
Krtap9-1 A C 11: 99,764,356 (GRCm39) T31P unknown Het
Lyrm9 A T 11: 78,728,967 (GRCm39) I60F probably damaging Het
Mast1 A G 8: 85,639,947 (GRCm39) probably null Het
Mmp28 T C 11: 83,334,752 (GRCm39) D334G probably damaging Het
Nr1h5 T C 3: 102,856,931 (GRCm39) T194A possibly damaging Het
Nrf1 A G 6: 30,090,299 (GRCm39) I85M probably benign Het
Nrp2 C T 1: 62,822,680 (GRCm39) R758C probably damaging Het
Or5b116 A T 19: 13,422,951 (GRCm39) T192S probably benign Het
Pcdhga4 A G 18: 37,819,681 (GRCm39) D410G probably damaging Het
Pld1 T C 3: 28,099,158 (GRCm39) V275A probably damaging Het
Plxnc1 A T 10: 94,679,698 (GRCm39) F895I probably benign Het
Polr2a A G 11: 69,627,000 (GRCm39) I1486T possibly damaging Het
Ptprz1 A G 6: 23,002,256 (GRCm39) M1449V probably benign Het
Rspo4 C A 2: 151,711,746 (GRCm39) T156N probably damaging Het
Sacs A G 14: 61,444,520 (GRCm39) I2189V probably benign Het
Stat5b A C 11: 100,674,601 (GRCm39) F711V possibly damaging Het
Stk11ip C A 1: 75,506,108 (GRCm39) Q543K probably benign Het
Tarbp1 G A 8: 127,183,232 (GRCm39) T529M probably damaging Het
Thada A T 17: 84,736,624 (GRCm39) C886S possibly damaging Het
Tmem19 A G 10: 115,179,608 (GRCm39) F296S probably benign Het
Tnfsf13b A G 8: 10,057,078 (GRCm39) N79S not run Het
Vdac3 C A 8: 23,069,073 (GRCm39) G214C probably damaging Het
Vmn2r18 A C 5: 151,485,329 (GRCm39) F722V probably damaging Het
Vmn2r88 C G 14: 51,650,503 (GRCm39) A72G probably benign Het
Xpot A G 10: 121,454,996 (GRCm39) probably null Het
Zfp526 G A 7: 24,920,860 (GRCm39) probably benign Het
Zfp532 A G 18: 65,756,561 (GRCm39) T165A probably benign Het
Other mutations in Vmn2r45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Vmn2r45 APN 7 8,488,622 (GRCm39) missense probably benign 0.00
IGL01322:Vmn2r45 APN 7 8,484,332 (GRCm39) missense possibly damaging 0.49
IGL01402:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01404:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01529:Vmn2r45 APN 7 8,486,493 (GRCm39) missense probably benign
IGL01596:Vmn2r45 APN 7 8,486,272 (GRCm39) missense probably damaging 0.98
IGL01646:Vmn2r45 APN 7 8,486,337 (GRCm39) missense probably benign 0.18
IGL01819:Vmn2r45 APN 7 8,488,556 (GRCm39) missense probably benign 0.00
IGL02096:Vmn2r45 APN 7 8,484,443 (GRCm39) missense probably damaging 0.99
IGL02130:Vmn2r45 APN 7 8,486,556 (GRCm39) missense possibly damaging 0.46
IGL02409:Vmn2r45 APN 7 8,488,727 (GRCm39) missense probably benign 0.03
IGL02517:Vmn2r45 APN 7 8,486,185 (GRCm39) nonsense probably null
IGL02633:Vmn2r45 APN 7 8,488,728 (GRCm39) missense probably benign 0.01
IGL02940:Vmn2r45 APN 7 8,475,369 (GRCm39) missense probably damaging 0.99
IGL03281:Vmn2r45 APN 7 8,486,603 (GRCm39) missense probably damaging 1.00
IGL03358:Vmn2r45 APN 7 8,474,715 (GRCm39) missense probably damaging 1.00
BB004:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
BB014:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R0382:Vmn2r45 UTSW 7 8,486,098 (GRCm39) missense probably benign 0.06
R0532:Vmn2r45 UTSW 7 8,474,820 (GRCm39) missense probably damaging 0.99
R0932:Vmn2r45 UTSW 7 8,478,380 (GRCm39) missense probably damaging 1.00
R1125:Vmn2r45 UTSW 7 8,488,542 (GRCm39) missense probably benign 0.00
R1580:Vmn2r45 UTSW 7 8,474,746 (GRCm39) missense possibly damaging 0.95
R1817:Vmn2r45 UTSW 7 8,475,372 (GRCm39) missense probably damaging 1.00
R1996:Vmn2r45 UTSW 7 8,475,024 (GRCm39) missense probably damaging 1.00
R2050:Vmn2r45 UTSW 7 8,475,021 (GRCm39) missense probably damaging 1.00
R2284:Vmn2r45 UTSW 7 8,488,765 (GRCm39) missense probably benign 0.02
R4019:Vmn2r45 UTSW 7 8,474,580 (GRCm39) nonsense probably null
R4227:Vmn2r45 UTSW 7 8,486,277 (GRCm39) missense probably damaging 0.98
R4381:Vmn2r45 UTSW 7 8,474,912 (GRCm39) nonsense probably null
R4618:Vmn2r45 UTSW 7 8,486,436 (GRCm39) missense probably benign 0.00
R4624:Vmn2r45 UTSW 7 8,484,341 (GRCm39) missense probably damaging 1.00
R4704:Vmn2r45 UTSW 7 8,486,535 (GRCm39) nonsense probably null
R4735:Vmn2r45 UTSW 7 8,486,472 (GRCm39) missense probably damaging 1.00
R4868:Vmn2r45 UTSW 7 8,484,480 (GRCm39) missense probably benign 0.06
R4983:Vmn2r45 UTSW 7 8,486,116 (GRCm39) missense probably damaging 0.99
R5246:Vmn2r45 UTSW 7 8,486,251 (GRCm39) missense probably benign 0.00
R5430:Vmn2r45 UTSW 7 8,486,333 (GRCm39) nonsense probably null
R5504:Vmn2r45 UTSW 7 8,486,176 (GRCm39) missense probably benign 0.03
R5511:Vmn2r45 UTSW 7 8,474,832 (GRCm39) missense probably benign 0.19
R5745:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R5814:Vmn2r45 UTSW 7 8,474,475 (GRCm39) missense probably benign 0.00
R6223:Vmn2r45 UTSW 7 8,486,301 (GRCm39) missense probably benign
R6267:Vmn2r45 UTSW 7 8,475,207 (GRCm39) missense probably benign 0.26
R6623:Vmn2r45 UTSW 7 8,474,500 (GRCm39) missense probably benign 0.09
R6999:Vmn2r45 UTSW 7 8,486,219 (GRCm39) missense probably benign
R7242:Vmn2r45 UTSW 7 8,488,612 (GRCm39) nonsense probably null
R7491:Vmn2r45 UTSW 7 8,484,342 (GRCm39) missense probably benign 0.27
R7620:Vmn2r45 UTSW 7 8,486,222 (GRCm39) nonsense probably null
R7719:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7720:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7853:Vmn2r45 UTSW 7 8,485,987 (GRCm39) missense possibly damaging 0.90
R7873:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R7927:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R8684:Vmn2r45 UTSW 7 8,486,511 (GRCm39) missense probably damaging 0.99
R8780:Vmn2r45 UTSW 7 8,484,371 (GRCm39) missense possibly damaging 0.94
R8811:Vmn2r45 UTSW 7 8,474,881 (GRCm39) missense probably damaging 1.00
R8893:Vmn2r45 UTSW 7 8,488,619 (GRCm39) missense probably damaging 1.00
R9043:Vmn2r45 UTSW 7 8,474,904 (GRCm39) missense possibly damaging 0.92
R9208:Vmn2r45 UTSW 7 8,486,298 (GRCm39) missense probably damaging 1.00
R9327:Vmn2r45 UTSW 7 8,474,532 (GRCm39) missense probably damaging 1.00
R9586:Vmn2r45 UTSW 7 8,486,050 (GRCm39) missense probably benign 0.01
R9599:Vmn2r45 UTSW 7 8,478,457 (GRCm39) critical splice acceptor site probably null
U24488:Vmn2r45 UTSW 7 8,475,361 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r45 UTSW 7 8,474,484 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TTACAGGTAGATGCTGAGTCTTC -3'
(R):5'- CATCCCAGATGATGACCAAGG -3'

Sequencing Primer
(F):5'- AAGTATTTCCACTCTTGCATTACTAG -3'
(R):5'- GATGATGACCAAGGAAACCAATTTC -3'
Posted On 2019-12-20