Incidental Mutation 'R7882:Or5b116'
ID 608847
Institutional Source Beutler Lab
Gene Symbol Or5b116
Ensembl Gene ENSMUSG00000096320
Gene Name olfactory receptor family 5 subfamily B member 116
Synonyms GA_x6K02T2RE5P-3777626-3778570, Olfr1471, MOR202-47_p, MOR202-38
MMRRC Submission 045934-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R7882 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13422378-13423322 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13422951 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 192 (T192S)
Ref Sequence ENSEMBL: ENSMUSP00000149948 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096203] [ENSMUST00000217249] [ENSMUST00000217482]
AlphaFold F6QVZ8
Predicted Effect probably benign
Transcript: ENSMUST00000096203
AA Change: T192S

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000093917
Gene: ENSMUSG00000096320
AA Change: T192S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1.1e-8 PFAM
Pfam:7tm_1 39 288 4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217249
AA Change: T192S

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000217482
AA Change: T192S

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadm C A 3: 153,644,250 (GRCm39) E110* probably null Het
Adad1 G T 3: 37,133,951 (GRCm39) V289F probably damaging Het
Adgra2 A G 8: 27,607,440 (GRCm39) D717G probably benign Het
Arid3b T C 9: 57,703,780 (GRCm39) I389M possibly damaging Het
Axdnd1 A G 1: 156,225,023 (GRCm39) V47A Het
Cachd1 T A 4: 100,824,244 (GRCm39) L562M probably benign Het
Cadm2 A T 16: 66,528,357 (GRCm39) I326N probably benign Het
Ccpg1 T C 9: 72,922,787 (GRCm39) F799S probably damaging Het
Ces1c T C 8: 93,833,231 (GRCm39) I411M probably benign Het
Cgn T G 3: 94,669,941 (GRCm39) K1066N probably damaging Het
Cntn4 A G 6: 106,330,684 (GRCm39) I101V probably benign Het
Cntrl A G 2: 35,060,592 (GRCm39) E1928G probably benign Het
Cxcl12 A G 6: 117,148,464 (GRCm39) Y28C probably damaging Het
Cyp2r1 A T 7: 114,153,824 (GRCm39) probably null Het
D430041D05Rik C T 2: 104,087,974 (GRCm39) W334* probably null Het
Dsp G A 13: 38,367,994 (GRCm39) R671Q possibly damaging Het
Fancm A G 12: 65,173,568 (GRCm39) K1960R probably benign Het
Fgd5 T A 6: 92,045,459 (GRCm39) Y1331N probably damaging Het
Ina G A 19: 47,004,100 (GRCm39) E303K Het
Kctd3 C A 1: 188,715,243 (GRCm39) V369F possibly damaging Het
Kif14 T C 1: 136,399,314 (GRCm39) probably null Het
Kif14 T C 1: 136,443,763 (GRCm39) V1312A probably benign Het
Krt84 T C 15: 101,436,826 (GRCm39) I403V probably benign Het
Krtap9-1 A C 11: 99,764,356 (GRCm39) T31P unknown Het
Lyrm9 A T 11: 78,728,967 (GRCm39) I60F probably damaging Het
Mast1 A G 8: 85,639,947 (GRCm39) probably null Het
Mmp28 T C 11: 83,334,752 (GRCm39) D334G probably damaging Het
Nr1h5 T C 3: 102,856,931 (GRCm39) T194A possibly damaging Het
Nrf1 A G 6: 30,090,299 (GRCm39) I85M probably benign Het
Nrp2 C T 1: 62,822,680 (GRCm39) R758C probably damaging Het
Pcdhga4 A G 18: 37,819,681 (GRCm39) D410G probably damaging Het
Pld1 T C 3: 28,099,158 (GRCm39) V275A probably damaging Het
Plxnc1 A T 10: 94,679,698 (GRCm39) F895I probably benign Het
Polr2a A G 11: 69,627,000 (GRCm39) I1486T possibly damaging Het
Ptprz1 A G 6: 23,002,256 (GRCm39) M1449V probably benign Het
Rspo4 C A 2: 151,711,746 (GRCm39) T156N probably damaging Het
Sacs A G 14: 61,444,520 (GRCm39) I2189V probably benign Het
Stat5b A C 11: 100,674,601 (GRCm39) F711V possibly damaging Het
Stk11ip C A 1: 75,506,108 (GRCm39) Q543K probably benign Het
Tarbp1 G A 8: 127,183,232 (GRCm39) T529M probably damaging Het
Thada A T 17: 84,736,624 (GRCm39) C886S possibly damaging Het
Tmem19 A G 10: 115,179,608 (GRCm39) F296S probably benign Het
Tnfsf13b A G 8: 10,057,078 (GRCm39) N79S not run Het
Vdac3 C A 8: 23,069,073 (GRCm39) G214C probably damaging Het
Vmn2r18 A C 5: 151,485,329 (GRCm39) F722V probably damaging Het
Vmn2r45 A G 7: 8,486,409 (GRCm39) L293S possibly damaging Het
Vmn2r88 C G 14: 51,650,503 (GRCm39) A72G probably benign Het
Xpot A G 10: 121,454,996 (GRCm39) probably null Het
Zfp526 G A 7: 24,920,860 (GRCm39) probably benign Het
Zfp532 A G 18: 65,756,561 (GRCm39) T165A probably benign Het
Other mutations in Or5b116
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Or5b116 APN 19 13,422,988 (GRCm39) missense probably benign 0.00
IGL01790:Or5b116 APN 19 13,422,526 (GRCm39) missense probably damaging 1.00
IGL02515:Or5b116 APN 19 13,422,472 (GRCm39) missense probably damaging 1.00
IGL02838:Or5b116 APN 19 13,423,299 (GRCm39) missense probably benign
IGL03182:Or5b116 APN 19 13,422,807 (GRCm39) missense possibly damaging 0.93
R0267:Or5b116 UTSW 19 13,422,792 (GRCm39) missense probably damaging 0.99
R0524:Or5b116 UTSW 19 13,423,228 (GRCm39) missense probably damaging 1.00
R1584:Or5b116 UTSW 19 13,423,023 (GRCm39) missense probably damaging 1.00
R2253:Or5b116 UTSW 19 13,422,549 (GRCm39) missense probably damaging 1.00
R5267:Or5b116 UTSW 19 13,422,475 (GRCm39) missense probably damaging 1.00
R6419:Or5b116 UTSW 19 13,423,131 (GRCm39) missense probably benign 0.00
R6495:Or5b116 UTSW 19 13,422,989 (GRCm39) missense probably benign 0.43
R7714:Or5b116 UTSW 19 13,423,252 (GRCm39) missense probably damaging 1.00
R7830:Or5b116 UTSW 19 13,422,985 (GRCm39) missense probably benign 0.33
R7892:Or5b116 UTSW 19 13,422,662 (GRCm39) nonsense probably null
Z1088:Or5b116 UTSW 19 13,423,213 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- ATGACAAGTACCACCTGCATTC -3'
(R):5'- CCATGGAATGATTGAAACTGGGC -3'

Sequencing Primer
(F):5'- GACAAGTACCACCTGCATTCTAATTG -3'
(R):5'- TTGAAACTGGGCTGTAAGTACATG -3'
Posted On 2019-12-20