Incidental Mutation 'R7883:Dab2ip'
| ID |
608856 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dab2ip
|
| Ensembl Gene |
ENSMUSG00000026883 |
| Gene Name |
disabled 2 interacting protein |
| Synonyms |
2310011D08Rik, AIP1 |
| MMRRC Submission |
045935-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.321)
|
| Stock # |
R7883 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
35448285-35621006 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 35610218 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 811
(G811D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088532
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000065001]
[ENSMUST00000091010]
[ENSMUST00000112983]
[ENSMUST00000112986]
[ENSMUST00000112987]
[ENSMUST00000112992]
[ENSMUST00000135741]
[ENSMUST00000145698]
|
| AlphaFold |
Q3UHC7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000065001
AA Change: G746D
PolyPhen 2
Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000068832
Gene: ENSMUSG00000026883
AA Change: G746D
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
10 |
139 |
3.63e-2 |
SMART |
|
C2
|
149 |
245 |
1.34e-7 |
SMART |
|
RasGAP
|
255 |
592 |
1.08e-126 |
SMART |
|
low complexity region
|
604 |
616 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
629 |
694 |
4e-29 |
BLAST |
|
low complexity region
|
733 |
745 |
N/A |
INTRINSIC |
|
low complexity region
|
780 |
805 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
873 |
N/A |
INTRINSIC |
|
coiled coil region
|
961 |
1095 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000091010
AA Change: G811D
PolyPhen 2
Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000088532
Gene: ENSMUSG00000026883
AA Change: G811D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
39 |
N/A |
INTRINSIC |
|
PH
|
73 |
204 |
5.58e-3 |
SMART |
|
C2
|
214 |
310 |
1.34e-7 |
SMART |
|
RasGAP
|
320 |
657 |
1.08e-126 |
SMART |
|
low complexity region
|
669 |
681 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
694 |
759 |
4e-29 |
BLAST |
|
low complexity region
|
798 |
810 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
938 |
N/A |
INTRINSIC |
|
coiled coil region
|
1026 |
1160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112981
|
| SMART Domains |
Protein: ENSMUSP00000108605
Gene: ENSMUSG00000026883
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PH
|
2 |
80 |
6e-35 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112983
AA Change: G687D
PolyPhen 2
Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000108607
Gene: ENSMUSG00000026883
AA Change: G687D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
18 |
N/A |
INTRINSIC |
|
C2
|
90 |
186 |
1.34e-7 |
SMART |
|
RasGAP
|
196 |
533 |
1.08e-126 |
SMART |
|
low complexity region
|
545 |
557 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
570 |
635 |
3e-29 |
BLAST |
|
low complexity region
|
674 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
746 |
N/A |
INTRINSIC |
|
low complexity region
|
796 |
814 |
N/A |
INTRINSIC |
|
coiled coil region
|
902 |
1036 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112986
AA Change: G783D
PolyPhen 2
Score 0.450 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000108610
Gene: ENSMUSG00000026883
AA Change: G783D
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
45 |
176 |
5.58e-3 |
SMART |
|
C2
|
186 |
282 |
1.34e-7 |
SMART |
|
RasGAP
|
292 |
629 |
1.08e-126 |
SMART |
|
low complexity region
|
641 |
653 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
666 |
731 |
4e-29 |
BLAST |
|
low complexity region
|
770 |
782 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
842 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
910 |
N/A |
INTRINSIC |
|
coiled coil region
|
998 |
1129 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112987
AA Change: G754D
PolyPhen 2
Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000108611
Gene: ENSMUSG00000026883
AA Change: G754D
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
16 |
147 |
5.58e-3 |
SMART |
|
C2
|
157 |
253 |
1.34e-7 |
SMART |
|
RasGAP
|
263 |
600 |
1.08e-126 |
SMART |
|
low complexity region
|
612 |
624 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
637 |
702 |
4e-29 |
BLAST |
|
low complexity region
|
741 |
753 |
N/A |
INTRINSIC |
|
low complexity region
|
788 |
813 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
881 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112992
AA Change: G811D
PolyPhen 2
Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000108616
Gene: ENSMUSG00000026883
AA Change: G811D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
39 |
N/A |
INTRINSIC |
|
PH
|
73 |
204 |
5.58e-3 |
SMART |
|
C2
|
214 |
310 |
1.34e-7 |
SMART |
|
RasGAP
|
320 |
657 |
1.08e-126 |
SMART |
|
low complexity region
|
669 |
681 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
694 |
759 |
4e-29 |
BLAST |
|
low complexity region
|
798 |
810 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
938 |
N/A |
INTRINSIC |
|
Pfam:DUF3498
|
986 |
1108 |
3.3e-61 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000119058
Gene: ENSMUSG00000026883
AA Change: G704D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
36 |
N/A |
INTRINSIC |
|
C2
|
108 |
204 |
1.34e-7 |
SMART |
|
RasGAP
|
214 |
551 |
1.08e-126 |
SMART |
|
low complexity region
|
563 |
575 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
588 |
653 |
3e-29 |
BLAST |
|
low complexity region
|
692 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
814 |
832 |
N/A |
INTRINSIC |
|
coiled coil region
|
919 |
1053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135741
AA Change: G754D
PolyPhen 2
Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000122341
Gene: ENSMUSG00000026883
AA Change: G754D
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
16 |
147 |
5.58e-3 |
SMART |
|
C2
|
157 |
253 |
1.34e-7 |
SMART |
|
RasGAP
|
263 |
600 |
1.08e-126 |
SMART |
|
low complexity region
|
612 |
624 |
N/A |
INTRINSIC |
|
Blast:RasGAP
|
637 |
702 |
4e-29 |
BLAST |
|
low complexity region
|
741 |
753 |
N/A |
INTRINSIC |
|
low complexity region
|
788 |
813 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
881 |
N/A |
INTRINSIC |
|
coiled coil region
|
969 |
1100 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145698
|
| SMART Domains |
Protein: ENSMUSP00000114915
Gene: ENSMUSG00000026883
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PH
|
1 |
79 |
3e-18 |
BLAST |
|
low complexity region
|
80 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
135 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000121506
Gene: ENSMUSG00000026883
AA Change: G414D
| Domain | Start | End | E-Value | Type |
|---|
|
RasGAP
|
1 |
283 |
1.97e-88 |
SMART |
|
low complexity region
|
295 |
307 |
N/A |
INTRINSIC |
|
Pfam:DUF3498
|
317 |
594 |
2.9e-78 |
PFAM |
|
Pfam:DUF3498
|
591 |
712 |
4.2e-70 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
99% (79/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired IRE1-mediated endoplasmic reticulum (ER) stress-induced responses. Mice homozygous for a gene trap allele exhibit delayed Purkinje cell dendritogenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110065P20Rik |
A |
T |
4: 124,744,440 (GRCm39) |
W5R |
unknown |
Het |
| Abcb6 |
A |
T |
1: 75,154,660 (GRCm39) |
S258R |
possibly damaging |
Het |
| Abcc10 |
A |
G |
17: 46,618,027 (GRCm39) |
V1082A |
probably benign |
Het |
| Adrb2 |
A |
G |
18: 62,312,447 (GRCm39) |
V126A |
probably damaging |
Het |
| Apol11a |
A |
G |
15: 77,400,774 (GRCm39) |
E87G |
probably damaging |
Het |
| Arhgap45 |
T |
A |
10: 79,863,423 (GRCm39) |
C755* |
probably null |
Het |
| Arl13b |
A |
T |
16: 62,647,629 (GRCm39) |
I93K |
probably damaging |
Het |
| Aspm |
A |
G |
1: 139,406,405 (GRCm39) |
K1764R |
possibly damaging |
Het |
| Atp8b5 |
A |
G |
4: 43,342,471 (GRCm39) |
I381V |
probably damaging |
Het |
| Atxn2 |
A |
G |
5: 121,940,180 (GRCm39) |
H985R |
possibly damaging |
Het |
| Bms1 |
G |
T |
6: 118,365,735 (GRCm39) |
N1150K |
probably benign |
Het |
| C1ra |
G |
A |
6: 124,494,684 (GRCm39) |
E316K |
probably benign |
Het |
| Camta2 |
T |
C |
11: 70,566,037 (GRCm39) |
D749G |
probably damaging |
Het |
| Cd300ld2 |
CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG |
CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG |
11: 114,903,257 (GRCm39) |
|
probably benign |
Het |
| Cep152 |
G |
A |
2: 125,454,978 (GRCm39) |
A274V |
possibly damaging |
Het |
| Chd7 |
A |
G |
4: 8,826,504 (GRCm39) |
N956S |
probably damaging |
Het |
| Cpt1c |
A |
T |
7: 44,613,438 (GRCm39) |
|
probably null |
Het |
| Cttn |
C |
T |
7: 143,999,555 (GRCm39) |
V338I |
probably benign |
Het |
| Dmtf1 |
T |
C |
5: 9,190,397 (GRCm39) |
T106A |
probably benign |
Het |
| Dync2h1 |
T |
C |
9: 7,005,566 (GRCm39) |
E3768G |
possibly damaging |
Het |
| Exoc1 |
T |
A |
5: 76,709,229 (GRCm39) |
D612E |
probably damaging |
Het |
| Fat2 |
T |
C |
11: 55,144,190 (GRCm39) |
|
probably null |
Het |
| Fat4 |
G |
A |
3: 39,035,968 (GRCm39) |
E3207K |
probably damaging |
Het |
| Fbxw18 |
A |
G |
9: 109,517,474 (GRCm39) |
Y410H |
probably damaging |
Het |
| Fgfr3 |
T |
A |
5: 33,891,235 (GRCm39) |
S518T |
probably damaging |
Het |
| Fzr1 |
G |
A |
10: 81,204,469 (GRCm39) |
T377M |
probably damaging |
Het |
| Gcnt3 |
T |
A |
9: 69,941,453 (GRCm39) |
I372F |
probably damaging |
Het |
| Gm10577 |
A |
T |
4: 100,877,719 (GRCm39) |
Y59N |
unknown |
Het |
| Gm826 |
A |
G |
2: 160,169,213 (GRCm39) |
L32P |
unknown |
Het |
| Grid1 |
T |
G |
14: 35,172,259 (GRCm39) |
|
probably null |
Het |
| Hid1 |
T |
A |
11: 115,245,435 (GRCm39) |
T457S |
probably damaging |
Het |
| Hsd3b5 |
A |
G |
3: 98,529,456 (GRCm39) |
V58A |
probably benign |
Het |
| Iqcj |
A |
G |
3: 67,954,641 (GRCm39) |
K49E |
probably damaging |
Het |
| Itpk1 |
A |
G |
12: 102,572,434 (GRCm39) |
V93A |
probably benign |
Het |
| Kcnt2 |
A |
G |
1: 140,450,888 (GRCm39) |
I722M |
probably damaging |
Het |
| Klhl36 |
T |
C |
8: 120,601,217 (GRCm39) |
V412A |
possibly damaging |
Het |
| Krt18 |
G |
A |
15: 101,936,885 (GRCm39) |
V58M |
possibly damaging |
Het |
| Lats2 |
T |
C |
14: 57,934,657 (GRCm39) |
Y691C |
probably damaging |
Het |
| Lrp1b |
A |
T |
2: 40,555,141 (GRCm39) |
I4095N |
|
Het |
| Map1a |
A |
G |
2: 121,135,853 (GRCm39) |
E2223G |
probably damaging |
Het |
| Med25 |
A |
G |
7: 44,541,232 (GRCm39) |
F94L |
possibly damaging |
Het |
| Mertk |
A |
G |
2: 128,618,265 (GRCm39) |
I499V |
probably benign |
Het |
| Mrps12 |
A |
G |
7: 28,439,568 (GRCm39) |
L49P |
probably benign |
Het |
| Nwd1 |
T |
A |
8: 73,393,754 (GRCm39) |
V339D |
probably damaging |
Het |
| Obscn |
G |
A |
11: 58,960,835 (GRCm39) |
Q3159* |
probably null |
Het |
| Patj |
G |
A |
4: 98,499,372 (GRCm39) |
V1349I |
probably benign |
Het |
| Pcdha8 |
T |
A |
18: 37,126,196 (GRCm39) |
V226D |
probably damaging |
Het |
| Pdgfd |
T |
A |
9: 6,293,939 (GRCm39) |
|
probably null |
Het |
| Pdzd7 |
A |
C |
19: 45,018,679 (GRCm39) |
I600S |
probably damaging |
Het |
| Pgpep1l |
G |
A |
7: 67,888,897 (GRCm39) |
R45* |
probably null |
Het |
| Pik3c3 |
T |
C |
18: 30,407,416 (GRCm39) |
S55P |
probably benign |
Het |
| Pkhd1l1 |
A |
T |
15: 44,392,522 (GRCm39) |
D1619V |
probably damaging |
Het |
| Pkp1 |
A |
G |
1: 135,812,641 (GRCm39) |
|
probably null |
Het |
| Ppan |
T |
A |
9: 20,802,777 (GRCm39) |
I311N |
probably benign |
Het |
| Ppih |
C |
A |
4: 119,167,987 (GRCm39) |
G175W |
probably damaging |
Het |
| Ppp1r8 |
G |
T |
4: 132,562,026 (GRCm39) |
Q65K |
probably damaging |
Het |
| Psmd5 |
T |
A |
2: 34,746,524 (GRCm39) |
K351M |
possibly damaging |
Het |
| Pth1r |
T |
C |
9: 110,560,626 (GRCm39) |
K53R |
probably benign |
Het |
| Ptprn |
A |
T |
1: 75,239,007 (GRCm39) |
F9L |
probably damaging |
Het |
| Rgl3 |
T |
C |
9: 21,892,723 (GRCm39) |
I288V |
probably benign |
Het |
| Sds |
A |
G |
5: 120,617,278 (GRCm39) |
I45V |
possibly damaging |
Het |
| Sfxn4 |
A |
T |
19: 60,847,187 (GRCm39) |
|
probably null |
Het |
| Sis |
A |
T |
3: 72,828,329 (GRCm39) |
C1220S |
possibly damaging |
Het |
| Slc22a16 |
T |
G |
10: 40,479,660 (GRCm39) |
D577E |
probably benign |
Het |
| Slc25a10 |
T |
A |
11: 120,385,340 (GRCm39) |
M43K |
possibly damaging |
Het |
| Smpd1 |
T |
C |
7: 105,206,192 (GRCm39) |
I440T |
probably damaging |
Het |
| Spata6l |
A |
C |
19: 28,906,013 (GRCm39) |
S297A |
probably benign |
Het |
| St6galnac6 |
A |
G |
2: 32,504,941 (GRCm39) |
N151S |
probably benign |
Het |
| Taf4 |
G |
T |
2: 179,571,088 (GRCm39) |
L742M |
probably damaging |
Het |
| Tctn1 |
A |
G |
5: 122,402,375 (GRCm39) |
S20P |
possibly damaging |
Het |
| Tkfc |
A |
T |
19: 10,572,394 (GRCm39) |
|
probably null |
Het |
| Tmem270 |
A |
G |
5: 134,931,681 (GRCm39) |
V87A |
possibly damaging |
Het |
| Tpo |
T |
C |
12: 30,153,169 (GRCm39) |
H395R |
probably damaging |
Het |
| Tufm |
T |
C |
7: 126,088,114 (GRCm39) |
F206L |
possibly damaging |
Het |
| Tulp2 |
A |
G |
7: 45,166,188 (GRCm39) |
|
probably null |
Het |
| Tulp3 |
G |
A |
6: 128,303,807 (GRCm39) |
T264M |
probably damaging |
Het |
| Uqcrc2 |
A |
G |
7: 120,244,440 (GRCm39) |
D194G |
possibly damaging |
Het |
| Vill |
C |
A |
9: 118,894,589 (GRCm39) |
C415* |
probably null |
Het |
| Zfp799 |
A |
G |
17: 33,039,256 (GRCm39) |
C337R |
probably damaging |
Het |
| Zhx2 |
A |
G |
15: 57,685,270 (GRCm39) |
E213G |
possibly damaging |
Het |
|
| Other mutations in Dab2ip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00509:Dab2ip
|
APN |
2 |
35,610,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00799:Dab2ip
|
APN |
2 |
35,597,787 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL00902:Dab2ip
|
APN |
2 |
35,607,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00929:Dab2ip
|
APN |
2 |
35,598,889 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03052:Dab2ip
|
UTSW |
2 |
35,533,909 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0097:Dab2ip
|
UTSW |
2 |
35,608,928 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0137:Dab2ip
|
UTSW |
2 |
35,582,388 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0184:Dab2ip
|
UTSW |
2 |
35,608,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Dab2ip
|
UTSW |
2 |
35,608,757 (GRCm39) |
splice site |
probably benign |
|
|
R1195:Dab2ip
|
UTSW |
2 |
35,608,757 (GRCm39) |
splice site |
probably benign |
|
|
R1388:Dab2ip
|
UTSW |
2 |
35,611,268 (GRCm39) |
intron |
probably benign |
|
|
R1442:Dab2ip
|
UTSW |
2 |
35,600,268 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1496:Dab2ip
|
UTSW |
2 |
35,608,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Dab2ip
|
UTSW |
2 |
35,610,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Dab2ip
|
UTSW |
2 |
35,608,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3625:Dab2ip
|
UTSW |
2 |
35,533,903 (GRCm39) |
nonsense |
probably null |
|
|
R3819:Dab2ip
|
UTSW |
2 |
35,603,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4333:Dab2ip
|
UTSW |
2 |
35,551,632 (GRCm39) |
makesense |
probably null |
|
|
R4869:Dab2ip
|
UTSW |
2 |
35,610,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4894:Dab2ip
|
UTSW |
2 |
35,620,539 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5035:Dab2ip
|
UTSW |
2 |
35,599,953 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5180:Dab2ip
|
UTSW |
2 |
35,610,503 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5425:Dab2ip
|
UTSW |
2 |
35,600,003 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5513:Dab2ip
|
UTSW |
2 |
35,600,266 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5579:Dab2ip
|
UTSW |
2 |
35,605,339 (GRCm39) |
nonsense |
probably null |
|
|
R5829:Dab2ip
|
UTSW |
2 |
35,597,787 (GRCm39) |
unclassified |
probably benign |
|
|
R5840:Dab2ip
|
UTSW |
2 |
35,617,511 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5890:Dab2ip
|
UTSW |
2 |
35,605,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Dab2ip
|
UTSW |
2 |
35,582,267 (GRCm39) |
nonsense |
probably null |
|
|
R6235:Dab2ip
|
UTSW |
2 |
35,613,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6360:Dab2ip
|
UTSW |
2 |
35,600,278 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6571:Dab2ip
|
UTSW |
2 |
35,602,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Dab2ip
|
UTSW |
2 |
35,620,485 (GRCm39) |
nonsense |
probably null |
|
|
R7262:Dab2ip
|
UTSW |
2 |
35,512,298 (GRCm39) |
splice site |
probably null |
|
|
R8127:Dab2ip
|
UTSW |
2 |
35,534,138 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R8313:Dab2ip
|
UTSW |
2 |
35,617,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8387:Dab2ip
|
UTSW |
2 |
35,609,870 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8422:Dab2ip
|
UTSW |
2 |
35,597,767 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8560:Dab2ip
|
UTSW |
2 |
35,603,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Dab2ip
|
UTSW |
2 |
35,602,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9342:Dab2ip
|
UTSW |
2 |
35,613,105 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9353:Dab2ip
|
UTSW |
2 |
35,598,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9423:Dab2ip
|
UTSW |
2 |
35,599,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9551:Dab2ip
|
UTSW |
2 |
35,605,330 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9563:Dab2ip
|
UTSW |
2 |
35,609,915 (GRCm39) |
nonsense |
probably null |
|
|
X0011:Dab2ip
|
UTSW |
2 |
35,613,097 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Dab2ip
|
UTSW |
2 |
35,598,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACCTGCAGATGGCCAATG -3'
(R):5'- ACTTCCTAGTTTGGCAGCGG -3'
Sequencing Primer
(F):5'- AGCAAGAGCCTGTCCATGGTG -3'
(R):5'- GGCTGCCAGCTCTTCACTG -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation