Incidental Mutation 'R7885:Sltm'
ID 609013
Institutional Source Beutler Lab
Gene Symbol Sltm
Ensembl Gene ENSMUSG00000032212
Gene Name SAFB-like, transcription modulator
Synonyms 9130215G10Rik, 5730555F13Rik, 5730455C01Rik
MMRRC Submission 045937-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.953) question?
Stock # R7885 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 70542754-70592234 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to G at 70586673 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Arginine at position 802 (P802R)
Ref Sequence ENSEMBL: ENSMUSP00000049112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049263] [ENSMUST00000216816] [ENSMUST00000217593]
AlphaFold Q8CH25
Predicted Effect possibly damaging
Transcript: ENSMUST00000049263
AA Change: P802R

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000049112
Gene: ENSMUSG00000032212
AA Change: P802R

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
SAP 22 56 2.49e-10 SMART
low complexity region 74 86 N/A INTRINSIC
coiled coil region 152 180 N/A INTRINSIC
low complexity region 318 330 N/A INTRINSIC
low complexity region 352 384 N/A INTRINSIC
RRM 385 458 2.06e-16 SMART
low complexity region 498 526 N/A INTRINSIC
low complexity region 536 552 N/A INTRINSIC
low complexity region 591 601 N/A INTRINSIC
coiled coil region 635 727 N/A INTRINSIC
low complexity region 824 853 N/A INTRINSIC
low complexity region 979 990 N/A INTRINSIC
low complexity region 1015 1028 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000216816
AA Change: P784R

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000217593
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110002H16Rik T C 18: 12,189,314 (GRCm38) L608P probably damaging Het
Adarb1 A G 10: 77,295,708 (GRCm38) V649A possibly damaging Het
Arglu1 C T 8: 8,667,337 (GRCm38) R244H possibly damaging Het
Asic5 A T 3: 82,006,505 (GRCm38) Y204F probably benign Het
Asz1 A G 6: 18,104,877 (GRCm38) F76S probably damaging Het
Bin1 G A 18: 32,419,843 (GRCm38) A174T probably damaging Het
Bnipl A C 3: 95,250,240 (GRCm38) S23A probably benign Het
Cd19 T C 7: 126,412,131 (GRCm38) T294A probably benign Het
Cdon G A 9: 35,456,522 (GRCm38) V238I probably benign Het
Chd3 A T 11: 69,356,625 (GRCm38) D957E probably benign Het
Crhbp T C 13: 95,432,007 (GRCm38) Q307R probably damaging Het
Cst3 A G 2: 148,872,821 (GRCm38) M112T probably benign Het
Dgkb A G 12: 38,139,426 (GRCm38) E276G probably damaging Het
Exoc4 T A 6: 33,758,066 (GRCm38) N539K probably benign Het
Gm3099 A G 14: 3,999,461 (GRCm38) E85G probably benign Het
Gpatch2 A G 1: 187,225,501 (GRCm38) probably null Het
Hs3st5 T A 10: 36,828,780 (GRCm38) Y26* probably null Het
Hspg2 A T 4: 137,516,837 (GRCm38) D802V probably damaging Het
Ifih1 A G 2: 62,601,469 (GRCm38) V846A possibly damaging Het
Lama4 T A 10: 39,088,844 (GRCm38) S1402T probably benign Het
Lrmda A G 14: 22,598,320 (GRCm38) T73A unknown Het
Lrrc1 A T 9: 77,442,189 (GRCm38) V365E probably damaging Het
Lrrc37a T A 11: 103,503,042 (GRCm38) Q519L probably benign Het
Mlc1 G T 15: 88,977,904 (GRCm38) D36E probably benign Het
Mrc2 A T 11: 105,332,266 (GRCm38) D445V probably damaging Het
Muc16 A G 9: 18,639,464 (GRCm38) S5178P probably benign Het
Nbea A G 3: 55,665,689 (GRCm38) I2491T probably damaging Het
Ncoa1 A G 12: 4,339,044 (GRCm38) I77T probably damaging Het
Npepps G T 11: 97,218,648 (GRCm38) H701N probably damaging Het
Olfr733 T G 14: 50,298,584 (GRCm38) T242P probably damaging Het
Olfr837 A T 9: 19,137,535 (GRCm38) I181F possibly damaging Het
Pclo T TTCTAG 5: 14,714,195 (GRCm38) probably null Het
Pclo TCTAT TCTATACTAT 5: 14,714,191 (GRCm38) probably null Het
Pclo GTCTAT GTCTATTCTAT 5: 14,714,190 (GRCm38) probably null Het
Pi4kb T C 3: 94,999,076 (GRCm38) Y645H probably damaging Het
Pik3r5 C T 11: 68,492,702 (GRCm38) A449V possibly damaging Het
Plat A G 8: 22,771,720 (GRCm38) T45A probably benign Het
Platr25 T C 13: 62,700,862 (GRCm38) K62R possibly damaging Het
Ppp5c A G 7: 17,006,186 (GRCm38) V410A possibly damaging Het
Prdm2 C T 4: 143,134,570 (GRCm38) A717T probably benign Het
Pstpip2 C A 18: 77,794,722 (GRCm38) T2K probably benign Het
Ptpn12 A C 5: 20,998,525 (GRCm38) S418R possibly damaging Het
Rint1 A G 5: 23,805,644 (GRCm38) S255G probably benign Het
Stab2 T C 10: 86,878,912 (GRCm38) H1581R probably benign Het
Stau2 T C 1: 16,460,353 (GRCm38) Y114C unknown Het
Ticam1 T C 17: 56,271,067 (GRCm38) T343A probably benign Het
Tmem131l T C 3: 83,910,417 (GRCm38) K1259E possibly damaging Het
Vmn2r103 T A 17: 19,793,123 (GRCm38) F169I probably benign Het
Vps33a T C 5: 123,535,249 (GRCm38) K425E possibly damaging Het
Vwa8 T C 14: 79,020,649 (GRCm38) M746T probably benign Het
Zc3hav1 A G 6: 38,336,663 (GRCm38) I149T possibly damaging Het
Zfp708 A T 13: 67,074,129 (GRCm38) D62E probably benign Het
Other mutations in Sltm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Sltm APN 9 70,579,342 (GRCm38) missense probably damaging 1.00
IGL01755:Sltm APN 9 70,583,922 (GRCm38) splice site probably null
IGL01782:Sltm APN 9 70,573,641 (GRCm38) missense probably damaging 1.00
IGL02441:Sltm APN 9 70,587,185 (GRCm38) missense probably damaging 1.00
IGL02831:Sltm APN 9 70,584,865 (GRCm38) missense probably damaging 1.00
IGL02947:Sltm APN 9 70,591,664 (GRCm38) missense probably benign 0.05
IGL03166:Sltm APN 9 70,542,969 (GRCm38) missense possibly damaging 0.87
R0288:Sltm UTSW 9 70,579,351 (GRCm38) missense probably damaging 1.00
R0555:Sltm UTSW 9 70,586,081 (GRCm38) missense probably damaging 1.00
R0815:Sltm UTSW 9 70,561,908 (GRCm38) missense probably benign 0.04
R0863:Sltm UTSW 9 70,561,908 (GRCm38) missense probably benign 0.04
R1315:Sltm UTSW 9 70,543,065 (GRCm38) missense probably benign 0.13
R1533:Sltm UTSW 9 70,586,666 (GRCm38) missense probably damaging 1.00
R1676:Sltm UTSW 9 70,573,647 (GRCm38) missense probably damaging 1.00
R1764:Sltm UTSW 9 70,561,800 (GRCm38) missense probably benign 0.00
R1845:Sltm UTSW 9 70,543,032 (GRCm38) missense possibly damaging 0.60
R2049:Sltm UTSW 9 70,581,301 (GRCm38) missense probably benign 0.00
R2163:Sltm UTSW 9 70,591,682 (GRCm38) missense probably damaging 0.99
R3410:Sltm UTSW 9 70,585,958 (GRCm38) missense probably damaging 0.97
R4323:Sltm UTSW 9 70,580,247 (GRCm38) missense probably benign
R4632:Sltm UTSW 9 70,579,369 (GRCm38) missense possibly damaging 0.86
R4748:Sltm UTSW 9 70,581,365 (GRCm38) missense probably damaging 1.00
R4756:Sltm UTSW 9 70,591,610 (GRCm38) missense possibly damaging 0.57
R4782:Sltm UTSW 9 70,589,057 (GRCm38) missense probably damaging 1.00
R4799:Sltm UTSW 9 70,589,057 (GRCm38) missense probably damaging 1.00
R4887:Sltm UTSW 9 70,588,978 (GRCm38) missense probably damaging 1.00
R5221:Sltm UTSW 9 70,579,403 (GRCm38) missense probably damaging 1.00
R5263:Sltm UTSW 9 70,584,799 (GRCm38) missense unknown
R5982:Sltm UTSW 9 70,586,804 (GRCm38) missense probably damaging 1.00
R6297:Sltm UTSW 9 70,581,359 (GRCm38) missense probably damaging 0.99
R6456:Sltm UTSW 9 70,542,987 (GRCm38) missense probably damaging 1.00
R6658:Sltm UTSW 9 70,581,362 (GRCm38) missense probably damaging 1.00
R6720:Sltm UTSW 9 70,573,710 (GRCm38) missense probably damaging 1.00
R6770:Sltm UTSW 9 70,584,777 (GRCm38) missense unknown
R6923:Sltm UTSW 9 70,574,610 (GRCm38) missense probably damaging 1.00
R7051:Sltm UTSW 9 70,559,066 (GRCm38) missense probably damaging 1.00
R7166:Sltm UTSW 9 70,584,850 (GRCm38) missense probably damaging 1.00
R7257:Sltm UTSW 9 70,543,965 (GRCm38) splice site probably null
R7400:Sltm UTSW 9 70,586,070 (GRCm38) missense probably damaging 1.00
R7438:Sltm UTSW 9 70,573,466 (GRCm38) missense unknown
R7484:Sltm UTSW 9 70,573,897 (GRCm38) missense unknown
R7630:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7631:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7632:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7633:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7862:Sltm UTSW 9 70,572,164 (GRCm38) nonsense probably null
R7886:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7888:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7889:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7891:Sltm UTSW 9 70,586,673 (GRCm38) missense possibly damaging 0.94
R7915:Sltm UTSW 9 70,587,149 (GRCm38) missense probably damaging 1.00
R8030:Sltm UTSW 9 70,585,979 (GRCm38) nonsense probably null
R8062:Sltm UTSW 9 70,573,497 (GRCm38) missense unknown
R8099:Sltm UTSW 9 70,586,078 (GRCm38) missense probably damaging 1.00
R8374:Sltm UTSW 9 70,561,945 (GRCm38) missense probably null
R8698:Sltm UTSW 9 70,587,070 (GRCm38) missense probably benign 0.27
R9541:Sltm UTSW 9 70,573,775 (GRCm38) missense unknown
R9563:Sltm UTSW 9 70,573,559 (GRCm38) missense unknown
Predicted Primers PCR Primer
(F):5'- TAATGAGGGCTTTTCTGGCAGC -3'
(R):5'- TGGTCTAGAAGGATTGGGCAC -3'

Sequencing Primer
(F):5'- GCCTTGCCATAATTTCCCTTAAAAG -3'
(R):5'- CTAGAAGGATTGGGCACAGTCTCTC -3'
Posted On 2019-12-20