Incidental Mutation 'R7885:Or4n4b'
ID 609031
Institutional Source Beutler Lab
Gene Symbol Or4n4b
Ensembl Gene ENSMUSG00000090874
Gene Name olfactory receptor family 4 subfamily N member 4B
Synonyms Olfr733, GA_x6K02T2PMLR-5992342-5991416, MOR241-2
MMRRC Submission 045937-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R7885 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 50535794-50536787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 50536041 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 242 (T242P)
Ref Sequence ENSEMBL: ENSMUSP00000149085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163469] [ENSMUST00000214372] [ENSMUST00000214756] [ENSMUST00000216195]
AlphaFold Q14AK5
Predicted Effect probably damaging
Transcript: ENSMUST00000163469
AA Change: T242P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000128332
Gene: ENSMUSG00000090874
AA Change: T242P

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 6.4e-41 PFAM
Pfam:7tm_1 41 288 1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214372
AA Change: T242P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000214756
AA Change: T242P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216195
AA Change: T242P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adarb1 A G 10: 77,131,542 (GRCm39) V649A possibly damaging Het
Arglu1 C T 8: 8,717,337 (GRCm39) R244H possibly damaging Het
Asic5 A T 3: 81,913,812 (GRCm39) Y204F probably benign Het
Asz1 A G 6: 18,104,876 (GRCm39) F76S probably damaging Het
Bin1 G A 18: 32,552,896 (GRCm39) A174T probably damaging Het
Bnipl A C 3: 95,157,551 (GRCm39) S23A probably benign Het
Cd19 T C 7: 126,011,303 (GRCm39) T294A probably benign Het
Cdon G A 9: 35,367,818 (GRCm39) V238I probably benign Het
Chd3 A T 11: 69,247,451 (GRCm39) D957E probably benign Het
Crhbp T C 13: 95,568,515 (GRCm39) Q307R probably damaging Het
Cst3 A G 2: 148,714,741 (GRCm39) M112T probably benign Het
Dgkb A G 12: 38,189,425 (GRCm39) E276G probably damaging Het
Exoc4 T A 6: 33,735,001 (GRCm39) N539K probably benign Het
Gm3099 A G 14: 15,345,429 (GRCm39) E85G probably benign Het
Gpatch2 A G 1: 186,957,698 (GRCm39) probably null Het
Hs3st5 T A 10: 36,704,776 (GRCm39) Y26* probably null Het
Hspg2 A T 4: 137,244,148 (GRCm39) D802V probably damaging Het
Ifih1 A G 2: 62,431,813 (GRCm39) V846A possibly damaging Het
Lama4 T A 10: 38,964,840 (GRCm39) S1402T probably benign Het
Lrmda A G 14: 22,648,388 (GRCm39) T73A unknown Het
Lrrc1 A T 9: 77,349,471 (GRCm39) V365E probably damaging Het
Lrrc37a T A 11: 103,393,868 (GRCm39) Q519L probably benign Het
Mlc1 G T 15: 88,862,107 (GRCm39) D36E probably benign Het
Mrc2 A T 11: 105,223,092 (GRCm39) D445V probably damaging Het
Muc16 A G 9: 18,550,760 (GRCm39) S5178P probably benign Het
Nbea A G 3: 55,573,110 (GRCm39) I2491T probably damaging Het
Ncoa1 A G 12: 4,389,044 (GRCm39) I77T probably damaging Het
Npepps G T 11: 97,109,474 (GRCm39) H701N probably damaging Het
Or7g22 A T 9: 19,048,831 (GRCm39) I181F possibly damaging Het
Pclo T TTCTAG 5: 14,764,209 (GRCm39) probably null Het
Pclo GTCTAT GTCTATTCTAT 5: 14,764,204 (GRCm39) probably null Het
Pclo TCTAT TCTATACTAT 5: 14,764,205 (GRCm39) probably null Het
Pi4kb T C 3: 94,906,387 (GRCm39) Y645H probably damaging Het
Pik3r5 C T 11: 68,383,528 (GRCm39) A449V possibly damaging Het
Plat A G 8: 23,261,736 (GRCm39) T45A probably benign Het
Platr25 T C 13: 62,848,676 (GRCm39) K62R possibly damaging Het
Ppp5c A G 7: 16,740,111 (GRCm39) V410A possibly damaging Het
Prdm2 C T 4: 142,861,140 (GRCm39) A717T probably benign Het
Pstpip2 C A 18: 77,882,422 (GRCm39) T2K probably benign Het
Ptpn12 A C 5: 21,203,523 (GRCm39) S418R possibly damaging Het
Rint1 A G 5: 24,010,642 (GRCm39) S255G probably benign Het
Rmc1 T C 18: 12,322,371 (GRCm39) L608P probably damaging Het
Sltm C G 9: 70,493,955 (GRCm39) P802R possibly damaging Het
Stab2 T C 10: 86,714,776 (GRCm39) H1581R probably benign Het
Stau2 T C 1: 16,530,577 (GRCm39) Y114C unknown Het
Ticam1 T C 17: 56,578,067 (GRCm39) T343A probably benign Het
Tmem131l T C 3: 83,817,724 (GRCm39) K1259E possibly damaging Het
Vmn2r103 T A 17: 20,013,385 (GRCm39) F169I probably benign Het
Vps33a T C 5: 123,673,312 (GRCm39) K425E possibly damaging Het
Vwa8 T C 14: 79,258,089 (GRCm39) M746T probably benign Het
Zc3hav1 A G 6: 38,313,598 (GRCm39) I149T possibly damaging Het
Zfp708 A T 13: 67,222,193 (GRCm39) D62E probably benign Het
Other mutations in Or4n4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01879:Or4n4b APN 14 50,535,969 (GRCm39) missense probably benign 0.00
IGL02247:Or4n4b APN 14 50,536,571 (GRCm39) missense probably damaging 1.00
IGL02307:Or4n4b APN 14 50,536,295 (GRCm39) missense probably damaging 1.00
IGL02492:Or4n4b APN 14 50,536,060 (GRCm39) missense probably damaging 1.00
PIT4378001:Or4n4b UTSW 14 50,536,355 (GRCm39) missense probably benign
R0544:Or4n4b UTSW 14 50,536,139 (GRCm39) missense probably benign 0.20
R1603:Or4n4b UTSW 14 50,536,491 (GRCm39) missense possibly damaging 0.95
R1881:Or4n4b UTSW 14 50,536,472 (GRCm39) missense probably damaging 1.00
R3731:Or4n4b UTSW 14 50,535,962 (GRCm39) missense probably damaging 1.00
R4271:Or4n4b UTSW 14 50,535,908 (GRCm39) missense probably damaging 1.00
R4512:Or4n4b UTSW 14 50,536,453 (GRCm39) missense probably damaging 1.00
R5601:Or4n4b UTSW 14 50,536,318 (GRCm39) missense probably damaging 1.00
R6468:Or4n4b UTSW 14 50,535,924 (GRCm39) missense probably benign 0.02
R6614:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign 0.00
R7013:Or4n4b UTSW 14 50,536,656 (GRCm39) missense probably damaging 0.99
R7083:Or4n4b UTSW 14 50,536,736 (GRCm39) missense possibly damaging 0.81
R7274:Or4n4b UTSW 14 50,535,879 (GRCm39) missense probably benign 0.01
R7493:Or4n4b UTSW 14 50,536,281 (GRCm39) missense probably benign 0.02
R7653:Or4n4b UTSW 14 50,536,604 (GRCm39) missense possibly damaging 0.82
R7659:Or4n4b UTSW 14 50,536,698 (GRCm39) missense probably benign 0.00
R9138:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign
R9497:Or4n4b UTSW 14 50,536,362 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATGTCAAATCTTTCCTGCCTGATTG -3'
(R):5'- ATCAAGCTAGCCTGTACAGAC -3'

Sequencing Primer
(F):5'- CTGCCTGATTGATTCTTTAAAAACCC -3'
(R):5'- TGTACAGACACCTTTGCAGTCGAG -3'
Posted On 2019-12-20