Incidental Mutation 'R7887:Scly'
ID 609093
Institutional Source Beutler Lab
Gene Symbol Scly
Ensembl Gene ENSMUSG00000026307
Gene Name selenocysteine lyase
Synonyms SCL, A930015N15Rik, Selenocysteine reductase, Scly2, Scly1
MMRRC Submission 045939-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R7887 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 91226060-91248797 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 91228363 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000027532 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027532] [ENSMUST00000137074] [ENSMUST00000142488] [ENSMUST00000145843] [ENSMUST00000147523] [ENSMUST00000154045]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000027532
SMART Domains Protein: ENSMUSP00000027532
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 20 417 1.7e-58 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000124832
SMART Domains Protein: ENSMUSP00000116382
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 18 215 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000137074
SMART Domains Protein: ENSMUSP00000122449
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 48 216 7.4e-30 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000142488
SMART Domains Protein: ENSMUSP00000119979
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 42 238 2.2e-32 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000145843
SMART Domains Protein: ENSMUSP00000116824
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 1 68 1.5e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000147523
SMART Domains Protein: ENSMUSP00000114759
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 22 249 2.5e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000154045
SMART Domains Protein: ENSMUSP00000137796
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
PDB:3A9Z|B 1 57 5e-30 PDB
SCOP:d1eg5a_ 20 57 3e-10 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice fed a selenium-deficient diet exhibit mild learning impairment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkbh8 T A 9: 3,385,343 (GRCm39) I580N probably damaging Het
Ankrd35 C T 3: 96,592,216 (GRCm39) T834M probably damaging Het
Astn2 C T 4: 65,563,103 (GRCm39) V893I possibly damaging Het
B4galt1 A G 4: 40,823,501 (GRCm39) Y197H probably benign Het
Brdt T C 5: 107,507,799 (GRCm39) S676P possibly damaging Het
Chrdl2 T C 7: 99,678,457 (GRCm39) V343A possibly damaging Het
Clcn3 A T 8: 61,394,433 (GRCm39) M59K probably benign Het
Cpne4 A T 9: 104,909,990 (GRCm39) N529I probably damaging Het
Crcp G T 5: 130,066,711 (GRCm39) K32N possibly damaging Het
Ddx54 C T 5: 120,765,268 (GRCm39) R846C probably damaging Het
Dennd6a T C 14: 26,320,812 (GRCm39) S118P possibly damaging Het
Egr3 A G 14: 70,316,651 (GRCm39) Y116C probably damaging Het
Fbxw25 A G 9: 109,478,662 (GRCm39) probably null Het
Focad T G 4: 88,100,853 (GRCm39) I313M probably damaging Het
Gm10272 C T 10: 77,542,779 (GRCm39) P107L probably benign Het
Gpr26 A C 7: 131,568,702 (GRCm39) I16L probably benign Het
Gpr39 C A 1: 125,605,279 (GRCm39) T69K probably damaging Het
Hacl1 C T 14: 31,356,184 (GRCm39) G97S probably damaging Het
Idh3b A C 2: 130,123,678 (GRCm39) D136E probably damaging Het
Irf6 G A 1: 192,850,040 (GRCm39) V321M probably damaging Het
Klrg2 T A 6: 38,613,506 (GRCm39) T166S probably damaging Het
Lnx2 T C 5: 146,955,853 (GRCm39) I648V probably damaging Het
Mecr A G 4: 131,588,177 (GRCm39) probably null Het
Mnat1 T A 12: 73,234,965 (GRCm39) S205T probably benign Het
Mpnd G A 17: 56,318,097 (GRCm39) G204D probably benign Het
Myh7 C T 14: 55,221,119 (GRCm39) E935K possibly damaging Het
Nid1 G T 13: 13,674,318 (GRCm39) R899L possibly damaging Het
Nisch C T 14: 30,898,652 (GRCm39) W664* probably null Het
Nudt6 C T 3: 37,466,529 (GRCm39) V157I possibly damaging Het
Onecut2 T A 18: 64,474,046 (GRCm39) M180K possibly damaging Het
Or51h7 A C 7: 102,591,358 (GRCm39) L142R possibly damaging Het
Or5l13 T C 2: 87,780,224 (GRCm39) M118V probably damaging Het
Or8g31-ps1 A T 9: 39,276,175 (GRCm39) M107L unknown Het
Parg T A 14: 31,939,619 (GRCm39) D548E possibly damaging Het
Pclo GTCTAT GTCTATTCTAT 5: 14,764,204 (GRCm39) probably null Het
Phf11d A G 14: 59,597,029 (GRCm39) Y57H probably damaging Het
Prkaca T C 8: 84,713,524 (GRCm39) V99A probably benign Het
Rnf144b T A 13: 47,393,287 (GRCm39) C209S probably damaging Het
Selplg GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT 5: 113,957,756 (GRCm39) probably benign Het
Sphkap T C 1: 83,255,133 (GRCm39) Y872C probably benign Het
Ssh1 C T 5: 114,099,410 (GRCm39) probably null Het
Strap T G 6: 137,716,807 (GRCm39) L129V possibly damaging Het
Sympk T C 7: 18,768,364 (GRCm39) I111T possibly damaging Het
Tprn C A 2: 25,154,024 (GRCm39) A442E probably damaging Het
Tsen34 T C 7: 3,697,707 (GRCm39) L36P probably damaging Het
Ubr4 T C 4: 139,135,121 (GRCm39) F818L probably damaging Het
Uggt1 T C 1: 36,247,115 (GRCm39) Y294C probably damaging Het
Usp20 A G 2: 30,910,906 (GRCm39) K862E probably benign Het
Vmn1r201 A T 13: 22,658,956 (GRCm39) I57F probably damaging Het
Wdr64 C T 1: 175,613,111 (GRCm39) A662V not run Het
Other mutations in Scly
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Scly APN 1 91,246,763 (GRCm39) missense probably benign 0.00
IGL02690:Scly APN 1 91,233,047 (GRCm39) missense probably benign
R0597:Scly UTSW 1 91,237,555 (GRCm39) missense probably damaging 1.00
R1782:Scly UTSW 1 91,236,102 (GRCm39) missense probably damaging 1.00
R1950:Scly UTSW 1 91,233,116 (GRCm39) missense probably benign 0.08
R1978:Scly UTSW 1 91,247,891 (GRCm39) missense probably damaging 0.98
R2290:Scly UTSW 1 91,226,172 (GRCm39) critical splice donor site probably null
R3861:Scly UTSW 1 91,230,573 (GRCm39) utr 3 prime probably benign
R4508:Scly UTSW 1 91,236,047 (GRCm39) missense possibly damaging 0.95
R4876:Scly UTSW 1 91,247,850 (GRCm39) missense probably damaging 0.98
R7035:Scly UTSW 1 91,236,125 (GRCm39) missense probably damaging 0.98
R7701:Scly UTSW 1 91,236,030 (GRCm39) missense
R8079:Scly UTSW 1 91,236,089 (GRCm39) missense probably damaging 0.99
R8501:Scly UTSW 1 91,246,798 (GRCm39) missense probably damaging 1.00
R8828:Scly UTSW 1 91,244,830 (GRCm39) missense possibly damaging 0.83
R9533:Scly UTSW 1 91,228,413 (GRCm39) intron probably benign
X0021:Scly UTSW 1 91,247,828 (GRCm39) missense probably damaging 0.98
Z1176:Scly UTSW 1 91,233,035 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGACCCTCACTGTGGTCC -3'
(R):5'- TGAAAGTCCACCCCATTCCC -3'

Sequencing Primer
(F):5'- CTGTGGTCCCCCAAAAGAGTATTG -3'
(R):5'- ACACGGATTCTCAGTTTAGGTAGCC -3'
Posted On 2019-12-20