Incidental Mutation 'R0158:Zfp820'
ID60914
Institutional Source Beutler Lab
Gene Symbol Zfp820
Ensembl Gene ENSMUSG00000069743
Gene Namezinc finger protein 820
Synonyms2610036F08Rik
MMRRC Submission 038438-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.110) question?
Stock #R0158 (G1)
Quality Score150
Status Validated
Chromosome17
Chromosomal Location21816876-21845759 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 21819819 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 176 (T176I)
Ref Sequence ENSEMBL: ENSMUSP00000081158 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084141]
Predicted Effect probably benign
Transcript: ENSMUST00000084141
AA Change: T176I

PolyPhen 2 Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000081158
Gene: ENSMUSG00000069743
AA Change: T176I

DomainStartEndE-ValueType
KRAB 13 73 8.77e-20 SMART
ZnF_C2H2 183 205 6.32e-3 SMART
ZnF_C2H2 211 233 2.79e-4 SMART
ZnF_C2H2 239 261 4.3e-5 SMART
ZnF_C2H2 267 289 4.61e-5 SMART
ZnF_C2H2 295 317 1.2e-3 SMART
ZnF_C2H2 323 345 1.22e-4 SMART
ZnF_C2H2 351 373 2.75e-3 SMART
ZnF_C2H2 379 401 2.95e-3 SMART
ZnF_C2H2 407 429 5.29e-5 SMART
ZnF_C2H2 435 457 1.42e-5 SMART
ZnF_C2H2 463 485 1.2e-3 SMART
ZnF_C2H2 491 513 1.13e-4 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.3%
  • 20x: 89.1%
Validation Efficiency 93% (79/85)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931408C20Rik T G 1: 26,683,951 H716P probably damaging Het
9530053A07Rik A G 7: 28,155,492 I1848V probably damaging Het
Abcf3 C T 16: 20,552,566 R437C probably damaging Het
Abhd3 A G 18: 10,647,840 Y315H possibly damaging Het
Adam19 C T 11: 46,143,034 P891L probably damaging Het
Ampd1 T A 3: 103,091,730 Y400* probably null Het
Ap1g1 T C 8: 109,855,635 S724P probably benign Het
BC067074 T A 13: 113,369,153 L2272* probably null Het
Bst2 T A 8: 71,537,217 T71S possibly damaging Het
C3 A G 17: 57,224,851 probably null Het
Cacna2d1 C A 5: 16,361,817 probably benign Het
Cacna2d4 C T 6: 119,236,748 H43Y possibly damaging Het
Ccdc71 T G 9: 108,464,137 V383G probably benign Het
Cd109 A T 9: 78,688,932 Q849L possibly damaging Het
Cdkn2a A T 4: 89,276,767 H115Q possibly damaging Het
Ces1e T C 8: 93,219,429 E161G probably benign Het
Cggbp1 C T 16: 64,855,838 S89L possibly damaging Het
Crocc A T 4: 141,042,242 probably benign Het
Eef1akmt3 G A 10: 127,033,273 Q111* probably null Het
Exoc7 T C 11: 116,295,292 N361S probably benign Het
Fat2 G T 11: 55,296,185 S1278R probably benign Het
Fbxo42 A G 4: 141,200,329 N640S probably benign Het
Fbxw25 A G 9: 109,654,652 V164A possibly damaging Het
Foxs1 T C 2: 152,932,410 E241G probably damaging Het
Fras1 A T 5: 96,776,634 I3645F possibly damaging Het
Gm14496 T A 2: 181,997,413 V432E probably benign Het
Herc1 T A 9: 66,495,921 L4374* probably null Het
Hist1h3b T A 13: 23,752,710 C111S probably damaging Het
Ift122 T C 6: 115,924,484 probably benign Het
Itgav C A 2: 83,792,037 N654K probably benign Het
Itih5 T C 2: 10,234,992 probably benign Het
Jak2 C A 19: 29,311,757 T1103K probably benign Het
Kcnc4 C A 3: 107,458,604 C96F probably benign Het
Med13l C A 5: 118,742,449 S1202Y unknown Het
Mefv T C 16: 3,715,456 E317G possibly damaging Het
Ncoa2 T C 1: 13,152,384 T1226A probably benign Het
Nktr C T 9: 121,750,691 probably benign Het
Nudt5 G A 2: 5,862,303 V61M probably damaging Het
Olfr33 C T 7: 102,713,955 A153T probably benign Het
Palm2 A G 4: 57,709,649 D198G possibly damaging Het
Papd5 G A 8: 88,250,743 G391D probably damaging Het
Pcdhb2 A C 18: 37,297,230 Y752S probably damaging Het
Pcnx4 A G 12: 72,556,302 D446G probably benign Het
Pnp2 G A 14: 50,964,304 R249H probably damaging Het
Rgs3 A T 4: 62,623,884 I32F probably damaging Het
Rnf139 A G 15: 58,898,878 T251A probably benign Het
Rnf41 A G 10: 128,438,235 E252G probably damaging Het
Rxfp2 T A 5: 150,051,628 F220Y probably benign Het
Sdcbp A G 4: 6,379,042 D43G possibly damaging Het
Serpina3f A G 12: 104,217,008 D43G probably damaging Het
Sftpc T C 14: 70,521,447 K154R probably null Het
Simc1 A G 13: 54,524,717 T293A probably benign Het
Skint6 A T 4: 113,184,814 probably benign Het
Slc6a15 T C 10: 103,389,347 probably benign Het
Ston2 A T 12: 91,740,602 I78N probably damaging Het
Taok3 T C 5: 117,217,242 probably null Het
Tiam1 C T 16: 89,793,001 probably benign Het
Tnfsf15 T C 4: 63,729,992 H137R possibly damaging Het
Tpte G A 8: 22,327,739 R247H possibly damaging Het
Trim2 T C 3: 84,210,169 probably benign Het
Ulk1 A T 5: 110,788,944 probably benign Het
Utp4 T G 8: 106,913,386 H442Q probably null Het
Vmn1r193 T A 13: 22,219,628 I65F probably damaging Het
Vps54 A T 11: 21,306,962 Q690L probably damaging Het
Ybx2 T C 11: 69,940,319 probably benign Het
Zbtb38 C T 9: 96,686,940 G697D possibly damaging Het
Zfp202 C T 9: 40,208,916 Q218* probably null Het
Other mutations in Zfp820
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00424:Zfp820 APN 17 21819311 missense probably damaging 1.00
IGL00954:Zfp820 APN 17 21819879 missense probably damaging 1.00
IGL01088:Zfp820 APN 17 21821181 nonsense probably null
IGL03067:Zfp820 APN 17 21819820 missense possibly damaging 0.68
R0617:Zfp820 UTSW 17 21819704 missense probably damaging 0.99
R0658:Zfp820 UTSW 17 21818920 missense probably benign 0.00
R0696:Zfp820 UTSW 17 21820060 missense possibly damaging 0.94
R0791:Zfp820 UTSW 17 21819528 missense probably benign 0.05
R0792:Zfp820 UTSW 17 21819528 missense probably benign 0.05
R0882:Zfp820 UTSW 17 21823836 splice site probably benign
R1421:Zfp820 UTSW 17 21819880 missense possibly damaging 0.85
R1573:Zfp820 UTSW 17 21818756 missense probably benign 0.00
R1928:Zfp820 UTSW 17 21819335 missense probably benign 0.00
R3889:Zfp820 UTSW 17 21818896 missense probably benign 0.25
R4782:Zfp820 UTSW 17 21818985 missense probably benign 0.00
R4799:Zfp820 UTSW 17 21818985 missense probably benign 0.00
R4807:Zfp820 UTSW 17 21823872 start codon destroyed probably null 1.00
R4913:Zfp820 UTSW 17 21819219 missense probably benign 0.42
R5100:Zfp820 UTSW 17 21821073 missense possibly damaging 0.64
R5766:Zfp820 UTSW 17 21820002 missense probably damaging 0.96
R5772:Zfp820 UTSW 17 21818721 missense probably damaging 1.00
R6516:Zfp820 UTSW 17 21819373 missense probably damaging 1.00
R6577:Zfp820 UTSW 17 21819403 missense probably benign 0.00
R7094:Zfp820 UTSW 17 21819265 missense probably benign 0.41
R7570:Zfp820 UTSW 17 21819013 missense probably benign 0.14
R7794:Zfp820 UTSW 17 21820128 missense probably damaging 0.98
Predicted Primers
Posted On2013-07-24