Mutagenetix > Incidental Mutations

Incidental Mutation 'R7888:Olfr364-ps1'

609145

Institutional Source

Beutler Lab

Gene Symbol

Olfr364-ps1

Ensembl Gene

ENSMUSG00000078198

Gene Name

olfactory receptor 364, pseudogene 1

Synonyms

GA_x6K02T2NLDC-33831282-33832243, MOR138-4P, MOR138-7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R7888 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

37139322-37148585 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 37146322 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 37 (M37L)

Ref Sequence

ENSEMBL: ENSMUSP00000100611 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000104995] [ENSMUST00000214905] [ENSMUST00000217298]

Predicted Effect

probably benign
Transcript: ENSMUST00000104995
AA Change: M37L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000100611
Gene: ENSMUSG00000078198
AA Change: M37L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	303	4.8e-58	PFAM
Pfam:7tm_1	38	287	5e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214905
AA Change: M37L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000217298
AA Change: M37L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acox2	G	T	14: 8,246,415	Q459K	probably benign	Het
Ano3	T	A	2: 110,666,428	Y792F	probably damaging	Het
Aoc3	C	T	11: 101,332,497	H520Y	probably damaging	Het
Atp4b	A	G	8: 13,389,811	F137S	probably damaging	Het
Bcorl1	G	A	X: 48,361,607	V11M	unknown	Het
Blvrb	A	G	7: 27,465,734	T160A	probably damaging	Het
Brd2	G	A	17: 34,117,021	R73W	probably damaging	Het
Btaf1	A	G	19: 36,965,636	T306A	probably benign	Het
Ccdc154	G	A	17: 25,164,604	V212M	possibly damaging	Het
Ccdc40	A	G	11: 119,229,141	E3G	unknown	Het
Cenpb	T	A	2: 131,179,842	E12V	probably damaging	Het
Cnot8	T	C	11: 58,111,311	S57P	probably benign	Het
Cryba4	T	C	5: 112,251,052	E42G	probably benign	Het
Fam129b	T	A	2: 32,922,125	Y406*	probably null	Het
Fam72a	T	A	1: 131,528,840	I47N	probably damaging	Het
Itgb2	T	C	10: 77,564,644	V697A	probably benign	Het
Jakmip1	A	G	5: 37,104,864	N336D	probably damaging	Het
Kansl1	T	C	11: 104,342,422	T760A	probably benign	Het
Lrrc37a	T	A	11: 103,501,481	E1039D	probably benign	Het
Mpz	T	C	1: 171,159,635		probably null	Het
Mtss1	A	T	15: 58,972,524	M82K	probably damaging	Het
Myo6	T	C	9: 80,296,665	S1063P	probably damaging	Het
Nsun6	T	A	2: 14,996,544	E400D	probably benign	Het
Olfr1057	C	A	2: 86,374,926	C162F	probably benign	Het
Olfr121	A	T	17: 37,751,997	N48Y	probably damaging	Het
Olfr1395	T	C	11: 49,148,439	Y61H	probably damaging	Het
Olfr221	A	G	14: 52,035,890	S74P	probably damaging	Het
Olfr385	T	C	11: 73,589,528	D70G	probably damaging	Het
Olfr608	T	A	7: 103,470,799	Y253*	probably null	Het
Pfdn5	T	A	15: 102,328,589	V92E	probably damaging	Het
Pik3c2g	T	C	6: 139,896,744	V801A		Het
Psme2b	T	A	11: 48,945,575	T182S	possibly damaging	Het
Ptcd3	G	A	6: 71,883,447	A592V	probably damaging	Het
Rabgap1	T	A	2: 37,537,307	Y633*	probably null	Het
Rnf39	A	T	17: 36,947,241	T222S	probably damaging	Het
Scnn1g	A	G	7: 121,743,655	N277S	probably damaging	Het
Slc16a13	T	G	11: 70,218,980	I232L	possibly damaging	Het
Slco2b1	T	G	7: 99,688,843	R111S	unknown	Het
Sltm	C	G	9: 70,586,673	P802R	possibly damaging	Het
Tmc3	T	C	7: 83,600,009	W269R	probably damaging	Het
Vmn2r4	T	C	3: 64,406,522	E346G	probably damaging	Het
Vps52	A	G	17: 33,965,751	N666S	probably damaging	Het
Wdfy4	C	T	14: 33,090,963	D1618N		Het
Zfp773	C	A	7: 7,132,979	C206F	probably benign	Het

Other mutations in Olfr364-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Olfr364-ps1	APN	2	37147067	missense	probably damaging	1.00
IGL01550:Olfr364-ps1	APN	2	37146974	missense	probably damaging	1.00
IGL01791:Olfr364-ps1	APN	2	37146536	missense	probably damaging	1.00
IGL01886:Olfr364-ps1	APN	2	37146509	missense	probably damaging	1.00
IGL02680:Olfr364-ps1	APN	2	37146415	missense	probably damaging	1.00
IGL03003:Olfr364-ps1	APN	2	37146452	missense	probably benign	0.00
IGL03289:Olfr364-ps1	APN	2	37146578	missense	probably damaging	1.00
R0627:Olfr364-ps1	UTSW	2	37146330	missense	probably damaging	0.96
R1163:Olfr364-ps1	UTSW	2	37147027	missense	probably damaging	1.00
R1253:Olfr364-ps1	UTSW	2	37146872	missense	possibly damaging	0.89
R1340:Olfr364-ps1	UTSW	2	37146757	missense	probably benign	0.03
R1542:Olfr364-ps1	UTSW	2	37146966	missense	probably damaging	1.00
R1633:Olfr364-ps1	UTSW	2	37146971	missense	probably damaging	0.99
R2935:Olfr364-ps1	UTSW	2	37147111	missense	possibly damaging	0.75
R2982:Olfr364-ps1	UTSW	2	37146381	missense	probably damaging	0.99
R3855:Olfr364-ps1	UTSW	2	37146823	missense	possibly damaging	0.95
R4849:Olfr364-ps1	UTSW	2	37146254	missense	probably damaging	0.97
R4903:Olfr364-ps1	UTSW	2	37146371	missense	probably benign	0.35
R5160:Olfr364-ps1	UTSW	2	37146803	missense	probably benign	0.03
R7092:Olfr364-ps1	UTSW	2	37146611	missense	probably damaging	1.00
R7108:Olfr364-ps1	UTSW	2	37146260	missense	probably benign	0.00
R7143:Olfr364-ps1	UTSW	2	37146874	missense	probably benign	0.00
R7278:Olfr364-ps1	UTSW	2	37147009	missense	probably benign	0.29
R7630:Olfr364-ps1	UTSW	2	37146359	missense	probably damaging	1.00
R7754:Olfr364-ps1	UTSW	2	37146846	missense	possibly damaging	0.83
R7971:Olfr364-ps1	UTSW	2	37146322	missense	probably benign
Z1088:Olfr364-ps1	UTSW	2	37146385	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- GATTTCATTGCAGGCCAGAGG -3'
(R):5'- ATCCGTGTTTGCTAATGCTATGAAG -3'

Sequencing Primer
(F):5'- TTTCATTGCAGGCCAGAGGATAGG -3'
(R):5'- GAAGTACATCTGAACTAGGCATCC -3'

Posted On

2019-12-20