Incidental Mutation 'R7889:Clca3a2'
ID 609202
Institutional Source Beutler Lab
Gene Symbol Clca3a2
Ensembl Gene ENSMUSG00000028262
Gene Name chloride channel accessory 3A2
Synonyms Clca2
MMRRC Submission 045941-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R7889 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 144796559-144819494 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 144810813 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 341 (E341*)
Ref Sequence ENSEMBL: ENSMUSP00000029929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029929]
AlphaFold Q9EQR4
Predicted Effect probably null
Transcript: ENSMUST00000029929
AA Change: E341*
SMART Domains Protein: ENSMUSP00000029929
Gene: ENSMUSG00000028262
AA Change: E341*

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
VWA 306 478 1.5e-21 SMART
FN3 758 857 5.49e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000197013
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angptl3 C T 4: 99,031,071 (GRCm38) L23F probably benign Het
Art2a-ps C T 7: 101,555,211 (GRCm38) S40N not run Het
Ash1l A G 3: 88,966,038 (GRCm38) T43A probably benign Het
Atp1a2 G A 1: 172,278,064 (GRCm38) probably null Het
Azi2 A G 9: 118,061,915 (GRCm38) E336G probably benign Het
Cap2 A G 13: 46,646,575 (GRCm38) H419R probably damaging Het
Ccdc14 T A 16: 34,723,836 (GRCm38) S903T probably damaging Het
Cep72 A T 13: 74,050,122 (GRCm38) S380T possibly damaging Het
Clcnkb T G 4: 141,410,604 (GRCm38) I294L probably benign Het
Cyp2d9 T A 15: 82,455,826 (GRCm38) M350K probably damaging Het
Dhx40 T G 11: 86,798,967 (GRCm38) I266L probably benign Het
Dnah5 G T 15: 28,448,414 (GRCm38) E4208* probably null Het
Ephb2 T C 4: 136,771,042 (GRCm38) N242S probably damaging Het
Fam13b A T 18: 34,457,691 (GRCm38) F478Y probably benign Het
Fastkd2 C G 1: 63,735,460 (GRCm38) probably null Het
Fbxo40 T A 16: 36,969,650 (GRCm38) D366V probably damaging Het
Fhod3 A T 18: 24,770,494 (GRCm38) K95M probably damaging Het
Foxo3 T A 10: 42,275,027 (GRCm38) Q136L probably benign Het
Gadl1 A T 9: 115,954,815 (GRCm38) Q236L possibly damaging Het
Galnt13 A G 2: 55,112,861 (GRCm38) D560G probably benign Het
Ghsr A G 3: 27,372,166 (GRCm38) S124G probably benign Het
Gkn2 A G 6: 87,378,286 (GRCm38) probably null Het
Glyctk T A 9: 106,156,439 (GRCm38) R68W unknown Het
Gm10031 G A 1: 156,525,395 (GRCm38) A389T probably benign Het
Gm14025 T C 2: 129,036,994 (GRCm38) E1004G unknown Het
Gm5157 G A 7: 21,184,716 (GRCm38) P301S unknown Het
Hdc A T 2: 126,616,210 (GRCm38) I64N probably damaging Het
Helq A T 5: 100,792,561 (GRCm38) probably null Het
Ighv1-43 T C 12: 114,945,963 (GRCm38) Y113C probably damaging Het
Ipo9 T C 1: 135,406,853 (GRCm38) T273A probably benign Het
Itga4 G A 2: 79,316,045 (GRCm38) V774I probably benign Het
Itpr3 T C 17: 27,116,777 (GRCm38) L2287P probably damaging Het
Llgl1 T A 11: 60,707,312 (GRCm38) I394N probably damaging Het
Mta1 G A 12: 113,131,688 (GRCm38) R487H probably benign Het
Neb T C 2: 52,147,669 (GRCm38) D7049G probably benign Het
Nlrp4f G A 13: 65,195,018 (GRCm38) S271F probably damaging Het
Noxo1 A G 17: 24,699,382 (GRCm38) D172G probably damaging Het
Nup155 T A 15: 8,121,507 (GRCm38) V347E probably damaging Het
Oaf G T 9: 43,222,671 (GRCm38) A251E possibly damaging Het
Pds5b T A 5: 150,792,172 (GRCm38) F1039I probably damaging Het
Pla2g12b T A 10: 59,421,240 (GRCm38) probably null Het
Prmt3 A G 7: 49,787,301 (GRCm38) D208G possibly damaging Het
Ptcd3 G A 6: 71,888,608 (GRCm38) T441M probably damaging Het
Rabl6 A G 2: 25,584,774 (GRCm38) probably null Het
Shtn1 T A 19: 59,003,896 (GRCm38) I417F probably damaging Het
Slc20a2 T C 8: 22,540,401 (GRCm38) S158P probably damaging Het
Sltm C G 9: 70,586,673 (GRCm38) P802R possibly damaging Het
Spata5 A G 3: 37,578,810 (GRCm38) D855G probably benign Het
Spef2 T C 15: 9,717,563 (GRCm38) Y232C probably damaging Het
Stard9 C T 2: 120,704,461 (GRCm38) T3733I probably benign Het
Thrap3 A T 4: 126,178,062 (GRCm38) F512L probably benign Het
Tmem150c A T 5: 100,093,104 (GRCm38) I30K probably damaging Het
Tnnt1 C T 7: 4,508,583 (GRCm38) A168T probably damaging Het
Trak2 A G 1: 58,918,824 (GRCm38) L308P probably damaging Het
Trp53i11 T C 2: 93,198,899 (GRCm38) L81P probably damaging Het
Usp16 T C 16: 87,474,584 (GRCm38) Y344H probably benign Het
Wdr60 T A 12: 116,255,939 (GRCm38) K128* probably null Het
Xrcc5 G T 1: 72,356,826 (GRCm38) V593L probably benign Het
Zcchc14 A T 8: 121,604,895 (GRCm38) H576Q unknown Het
Zfp616 T A 11: 74,085,445 (GRCm38) C847S probably damaging Het
Zfp626 A T 7: 27,819,499 (GRCm38) Y635F probably benign Het
Zfp799 G A 17: 32,819,499 (GRCm38) R598* probably null Het
Zfp831 A G 2: 174,645,304 (GRCm38) K591E possibly damaging Het
Other mutations in Clca3a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Clca3a2 APN 3 144,813,627 (GRCm38) nonsense probably null
IGL01663:Clca3a2 APN 3 144,817,155 (GRCm38) missense probably damaging 0.97
IGL01779:Clca3a2 APN 3 144,819,378 (GRCm38) missense possibly damaging 0.47
IGL02066:Clca3a2 APN 3 144,813,455 (GRCm38) missense probably benign
IGL02301:Clca3a2 APN 3 144,806,372 (GRCm38) missense probably damaging 0.98
IGL02619:Clca3a2 APN 3 144,806,322 (GRCm38) missense probably damaging 1.00
IGL02852:Clca3a2 APN 3 144,806,343 (GRCm38) missense probably damaging 0.98
IGL02901:Clca3a2 APN 3 144,816,768 (GRCm38) missense probably damaging 1.00
IGL03162:Clca3a2 APN 3 144,806,416 (GRCm38) missense probably damaging 1.00
R0032:Clca3a2 UTSW 3 144,816,733 (GRCm38) missense probably benign 0.01
R0244:Clca3a2 UTSW 3 144,813,898 (GRCm38) missense possibly damaging 0.90
R1249:Clca3a2 UTSW 3 144,803,004 (GRCm38) missense possibly damaging 0.80
R1370:Clca3a2 UTSW 3 144,813,863 (GRCm38) splice site probably benign
R1586:Clca3a2 UTSW 3 144,810,716 (GRCm38) missense possibly damaging 0.94
R1776:Clca3a2 UTSW 3 144,813,920 (GRCm38) missense probably damaging 1.00
R1797:Clca3a2 UTSW 3 144,797,637 (GRCm38) missense probably benign 0.01
R1869:Clca3a2 UTSW 3 144,806,403 (GRCm38) missense probably benign 0.44
R1871:Clca3a2 UTSW 3 144,797,637 (GRCm38) missense probably benign 0.01
R1919:Clca3a2 UTSW 3 144,810,696 (GRCm38) missense probably benign
R1923:Clca3a2 UTSW 3 144,805,730 (GRCm38) missense probably damaging 1.00
R2200:Clca3a2 UTSW 3 144,813,924 (GRCm38) missense probably benign 0.10
R2324:Clca3a2 UTSW 3 144,806,280 (GRCm38) critical splice donor site probably null
R2937:Clca3a2 UTSW 3 144,813,918 (GRCm38) missense probably benign 0.06
R3429:Clca3a2 UTSW 3 144,806,327 (GRCm38) missense probably benign 0.07
R3434:Clca3a2 UTSW 3 144,808,761 (GRCm38) unclassified probably benign
R3551:Clca3a2 UTSW 3 144,803,081 (GRCm38) missense probably damaging 1.00
R3952:Clca3a2 UTSW 3 144,803,061 (GRCm38) missense probably damaging 1.00
R4120:Clca3a2 UTSW 3 144,810,852 (GRCm38) missense probably benign 0.25
R4383:Clca3a2 UTSW 3 144,806,320 (GRCm38) missense probably benign 0.02
R4518:Clca3a2 UTSW 3 144,808,705 (GRCm38) missense probably damaging 1.00
R4598:Clca3a2 UTSW 3 144,805,683 (GRCm38) missense probably damaging 1.00
R4801:Clca3a2 UTSW 3 144,807,351 (GRCm38) missense possibly damaging 0.95
R4802:Clca3a2 UTSW 3 144,807,351 (GRCm38) missense possibly damaging 0.95
R4816:Clca3a2 UTSW 3 144,810,852 (GRCm38) missense probably benign 0.25
R4934:Clca3a2 UTSW 3 144,817,931 (GRCm38) missense probably damaging 1.00
R4942:Clca3a2 UTSW 3 144,806,502 (GRCm38) missense probably damaging 1.00
R5123:Clca3a2 UTSW 3 144,806,343 (GRCm38) missense probably damaging 1.00
R5156:Clca3a2 UTSW 3 144,805,838 (GRCm38) missense probably benign 0.26
R5275:Clca3a2 UTSW 3 144,813,579 (GRCm38) missense probably damaging 1.00
R5372:Clca3a2 UTSW 3 144,797,525 (GRCm38) missense probably benign 0.00
R5656:Clca3a2 UTSW 3 144,797,632 (GRCm38) missense probably benign 0.26
R6059:Clca3a2 UTSW 3 144,810,770 (GRCm38) missense probably damaging 1.00
R6155:Clca3a2 UTSW 3 144,819,357 (GRCm38) missense probably damaging 0.99
R6254:Clca3a2 UTSW 3 144,802,134 (GRCm38) missense probably benign
R6336:Clca3a2 UTSW 3 144,806,478 (GRCm38) missense probably benign
R6470:Clca3a2 UTSW 3 144,804,263 (GRCm38) splice site probably null
R6593:Clca3a2 UTSW 3 144,808,577 (GRCm38) critical splice donor site probably null
R6631:Clca3a2 UTSW 3 144,813,644 (GRCm38) missense probably benign
R6826:Clca3a2 UTSW 3 144,818,054 (GRCm38) missense possibly damaging 0.46
R6836:Clca3a2 UTSW 3 144,806,383 (GRCm38) missense probably damaging 0.97
R6896:Clca3a2 UTSW 3 144,808,701 (GRCm38) missense probably damaging 1.00
R7211:Clca3a2 UTSW 3 144,814,014 (GRCm38) missense probably benign 0.00
R7324:Clca3a2 UTSW 3 144,808,611 (GRCm38) missense probably damaging 0.99
R7411:Clca3a2 UTSW 3 144,802,099 (GRCm38) missense probably damaging 1.00
R7486:Clca3a2 UTSW 3 144,797,601 (GRCm38) missense probably damaging 1.00
R7491:Clca3a2 UTSW 3 144,813,579 (GRCm38) missense probably damaging 1.00
R7521:Clca3a2 UTSW 3 144,801,913 (GRCm38) makesense probably null
R7946:Clca3a2 UTSW 3 144,807,314 (GRCm38) critical splice donor site probably null
R7991:Clca3a2 UTSW 3 144,813,995 (GRCm38) missense probably benign 0.00
R8022:Clca3a2 UTSW 3 144,805,766 (GRCm38) missense probably damaging 1.00
R8344:Clca3a2 UTSW 3 144,805,942 (GRCm38) critical splice acceptor site probably null
R8367:Clca3a2 UTSW 3 144,817,747 (GRCm38) splice site probably null
R8371:Clca3a2 UTSW 3 144,807,353 (GRCm38) nonsense probably null
R8814:Clca3a2 UTSW 3 144,797,764 (GRCm38) missense probably benign 0.18
R9031:Clca3a2 UTSW 3 144,805,714 (GRCm38) missense probably damaging 1.00
R9069:Clca3a2 UTSW 3 144,813,686 (GRCm38) splice site probably benign
R9201:Clca3a2 UTSW 3 144,813,923 (GRCm38) missense probably benign 0.00
R9261:Clca3a2 UTSW 3 144,819,397 (GRCm38) missense probably benign
R9469:Clca3a2 UTSW 3 144,802,177 (GRCm38) missense probably damaging 1.00
R9515:Clca3a2 UTSW 3 144,803,047 (GRCm38) nonsense probably null
R9569:Clca3a2 UTSW 3 144,807,314 (GRCm38) critical splice donor site probably null
R9664:Clca3a2 UTSW 3 144,797,814 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACCTGAAATCCTGCCTG -3'
(R):5'- AGCATAGACTTTGAAGGTTGTCAG -3'

Sequencing Primer
(F):5'- CCTGGAGTCCATGGCAAATTG -3'
(R):5'- TGAAGGTTGTCAGAACTATAACAAC -3'
Posted On 2019-12-20