Mutagenetix > Incidental Mutation

Incidental Mutation 'R7890:Or7g19'

609272

Institutional Source

Beutler Lab

Gene Symbol

Or7g19

Ensembl Gene

ENSMUSG00000095957

Gene Name

olfactory receptor family 7 subfamily G member 19

Synonyms

GA_x6K02T2PVTD-12687800-12688738, Olfr832, MOR153-1

MMRRC Submission

045942-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.238) question?

Stock #

R7890 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

18855946-18856884 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 18856799 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 285 (M285T)

Ref Sequence

ENSEMBL: ENSMUSP00000151834 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060601] [ENSMUST00000218385]

AlphaFold

Q7TRG9

Predicted Effect

probably benign
Transcript: ENSMUST00000060601
AA Change: M285T

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000056724
Gene: ENSMUSG00000095957
AA Change: M285T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	4.1e-51	PFAM
Pfam:7TM_GPCR_Srsx	35	305	3.1e-6	PFAM
Pfam:7tm_1	41	290	1.4e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000218385
AA Change: M285T

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (61/61)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	T	A	5: 77,031,969 (GRCm39)	K551N	probably benign	Het
Acp4	A	C	7: 43,903,528 (GRCm39)	L262R	probably damaging	Het
Acsf3	G	T	8: 123,512,704 (GRCm39)		probably null	Het
Ago4	T	C	4: 126,419,869 (GRCm39)	Q36R	probably benign	Het
Ankrd31	T	A	13: 96,968,379 (GRCm39)	I672K	probably benign	Het
Astn1	A	T	1: 158,407,903 (GRCm39)	D628V	probably damaging	Het
Brca2	T	C	5: 150,462,846 (GRCm39)	V870A	possibly damaging	Het
Camk4	T	C	18: 33,318,058 (GRCm39)	V405A	probably benign	Het
Carmil1	A	T	13: 24,197,215 (GRCm39)	S146T		Het
Cflar	T	A	1: 58,791,915 (GRCm39)	L406Q		Het
Clic6	T	A	16: 92,296,275 (GRCm39)	S312T	probably benign	Het
Col5a2	T	C	1: 45,444,147 (GRCm39)		probably null	Het
Ctc1	C	A	11: 68,917,355 (GRCm39)	Q384K	probably damaging	Het
Defa24	A	G	8: 22,224,556 (GRCm39)	K2E	probably damaging	Het
Dis3l	C	A	9: 64,229,753 (GRCm39)	A309S	probably benign	Het
Dnah9	A	G	11: 65,962,898 (GRCm39)	S1806P	probably damaging	Het
Dolk	C	T	2: 30,174,726 (GRCm39)	V440I	probably damaging	Het
Erc2	A	G	14: 27,762,298 (GRCm39)		probably null	Het
Fntb	T	C	12: 76,920,224 (GRCm39)		probably null	Het
Gm4846	A	T	1: 166,322,228 (GRCm39)	V113E	probably benign	Het
Gm5592	G	T	7: 40,936,183 (GRCm39)	Q228H	probably damaging	Het
Gm5916	T	A	9: 36,032,291 (GRCm39)	T48S	possibly damaging	Het
Ift172	G	T	5: 31,440,425 (GRCm39)	Y287*	probably null	Het
Il27ra	T	C	8: 84,760,614 (GRCm39)	I450M	probably damaging	Het
Krtap31-2	T	A	11: 99,827,377 (GRCm39)	C70S	possibly damaging	Het
Lipo4	T	A	19: 33,478,964 (GRCm39)	H292L	probably damaging	Het
Lyst	T	C	13: 13,915,154 (GRCm39)	F3283L	probably damaging	Het
Mctp1	T	G	13: 76,975,876 (GRCm39)	C750G	probably damaging	Het
Msantd5	C	T	11: 51,125,665 (GRCm39)	S196L	probably damaging	Het
Mtmr7	T	C	8: 41,004,776 (GRCm39)	D600G	possibly damaging	Het
Mylk	C	T	16: 34,784,018 (GRCm39)	Q1395*	probably null	Het
Nap1l5	T	A	6: 58,883,873 (GRCm39)	D27V	probably damaging	Het
Nfkbib	T	C	7: 28,461,512 (GRCm39)	D75G	probably damaging	Het
Nlrc4	T	A	17: 74,744,503 (GRCm39)	M793L	probably benign	Het
Or13m2-ps1	T	A	6: 42,778,426 (GRCm39)	C250*	probably null	Het
Or52ab4	G	T	7: 102,987,537 (GRCm39)	C92F	probably benign	Het
Or5p52	T	C	7: 107,502,250 (GRCm39)	S109P	probably benign	Het
Or8g37	C	T	9: 39,731,310 (GRCm39)	A125V	probably damaging	Het
Pcdh15	G	A	10: 74,478,146 (GRCm39)	R207Q	probably damaging	Het
Plek	T	C	11: 16,945,238 (GRCm39)	T54A	probably benign	Het
Pno1	C	A	11: 17,161,443 (GRCm39)	R22L	probably benign	Het
Prkca	A	T	11: 107,903,510 (GRCm39)	N287K	probably damaging	Het
Rapgef6	C	G	11: 54,517,549 (GRCm39)	H414D	probably damaging	Het
Rpa1	CA	C	11: 75,198,050 (GRCm39)		probably null	Het
Rpap2	T	C	5: 107,754,777 (GRCm39)	C136R	probably damaging	Het
Rtl1	C	T	12: 109,559,251 (GRCm39)	E863K	possibly damaging	Het
Ryr3	A	T	2: 112,757,257 (GRCm39)	I366N	probably damaging	Het
Scn9a	T	C	2: 66,373,456 (GRCm39)	I508V	probably benign	Het
Sec14l3	A	G	11: 4,024,795 (GRCm39)	D248G	probably damaging	Het
Six6	A	T	12: 72,987,317 (GRCm39)	Q163L	probably benign	Het
Slco6c1	A	G	1: 96,990,192 (GRCm39)	V683A	possibly damaging	Het
Smc1b	A	G	15: 84,950,529 (GRCm39)	V1165A	probably damaging	Het
Smgc	A	T	15: 91,731,279 (GRCm39)	Q241L	possibly damaging	Het
Tdrp	A	T	8: 14,005,727 (GRCm39)	S65T	probably damaging	Het
Tg	A	T	15: 66,555,663 (GRCm39)	Y785F	probably damaging	Het
Themis2	T	G	4: 132,516,954 (GRCm39)	Q182P	probably damaging	Het
Tmem86b	G	T	7: 4,631,404 (GRCm39)	S216*	probably null	Het
Ttyh2	T	A	11: 114,577,272 (GRCm39)	I61N	possibly damaging	Het
Vmn2r97	A	T	17: 19,149,802 (GRCm39)	T397S	probably benign	Het
Zfp141	C	T	7: 42,125,903 (GRCm39)	D190N	probably damaging	Het
Zfp58	T	C	13: 67,640,114 (GRCm39)	R126G	possibly damaging	Het

Other mutations in Or7g19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03018:Or7g19	APN	9	18,856,177 (GRCm39)	missense	probably damaging	0.98
IGL03172:Or7g19	APN	9	18,856,757 (GRCm39)	missense	probably benign	0.01
R0537:Or7g19	UTSW	9	18,856,444 (GRCm39)	missense	probably damaging	1.00
R1923:Or7g19	UTSW	9	18,856,781 (GRCm39)	missense	probably benign	0.21
R2226:Or7g19	UTSW	9	18,856,177 (GRCm39)	missense	probably damaging	0.98
R2234:Or7g19	UTSW	9	18,856,112 (GRCm39)	missense	probably damaging	1.00
R2402:Or7g19	UTSW	9	18,856,496 (GRCm39)	missense	probably damaging	0.98
R4060:Or7g19	UTSW	9	18,856,346 (GRCm39)	missense	probably benign	0.09
R4537:Or7g19	UTSW	9	18,856,526 (GRCm39)	missense	possibly damaging	0.85
R4715:Or7g19	UTSW	9	18,856,742 (GRCm39)	missense	probably benign	0.01
R5557:Or7g19	UTSW	9	18,856,466 (GRCm39)	missense	possibly damaging	0.94
R6001:Or7g19	UTSW	9	18,856,340 (GRCm39)	missense	probably damaging	1.00
R6172:Or7g19	UTSW	9	18,856,042 (GRCm39)	missense	probably benign	0.00
R6415:Or7g19	UTSW	9	18,856,415 (GRCm39)	missense	probably damaging	1.00
R6594:Or7g19	UTSW	9	18,856,127 (GRCm39)	missense	probably damaging	0.98
R6874:Or7g19	UTSW	9	18,856,777 (GRCm39)	missense	possibly damaging	0.95
R7801:Or7g19	UTSW	9	18,856,555 (GRCm39)	missense	probably damaging	0.97
R7818:Or7g19	UTSW	9	18,856,305 (GRCm39)	nonsense	probably null
R7880:Or7g19	UTSW	9	18,856,024 (GRCm39)	missense	probably benign	0.06
R8352:Or7g19	UTSW	9	18,856,459 (GRCm39)	missense	possibly damaging	0.51
R8452:Or7g19	UTSW	9	18,856,459 (GRCm39)	missense	possibly damaging	0.51
R8776:Or7g19	UTSW	9	18,856,286 (GRCm39)	missense	possibly damaging	0.93
R8776-TAIL:Or7g19	UTSW	9	18,856,286 (GRCm39)	missense	possibly damaging	0.93
R8931:Or7g19	UTSW	9	18,855,920 (GRCm39)	splice site	probably benign
R9438:Or7g19	UTSW	9	18,856,326 (GRCm39)	nonsense	probably null
Z1088:Or7g19	UTSW	9	18,856,717 (GRCm39)	missense	possibly damaging	0.69

Predicted Primers

PCR Primer
(F):5'- GACAAGCCTGTTTGGTATTCTTC -3'
(R):5'- CCATCTGATGTATGGTTTCATGACC -3'

Sequencing Primer
(F):5'- GTTTTGAAAATTCCATCAGCTGCAGG -3'
(R):5'- GGTTTCATGACCAAAAACTCATTG -3'

Posted On

2019-12-20