Mutagenetix > Incidental Mutation

Incidental Mutation 'R7891:Vmn1r73'

609331

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r73

Ensembl Gene

ENSMUSG00000051687

Gene Name

vomeronasal 1 receptor 73

Synonyms

V1rg2

MMRRC Submission

045943-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

R7891 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

11490184-11491095 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 11491036 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 285 (V285I)

Ref Sequence

ENSEMBL: ENSMUSP00000055353 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055070] [ENSMUST00000226516]

AlphaFold

Q8R293

Predicted Effect

possibly damaging
Transcript: ENSMUST00000055070
AA Change: V285I

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000055353
Gene: ENSMUSG00000051687
AA Change: V285I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	301	7.5e-7	PFAM
Pfam:V1R	32	297	1.9e-27	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226516
AA Change: V285I

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700025C18Rik	T	G	2: 164,920,864 (GRCm39)	E56D	unknown	Het
9930111J21Rik2	T	C	11: 48,910,543 (GRCm39)	Q630R	probably benign	Het
Abca9	A	G	11: 110,054,098 (GRCm39)	V68A	probably benign	Het
Acnat1	G	A	4: 49,449,181 (GRCm39)	A195V	possibly damaging	Het
Acsl3	C	T	1: 78,681,305 (GRCm39)	A612V	probably benign	Het
Adam12	A	T	7: 133,599,961 (GRCm39)	D115E	probably benign	Het
Adam3	T	A	8: 25,197,513 (GRCm39)		probably null	Het
Aif1	G	A	17: 35,391,600 (GRCm39)		probably benign	Het
Ank3	A	G	10: 69,824,139 (GRCm39)	D154G	probably damaging	Het
Arid3b	A	G	9: 57,717,442 (GRCm39)	C233R	probably benign	Het
Ccdc7b	T	A	8: 129,799,146 (GRCm39)	D74E	unknown	Het
Cckbr	T	A	7: 105,084,557 (GRCm39)	D430E	probably benign	Het
Chpf	T	C	1: 75,451,939 (GRCm39)	H667R	probably benign	Het
Dnah8	A	G	17: 30,931,263 (GRCm39)	E1426G	probably benign	Het
Dync1h1	A	G	12: 110,609,590 (GRCm39)	I2791V	probably benign	Het
Ehd3	A	G	17: 74,123,387 (GRCm39)	N130S	probably benign	Het
Fgfr4	A	G	13: 55,306,964 (GRCm39)	T218A	probably benign	Het
Foxe1	G	A	4: 46,344,599 (GRCm39)	E136K	possibly damaging	Het
Frmpd1	A	G	4: 45,284,478 (GRCm39)	S1100G	probably benign	Het
Gask1b	G	A	3: 79,793,591 (GRCm39)	A20T	probably benign	Het
Gm21886	T	G	18: 80,132,972 (GRCm39)	Q62P	probably null	Het
Golga4	A	G	9: 118,385,434 (GRCm39)	E852G	probably damaging	Het
Gprin3	T	C	6: 59,330,696 (GRCm39)	D537G	probably benign	Het
Gpx5	C	A	13: 21,472,918 (GRCm39)	D139Y	probably damaging	Het
Hmcn1	T	C	1: 150,468,940 (GRCm39)	Y5007C	probably damaging	Het
Igsf10	G	A	3: 59,235,832 (GRCm39)	R1450*	probably null	Het
Kif21a	G	A	15: 90,840,517 (GRCm39)	P1200S	probably damaging	Het
Kmt2c	G	A	5: 25,505,109 (GRCm39)	R3400C	probably damaging	Het
Miox	A	C	15: 89,220,742 (GRCm39)	M216L	probably benign	Het
Mphosph9	T	C	5: 124,428,967 (GRCm39)	Y687C	probably damaging	Het
Mxi1	T	A	19: 53,299,192 (GRCm39)	V21D	probably benign	Het
Nbeal1	T	C	1: 60,299,591 (GRCm39)	L1309P	probably benign	Het
Onecut2	T	A	18: 64,474,046 (GRCm39)	M180K	possibly damaging	Het
Or10ag54	A	T	2: 87,099,421 (GRCm39)	T99S	possibly damaging	Het
Or13c25	C	T	4: 52,911,663 (GRCm39)	V44I	probably benign	Het
Or4c100	G	A	2: 88,356,289 (GRCm39)	V121I	probably benign	Het
Or7g22	T	C	9: 19,049,141 (GRCm39)	M284T	possibly damaging	Het
Polq	A	G	16: 36,848,244 (GRCm39)	T284A	probably damaging	Het
Polrmt	A	T	10: 79,577,714 (GRCm39)	M295K	probably damaging	Het
Pou2af1	G	T	9: 51,144,297 (GRCm39)	M70I	probably damaging	Het
Pou3f1	G	A	4: 124,552,232 (GRCm39)	E245K	probably damaging	Het
Psmb1	C	T	17: 15,714,748 (GRCm39)	V50I	probably benign	Het
Ptgis	T	C	2: 167,069,434 (GRCm39)	D50G	probably damaging	Het
R3hdm2	A	G	10: 127,334,443 (GRCm39)	I955M	probably benign	Het
Rasef	G	A	4: 73,677,935 (GRCm39)	T97I	probably benign	Het
Rasef	T	C	4: 73,709,201 (GRCm39)	T11A	probably benign	Het
Sema4c	C	A	1: 36,588,995 (GRCm39)	L710F	probably damaging	Het
Slc39a10	C	T	1: 46,851,328 (GRCm39)	A721T	probably damaging	Het
Sltm	C	G	9: 70,493,955 (GRCm39)	P802R	possibly damaging	Het
Spata31d1a	A	G	13: 59,848,139 (GRCm39)	C1330R	possibly damaging	Het
Susd1	T	C	4: 59,349,915 (GRCm39)	D560G	possibly damaging	Het
Tnfrsf1b	T	C	4: 144,955,660 (GRCm39)	Y32C	probably damaging	Het
Trhr2	C	A	8: 123,084,083 (GRCm39)	V306F	probably damaging	Het
Trpm6	A	T	19: 18,754,074 (GRCm39)	Q35L	probably benign	Het
Ttbk2	A	G	2: 120,616,510 (GRCm39)	S197P	probably damaging	Het
Uggt2	T	A	14: 119,280,059 (GRCm39)	E806D	probably benign	Het
Ushbp1	T	G	8: 71,841,422 (GRCm39)	Q469P	possibly damaging	Het
Zfp934	A	C	13: 62,668,003 (GRCm39)	S63R	probably benign	Het

Other mutations in Vmn1r73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01782:Vmn1r73	APN	7	11,490,665 (GRCm39)	missense	probably benign	0.02
IGL02337:Vmn1r73	APN	7	11,490,640 (GRCm39)	missense	possibly damaging	0.69
IGL02666:Vmn1r73	APN	7	11,490,865 (GRCm39)	missense	probably damaging	1.00
IGL02741:Vmn1r73	APN	7	11,490,710 (GRCm39)	missense	probably benign	0.05
IGL02756:Vmn1r73	APN	7	11,490,574 (GRCm39)	missense	possibly damaging	0.95
IGL03113:Vmn1r73	APN	7	11,490,527 (GRCm39)	missense	probably benign
IGL03195:Vmn1r73	APN	7	11,491,007 (GRCm39)	missense	probably damaging	1.00
R0023:Vmn1r73	UTSW	7	11,490,997 (GRCm39)	missense	probably benign	0.43
R0379:Vmn1r73	UTSW	7	11,490,773 (GRCm39)	missense	probably benign	0.16
R3941:Vmn1r73	UTSW	7	11,490,682 (GRCm39)	missense	probably damaging	1.00
R4224:Vmn1r73	UTSW	7	11,490,506 (GRCm39)	missense	probably damaging	0.99
R4631:Vmn1r73	UTSW	7	11,490,758 (GRCm39)	missense	probably benign	0.22
R4912:Vmn1r73	UTSW	7	11,490,596 (GRCm39)	missense	probably damaging	0.99
R5060:Vmn1r73	UTSW	7	11,490,683 (GRCm39)	missense	probably damaging	1.00
R5450:Vmn1r73	UTSW	7	11,490,376 (GRCm39)	missense	possibly damaging	0.63
R5609:Vmn1r73	UTSW	7	11,490,591 (GRCm39)	nonsense	probably null
R6059:Vmn1r73	UTSW	7	11,490,538 (GRCm39)	missense	probably benign	0.40
R6508:Vmn1r73	UTSW	7	11,490,631 (GRCm39)	missense	possibly damaging	0.73
R6967:Vmn1r73	UTSW	7	11,490,544 (GRCm39)	nonsense	probably null
R7099:Vmn1r73	UTSW	7	11,490,320 (GRCm39)	missense	probably damaging	1.00
R7304:Vmn1r73	UTSW	7	11,490,824 (GRCm39)	missense	probably damaging	1.00
R7579:Vmn1r73	UTSW	7	11,491,082 (GRCm39)	missense	probably benign	0.08
R8914:Vmn1r73	UTSW	7	11,490,328 (GRCm39)	missense	probably damaging	1.00
R9072:Vmn1r73	UTSW	7	11,490,203 (GRCm39)	missense	probably benign	0.00
R9073:Vmn1r73	UTSW	7	11,490,203 (GRCm39)	missense	probably benign	0.00
R9275:Vmn1r73	UTSW	7	11,490,479 (GRCm39)	missense	probably benign	0.04
R9632:Vmn1r73	UTSW	7	11,490,407 (GRCm39)	missense	possibly damaging	0.56
R9710:Vmn1r73	UTSW	7	11,490,407 (GRCm39)	missense	possibly damaging	0.56
Z1176:Vmn1r73	UTSW	7	11,490,883 (GRCm39)	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- CTAAATGCTTCACCTGAAAACAGAG -3'
(R):5'- GACTGATAACTGACTTCTAATGAGTCC -3'

Sequencing Primer
(F):5'- GCCACCCAATCTATCCTCATCCTAG -3'
(R):5'- AATGAGTCCATATAGTGAAGGAATTG -3'

Posted On

2019-12-20