Mutagenetix > Incidental Mutations

Incidental Mutation 'R7892:Vmn2r15'

609380

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r15

Ensembl Gene

ENSMUSG00000091375

Gene Name

vomeronasal 2, receptor 15

Synonyms

EG211223

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

R7892 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

109286269-109297556 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109286351 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 829 (I829N)

Ref Sequence

ENSEMBL: ENSMUSP00000128333 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167133]

Predicted Effect

probably damaging
Transcript: ENSMUST00000167133
AA Change: I829N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: I829N

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	75	472	1e-29	PFAM
Pfam:NCD3G	514	568	5.8e-18	PFAM
Pfam:7tm_3	601	836	9.1e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630010A05Rik	A	G	16: 14,618,485	E134G		Het
Acsm4	G	A	7: 119,694,666	V87M	possibly damaging	Het
Adamts3	T	C	5: 89,861,429	N125S	probably benign	Het
AI314180	T	C	4: 58,828,593	I947V	probably benign	Het
Arhgef4	A	G	1: 34,721,804	E47G	unknown	Het
BC067074	C	T	13: 113,319,606	R729C		Het
C1ra	A	G	6: 124,519,415	M367V	probably benign	Het
Ces2b	T	C	8: 104,832,753	W84R	probably damaging	Het
Clca3a1	T	C	3: 144,730,818	T835A	probably benign	Het
Cmya5	T	C	13: 93,096,357	E741G	probably damaging	Het
D330020A13Rik	T	C	6: 120,294,858	L165P	unknown	Het
Dtnbp1	A	T	13: 44,922,289	L326*	probably null	Het
Fat4	A	T	3: 38,949,439		probably null	Het
Fuom	T	A	7: 140,099,579	I143F	unknown	Het
Gm12569	G	A	11: 51,234,786	E179K	possibly damaging	Het
Gm14444	A	T	2: 175,016,731	M33L	probably damaging	Het
Gm21818	G	T	13: 120,173,159		probably benign	Het
Hmcn1	T	C	1: 150,664,892	T2889A	probably benign	Het
Kif5b	G	A	18: 6,212,517	T769M	probably benign	Het
Kif9	G	A	9: 110,514,614	R567H	not run	Het
Kmt2c	A	T	5: 25,299,816	M3498K	probably benign	Het
Lrrc29	A	T	8: 105,315,533	I221N	possibly damaging	Het
Ly6e	T	A	15: 74,957,851	L15*	probably null	Het
Malt1	G	A	18: 65,464,116		probably null	Het
Mylk	G	C	16: 34,879,524	S419T	probably benign	Het
Oacyl	T	C	18: 65,737,847	L373P	probably benign	Het
Olfr1444	C	T	19: 12,862,479	R235*	probably null	Het
Olfr1471	T	A	19: 13,445,298	C95*	probably null	Het
Olfr32	T	C	2: 90,138,492	I216V	probably benign	Het
Olfr959	A	C	9: 39,572,549	S237A	possibly damaging	Het
Pcdh20	A	T	14: 88,467,431	L811*	probably null	Het
Pgrmc2	A	T	3: 41,082,980	D5E	probably damaging	Het
Pign	A	C	1: 105,657,676	F49L	probably benign	Het
Pip5k1b	T	C	19: 24,360,093	D277G	probably benign	Het
Ppm1m	A	G	9: 106,198,696	V11A	probably benign	Het
Prl7a1	A	T	13: 27,633,678	V201E	not run	Het
Samhd1	A	G	2: 157,116,495	S269P	probably damaging	Het
Sik2	A	G	9: 51,008,832	V15A	probably damaging	Het
Slc4a7	G	A	14: 14,773,348	E773K	probably benign	Het
Sntg1	T	C	1: 8,782,800	D42G	probably damaging	Het
Speg	A	T	1: 75,427,166	N2664Y	probably damaging	Het
Treh	A	G	9: 44,684,718	Y435C	probably damaging	Het
Trim59	A	G	3: 69,037,807	S67P	probably benign	Het
Trim68	A	T	7: 102,678,797	C309S	unknown	Het
Tubb4a	G	T	17: 57,080,880	S382*	probably null	Het
Vmn2r68	T	C	7: 85,234,514	T128A	probably benign	Het
Vmn2r70	T	A	7: 85,559,380	I630L	possibly damaging	Het
Zc3hav1	A	G	6: 38,329,221	I632T	probably benign	Het
Zfp558	A	G	9: 18,468,697	S13P	possibly damaging	Het

Other mutations in Vmn2r15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r15	APN	5	109286736	missense	possibly damaging	0.70
IGL01367:Vmn2r15	APN	5	109293209	missense	probably damaging	0.99
IGL01844:Vmn2r15	APN	5	109286269	makesense	probably null
IGL02190:Vmn2r15	APN	5	109293374	missense	probably damaging	1.00
IGL02754:Vmn2r15	APN	5	109293268	nonsense	probably null
IGL02797:Vmn2r15	APN	5	109297384	missense	probably benign	0.18
IGL03301:Vmn2r15	APN	5	109297355	critical splice donor site	probably null
IGL03407:Vmn2r15	APN	5	109286319	nonsense	probably null
PIT4445001:Vmn2r15	UTSW	5	109287142	missense	probably damaging	0.99
PIT4520001:Vmn2r15	UTSW	5	109287005	missense	probably damaging	1.00
R0038:Vmn2r15	UTSW	5	109293144	missense	possibly damaging	0.46
R0111:Vmn2r15	UTSW	5	109287156	missense	possibly damaging	0.56
R0379:Vmn2r15	UTSW	5	109286478	missense	probably damaging	1.00
R0427:Vmn2r15	UTSW	5	109287087	missense	probably damaging	1.00
R0639:Vmn2r15	UTSW	5	109293015	missense	probably benign	0.22
R0964:Vmn2r15	UTSW	5	109297535	missense	probably benign	0.34
R1147:Vmn2r15	UTSW	5	109293206	missense	probably damaging	1.00
R1147:Vmn2r15	UTSW	5	109293206	missense	probably damaging	1.00
R1232:Vmn2r15	UTSW	5	109293302	missense	probably benign	0.39
R1241:Vmn2r15	UTSW	5	109292904	missense	probably damaging	1.00
R1244:Vmn2r15	UTSW	5	109293226	nonsense	probably null
R1394:Vmn2r15	UTSW	5	109294148	missense	probably benign	0.44
R1395:Vmn2r15	UTSW	5	109294148	missense	probably benign	0.44
R1423:Vmn2r15	UTSW	5	109293227	missense	probably damaging	1.00
R1439:Vmn2r15	UTSW	5	109294087	missense	probably damaging	1.00
R1513:Vmn2r15	UTSW	5	109293329	missense	probably damaging	1.00
R1777:Vmn2r15	UTSW	5	109294270	missense	possibly damaging	0.79
R1844:Vmn2r15	UTSW	5	109286994	nonsense	probably null
R2072:Vmn2r15	UTSW	5	109286753	missense	possibly damaging	0.65
R2074:Vmn2r15	UTSW	5	109286753	missense	possibly damaging	0.65
R2122:Vmn2r15	UTSW	5	109286456	missense	probably damaging	1.00
R2208:Vmn2r15	UTSW	5	109297443	missense	possibly damaging	0.64
R2268:Vmn2r15	UTSW	5	109293207	missense	probably benign	0.31
R2831:Vmn2r15	UTSW	5	109286592	missense	probably damaging	1.00
R3848:Vmn2r15	UTSW	5	109297446	missense	probably benign	0.00
R4058:Vmn2r15	UTSW	5	109293446	missense	probably damaging	0.99
R4615:Vmn2r15	UTSW	5	109293482	missense	possibly damaging	0.91
R4663:Vmn2r15	UTSW	5	109294074	missense	probably benign
R4681:Vmn2r15	UTSW	5	109286622	missense	probably damaging	0.97
R4751:Vmn2r15	UTSW	5	109286754	missense	probably benign	0.01
R5095:Vmn2r15	UTSW	5	109288451	critical splice acceptor site	probably null
R5300:Vmn2r15	UTSW	5	109294108	missense	probably damaging	0.99
R5309:Vmn2r15	UTSW	5	109293090	missense	probably damaging	0.99
R5335:Vmn2r15	UTSW	5	109286807	missense	probably damaging	0.99
R5421:Vmn2r15	UTSW	5	109286535	missense	probably damaging	1.00
R5805:Vmn2r15	UTSW	5	109286940	missense	possibly damaging	0.88
R6280:Vmn2r15	UTSW	5	109293425	missense	possibly damaging	0.65
R6324:Vmn2r15	UTSW	5	109286271	makesense	probably null
R6383:Vmn2r15	UTSW	5	109293226	nonsense	probably null
R6772:Vmn2r15	UTSW	5	109286372	missense	probably damaging	0.99
R6991:Vmn2r15	UTSW	5	109293314	missense	probably damaging	1.00
R7194:Vmn2r15	UTSW	5	109292783	missense	probably damaging	1.00
R7365:Vmn2r15	UTSW	5	109293239	missense	probably benign	0.19
R7365:Vmn2r15	UTSW	5	109297522	missense	probably benign	0.15
R7423:Vmn2r15	UTSW	5	109297528	missense	probably benign	0.00
R7552:Vmn2r15	UTSW	5	109292908	nonsense	probably null
R7619:Vmn2r15	UTSW	5	109288324	critical splice donor site	probably null
R7975:Vmn2r15	UTSW	5	109286351	missense	probably damaging	1.00
R8058:Vmn2r15	UTSW	5	109293090	missense	probably damaging	0.99
X0065:Vmn2r15	UTSW	5	109293308	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGCTGCCCTACATTGTAAGTAC -3'
(R):5'- GCTTTCTTGGCTAGGAACCTTC -3'

Sequencing Primer
(F):5'- GCCCTACATTGTAAGTACTAACTTTG -3'
(R):5'- GGAACCTTCCTGACAGATTCAATG -3'

Posted On

2019-12-20