Incidental Mutation 'R7892:Vmn2r70'
| ID |
609385 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r70
|
| Ensembl Gene |
ENSMUSG00000090806 |
| Gene Name |
vomeronasal 2, receptor 70 |
| Synonyms |
EG620835 |
| MMRRC Submission |
045944-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.130)
|
| Stock # |
R7892 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85207911-85218296 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 85208588 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 630
(I630L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129703
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168230]
|
| AlphaFold |
K7N702 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168230
AA Change: I630L
PolyPhen 2
Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: I630L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
468 |
2.5e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
1.5e-19 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.2e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630010A05Rik |
A |
G |
16: 14,436,349 (GRCm39) |
E134G |
|
Het |
| Acsm4 |
G |
A |
7: 119,293,889 (GRCm39) |
V87M |
possibly damaging |
Het |
| Adamts3 |
T |
C |
5: 90,009,288 (GRCm39) |
N125S |
probably benign |
Het |
| Arhgef4 |
A |
G |
1: 34,760,885 (GRCm39) |
E47G |
unknown |
Het |
| C1ra |
A |
G |
6: 124,496,374 (GRCm39) |
M367V |
probably benign |
Het |
| Ces2b |
T |
C |
8: 105,559,385 (GRCm39) |
W84R |
probably damaging |
Het |
| Clca3a1 |
T |
C |
3: 144,436,579 (GRCm39) |
T835A |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,232,865 (GRCm39) |
E741G |
probably damaging |
Het |
| Cspg4b |
C |
T |
13: 113,456,140 (GRCm39) |
R729C |
|
Het |
| D330020A13Rik |
T |
C |
6: 120,271,819 (GRCm39) |
L165P |
unknown |
Het |
| Dtnbp1 |
A |
T |
13: 45,075,765 (GRCm39) |
L326* |
probably null |
Het |
| Ecpas |
T |
C |
4: 58,828,593 (GRCm39) |
I947V |
probably benign |
Het |
| Fat4 |
A |
T |
3: 39,003,588 (GRCm39) |
|
probably null |
Het |
| Fbxl9 |
A |
T |
8: 106,042,165 (GRCm39) |
I221N |
possibly damaging |
Het |
| Fuom |
T |
A |
7: 139,679,492 (GRCm39) |
I143F |
unknown |
Het |
| Gm14444 |
A |
T |
2: 174,858,524 (GRCm39) |
M33L |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,540,643 (GRCm39) |
T2889A |
probably benign |
Het |
| Kif5b |
G |
A |
18: 6,212,517 (GRCm39) |
T769M |
probably benign |
Het |
| Kif9 |
G |
A |
9: 110,343,682 (GRCm39) |
R567H |
not run |
Het |
| Kmt2c |
A |
T |
5: 25,504,814 (GRCm39) |
M3498K |
probably benign |
Het |
| Ly6e |
T |
A |
15: 74,829,700 (GRCm39) |
L15* |
probably null |
Het |
| Malt1 |
G |
A |
18: 65,597,187 (GRCm39) |
|
probably null |
Het |
| Msantd5 |
G |
A |
11: 51,125,613 (GRCm39) |
E179K |
possibly damaging |
Het |
| Mylk |
G |
C |
16: 34,699,894 (GRCm39) |
S419T |
probably benign |
Het |
| Oacyl |
T |
C |
18: 65,870,918 (GRCm39) |
L373P |
probably benign |
Het |
| Or10d1 |
A |
C |
9: 39,483,845 (GRCm39) |
S237A |
possibly damaging |
Het |
| Or4b1d |
T |
C |
2: 89,968,836 (GRCm39) |
I216V |
probably benign |
Het |
| Or5b116 |
T |
A |
19: 13,422,662 (GRCm39) |
C95* |
probably null |
Het |
| Or5b21 |
C |
T |
19: 12,839,843 (GRCm39) |
R235* |
probably null |
Het |
| Pcdh20 |
A |
T |
14: 88,704,867 (GRCm39) |
L811* |
probably null |
Het |
| Pgrmc2 |
A |
T |
3: 41,037,415 (GRCm39) |
D5E |
probably damaging |
Het |
| Pign |
A |
C |
1: 105,585,401 (GRCm39) |
F49L |
probably benign |
Het |
| Pip5k1b |
T |
C |
19: 24,337,457 (GRCm39) |
D277G |
probably benign |
Het |
| Ppm1m |
A |
G |
9: 106,075,895 (GRCm39) |
V11A |
probably benign |
Het |
| Prl7a1 |
A |
T |
13: 27,817,661 (GRCm39) |
V201E |
not run |
Het |
| Samhd1 |
A |
G |
2: 156,958,415 (GRCm39) |
S269P |
probably damaging |
Het |
| Sik2 |
A |
G |
9: 50,920,132 (GRCm39) |
V15A |
probably damaging |
Het |
| Slc4a7 |
G |
A |
14: 14,773,348 (GRCm38) |
E773K |
probably benign |
Het |
| Sntg1 |
T |
C |
1: 8,853,024 (GRCm39) |
D42G |
probably damaging |
Het |
| Speg |
A |
T |
1: 75,403,810 (GRCm39) |
N2664Y |
probably damaging |
Het |
| Tcstv1b |
G |
T |
13: 120,634,695 (GRCm39) |
|
probably benign |
Het |
| Treh |
A |
G |
9: 44,596,015 (GRCm39) |
Y435C |
probably damaging |
Het |
| Trim59 |
A |
G |
3: 68,945,140 (GRCm39) |
S67P |
probably benign |
Het |
| Trim68 |
A |
T |
7: 102,328,004 (GRCm39) |
C309S |
unknown |
Het |
| Tubb4a |
G |
T |
17: 57,387,880 (GRCm39) |
S382* |
probably null |
Het |
| Vmn2r15 |
A |
T |
5: 109,434,217 (GRCm39) |
I829N |
probably damaging |
Het |
| Vmn2r68 |
T |
C |
7: 84,883,722 (GRCm39) |
T128A |
probably benign |
Het |
| Zc3hav1 |
A |
G |
6: 38,306,156 (GRCm39) |
I632T |
probably benign |
Het |
| Zfp558 |
A |
G |
9: 18,379,993 (GRCm39) |
S13P |
possibly damaging |
Het |
|
| Other mutations in Vmn2r70 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00978:Vmn2r70
|
APN |
7 |
85,213,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01140:Vmn2r70
|
APN |
7 |
85,214,379 (GRCm39) |
nonsense |
probably null |
|
|
IGL01287:Vmn2r70
|
APN |
7 |
85,218,227 (GRCm39) |
nonsense |
probably null |
|
|
IGL01581:Vmn2r70
|
APN |
7 |
85,213,122 (GRCm39) |
splice site |
probably null |
|
|
IGL01632:Vmn2r70
|
APN |
7 |
85,215,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01725:Vmn2r70
|
APN |
7 |
85,208,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02244:Vmn2r70
|
APN |
7 |
85,214,211 (GRCm39) |
missense |
probably benign |
|
|
IGL02288:Vmn2r70
|
APN |
7 |
85,214,342 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02313:Vmn2r70
|
APN |
7 |
85,214,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02591:Vmn2r70
|
APN |
7 |
85,214,153 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02725:Vmn2r70
|
APN |
7 |
85,214,553 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL02797:Vmn2r70
|
APN |
7 |
85,208,295 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0045:Vmn2r70
|
UTSW |
7 |
85,215,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0729:Vmn2r70
|
UTSW |
7 |
85,215,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0967:Vmn2r70
|
UTSW |
7 |
85,208,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1217:Vmn2r70
|
UTSW |
7 |
85,208,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1351:Vmn2r70
|
UTSW |
7 |
85,214,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1387:Vmn2r70
|
UTSW |
7 |
85,207,969 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1483:Vmn2r70
|
UTSW |
7 |
85,208,375 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1796:Vmn2r70
|
UTSW |
7 |
85,213,011 (GRCm39) |
nonsense |
probably null |
|
|
R1809:Vmn2r70
|
UTSW |
7 |
85,215,130 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2154:Vmn2r70
|
UTSW |
7 |
85,212,923 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2173:Vmn2r70
|
UTSW |
7 |
85,214,290 (GRCm39) |
missense |
probably benign |
|
|
R2334:Vmn2r70
|
UTSW |
7 |
85,208,800 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2871:Vmn2r70
|
UTSW |
7 |
85,208,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Vmn2r70
|
UTSW |
7 |
85,208,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3975:Vmn2r70
|
UTSW |
7 |
85,208,540 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4525:Vmn2r70
|
UTSW |
7 |
85,208,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4527:Vmn2r70
|
UTSW |
7 |
85,208,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4535:Vmn2r70
|
UTSW |
7 |
85,214,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5181:Vmn2r70
|
UTSW |
7 |
85,208,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5600:Vmn2r70
|
UTSW |
7 |
85,212,935 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5641:Vmn2r70
|
UTSW |
7 |
85,208,572 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5726:Vmn2r70
|
UTSW |
7 |
85,208,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5943:Vmn2r70
|
UTSW |
7 |
85,215,199 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6166:Vmn2r70
|
UTSW |
7 |
85,215,189 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6272:Vmn2r70
|
UTSW |
7 |
85,208,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6324:Vmn2r70
|
UTSW |
7 |
85,208,087 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6429:Vmn2r70
|
UTSW |
7 |
85,208,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6449:Vmn2r70
|
UTSW |
7 |
85,214,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r70
|
UTSW |
7 |
85,215,305 (GRCm39) |
missense |
probably benign |
|
|
R7000:Vmn2r70
|
UTSW |
7 |
85,208,819 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7141:Vmn2r70
|
UTSW |
7 |
85,208,044 (GRCm39) |
missense |
probably benign |
|
|
R7153:Vmn2r70
|
UTSW |
7 |
85,214,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Vmn2r70
|
UTSW |
7 |
85,213,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7565:Vmn2r70
|
UTSW |
7 |
85,214,499 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7567:Vmn2r70
|
UTSW |
7 |
85,214,243 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7593:Vmn2r70
|
UTSW |
7 |
85,215,312 (GRCm39) |
nonsense |
probably null |
|
|
R7660:Vmn2r70
|
UTSW |
7 |
85,218,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7806:Vmn2r70
|
UTSW |
7 |
85,208,401 (GRCm39) |
missense |
probably benign |
|
|
R7965:Vmn2r70
|
UTSW |
7 |
85,211,071 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8052:Vmn2r70
|
UTSW |
7 |
85,212,923 (GRCm39) |
missense |
probably benign |
|
|
R8251:Vmn2r70
|
UTSW |
7 |
85,215,186 (GRCm39) |
nonsense |
probably null |
|
|
R8814:Vmn2r70
|
UTSW |
7 |
85,215,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8934:Vmn2r70
|
UTSW |
7 |
85,211,188 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9225:Vmn2r70
|
UTSW |
7 |
85,208,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9322:Vmn2r70
|
UTSW |
7 |
85,208,498 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9430:Vmn2r70
|
UTSW |
7 |
85,215,240 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9477:Vmn2r70
|
UTSW |
7 |
85,218,244 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
Z1088:Vmn2r70
|
UTSW |
7 |
85,213,968 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1176:Vmn2r70
|
UTSW |
7 |
85,218,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGGTGCCCCTATCTCAAG -3'
(R):5'- ATGAAGACCATACTCTCTGCCTC -3'
Sequencing Primer
(F):5'- ATCTCAAGCAGCCATCTCATTC -3'
(R):5'- CTCTGCCTCGAAAAAGTTGTGGC -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation