Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00310:Mettl25'

6094

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mettl25

Ensembl Gene

ENSMUSG00000036009

Gene Name

methyltransferase like 25

Synonyms

BC067068

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

IGL00310

Quality Score

Status

Chromosome

Chromosomal Location

105599050-105677241 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 105662295 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 225 (H225R)

Ref Sequence

ENSEMBL: ENSMUSP00000038665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176040] [ENSMUST00000176924]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000046638
AA Change: H225R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009
AA Change: H225R

Domain	Start	End	E-Value	Type
Pfam:Methyltransf_32	149	413	1.9e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176040

Predicted Effect

probably benign
Transcript: ENSMUST00000176924

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 10 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agap1	T	G	1: 89,815,392 (GRCm39)	V573G	probably damaging	Het
Dpp6	T	A	5: 27,928,441 (GRCm39)	D786E	probably damaging	Het
Dync2h1	T	C	9: 7,155,072 (GRCm39)		probably benign	Het
Kcnq4	G	A	4: 120,555,213 (GRCm39)	Q657*	probably null	Het
Kif14	G	A	1: 136,396,756 (GRCm39)	S354N	probably benign	Het
Mocos	C	T	18: 24,793,101 (GRCm39)	T66I	possibly damaging	Het
Ptprk	T	A	10: 28,212,506 (GRCm39)	D221E	possibly damaging	Het
Slc13a3	A	T	2: 165,253,843 (GRCm39)	F437I	probably damaging	Het
Slc7a15	T	C	12: 8,589,121 (GRCm39)	Y142C	probably damaging	Het
Sox4	C	A	13: 29,136,956 (GRCm39)	G17W	probably damaging	Het

Other mutations in Mettl25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00698:Mettl25	APN	10	105,629,201 (GRCm39)	missense	probably null	0.31
IGL00766:Mettl25	APN	10	105,615,443 (GRCm39)	splice site	probably benign
IGL01360:Mettl25	APN	10	105,659,058 (GRCm39)	missense	probably damaging	1.00
IGL01954:Mettl25	APN	10	105,659,068 (GRCm39)	missense	probably damaging	1.00
IGL02088:Mettl25	APN	10	105,659,111 (GRCm39)	missense	probably damaging	1.00
IGL02623:Mettl25	APN	10	105,662,185 (GRCm39)	missense	probably damaging	0.96
IGL03245:Mettl25	APN	10	105,662,358 (GRCm39)	missense	possibly damaging	0.86
IGL03134:Mettl25	UTSW	10	105,661,888 (GRCm39)	nonsense	probably null
R0238:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R0238:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R1297:Mettl25	UTSW	10	105,659,126 (GRCm39)	missense	probably benign	0.11
R1482:Mettl25	UTSW	10	105,662,451 (GRCm39)	missense	possibly damaging	0.61
R1526:Mettl25	UTSW	10	105,668,844 (GRCm39)	missense	possibly damaging	0.56
R1542:Mettl25	UTSW	10	105,661,981 (GRCm39)	missense	probably benign	0.04
R1589:Mettl25	UTSW	10	105,615,493 (GRCm39)	missense	probably damaging	1.00
R1901:Mettl25	UTSW	10	105,661,948 (GRCm39)	missense	probably damaging	0.96
R1902:Mettl25	UTSW	10	105,661,948 (GRCm39)	missense	probably damaging	0.96
R2016:Mettl25	UTSW	10	105,633,167 (GRCm39)	missense	probably benign	0.00
R2355:Mettl25	UTSW	10	105,599,316 (GRCm39)	missense	probably benign	0.00
R2920:Mettl25	UTSW	10	105,601,038 (GRCm39)	splice site	probably null
R3149:Mettl25	UTSW	10	105,662,214 (GRCm39)	missense	probably benign	0.00
R4547:Mettl25	UTSW	10	105,661,878 (GRCm39)	missense	probably damaging	1.00
R4646:Mettl25	UTSW	10	105,662,416 (GRCm39)	missense	probably damaging	1.00
R4652:Mettl25	UTSW	10	105,615,509 (GRCm39)	nonsense	probably null
R5020:Mettl25	UTSW	10	105,662,068 (GRCm39)	missense	possibly damaging	0.87
R5435:Mettl25	UTSW	10	105,615,447 (GRCm39)	critical splice donor site	probably null
R6947:Mettl25	UTSW	10	105,662,053 (GRCm39)	missense	probably benign	0.00
R7075:Mettl25	UTSW	10	105,665,785 (GRCm39)	missense	possibly damaging	0.68
R7729:Mettl25	UTSW	10	105,601,871 (GRCm39)	missense	probably benign	0.03
R8074:Mettl25	UTSW	10	105,661,941 (GRCm39)	missense	probably benign	0.02
R8108:Mettl25	UTSW	10	105,659,040 (GRCm39)	missense	possibly damaging	0.53
R8415:Mettl25	UTSW	10	105,662,002 (GRCm39)	missense	probably benign	0.05
R8937:Mettl25	UTSW	10	105,601,122 (GRCm39)	missense	probably benign	0.17
R8949:Mettl25	UTSW	10	105,668,714 (GRCm39)	missense	probably benign	0.00
R9497:Mettl25	UTSW	10	105,677,090 (GRCm39)	missense	probably damaging	0.98
R9772:Mettl25	UTSW	10	105,633,127 (GRCm39)	missense	probably benign
RF009:Mettl25	UTSW	10	105,669,100 (GRCm39)	intron	probably benign
Z1176:Mettl25	UTSW	10	105,661,959 (GRCm39)	missense	possibly damaging	0.95

Posted On

2012-04-20