Incidental Mutation 'R7894:Cdon'
ID 609524
Institutional Source Beutler Lab
Gene Symbol Cdon
Ensembl Gene ENSMUSG00000038119
Gene Name cell adhesion molecule-related/down-regulated by oncogenes
Synonyms CAM-related/down-regulated by oncogenes, CDO
MMRRC Submission 045946-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.351) question?
Stock # R7894 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 35332836-35418948 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 35388244 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 740 (R740G)
Ref Sequence ENSEMBL: ENSMUSP00000045547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129]
AlphaFold Q32MD9
Predicted Effect probably damaging
Transcript: ENSMUST00000042842
AA Change: R740G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: R740G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000119129
AA Change: R740G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: R740G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Meta Mutation Damage Score 0.5478 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 99% (81/82)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 109,997,415 (GRCm39) M1551T possibly damaging Het
Abcc9 A G 6: 142,539,733 (GRCm39) *1547Q probably null Het
Adamts20 A C 15: 94,249,641 (GRCm39) C459G probably damaging Het
Adamts5 C T 16: 85,674,808 (GRCm39) W452* probably null Het
Adcy8 G T 15: 64,792,054 (GRCm39) Q301K possibly damaging Het
Adgrv1 A C 13: 81,715,570 (GRCm39) C873G probably benign Het
Ak9 A G 10: 41,296,535 (GRCm39) D1427G unknown Het
Amy2a1 T A 3: 113,324,190 (GRCm39) M117L possibly damaging Het
Ap5z1 G T 5: 142,452,039 (GRCm39) R23L probably benign Het
Ap5z1 C T 5: 142,456,191 (GRCm39) Q337* probably null Het
Astn1 C A 1: 158,429,508 (GRCm39) Q759K probably damaging Het
Cd276 T A 9: 58,444,762 (GRCm39) T70S possibly damaging Het
Cd38 C T 5: 44,057,746 (GRCm39) T106I probably damaging Het
Clk2 C T 3: 89,076,201 (GRCm39) R124W possibly damaging Het
Cyp1b1 C T 17: 80,021,644 (GRCm39) V33M possibly damaging Het
Dab1 T A 4: 104,589,335 (GRCm39) D547E probably benign Het
Degs1 A T 1: 182,104,416 (GRCm39) Y290N probably damaging Het
Degs1 G C 1: 182,104,417 (GRCm39) H289Q probably benign Het
Dop1b T A 16: 93,607,092 (GRCm39) C2249S probably benign Het
Ecpas T C 4: 58,853,708 (GRCm39) N361S probably damaging Het
Ehd4 A C 2: 119,932,909 (GRCm39) Y172* probably null Het
Erc2 A G 14: 27,499,165 (GRCm39) D347G probably damaging Het
Espl1 T G 15: 102,212,460 (GRCm39) V522G probably damaging Het
Fabp9 T A 3: 10,262,227 (GRCm39) T10S probably benign Het
Fam193a T C 5: 34,597,877 (GRCm39) I558T possibly damaging Het
Fhod1 T C 8: 106,057,789 (GRCm39) E912G probably damaging Het
Gja1 T C 10: 56,264,645 (GRCm39) F335L possibly damaging Het
Gm29106 A G 1: 118,127,265 (GRCm39) H319R probably damaging Het
Hunk C T 16: 90,269,353 (GRCm39) S299F probably damaging Het
Hydin C T 8: 111,239,642 (GRCm39) T1974M possibly damaging Het
Ighv10-1 T A 12: 114,442,650 (GRCm39) T112S probably damaging Het
Ireb2 T A 9: 54,789,620 (GRCm39) V98E probably damaging Het
Irf4 A C 13: 30,937,435 (GRCm39) H167P probably benign Het
Irf6 C T 1: 192,845,021 (GRCm39) P164L probably benign Het
Josd1 A G 15: 79,561,451 (GRCm39) I119T probably damaging Het
Kcna5 G T 6: 126,512,011 (GRCm39) T39K probably damaging Het
Klhl24 A G 16: 19,941,750 (GRCm39) D566G probably damaging Het
Kmt2a T A 9: 44,761,154 (GRCm39) K232* probably null Het
Krt36 A G 11: 99,996,061 (GRCm39) L121P probably damaging Het
Lama3 A T 18: 12,595,864 (GRCm39) H931L probably benign Het
Lamp3 A T 16: 19,474,141 (GRCm39) I411N probably damaging Het
Lingo3 C T 10: 80,670,610 (GRCm39) W440* probably null Het
Mia2 T C 12: 59,236,433 (GRCm39) Y712H probably damaging Het
Mlh1 T A 9: 111,059,145 (GRCm39) probably null Het
Mta3 T A 17: 84,070,363 (GRCm39) S174T probably benign Het
Myo15a A G 11: 60,381,963 (GRCm39) T347A Het
Naaladl2 C T 3: 23,900,718 (GRCm39) R704H possibly damaging Het
Nfib T C 4: 82,246,030 (GRCm39) N394S probably benign Het
Nr2f2 A G 7: 70,009,681 (GRCm39) Y133H probably damaging Het
Or2ak7 C T 11: 58,575,500 (GRCm39) S267F possibly damaging Het
Or2i1 C T 17: 37,508,047 (GRCm39) E196K probably damaging Het
Or4c115 A G 2: 88,927,932 (GRCm39) V113A possibly damaging Het
Or4f61 A T 2: 111,922,822 (GRCm39) C75S probably benign Het
Or5p62 T A 7: 107,771,391 (GRCm39) M187L probably benign Het
Phgdh C A 3: 98,247,124 (GRCm39) V9L probably damaging Het
Pkd2 T A 5: 104,628,103 (GRCm39) D392E probably damaging Het
Plekhm3 A G 1: 64,960,874 (GRCm39) S461P probably benign Het
Prss39 A G 1: 34,539,308 (GRCm39) T183A probably benign Het
Pter T A 2: 12,999,566 (GRCm39) I235K probably damaging Het
Ptp4a3 T C 15: 73,628,756 (GRCm39) V172A probably benign Het
Rasa2 T C 9: 96,484,780 (GRCm39) N145D probably benign Het
Rasal2 A T 1: 157,071,218 (GRCm39) H45Q probably benign Het
Rbm43 A G 2: 51,815,909 (GRCm39) V104A probably damaging Het
Rhbdd2 C A 5: 135,667,969 (GRCm39) probably null Het
Rictor C T 15: 6,801,635 (GRCm39) S441L probably benign Het
Rimbp2 T A 5: 128,838,528 (GRCm39) N1023I probably damaging Het
Rtl1 A T 12: 109,561,031 (GRCm39) D269E possibly damaging Het
Sbp A G 17: 24,161,163 (GRCm39) probably benign Het
Sorbs1 T A 19: 40,316,020 (GRCm39) T374S probably benign Het
Tgs1 A T 4: 3,598,652 (GRCm39) K655I probably benign Het
Thsd1 A C 8: 22,749,585 (GRCm39) T819P probably damaging Het
Tmprss11c C T 5: 86,379,655 (GRCm39) V418M probably damaging Het
Top2a A T 11: 98,900,431 (GRCm39) D645E probably damaging Het
Top2b G A 14: 16,413,081 (GRCm38) V997I possibly damaging Het
Ttc34 A G 4: 154,943,840 (GRCm39) D118G probably damaging Het
Ttll5 A G 12: 85,935,948 (GRCm39) D353G probably damaging Het
Uba6 A T 5: 86,265,924 (GRCm39) Y994* probably null Het
Vinac1 A C 2: 128,879,049 (GRCm39) V959G unknown Het
Vmn1r189 A T 13: 22,285,906 (GRCm39) Y310* probably null Het
Vps13c T A 9: 67,834,265 (GRCm39) I1644N probably damaging Het
Zfp811 T C 17: 33,017,821 (GRCm39) D73G possibly damaging Het
Zfp951 A T 5: 104,962,838 (GRCm39) C243S probably benign Het
Other mutations in Cdon
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Cdon APN 9 35,389,412 (GRCm39) missense probably damaging 1.00
IGL01307:Cdon APN 9 35,368,860 (GRCm39) missense probably benign 0.01
IGL01528:Cdon APN 9 35,381,403 (GRCm39) missense possibly damaging 0.95
IGL01663:Cdon APN 9 35,394,510 (GRCm39) missense possibly damaging 0.57
IGL01723:Cdon APN 9 35,414,634 (GRCm39) missense probably benign 0.05
IGL02200:Cdon APN 9 35,394,405 (GRCm39) missense probably benign 0.28
IGL02444:Cdon APN 9 35,384,744 (GRCm39) missense probably benign 0.09
IGL02547:Cdon APN 9 35,389,950 (GRCm39) missense probably damaging 1.00
IGL02620:Cdon APN 9 35,364,095 (GRCm39) missense probably benign 0.00
IGL02861:Cdon APN 9 35,398,253 (GRCm39) missense probably damaging 0.96
IGL02894:Cdon APN 9 35,366,722 (GRCm39) missense probably benign 0.01
IGL03153:Cdon APN 9 35,389,255 (GRCm39) missense probably damaging 1.00
IGL03206:Cdon APN 9 35,414,602 (GRCm39) missense probably benign
IGL03374:Cdon APN 9 35,389,299 (GRCm39) missense possibly damaging 0.46
corleone UTSW 9 35,398,252 (GRCm39) nonsense probably null
indentured UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
Molar UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
Servitude UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
PIT4280001:Cdon UTSW 9 35,398,231 (GRCm39) missense probably damaging 1.00
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0064:Cdon UTSW 9 35,400,523 (GRCm39) missense probably benign 0.03
R0396:Cdon UTSW 9 35,381,426 (GRCm39) missense probably damaging 1.00
R0403:Cdon UTSW 9 35,384,796 (GRCm39) missense probably benign 0.00
R0490:Cdon UTSW 9 35,363,978 (GRCm39) missense probably damaging 1.00
R0547:Cdon UTSW 9 35,368,794 (GRCm39) missense possibly damaging 0.88
R0609:Cdon UTSW 9 35,389,907 (GRCm39) missense probably damaging 1.00
R0645:Cdon UTSW 9 35,388,379 (GRCm39) splice site probably null
R0781:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1110:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1391:Cdon UTSW 9 35,415,485 (GRCm39) missense possibly damaging 0.51
R1574:Cdon UTSW 9 35,364,233 (GRCm39) splice site probably benign
R1851:Cdon UTSW 9 35,394,454 (GRCm39) missense probably damaging 1.00
R2031:Cdon UTSW 9 35,415,370 (GRCm39) missense probably damaging 0.96
R2230:Cdon UTSW 9 35,403,222 (GRCm39) critical splice donor site probably null
R3683:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3684:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3685:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3941:Cdon UTSW 9 35,375,467 (GRCm39) missense probably benign 0.09
R4030:Cdon UTSW 9 35,403,202 (GRCm39) missense probably damaging 1.00
R4084:Cdon UTSW 9 35,389,427 (GRCm39) missense probably damaging 0.98
R4462:Cdon UTSW 9 35,368,876 (GRCm39) missense probably damaging 0.97
R4569:Cdon UTSW 9 35,388,265 (GRCm39) missense probably damaging 1.00
R4677:Cdon UTSW 9 35,389,901 (GRCm39) missense probably damaging 1.00
R4869:Cdon UTSW 9 35,364,200 (GRCm39) missense possibly damaging 0.71
R5032:Cdon UTSW 9 35,400,330 (GRCm39) missense probably damaging 1.00
R5047:Cdon UTSW 9 35,389,935 (GRCm39) missense probably damaging 1.00
R5214:Cdon UTSW 9 35,394,504 (GRCm39) missense probably damaging 1.00
R5341:Cdon UTSW 9 35,381,431 (GRCm39) missense probably damaging 1.00
R5410:Cdon UTSW 9 35,381,331 (GRCm39) missense probably damaging 0.99
R5581:Cdon UTSW 9 35,415,377 (GRCm39) missense probably benign 0.01
R5696:Cdon UTSW 9 35,403,162 (GRCm39) missense possibly damaging 0.69
R5757:Cdon UTSW 9 35,364,068 (GRCm39) missense probably damaging 0.98
R5802:Cdon UTSW 9 35,365,716 (GRCm39) missense probably damaging 0.99
R5845:Cdon UTSW 9 35,368,762 (GRCm39) missense probably damaging 1.00
R5949:Cdon UTSW 9 35,398,247 (GRCm39) missense probably benign 0.32
R6106:Cdon UTSW 9 35,366,704 (GRCm39) nonsense probably null
R6245:Cdon UTSW 9 35,388,235 (GRCm39) missense probably damaging 1.00
R6845:Cdon UTSW 9 35,398,252 (GRCm39) nonsense probably null
R6896:Cdon UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
R7060:Cdon UTSW 9 35,398,205 (GRCm39) missense probably damaging 1.00
R7076:Cdon UTSW 9 35,415,446 (GRCm39) missense probably benign 0.00
R7184:Cdon UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
R7382:Cdon UTSW 9 35,389,944 (GRCm39) missense probably damaging 1.00
R7763:Cdon UTSW 9 35,365,711 (GRCm39) nonsense probably null
R7857:Cdon UTSW 9 35,367,908 (GRCm39) missense possibly damaging 0.79
R7885:Cdon UTSW 9 35,367,818 (GRCm39) missense probably benign 0.01
R7984:Cdon UTSW 9 35,414,598 (GRCm39) missense probably benign 0.00
R8287:Cdon UTSW 9 35,375,225 (GRCm39) missense probably benign
R8428:Cdon UTSW 9 35,403,163 (GRCm39) missense probably benign 0.21
R8519:Cdon UTSW 9 35,389,950 (GRCm39) missense probably damaging 1.00
R8698:Cdon UTSW 9 35,398,269 (GRCm39) critical splice donor site probably null
R8797:Cdon UTSW 9 35,389,931 (GRCm39) missense probably damaging 1.00
R8995:Cdon UTSW 9 35,398,093 (GRCm39) missense probably damaging 1.00
R9090:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9177:Cdon UTSW 9 35,381,230 (GRCm39) missense probably benign 0.00
R9200:Cdon UTSW 9 35,414,617 (GRCm39) missense probably benign 0.00
R9271:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9330:Cdon UTSW 9 35,400,275 (GRCm39) nonsense probably null
R9477:Cdon UTSW 9 35,403,201 (GRCm39) missense probably damaging 1.00
R9612:Cdon UTSW 9 35,398,201 (GRCm39) missense probably damaging 1.00
R9730:Cdon UTSW 9 35,398,263 (GRCm39) missense probably benign 0.00
Z1177:Cdon UTSW 9 35,403,196 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGCCTTTTAACACCAGGTCTG -3'
(R):5'- TATACTGTGCATGAATGGGTAGAG -3'

Sequencing Primer
(F):5'- GTCTGGAATTACCTACCCCTCAGAG -3'
(R):5'- GCATGAATGGGTAGAGTTGATATAAC -3'
Posted On 2019-12-20