Incidental Mutation 'R7896:Nrxn2'
| ID |
609727 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nrxn2
|
| Ensembl Gene |
ENSMUSG00000033768 |
| Gene Name |
neurexin II |
| Synonyms |
neurexin II alpha, neurexin II beta, 6430591O13Rik |
| MMRRC Submission |
045948-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7896 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
19 |
| Chromosomal Location |
6468786-6583247 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 6582083 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Lysine
at position 1673
(Q1673K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077182]
[ENSMUST00000113451]
[ENSMUST00000113458]
[ENSMUST00000113459]
[ENSMUST00000113461]
[ENSMUST00000113462]
[ENSMUST00000137166]
|
| AlphaFold |
E9Q7X7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077182
AA Change: Q1473K
PolyPhen 2
Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000076424
Gene: ENSMUSG00000033768
AA Change: Q1473K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
24 |
N/A |
INTRINSIC |
|
LamG
|
49 |
187 |
1.67e-33 |
SMART |
|
EGF
|
205 |
242 |
1.73e1 |
SMART |
|
low complexity region
|
268 |
276 |
N/A |
INTRINSIC |
|
LamG
|
310 |
444 |
1.18e-33 |
SMART |
|
LamG
|
498 |
651 |
1.51e-40 |
SMART |
|
EGF
|
678 |
712 |
8.91e-3 |
SMART |
|
LamG
|
737 |
875 |
4.91e-22 |
SMART |
|
LamG
|
923 |
1059 |
1.08e-41 |
SMART |
|
EGF
|
1084 |
1118 |
1.91e1 |
SMART |
|
LamG
|
1146 |
1303 |
4.48e-16 |
SMART |
|
low complexity region
|
1332 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1430 |
1445 |
N/A |
INTRINSIC |
|
4.1m
|
1448 |
1466 |
3.75e-4 |
SMART |
|
low complexity region
|
1480 |
1499 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113451
|
| SMART Domains |
Protein: ENSMUSP00000109078
Gene: ENSMUSG00000061742
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Sugar_tr
|
95 |
525 |
2e-26 |
PFAM |
|
Pfam:MFS_1
|
128 |
484 |
7.5e-26 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113458
AA Change: Q630K
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000109085
Gene: ENSMUSG00000033768
AA Change: Q630K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
46 |
N/A |
INTRINSIC |
|
low complexity region
|
49 |
69 |
N/A |
INTRINSIC |
|
LamG
|
111 |
268 |
4.48e-16 |
SMART |
|
low complexity region
|
297 |
327 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
404 |
N/A |
INTRINSIC |
|
low complexity region
|
587 |
602 |
N/A |
INTRINSIC |
|
4.1m
|
605 |
623 |
3.75e-4 |
SMART |
|
low complexity region
|
637 |
656 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113459
|
| SMART Domains |
Protein: ENSMUSP00000109086
Gene: ENSMUSG00000033768
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
46 |
N/A |
INTRINSIC |
|
low complexity region
|
49 |
69 |
N/A |
INTRINSIC |
|
LamG
|
111 |
238 |
1.26e-19 |
SMART |
|
low complexity region
|
267 |
297 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113461
AA Change: Q1610K
PolyPhen 2
Score 0.365 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000109088
Gene: ENSMUSG00000033768
AA Change: Q1610K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
24 |
N/A |
INTRINSIC |
|
LamG
|
49 |
187 |
1.67e-33 |
SMART |
|
EGF
|
205 |
242 |
1.73e1 |
SMART |
|
LamG
|
286 |
428 |
8.4e-30 |
SMART |
|
LamG
|
482 |
635 |
1.51e-40 |
SMART |
|
EGF
|
662 |
696 |
8.91e-3 |
SMART |
|
LamG
|
721 |
850 |
2.36e-24 |
SMART |
|
LamG
|
898 |
1034 |
1.08e-41 |
SMART |
|
EGF
|
1059 |
1093 |
1.91e1 |
SMART |
|
LamG
|
1121 |
1248 |
1.26e-19 |
SMART |
|
low complexity region
|
1277 |
1307 |
N/A |
INTRINSIC |
|
low complexity region
|
1363 |
1384 |
N/A |
INTRINSIC |
|
low complexity region
|
1567 |
1582 |
N/A |
INTRINSIC |
|
4.1m
|
1585 |
1603 |
3.75e-4 |
SMART |
|
low complexity region
|
1617 |
1636 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000113462
AA Change: Q1673K
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000109089
Gene: ENSMUSG00000033768
AA Change: Q1673K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
24 |
N/A |
INTRINSIC |
|
LamG
|
49 |
187 |
1.67e-33 |
SMART |
|
EGF
|
205 |
242 |
1.73e1 |
SMART |
|
low complexity region
|
268 |
276 |
N/A |
INTRINSIC |
|
LamG
|
310 |
452 |
8.4e-30 |
SMART |
|
LamG
|
506 |
659 |
1.51e-40 |
SMART |
|
EGF
|
686 |
720 |
8.91e-3 |
SMART |
|
LamG
|
745 |
883 |
4.91e-22 |
SMART |
|
LamG
|
931 |
1067 |
1.08e-41 |
SMART |
|
EGF
|
1092 |
1126 |
1.91e1 |
SMART |
|
LamG
|
1154 |
1311 |
4.48e-16 |
SMART |
|
low complexity region
|
1340 |
1370 |
N/A |
INTRINSIC |
|
low complexity region
|
1426 |
1447 |
N/A |
INTRINSIC |
|
low complexity region
|
1630 |
1645 |
N/A |
INTRINSIC |
|
4.1m
|
1648 |
1666 |
3.75e-4 |
SMART |
|
low complexity region
|
1680 |
1699 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000137166
AA Change: Q1680K
PolyPhen 2
Score 0.737 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000119762
Gene: ENSMUSG00000033768
AA Change: Q1680K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
24 |
N/A |
INTRINSIC |
|
LamG
|
49 |
187 |
1.67e-33 |
SMART |
|
EGF
|
205 |
242 |
1.73e1 |
SMART |
|
low complexity region
|
268 |
276 |
N/A |
INTRINSIC |
|
LamG
|
310 |
459 |
8.87e-29 |
SMART |
|
LamG
|
513 |
666 |
1.51e-40 |
SMART |
|
EGF
|
693 |
727 |
8.91e-3 |
SMART |
|
LamG
|
752 |
890 |
4.91e-22 |
SMART |
|
LamG
|
938 |
1074 |
1.08e-41 |
SMART |
|
EGF
|
1099 |
1133 |
1.91e1 |
SMART |
|
LamG
|
1161 |
1318 |
4.48e-16 |
SMART |
|
low complexity region
|
1347 |
1377 |
N/A |
INTRINSIC |
|
low complexity region
|
1433 |
1454 |
N/A |
INTRINSIC |
|
low complexity region
|
1637 |
1652 |
N/A |
INTRINSIC |
|
4.1m
|
1655 |
1673 |
3.75e-4 |
SMART |
|
low complexity region
|
1687 |
1706 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (82/83) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are generally non-viable; surviving homozygotes show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca7 |
A |
G |
10: 79,840,792 (GRCm39) |
T894A |
probably damaging |
Het |
| Abcc10 |
T |
A |
17: 46,635,235 (GRCm39) |
H256L |
probably benign |
Het |
| Abcc6 |
A |
G |
7: 45,626,803 (GRCm39) |
L1418P |
probably damaging |
Het |
| Actn2 |
G |
A |
13: 12,309,203 (GRCm39) |
A290V |
possibly damaging |
Het |
| Actrt2 |
A |
T |
4: 154,751,652 (GRCm39) |
D161E |
probably benign |
Het |
| Adam19 |
T |
A |
11: 46,028,370 (GRCm39) |
C668S |
probably damaging |
Het |
| Alg8 |
T |
C |
7: 97,040,123 (GRCm39) |
L435S |
probably damaging |
Het |
| Amz2 |
G |
A |
11: 109,327,413 (GRCm39) |
E322K |
possibly damaging |
Het |
| Ankrd12 |
T |
A |
17: 66,292,680 (GRCm39) |
R918* |
probably null |
Het |
| Atp5pb |
A |
G |
3: 105,863,259 (GRCm39) |
I59T |
probably damaging |
Het |
| Bach1 |
T |
A |
16: 87,515,893 (GRCm39) |
C145S |
possibly damaging |
Het |
| Bcl6b |
G |
T |
11: 70,117,848 (GRCm39) |
S309* |
probably null |
Het |
| Birc6 |
G |
T |
17: 74,929,077 (GRCm39) |
R2323L |
probably damaging |
Het |
| Catspere2 |
A |
T |
1: 177,938,740 (GRCm39) |
M538L |
probably benign |
Het |
| Ccdc154 |
A |
T |
17: 25,390,800 (GRCm39) |
M647L |
probably benign |
Het |
| Cdc14a |
T |
C |
3: 116,088,482 (GRCm39) |
T447A |
probably benign |
Het |
| Chst9 |
C |
T |
18: 15,585,846 (GRCm39) |
R239H |
probably damaging |
Het |
| Cs |
C |
T |
10: 128,189,004 (GRCm39) |
A171V |
probably damaging |
Het |
| D3Ertd751e |
T |
A |
3: 41,710,508 (GRCm39) |
F107I |
probably benign |
Het |
| D430041D05Rik |
T |
C |
2: 104,088,385 (GRCm39) |
D197G |
probably benign |
Het |
| Dcdc2c |
G |
A |
12: 28,520,619 (GRCm39) |
Q486* |
probably null |
Het |
| Dolk |
A |
T |
2: 30,175,961 (GRCm39) |
V28E |
possibly damaging |
Het |
| Dpf2 |
C |
T |
19: 5,954,333 (GRCm39) |
S191N |
probably benign |
Het |
| Eml3 |
T |
A |
19: 8,911,171 (GRCm39) |
F267I |
possibly damaging |
Het |
| Entrep2 |
T |
C |
7: 64,426,557 (GRCm39) |
H232R |
probably damaging |
Het |
| Fam184a |
C |
A |
10: 53,509,802 (GRCm39) |
E126* |
probably null |
Het |
| Foxo3 |
T |
C |
10: 42,073,732 (GRCm39) |
S262G |
possibly damaging |
Het |
| Gm1527 |
T |
G |
3: 28,975,742 (GRCm39) |
|
probably null |
Het |
| Gm49380 |
G |
A |
9: 44,024,096 (GRCm39) |
L51F |
probably damaging |
Het |
| Gm9195 |
A |
T |
14: 72,693,178 (GRCm39) |
H1582Q |
unknown |
Het |
| Grip1 |
A |
G |
10: 119,814,450 (GRCm39) |
Q327R |
possibly damaging |
Het |
| Gstt1 |
A |
G |
10: 75,619,976 (GRCm39) |
F207S |
probably damaging |
Het |
| Itsn1 |
G |
A |
16: 91,615,446 (GRCm39) |
R397H |
unknown |
Het |
| Kif16b |
A |
G |
2: 142,675,995 (GRCm39) |
|
probably null |
Het |
| Kif5a |
A |
G |
10: 127,077,873 (GRCm39) |
V407A |
probably benign |
Het |
| Lrrc57 |
C |
A |
2: 120,438,372 (GRCm39) |
D134Y |
probably damaging |
Het |
| Map1a |
A |
G |
2: 121,135,657 (GRCm39) |
T2158A |
probably benign |
Het |
| Mink1 |
A |
G |
11: 70,503,108 (GRCm39) |
N1068S |
possibly damaging |
Het |
| Mmp8 |
A |
T |
9: 7,564,978 (GRCm39) |
I295F |
probably damaging |
Het |
| Muc21 |
G |
A |
17: 35,930,917 (GRCm39) |
P1090S |
unknown |
Het |
| Mup18 |
G |
T |
4: 61,590,925 (GRCm39) |
|
probably null |
Het |
| Myo1h |
G |
T |
5: 114,474,372 (GRCm39) |
|
probably null |
Het |
| Nap1l5 |
C |
T |
6: 58,883,505 (GRCm39) |
G52S |
probably damaging |
Het |
| Npr3 |
A |
G |
15: 11,883,448 (GRCm39) |
F327S |
probably damaging |
Het |
| Or13a20 |
G |
T |
7: 140,232,814 (GRCm39) |
L307F |
probably benign |
Het |
| Or2r3 |
T |
A |
6: 42,449,100 (GRCm39) |
D4V |
probably benign |
Het |
| Paf1 |
T |
C |
7: 28,096,072 (GRCm39) |
Y260H |
probably damaging |
Het |
| Pcmtd2 |
T |
C |
2: 181,496,776 (GRCm39) |
I251T |
probably damaging |
Het |
| Pde9a |
C |
T |
17: 31,678,941 (GRCm39) |
Q261* |
probably null |
Het |
| Ppip5k1 |
T |
C |
2: 121,177,811 (GRCm39) |
D332G |
probably damaging |
Het |
| Ppl |
C |
T |
16: 4,906,725 (GRCm39) |
R1190H |
probably damaging |
Het |
| Ppp1r36 |
A |
G |
12: 76,474,923 (GRCm39) |
|
probably null |
Het |
| Pprc1 |
T |
C |
19: 46,049,888 (GRCm39) |
L67P |
unknown |
Het |
| Prkdc |
T |
G |
16: 15,526,767 (GRCm39) |
L1346R |
probably damaging |
Het |
| Prl7c1 |
A |
T |
13: 27,962,070 (GRCm39) |
M79K |
possibly damaging |
Het |
| Ptprb |
C |
T |
10: 116,205,362 (GRCm39) |
|
probably null |
Het |
| R3hdm1 |
T |
A |
1: 128,096,703 (GRCm39) |
|
probably null |
Het |
| Ralgapa1 |
A |
G |
12: 55,744,663 (GRCm39) |
V1276A |
probably benign |
Het |
| Rapsn |
T |
C |
2: 90,875,300 (GRCm39) |
L361P |
probably benign |
Het |
| Rbm22 |
G |
T |
18: 60,702,505 (GRCm39) |
A275S |
probably benign |
Het |
| Rsph3a |
A |
G |
17: 8,164,940 (GRCm39) |
Y100C |
probably damaging |
Het |
| Rsrp1 |
A |
T |
4: 134,651,274 (GRCm39) |
M13L |
unknown |
Het |
| Rtn4 |
T |
G |
11: 29,655,536 (GRCm39) |
D169E |
probably damaging |
Het |
| Setd7 |
C |
A |
3: 51,444,077 (GRCm39) |
|
probably null |
Het |
| Slc38a2 |
A |
G |
15: 96,591,466 (GRCm39) |
I206T |
probably damaging |
Het |
| Slc9a8 |
T |
C |
2: 167,307,278 (GRCm39) |
F321L |
probably benign |
Het |
| Sppl2c |
A |
G |
11: 104,077,956 (GRCm39) |
D252G |
possibly damaging |
Het |
| Srgap1 |
CTACCTCCTCTTAGGGACCACGCCCACCCCCTCCCAGGGACCATGCTTACCTCCTCTTAGGGACCACGCCCACCCCCTCCCAGGGACCATGCTTACCTCCTC |
CTACCTCCTCTTAGGGACCACGCCCACCCCCTCCCAGGGACCATGCTTACCTCCTC |
10: 121,689,458 (GRCm39) |
|
probably benign |
Het |
| Syne2 |
A |
G |
12: 76,082,397 (GRCm39) |
T117A |
probably damaging |
Het |
| Szt2 |
A |
T |
4: 118,260,110 (GRCm39) |
F79I |
possibly damaging |
Het |
| Tlr3 |
T |
A |
8: 45,850,090 (GRCm39) |
K860* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,625,018 (GRCm39) |
S15187G |
probably benign |
Het |
| Ubr5 |
A |
G |
15: 38,041,817 (GRCm39) |
V204A |
probably benign |
Het |
| Unc5c |
A |
T |
3: 141,476,922 (GRCm39) |
T363S |
possibly damaging |
Het |
| Usp40 |
G |
A |
1: 87,906,201 (GRCm39) |
T678I |
possibly damaging |
Het |
| Vmn1r62 |
A |
T |
7: 5,678,609 (GRCm39) |
T97S |
probably damaging |
Het |
| Vmn1r85 |
T |
A |
7: 12,818,448 (GRCm39) |
H232L |
probably benign |
Het |
| Vmn2r67 |
A |
G |
7: 84,785,920 (GRCm39) |
I695T |
probably damaging |
Het |
| Zfp383 |
C |
A |
7: 29,611,626 (GRCm39) |
D35E |
probably damaging |
Het |
| Zfp65 |
A |
T |
13: 67,877,174 (GRCm39) |
|
probably null |
Het |
| Zfp692 |
A |
G |
11: 58,205,062 (GRCm39) |
K437R |
probably damaging |
Het |
| Zfp831 |
A |
T |
2: 174,488,921 (GRCm39) |
T1199S |
possibly damaging |
Het |
| Zfr |
T |
A |
15: 12,146,463 (GRCm39) |
I338N |
probably damaging |
Het |
|
| Other mutations in Nrxn2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00490:Nrxn2
|
APN |
19 |
6,523,623 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01020:Nrxn2
|
APN |
19 |
6,543,473 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01064:Nrxn2
|
APN |
19 |
6,567,083 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01561:Nrxn2
|
APN |
19 |
6,540,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01759:Nrxn2
|
APN |
19 |
6,559,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02071:Nrxn2
|
APN |
19 |
6,531,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02085:Nrxn2
|
APN |
19 |
6,542,898 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02132:Nrxn2
|
APN |
19 |
6,522,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02476:Nrxn2
|
APN |
19 |
6,505,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02605:Nrxn2
|
APN |
19 |
6,500,610 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03123:Nrxn2
|
APN |
19 |
6,531,767 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03288:Nrxn2
|
APN |
19 |
6,540,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4687001:Nrxn2
|
UTSW |
19 |
6,531,338 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0019:Nrxn2
|
UTSW |
19 |
6,559,987 (GRCm39) |
splice site |
probably benign |
|
|
R0257:Nrxn2
|
UTSW |
19 |
6,540,728 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0305:Nrxn2
|
UTSW |
19 |
6,569,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0453:Nrxn2
|
UTSW |
19 |
6,541,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Nrxn2
|
UTSW |
19 |
6,567,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Nrxn2
|
UTSW |
19 |
6,543,434 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0571:Nrxn2
|
UTSW |
19 |
6,523,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1373:Nrxn2
|
UTSW |
19 |
6,522,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1434:Nrxn2
|
UTSW |
19 |
6,493,642 (GRCm39) |
splice site |
probably null |
|
|
R1454:Nrxn2
|
UTSW |
19 |
6,531,476 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1671:Nrxn2
|
UTSW |
19 |
6,523,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1692:Nrxn2
|
UTSW |
19 |
6,569,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1858:Nrxn2
|
UTSW |
19 |
6,538,825 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1859:Nrxn2
|
UTSW |
19 |
6,538,825 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2153:Nrxn2
|
UTSW |
19 |
6,554,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2196:Nrxn2
|
UTSW |
19 |
6,540,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Nrxn2
|
UTSW |
19 |
6,543,037 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2278:Nrxn2
|
UTSW |
19 |
6,531,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2441:Nrxn2
|
UTSW |
19 |
6,478,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3897:Nrxn2
|
UTSW |
19 |
6,569,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3943:Nrxn2
|
UTSW |
19 |
6,523,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4091:Nrxn2
|
UTSW |
19 |
6,523,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4162:Nrxn2
|
UTSW |
19 |
6,582,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Nrxn2
|
UTSW |
19 |
6,582,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4495:Nrxn2
|
UTSW |
19 |
6,581,429 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4599:Nrxn2
|
UTSW |
19 |
6,505,282 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4735:Nrxn2
|
UTSW |
19 |
6,548,484 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4757:Nrxn2
|
UTSW |
19 |
6,559,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4890:Nrxn2
|
UTSW |
19 |
6,498,308 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5052:Nrxn2
|
UTSW |
19 |
6,505,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Nrxn2
|
UTSW |
19 |
6,581,428 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5330:Nrxn2
|
UTSW |
19 |
6,540,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5331:Nrxn2
|
UTSW |
19 |
6,540,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5530:Nrxn2
|
UTSW |
19 |
6,548,397 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5556:Nrxn2
|
UTSW |
19 |
6,540,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Nrxn2
|
UTSW |
19 |
6,581,369 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5829:Nrxn2
|
UTSW |
19 |
6,540,879 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5988:Nrxn2
|
UTSW |
19 |
6,542,901 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6003:Nrxn2
|
UTSW |
19 |
6,548,358 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6032:Nrxn2
|
UTSW |
19 |
6,567,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6032:Nrxn2
|
UTSW |
19 |
6,567,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6288:Nrxn2
|
UTSW |
19 |
6,540,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6334:Nrxn2
|
UTSW |
19 |
6,581,322 (GRCm39) |
splice site |
probably null |
|
|
R6373:Nrxn2
|
UTSW |
19 |
6,559,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6397:Nrxn2
|
UTSW |
19 |
6,582,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6669:Nrxn2
|
UTSW |
19 |
6,531,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6980:Nrxn2
|
UTSW |
19 |
6,500,609 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6985:Nrxn2
|
UTSW |
19 |
6,531,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7184:Nrxn2
|
UTSW |
19 |
6,540,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nrxn2
|
UTSW |
19 |
6,567,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7576:Nrxn2
|
UTSW |
19 |
6,581,540 (GRCm39) |
nonsense |
probably null |
|
|
R7604:Nrxn2
|
UTSW |
19 |
6,581,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7631:Nrxn2
|
UTSW |
19 |
6,531,825 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7768:Nrxn2
|
UTSW |
19 |
6,531,409 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7805:Nrxn2
|
UTSW |
19 |
6,581,736 (GRCm39) |
missense |
probably benign |
|
|
R7998:Nrxn2
|
UTSW |
19 |
6,559,905 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8383:Nrxn2
|
UTSW |
19 |
6,522,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8505:Nrxn2
|
UTSW |
19 |
6,540,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8843:Nrxn2
|
UTSW |
19 |
6,555,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Nrxn2
|
UTSW |
19 |
6,554,920 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9086:Nrxn2
|
UTSW |
19 |
6,540,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9139:Nrxn2
|
UTSW |
19 |
6,498,299 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9420:Nrxn2
|
UTSW |
19 |
6,581,931 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9445:Nrxn2
|
UTSW |
19 |
6,522,448 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9564:Nrxn2
|
UTSW |
19 |
6,559,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9609:Nrxn2
|
UTSW |
19 |
6,540,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9708:Nrxn2
|
UTSW |
19 |
6,581,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9794:Nrxn2
|
UTSW |
19 |
6,567,064 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
X0022:Nrxn2
|
UTSW |
19 |
6,559,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nrxn2
|
UTSW |
19 |
6,548,547 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACGACGAGGACTTTTACACTAC -3'
(R):5'- TTTCCTCTTCGTGGGAGAAGC -3'
Sequencing Primer
(F):5'- CCAACCTCAGGACAGATGGG -3'
(R):5'- CTCTTCGTGGGAGAAGCCTGAG -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation