Incidental Mutation 'R7899:Dido1'
| ID |
609863 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dido1
|
| Ensembl Gene |
ENSMUSG00000038914 |
| Gene Name |
death inducer-obliterator 1 |
| Synonyms |
D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik |
| MMRRC Submission |
045951-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.960)
|
| Stock # |
R7899 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
180299757-180351792 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 180313390 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 961
(S961T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000084794
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037764]
[ENSMUST00000087517]
[ENSMUST00000103056]
[ENSMUST00000103057]
|
| AlphaFold |
Q8C9B9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000037764
AA Change: S421T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000048315
Gene: ENSMUSG00000038914
AA Change: S421T
| Domain | Start | End | E-Value | Type |
|---|
|
TFS2M
|
129 |
230 |
1.16e-45 |
SMART |
|
low complexity region
|
397 |
422 |
N/A |
INTRINSIC |
|
low complexity region
|
483 |
497 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
512 |
618 |
4.9e-23 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000087517
AA Change: S961T
PolyPhen 2
Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: S961T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
1e-22 |
PFAM |
|
low complexity region
|
1253 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1391 |
N/A |
INTRINSIC |
|
coiled coil region
|
1458 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1748 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1780 |
1792 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1815 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1816 |
1852 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1819 |
1859 |
6.92e-7 |
PROSPERO |
|
internal_repeat_2
|
1926 |
1964 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1940 |
1982 |
6.92e-7 |
PROSPERO |
|
low complexity region
|
2025 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2123 |
2160 |
N/A |
INTRINSIC |
|
low complexity region
|
2163 |
2177 |
N/A |
INTRINSIC |
|
low complexity region
|
2182 |
2239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000103056
AA Change: S961T
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000099345
Gene: ENSMUSG00000038914
AA Change: S961T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000103057
AA Change: S961T
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000099346
Gene: ENSMUSG00000038914
AA Change: S961T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Meta Mutation Damage Score |
0.1023 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
97% (70/72) |
| MGI Phenotype |
FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(245) : Targeted, knock-out(1) Gene trapped(244) |
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1500011B03Rik |
T |
C |
5: 114,947,381 (GRCm39) |
T49A |
possibly damaging |
Het |
| A530084C06Rik |
G |
T |
13: 31,742,978 (GRCm39) |
R92S |
unknown |
Het |
| Aagab |
T |
C |
9: 63,524,132 (GRCm39) |
F80L |
probably benign |
Het |
| Aox1 |
A |
G |
1: 58,320,396 (GRCm39) |
|
probably null |
Het |
| Arhgef2 |
T |
C |
3: 88,528,569 (GRCm39) |
S2P |
probably damaging |
Het |
| Bcar3 |
T |
G |
3: 122,301,902 (GRCm39) |
V199G |
probably damaging |
Het |
| C1ra |
G |
A |
6: 124,494,684 (GRCm39) |
E316K |
probably benign |
Het |
| Cacna1a |
G |
A |
8: 85,320,802 (GRCm39) |
V1587M |
possibly damaging |
Het |
| Caps2 |
C |
A |
10: 112,001,666 (GRCm39) |
S19Y |
possibly damaging |
Het |
| Ccdc196 |
A |
G |
12: 78,244,196 (GRCm39) |
N50D |
|
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Cobll1 |
A |
G |
2: 64,956,275 (GRCm39) |
C328R |
probably damaging |
Het |
| Colec11 |
A |
C |
12: 28,645,281 (GRCm39) |
V130G |
probably damaging |
Het |
| Dennd5b |
A |
T |
6: 148,943,159 (GRCm39) |
D572E |
probably damaging |
Het |
| Dnah7c |
A |
T |
1: 46,553,861 (GRCm39) |
M380L |
probably benign |
Het |
| Dnai2 |
T |
C |
11: 114,629,456 (GRCm39) |
I161T |
probably benign |
Het |
| Dnttip2 |
T |
A |
3: 122,076,018 (GRCm39) |
M650K |
probably damaging |
Het |
| Dpp6 |
C |
T |
5: 27,926,077 (GRCm39) |
P717L |
probably benign |
Het |
| Epha10 |
A |
G |
4: 124,808,628 (GRCm39) |
E759G |
|
Het |
| Frmd4a |
T |
C |
2: 4,608,900 (GRCm39) |
W923R |
probably damaging |
Het |
| Ftsj3 |
C |
A |
11: 106,143,115 (GRCm39) |
E400* |
probably null |
Het |
| Gabra4 |
C |
A |
5: 71,815,338 (GRCm39) |
|
probably benign |
Het |
| Gfm1 |
T |
A |
3: 67,380,860 (GRCm39) |
N658K |
probably benign |
Het |
| Gm21560 |
A |
T |
14: 6,218,220 (GRCm38) |
I86N |
probably damaging |
Het |
| Gpr68 |
C |
A |
12: 100,844,707 (GRCm39) |
C279F |
probably damaging |
Het |
| Hspg2 |
G |
A |
4: 137,275,427 (GRCm39) |
A2752T |
possibly damaging |
Het |
| Hydin |
A |
T |
8: 111,314,380 (GRCm39) |
D4288V |
probably benign |
Het |
| Ift74 |
A |
G |
4: 94,510,214 (GRCm39) |
T82A |
possibly damaging |
Het |
| Ints7 |
T |
A |
1: 191,353,427 (GRCm39) |
W918R |
probably damaging |
Het |
| Kcnc1 |
T |
A |
7: 46,077,245 (GRCm39) |
I349N |
probably damaging |
Het |
| Loxl1 |
C |
T |
9: 58,198,117 (GRCm39) |
D580N |
probably damaging |
Het |
| Mlph |
A |
T |
1: 90,869,485 (GRCm39) |
R496* |
probably null |
Het |
| Mtdh |
A |
G |
15: 34,123,865 (GRCm39) |
D364G |
possibly damaging |
Het |
| Mtmr11 |
C |
A |
3: 96,077,744 (GRCm39) |
L580I |
probably damaging |
Het |
| Muc16 |
T |
C |
9: 18,551,993 (GRCm39) |
I4767V |
probably benign |
Het |
| Muc21 |
TCAGGGTGGGGGTAGAGCCTGAGCCACTGCTAGATGCAGTGGTGGGCAGGGTGGGGGTAGAGCCTGAG |
TCAGGGTGGGGGTAGAGCCTGAG |
17: 35,931,493 (GRCm39) |
|
probably benign |
Het |
| Myot |
A |
G |
18: 44,487,251 (GRCm39) |
T363A |
probably benign |
Het |
| Nfxl1 |
G |
A |
5: 72,681,558 (GRCm39) |
P658S |
probably damaging |
Het |
| Nhlrc3 |
A |
C |
3: 53,369,080 (GRCm39) |
S120A |
probably benign |
Het |
| Nmur2 |
C |
A |
11: 55,931,161 (GRCm39) |
Q183H |
probably benign |
Het |
| Nucb2 |
T |
A |
7: 116,121,205 (GRCm39) |
I45K |
probably benign |
Het |
| Nup155 |
A |
T |
15: 8,148,663 (GRCm39) |
D277V |
probably damaging |
Het |
| Or5ak25 |
T |
C |
2: 85,268,741 (GRCm39) |
T254A |
probably benign |
Het |
| Orc1 |
T |
G |
4: 108,460,568 (GRCm39) |
|
probably null |
Het |
| Panx2 |
A |
G |
15: 88,952,936 (GRCm39) |
T468A |
possibly damaging |
Het |
| Pcdh7 |
A |
G |
5: 57,877,152 (GRCm39) |
S236G |
probably benign |
Het |
| Pcdhga2 |
G |
C |
18: 37,803,910 (GRCm39) |
G585R |
probably damaging |
Het |
| Perm1 |
TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT |
TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT |
4: 156,302,525 (GRCm39) |
|
probably benign |
Het |
| Pgr |
T |
G |
9: 8,903,743 (GRCm39) |
M588R |
probably benign |
Het |
| Ptpn18 |
A |
T |
1: 34,508,986 (GRCm39) |
|
probably null |
Het |
| Rbm8a2 |
T |
A |
1: 175,806,207 (GRCm39) |
H90L |
probably benign |
Het |
| Ryr3 |
A |
T |
2: 112,477,295 (GRCm39) |
L4507Q |
possibly damaging |
Het |
| Serpina12 |
A |
G |
12: 104,004,524 (GRCm39) |
V36A |
probably benign |
Het |
| Sis |
T |
A |
3: 72,844,584 (GRCm39) |
S717C |
probably damaging |
Het |
| Slit2 |
A |
G |
5: 48,404,527 (GRCm39) |
E846G |
possibly damaging |
Het |
| Smr3a |
C |
T |
5: 88,156,086 (GRCm39) |
H85Y |
unknown |
Het |
| Sned1 |
G |
C |
1: 93,201,804 (GRCm39) |
R590P |
probably benign |
Het |
| Spata31h1 |
A |
G |
10: 82,118,731 (GRCm39) |
S4760P |
unknown |
Het |
| Sting1 |
A |
G |
18: 35,867,626 (GRCm39) |
S357P |
probably damaging |
Het |
| Sult2a7 |
A |
G |
7: 14,199,134 (GRCm39) |
Y298H |
probably damaging |
Het |
| Syn3 |
A |
G |
10: 85,900,793 (GRCm39) |
V365A |
possibly damaging |
Het |
| Syne1 |
A |
T |
10: 5,177,956 (GRCm39) |
Y4839* |
probably null |
Het |
| Taf4 |
G |
A |
2: 179,573,822 (GRCm39) |
T682M |
probably damaging |
Het |
| Tbl3 |
G |
T |
17: 24,921,458 (GRCm39) |
H478N |
probably damaging |
Het |
| Tcirg1 |
A |
T |
19: 3,949,104 (GRCm39) |
I395N |
probably damaging |
Het |
| Ticrr |
T |
C |
7: 79,319,233 (GRCm39) |
I406T |
probably benign |
Het |
| Tmem120a |
C |
A |
5: 135,766,052 (GRCm39) |
K123N |
probably benign |
Het |
| Tmem184c |
A |
G |
8: 78,324,440 (GRCm39) |
V350A |
probably damaging |
Het |
| Tmem70 |
G |
T |
1: 16,747,268 (GRCm39) |
M128I |
probably benign |
Het |
| Tmx3 |
A |
T |
18: 90,545,998 (GRCm39) |
|
probably null |
Het |
| Topors |
G |
C |
4: 40,260,356 (GRCm39) |
S976W |
unknown |
Het |
| Trp53 |
T |
C |
11: 69,481,519 (GRCm39) |
L341P |
probably damaging |
Het |
| Usp14 |
T |
C |
18: 10,000,563 (GRCm39) |
K366E |
possibly damaging |
Het |
| Zbtb49 |
G |
T |
5: 38,371,274 (GRCm39) |
C202* |
probably null |
Het |
| Zkscan5 |
A |
C |
5: 145,157,676 (GRCm39) |
H726P |
probably damaging |
Het |
|
| Other mutations in Dido1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Dido1
|
APN |
2 |
180,325,782 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Dido1
|
APN |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01317:Dido1
|
APN |
2 |
180,313,550 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01588:Dido1
|
APN |
2 |
180,330,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01834:Dido1
|
APN |
2 |
180,325,824 (GRCm39) |
splice site |
probably benign |
|
|
IGL02102:Dido1
|
APN |
2 |
180,304,040 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL02556:Dido1
|
APN |
2 |
180,331,128 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02756:Dido1
|
APN |
2 |
180,303,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02826:Dido1
|
APN |
2 |
180,325,751 (GRCm39) |
missense |
probably benign |
|
|
IGL02970:Dido1
|
APN |
2 |
180,331,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03110:Dido1
|
APN |
2 |
180,331,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03116:Dido1
|
APN |
2 |
180,312,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3370:Dido1
|
UTSW |
2 |
180,313,335 (GRCm39) |
missense |
probably benign |
|
|
A4554:Dido1
|
UTSW |
2 |
180,317,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8441:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0127:Dido1
|
UTSW |
2 |
180,313,617 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0620:Dido1
|
UTSW |
2 |
180,301,644 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0734:Dido1
|
UTSW |
2 |
180,301,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1390:Dido1
|
UTSW |
2 |
180,326,917 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1445:Dido1
|
UTSW |
2 |
180,313,263 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dido1
|
UTSW |
2 |
180,302,513 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Dido1
|
UTSW |
2 |
180,326,763 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1584:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Dido1
|
UTSW |
2 |
180,301,378 (GRCm39) |
missense |
unknown |
|
|
R2025:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2026:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2027:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2089:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2495:Dido1
|
UTSW |
2 |
180,331,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2931:Dido1
|
UTSW |
2 |
180,303,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Dido1
|
UTSW |
2 |
180,302,728 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3735:Dido1
|
UTSW |
2 |
180,325,829 (GRCm39) |
splice site |
probably benign |
|
|
R4523:Dido1
|
UTSW |
2 |
180,314,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Dido1
|
UTSW |
2 |
180,329,352 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4729:Dido1
|
UTSW |
2 |
180,329,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4762:Dido1
|
UTSW |
2 |
180,331,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4786:Dido1
|
UTSW |
2 |
180,312,664 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4817:Dido1
|
UTSW |
2 |
180,303,209 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4892:Dido1
|
UTSW |
2 |
180,316,822 (GRCm39) |
nonsense |
probably null |
|
|
R4979:Dido1
|
UTSW |
2 |
180,302,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5510:Dido1
|
UTSW |
2 |
180,326,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Dido1
|
UTSW |
2 |
180,301,445 (GRCm39) |
nonsense |
probably null |
|
|
R5672:Dido1
|
UTSW |
2 |
180,313,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5863:Dido1
|
UTSW |
2 |
180,303,566 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5943:Dido1
|
UTSW |
2 |
180,303,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5974:Dido1
|
UTSW |
2 |
180,313,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6123:Dido1
|
UTSW |
2 |
180,325,760 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6214:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Dido1
|
UTSW |
2 |
180,302,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Dido1
|
UTSW |
2 |
180,302,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6349:Dido1
|
UTSW |
2 |
180,302,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6437:Dido1
|
UTSW |
2 |
180,316,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Dido1
|
UTSW |
2 |
180,302,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6836:Dido1
|
UTSW |
2 |
180,304,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7055:Dido1
|
UTSW |
2 |
180,303,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7289:Dido1
|
UTSW |
2 |
180,301,424 (GRCm39) |
missense |
unknown |
|
|
R7304:Dido1
|
UTSW |
2 |
180,329,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Dido1
|
UTSW |
2 |
180,316,914 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7363:Dido1
|
UTSW |
2 |
180,304,310 (GRCm39) |
nonsense |
probably null |
|
|
R7429:Dido1
|
UTSW |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7594:Dido1
|
UTSW |
2 |
180,316,905 (GRCm39) |
missense |
probably benign |
|
|
R7629:Dido1
|
UTSW |
2 |
180,303,266 (GRCm39) |
missense |
probably benign |
|
|
R7946:Dido1
|
UTSW |
2 |
180,303,501 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7951:Dido1
|
UTSW |
2 |
180,312,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8033:Dido1
|
UTSW |
2 |
180,316,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Dido1
|
UTSW |
2 |
180,302,705 (GRCm39) |
missense |
probably benign |
|
|
R8331:Dido1
|
UTSW |
2 |
180,302,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8479:Dido1
|
UTSW |
2 |
180,315,022 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8936:Dido1
|
UTSW |
2 |
180,303,195 (GRCm39) |
missense |
probably benign |
|
|
R9089:Dido1
|
UTSW |
2 |
180,303,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9647:Dido1
|
UTSW |
2 |
180,315,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9648:Dido1
|
UTSW |
2 |
180,302,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9784:Dido1
|
UTSW |
2 |
180,325,354 (GRCm39) |
missense |
probably benign |
0.27 |
|
V1024:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0011:Dido1
|
UTSW |
2 |
180,302,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Dido1
|
UTSW |
2 |
180,313,365 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGTACTGACAGGTATCTCGG -3'
(R):5'- TCCTAACACTGCTGATGAAGGG -3'
Sequencing Primer
(F):5'- ACTGACAGGTATCTCGGGTCAG -3'
(R):5'- CTAACACTGCTGATGAAGGGATTGC -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation