Incidental Mutation 'R7902:Zfp933'
| ID |
610033 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp933
|
| Ensembl Gene |
ENSMUSG00000059423 |
| Gene Name |
zinc finger protein 933 |
| Synonyms |
2810408P10Rik |
| MMRRC Submission |
045954-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
R7902 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
147907443-147932823 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 147911058 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 179
(R179S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101343
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105718]
[ENSMUST00000135798]
|
| AlphaFold |
Q6PEE4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105718
AA Change: R179S
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000101343
Gene: ENSMUSG00000059423
AA Change: R179S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
9.49e-16 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
4.79e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135798
|
| SMART Domains |
Protein: ENSMUSP00000118300
Gene: ENSMUSG00000059423
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
34 |
8e-18 |
BLAST |
|
PDB:2I13|B
|
32 |
98 |
1e-12 |
PDB |
|
SCOP:d1fgja_
|
33 |
98 |
5e-13 |
SMART |
|
Blast:PHD
|
44 |
98 |
6e-11 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
97% (34/35) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530084C06Rik |
G |
T |
13: 31,742,978 (GRCm39) |
R92S |
unknown |
Het |
| Adamts14 |
T |
C |
10: 61,041,176 (GRCm39) |
S842G |
possibly damaging |
Het |
| C1ra |
G |
A |
6: 124,494,684 (GRCm39) |
E316K |
probably benign |
Het |
| Card6 |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
15: 5,128,173 (GRCm39) |
|
probably benign |
Het |
| Ccdc7a |
A |
G |
8: 129,562,654 (GRCm39) |
I1108T |
possibly damaging |
Het |
| Col12a1 |
T |
A |
9: 79,548,863 (GRCm39) |
M2161L |
probably benign |
Het |
| Col14a1 |
T |
C |
15: 55,364,832 (GRCm39) |
I1647T |
probably benign |
Het |
| Defb26 |
A |
T |
2: 152,350,156 (GRCm39) |
C41* |
probably null |
Het |
| Dennd3 |
T |
G |
15: 73,439,964 (GRCm39) |
|
probably benign |
Het |
| Edem1 |
C |
T |
6: 108,831,338 (GRCm39) |
R600W |
possibly damaging |
Het |
| F13a1 |
C |
A |
13: 37,172,913 (GRCm39) |
G156W |
probably damaging |
Het |
| Foxk2 |
A |
G |
11: 121,190,553 (GRCm39) |
T565A |
probably benign |
Het |
| Fsip2 |
A |
T |
2: 82,808,168 (GRCm39) |
I1496F |
possibly damaging |
Het |
| Fyb1 |
T |
C |
15: 6,690,197 (GRCm39) |
|
probably null |
Het |
| Gapdhs |
T |
C |
7: 30,436,146 (GRCm39) |
Y148C |
probably damaging |
Het |
| H1f3 |
T |
C |
13: 23,739,505 (GRCm39) |
I81T |
probably damaging |
Het |
| Hddc2 |
A |
T |
10: 31,192,289 (GRCm39) |
R64S |
probably damaging |
Het |
| Hddc2 |
T |
A |
10: 31,196,338 (GRCm39) |
|
probably null |
Het |
| Klk10 |
T |
A |
7: 43,432,942 (GRCm39) |
S113T |
probably benign |
Het |
| Lin7a |
T |
C |
10: 107,159,843 (GRCm39) |
S52P |
possibly damaging |
Het |
| Nbeal1 |
A |
T |
1: 60,331,029 (GRCm39) |
I2213L |
probably damaging |
Het |
| Nbeal2 |
T |
C |
9: 110,466,615 (GRCm39) |
T763A |
probably benign |
Het |
| Nlrp4a |
T |
A |
7: 26,149,482 (GRCm39) |
I363N |
possibly damaging |
Het |
| Oat |
C |
T |
7: 132,161,393 (GRCm39) |
V381I |
probably benign |
Het |
| Or52n2c |
A |
G |
7: 104,574,557 (GRCm39) |
L138P |
probably damaging |
Het |
| Plpp2 |
A |
T |
10: 79,363,378 (GRCm39) |
I207N |
possibly damaging |
Het |
| Rps6ka4 |
T |
C |
19: 6,808,679 (GRCm39) |
E522G |
possibly damaging |
Het |
| Sars2 |
T |
C |
7: 28,441,628 (GRCm39) |
V63A |
probably benign |
Het |
| Sgf29 |
C |
T |
7: 126,271,350 (GRCm39) |
R209C |
probably damaging |
Het |
| Sptbn1 |
G |
A |
11: 30,086,048 (GRCm39) |
A1220V |
probably damaging |
Het |
| Taf4 |
G |
A |
2: 179,573,822 (GRCm39) |
T682M |
probably damaging |
Het |
| Tnrc18 |
T |
C |
5: 142,757,902 (GRCm39) |
E1055G |
|
Het |
| Vmn1r158 |
A |
T |
7: 22,489,433 (GRCm39) |
C259S |
possibly damaging |
Het |
| Vmn2r120 |
T |
G |
17: 57,816,244 (GRCm39) |
I704L |
possibly damaging |
Het |
| Vwa8 |
A |
G |
14: 79,329,731 (GRCm39) |
S1188G |
probably benign |
Het |
| Zfp12 |
A |
G |
5: 143,231,535 (GRCm39) |
K653E |
probably damaging |
Het |
| Zfp937 |
A |
T |
2: 150,080,681 (GRCm39) |
H237L |
probably damaging |
Het |
| Zkscan5 |
A |
C |
5: 145,157,676 (GRCm39) |
H726P |
probably damaging |
Het |
|
| Other mutations in Zfp933 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00576:Zfp933
|
APN |
4 |
147,910,778 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03377:Zfp933
|
APN |
4 |
147,913,168 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
F5770:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
FR4340:Zfp933
|
UTSW |
4 |
147,910,186 (GRCm39) |
frame shift |
probably null |
|
|
FR4548:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
|
R0388:Zfp933
|
UTSW |
4 |
147,910,899 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0523:Zfp933
|
UTSW |
4 |
147,910,919 (GRCm39) |
nonsense |
probably null |
|
|
R0539:Zfp933
|
UTSW |
4 |
147,911,005 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1672:Zfp933
|
UTSW |
4 |
147,910,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4049:Zfp933
|
UTSW |
4 |
147,910,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4895:Zfp933
|
UTSW |
4 |
147,910,892 (GRCm39) |
nonsense |
probably null |
|
|
R5133:Zfp933
|
UTSW |
4 |
147,911,321 (GRCm39) |
missense |
probably benign |
|
|
R5786:Zfp933
|
UTSW |
4 |
147,912,864 (GRCm39) |
splice site |
probably null |
|
|
R5891:Zfp933
|
UTSW |
4 |
147,911,231 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6111:Zfp933
|
UTSW |
4 |
147,913,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6382:Zfp933
|
UTSW |
4 |
147,910,325 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6968:Zfp933
|
UTSW |
4 |
147,910,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Zfp933
|
UTSW |
4 |
147,910,636 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7555:Zfp933
|
UTSW |
4 |
147,910,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8319:Zfp933
|
UTSW |
4 |
147,912,910 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8688:Zfp933
|
UTSW |
4 |
147,911,249 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9019:Zfp933
|
UTSW |
4 |
147,911,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF024:Zfp933
|
UTSW |
4 |
147,910,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF028:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
|
RF035:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
makesense |
probably null |
|
|
RF043:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
|
V7581:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V7582:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V7583:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCCGGTATGTGCTCGTTTATG -3'
(R):5'- CATGTGCCAATTATCTCTGCAG -3'
Sequencing Primer
(F):5'- CCCGGTATGTGCTCGTTTATGTATTC -3'
(R):5'- TATCTCTGCAGGCATGAAAGAAGTCC -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation