Mutagenetix > Incidental Mutation

Incidental Mutation 'R0682:Vmn2r26'

61007

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

038867-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R0682 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

124001717-124038994 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 124038129 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 568 (E568G)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably damaging
Transcript: ENSMUST00000032238
AA Change: E568G

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: E568G

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158682

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.6%
20x: 95.5%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001J03Rik	T	C	5: 146,121,650 (GRCm39)	H83R	probably benign	Het
Abcd3	A	C	3: 121,563,216 (GRCm39)	I471S	possibly damaging	Het
Abcg1	G	A	17: 31,330,225 (GRCm39)	V509I	probably benign	Het
Adamts9	A	T	6: 92,880,783 (GRCm39)	N497K	possibly damaging	Het
Agap2	A	G	10: 126,919,351 (GRCm39)	S479G	unknown	Het
Asic2	T	C	11: 80,777,506 (GRCm39)	I402V	possibly damaging	Het
Atp1a2	G	A	1: 172,112,164 (GRCm39)	T577I	probably benign	Het
Atraid	T	A	5: 31,209,612 (GRCm39)	I92K	probably damaging	Het
Dpp10	C	A	1: 123,832,852 (GRCm39)	A31S	probably damaging	Het
Erich6	A	T	3: 58,544,232 (GRCm39)	F118L	probably benign	Het
Galnt18	T	C	7: 111,119,222 (GRCm39)	Y418C	probably damaging	Het
Herc1	T	A	9: 66,389,263 (GRCm39)	C3927S	possibly damaging	Het
Ifit2	G	A	19: 34,551,012 (GRCm39)	R184H	probably benign	Het
Kif24	A	T	4: 41,428,620 (GRCm39)	N113K	probably benign	Het
Lrp1b	T	A	2: 41,185,653 (GRCm39)	Y1354F	probably benign	Het
Muc1	T	A	3: 89,138,439 (GRCm39)	I427N	probably damaging	Het
Muc5ac	A	G	7: 141,359,406 (GRCm39)	T1288A	possibly damaging	Het
Or7g32	C	A	9: 19,388,645 (GRCm39)	M300I	probably benign	Het
Or9i14	C	T	19: 13,792,501 (GRCm39)	C151Y	possibly damaging	Het
Pex26	T	A	6: 121,161,363 (GRCm39)	V47E	probably damaging	Het
Plekhm2	T	C	4: 141,355,436 (GRCm39)	I871V	probably damaging	Het
Rasal2	A	G	1: 157,006,779 (GRCm39)	S111P	probably damaging	Het
Rnf133	A	T	6: 23,649,569 (GRCm39)	I163N	probably damaging	Het
Rrp8	A	C	7: 105,383,218 (GRCm39)	D349E	probably damaging	Het
Sdhd	G	T	9: 50,511,905 (GRCm39)	Q38K	probably benign	Het
Ssh1	C	T	5: 114,098,718 (GRCm39)	S117N	probably damaging	Het
Tbc1d2b	A	G	9: 90,131,915 (GRCm39)	M148T	probably benign	Het
Tnni3k	A	G	3: 154,645,665 (GRCm39)	S470P	probably damaging	Het
Tnr	C	T	1: 159,679,877 (GRCm39)	Q284*	probably null	Het
Trim30a	A	C	7: 104,078,389 (GRCm39)	V229G	probably damaging	Het
Trim43a	G	A	9: 88,464,199 (GRCm39)	E37K	probably benign	Het
U2surp	C	T	9: 95,366,496 (GRCm39)	V470I	probably benign	Het
Uck2	T	C	1: 167,064,259 (GRCm39)	D90G	probably damaging	Het
Vmn1r229	A	T	17: 21,034,950 (GRCm39)	E65V	probably benign	Het
Whamm	A	G	7: 81,235,886 (GRCm39)	E363G	probably damaging	Het
Wrap53	A	G	11: 69,453,272 (GRCm39)	S390P	probably damaging	Het
Wrn	A	G	8: 33,757,848 (GRCm39)	S814P	probably benign	Het
Zfp329	A	G	7: 12,544,211 (GRCm39)	C438R	probably damaging	Het
Zkscan8	T	C	13: 21,710,930 (GRCm39)	Y60C	probably damaging	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124,038,566 (GRCm39)	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124,038,715 (GRCm39)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,030,833 (GRCm39)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,027,632 (GRCm39)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,038,584 (GRCm39)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,038,777 (GRCm39)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,003,100 (GRCm39)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,003,091 (GRCm39)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,016,754 (GRCm39)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,027,778 (GRCm39)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,016,858 (GRCm39)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,038,992 (GRCm39)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,030,940 (GRCm39)	splice site	probably null
R1061:Vmn2r26	UTSW	6	124,038,603 (GRCm39)	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124,030,872 (GRCm39)	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124,027,667 (GRCm39)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,016,706 (GRCm39)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,038,431 (GRCm39)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,038,369 (GRCm39)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,001,730 (GRCm39)	missense	probably benign
R1956:Vmn2r26	UTSW	6	124,030,846 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124,038,144 (GRCm39)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,038,196 (GRCm39)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,016,708 (GRCm39)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,038,309 (GRCm39)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,002,938 (GRCm39)	missense	probably benign
R4490:Vmn2r26	UTSW	6	124,027,697 (GRCm39)	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124,038,150 (GRCm39)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,038,375 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,030,924 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,003,070 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,038,832 (GRCm39)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,038,285 (GRCm39)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,027,676 (GRCm39)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,016,408 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124,002,925 (GRCm39)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,038,633 (GRCm39)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,016,830 (GRCm39)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,016,519 (GRCm39)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,038,444 (GRCm39)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,038,348 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,003,039 (GRCm39)	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124,038,650 (GRCm39)	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124,016,057 (GRCm39)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,016,741 (GRCm39)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,038,255 (GRCm39)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,016,727 (GRCm39)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,038,948 (GRCm39)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,002,914 (GRCm39)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,016,700 (GRCm39)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,016,606 (GRCm39)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,016,321 (GRCm39)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,038,494 (GRCm39)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,038,704 (GRCm39)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,016,758 (GRCm39)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,001,914 (GRCm39)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,038,887 (GRCm39)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,002,995 (GRCm39)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,001,877 (GRCm39)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,038,983 (GRCm39)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,003,009 (GRCm39)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,016,333 (GRCm39)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,002,826 (GRCm39)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,038,137 (GRCm39)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,016,448 (GRCm39)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- TCTGATACTCTGATTGTTCAAGTCCACCTA -3'
(R):5'- GAGTCGGGTCACCATCCCCA -3'

Sequencing Primer
(F):5'- GATTGTTCAAGTCCACCTACTTTCTG -3'
(R):5'- GTCTCAAGACACAAGTGACTGTTC -3'

Posted On

2013-07-30