Incidental Mutation 'R7904:Wnt16'
ID 610155
Institutional Source Beutler Lab
Gene Symbol Wnt16
Ensembl Gene ENSMUSG00000029671
Gene Name wingless-type MMTV integration site family, member 16
Synonyms E130309I19Rik
MMRRC Submission 045956-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7904 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 22288226-22298521 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 22297989 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 285 (Y285C)
Ref Sequence ENSEMBL: ENSMUSP00000031681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031681] [ENSMUST00000128245] [ENSMUST00000148639]
AlphaFold Q9QYS1
Predicted Effect probably damaging
Transcript: ENSMUST00000031681
AA Change: Y285C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031681
Gene: ENSMUSG00000029671
AA Change: Y285C

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
WNT1 48 364 1.13e-146 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000128245
SMART Domains Protein: ENSMUSP00000134822
Gene: ENSMUSG00000029671

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
WNT1 48 225 1.04e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148639
SMART Domains Protein: ENSMUSP00000135016
Gene: ENSMUSG00000029671

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
WNT1 48 225 1.61e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176681
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 97% (72/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bone mineral density, cortical bone thickness and bone strength. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam8 G A 7: 139,567,591 (GRCm39) T384I probably benign Het
Astn1 T C 1: 158,424,886 (GRCm39) F691L probably benign Het
Azgp1 A G 5: 137,985,869 (GRCm39) E164G probably damaging Het
Bdp1 A G 13: 100,177,944 (GRCm39) V1975A probably benign Het
Cactin T C 10: 81,161,699 (GRCm39) Y744H possibly damaging Het
Clstn1 T A 4: 149,698,594 (GRCm39) I60N probably benign Het
Col16a1 T A 4: 129,948,001 (GRCm39) C240* probably null Het
Col6a5 T C 9: 105,805,720 (GRCm39) D1062G unknown Het
Csmd2 T C 4: 128,313,346 (GRCm39) L1341P Het
Cyp51 A T 5: 4,150,173 (GRCm39) F183L probably damaging Het
Dbnl T A 11: 5,741,779 (GRCm39) probably null Het
Ddx60 G A 8: 62,430,924 (GRCm39) V820I possibly damaging Het
Dnaaf9 A T 2: 130,633,923 (GRCm39) probably null Het
Dnah11 T A 12: 117,867,003 (GRCm39) D4046V possibly damaging Het
Dnah6 G A 6: 73,112,450 (GRCm39) probably null Het
Dnttip1 A G 2: 164,589,472 (GRCm39) Y89C probably benign Het
Efr3a T A 15: 65,696,527 (GRCm39) V144E probably damaging Het
Epha8 T C 4: 136,659,050 (GRCm39) Q868R possibly damaging Het
Ercc5 G T 1: 44,214,998 (GRCm39) probably null Het
Fam118a A G 15: 84,929,834 (GRCm39) S21G probably damaging Het
Fam171b T C 2: 83,683,849 (GRCm39) I122T probably damaging Het
Fat4 T A 3: 38,941,690 (GRCm39) S194R probably damaging Het
Fcho2 T A 13: 98,932,871 (GRCm39) T44S possibly damaging Het
Gm21698 C A 5: 26,189,256 (GRCm39) L232F probably benign Het
Gpr149 T A 3: 62,502,356 (GRCm39) D500V probably benign Het
Gpx8 T A 13: 113,182,035 (GRCm39) T133S probably benign Het
Hdlbp A T 1: 93,351,092 (GRCm39) I542N probably damaging Het
Hid1 G A 11: 115,246,187 (GRCm39) S361F probably damaging Het
Igdcc4 C A 9: 65,041,801 (GRCm39) A1076E probably benign Het
Il4ra A G 7: 125,164,845 (GRCm39) K7E probably benign Het
Inka2 T C 3: 105,623,730 (GRCm39) C35R probably damaging Het
Itga9 G T 9: 118,706,294 (GRCm39) probably null Het
Kif5c T C 2: 49,591,095 (GRCm39) S316P probably damaging Het
Kmt5c A T 7: 4,749,158 (GRCm39) T264S probably damaging Het
Litafd A G 16: 8,501,681 (GRCm39) H61R Het
Lrrc18 A G 14: 32,731,052 (GRCm39) N197S probably benign Het
Mcoln1 C A 8: 3,558,356 (GRCm39) D203E probably benign Het
Mitf T C 6: 97,990,671 (GRCm39) V358A probably damaging Het
Mki67 A T 7: 135,294,816 (GRCm39) L3161Q possibly damaging Het
Mmp20 T A 9: 7,644,076 (GRCm39) F255I possibly damaging Het
Muc16 T C 9: 18,566,946 (GRCm39) T1858A unknown Het
Mug1 G A 6: 121,828,424 (GRCm39) V279I probably benign Het
Or6c68 T C 10: 129,157,665 (GRCm39) Y58H probably damaging Het
Otulin G T 15: 27,630,580 (GRCm39) A39E probably benign Het
Pcdh17 A T 14: 84,685,924 (GRCm39) D797V possibly damaging Het
Pdlim5 G A 3: 142,018,154 (GRCm39) S147L probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Ppp2r1a T G 17: 21,182,003 (GRCm39) probably null Het
Ranbp6 T C 19: 29,789,813 (GRCm39) I180V probably benign Het
Rbm27 G T 18: 42,465,921 (GRCm39) R869L probably damaging Het
Rtn4r A G 16: 17,969,349 (GRCm39) D259G probably benign Het
Ryr3 T C 2: 112,611,369 (GRCm39) E2271G probably damaging Het
Sbk1 A G 7: 125,891,208 (GRCm39) Y214C probably damaging Het
Scg3 C T 9: 75,551,149 (GRCm39) E459K probably damaging Het
Scin T G 12: 40,126,999 (GRCm39) E449D probably damaging Het
Sel1l3 T C 5: 53,297,166 (GRCm39) K760R probably benign Het
Sh3pxd2a A G 19: 47,308,753 (GRCm39) L145S possibly damaging Het
Sh3yl1 A G 12: 30,991,995 (GRCm39) D188G probably benign Het
Slc38a1 A T 15: 96,521,921 (GRCm39) L13Q possibly damaging Het
Smyd4 T C 11: 75,240,613 (GRCm39) I36T possibly damaging Het
Spata31f1a A G 4: 42,850,765 (GRCm39) S464P possibly damaging Het
Stab2 A T 10: 86,790,056 (GRCm39) L570* probably null Het
Tg G T 15: 66,577,128 (GRCm39) A1484S probably benign Het
Tm7sf2 A T 19: 6,118,942 (GRCm39) N677K probably damaging Het
Tmem235 T G 11: 117,751,717 (GRCm39) L47R probably damaging Het
Tmem87a A G 2: 120,210,198 (GRCm39) S252P probably damaging Het
Unc13b A G 4: 43,217,075 (GRCm39) D458G probably benign Het
Wfdc1 A G 8: 120,406,770 (GRCm39) probably null Het
Wwc2 A T 8: 48,309,270 (GRCm39) N837K unknown Het
Xdh A G 17: 74,229,467 (GRCm39) F329L probably benign Het
Yaf2 G T 15: 93,183,466 (GRCm39) H115N probably benign Het
Zbtb16 G T 9: 48,744,272 (GRCm39) N13K probably damaging Het
Zfhx3 A T 8: 109,677,695 (GRCm39) D2915V probably damaging Het
Zfp236 A T 18: 82,627,507 (GRCm39) V1564E possibly damaging Het
Zfp407 G T 18: 84,579,381 (GRCm39) H577Q not run Het
Other mutations in Wnt16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00488:Wnt16 APN 6 22,291,012 (GRCm39) missense probably damaging 1.00
IGL01306:Wnt16 APN 6 22,297,934 (GRCm39) missense probably damaging 0.99
IGL02297:Wnt16 APN 6 22,297,990 (GRCm39) nonsense probably null
ANU23:Wnt16 UTSW 6 22,297,934 (GRCm39) missense probably damaging 0.99
R0320:Wnt16 UTSW 6 22,297,992 (GRCm39) missense possibly damaging 0.68
R1671:Wnt16 UTSW 6 22,298,178 (GRCm39) missense probably damaging 1.00
R2342:Wnt16 UTSW 6 22,288,923 (GRCm39) missense probably damaging 1.00
R3437:Wnt16 UTSW 6 22,298,133 (GRCm39) missense probably damaging 0.99
R3786:Wnt16 UTSW 6 22,298,021 (GRCm39) missense probably benign
R5301:Wnt16 UTSW 6 22,297,848 (GRCm39) missense probably damaging 0.99
R5357:Wnt16 UTSW 6 22,291,231 (GRCm39) intron probably benign
R5468:Wnt16 UTSW 6 22,291,160 (GRCm39) missense probably benign 0.00
R5843:Wnt16 UTSW 6 22,290,947 (GRCm39) missense probably damaging 0.99
R6655:Wnt16 UTSW 6 22,290,965 (GRCm39) missense probably damaging 1.00
R6731:Wnt16 UTSW 6 22,297,891 (GRCm39) nonsense probably null
R6988:Wnt16 UTSW 6 22,288,510 (GRCm39) missense probably damaging 1.00
R7437:Wnt16 UTSW 6 22,288,560 (GRCm39) missense probably benign 0.17
R7919:Wnt16 UTSW 6 22,291,049 (GRCm39) missense probably benign 0.01
R7940:Wnt16 UTSW 6 22,291,188 (GRCm39) missense possibly damaging 0.78
R8071:Wnt16 UTSW 6 22,288,997 (GRCm39) missense probably benign
R9057:Wnt16 UTSW 6 22,288,823 (GRCm39) missense probably damaging 1.00
R9195:Wnt16 UTSW 6 22,297,932 (GRCm39) missense probably benign 0.00
R9618:Wnt16 UTSW 6 22,297,892 (GRCm39) nonsense probably null
R9618:Wnt16 UTSW 6 22,297,891 (GRCm39) nonsense probably null
R9781:Wnt16 UTSW 6 22,291,114 (GRCm39) missense probably damaging 1.00
Z1177:Wnt16 UTSW 6 22,288,587 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTCCTGTGCTGTGAAAACCTG -3'
(R):5'- GGACATCGGTCATACTTTCACAC -3'

Sequencing Primer
(F):5'- ACCTGCTGGAAAACTATGTCTTC -3'
(R):5'- TTCACACCTCCTGCAGCGG -3'
Posted On 2019-12-20