Incidental Mutation 'R7905:Or6c203'
ID 610231
Institutional Source Beutler Lab
Gene Symbol Or6c203
Ensembl Gene ENSMUSG00000107662
Gene Name olfactory receptor family 6 subfamily C member 203
Synonyms MOR114-3, GA_x6K02T2PULF-10860457-10859522, Olfr772
MMRRC Submission 045957-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R7905 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129009920-129010923 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129010056 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 278 (I278N)
Ref Sequence ENSEMBL: ENSMUSP00000148854 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169800] [ENSMUST00000214672]
AlphaFold Q8VGC5
Predicted Effect probably damaging
Transcript: ENSMUST00000169800
AA Change: I278N

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000132389
Gene: ENSMUSG00000107662
AA Change: I278N

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.6e-47 PFAM
Pfam:7tm_1 38 287 1.1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214672
AA Change: I278N

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl9 T C 17: 33,652,801 (GRCm39) V287A possibly damaging Het
Adcy10 T A 1: 165,340,737 (GRCm39) probably null Het
Aox1 G A 1: 58,143,557 (GRCm39) S1225N possibly damaging Het
B430306N03Rik T A 17: 48,623,988 (GRCm39) S96R probably benign Het
Bpifa5 T C 2: 154,007,508 (GRCm39) I150T probably damaging Het
Ccdc28a A T 10: 18,094,076 (GRCm39) V181D probably benign Het
Cd40 T C 2: 164,904,245 (GRCm39) Y31H probably damaging Het
Cep290 A G 10: 100,390,352 (GRCm39) T2032A probably benign Het
Cnbd1 T C 4: 18,907,100 (GRCm39) K158R possibly damaging Het
Degs1 A C 1: 182,106,601 (GRCm39) N255K possibly damaging Het
Dll3 T G 7: 28,000,960 (GRCm39) I32L possibly damaging Het
Dsg4 A T 18: 20,587,726 (GRCm39) I278F probably damaging Het
Ets2 T A 16: 95,507,304 (GRCm39) I6N probably damaging Het
Gbp4 A G 5: 105,268,953 (GRCm39) F400S probably damaging Het
Golgb1 C T 16: 36,734,047 (GRCm39) A1139V probably benign Het
Hfm1 A T 5: 107,046,419 (GRCm39) L489H probably damaging Het
Kcna5 T C 6: 126,511,831 (GRCm39) D99G probably benign Het
Ldhc A G 7: 46,524,955 (GRCm39) probably null Het
Mief1 C G 15: 80,133,599 (GRCm39) P219A probably damaging Het
Myh11 A T 16: 14,025,545 (GRCm39) Y1408* probably null Het
Myo1b A G 1: 51,803,043 (GRCm39) probably null Het
Nedd4 A T 9: 72,584,661 (GRCm39) K121* probably null Het
Nek9 A C 12: 85,352,370 (GRCm39) M831R probably damaging Het
Nf1 G A 11: 79,437,938 (GRCm39) A83T possibly damaging Het
Osbpl10 T C 9: 114,891,078 (GRCm39) probably null Het
Pcdhb6 T C 18: 37,467,607 (GRCm39) L176P probably benign Het
Plxnb1 G A 9: 108,938,300 (GRCm39) V1285M probably damaging Het
Psg26 T A 7: 18,209,242 (GRCm39) M389L probably benign Het
Slc49a4 G A 16: 35,589,320 (GRCm39) P98S probably benign Het
Slc4a10 A G 2: 62,098,495 (GRCm39) E543G probably damaging Het
Spata31h1 A G 10: 82,131,936 (GRCm39) I358T probably benign Het
Spink7 G T 18: 62,725,487 (GRCm39) C85* probably null Het
Stard9 T C 2: 120,526,562 (GRCm39) W940R not run Het
Susd2 A T 10: 75,475,491 (GRCm39) L471* probably null Het
Taf2 A T 15: 54,910,828 (GRCm39) D615E possibly damaging Het
Taf4 G A 2: 179,573,822 (GRCm39) T682M probably damaging Het
Tfdp2 T C 9: 96,192,659 (GRCm39) S14P Het
Tha1 A C 11: 117,761,893 (GRCm39) V116G possibly damaging Het
Trim46 T C 3: 89,151,633 (GRCm39) H50R probably damaging Het
Trit1 A G 4: 122,910,508 (GRCm39) K36E probably damaging Het
Ttc13 A T 8: 125,415,335 (GRCm39) M268K probably benign Het
Ufc1 T A 1: 171,117,508 (GRCm39) K68N probably damaging Het
Zbbx T C 3: 74,992,820 (GRCm39) T225A probably benign Het
Zfp768 T C 7: 126,943,831 (GRCm39) E102G probably damaging Het
Other mutations in Or6c203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Or6c203 APN 10 129,010,119 (GRCm39) missense possibly damaging 0.65
IGL03072:Or6c203 APN 10 129,010,358 (GRCm39) missense probably damaging 1.00
IGL03336:Or6c203 APN 10 129,010,098 (GRCm39) missense probably benign 0.00
R1852:Or6c203 UTSW 10 129,010,197 (GRCm39) missense probably benign 0.00
R2496:Or6c203 UTSW 10 129,009,966 (GRCm39) missense probably benign 0.00
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6168:Or6c203 UTSW 10 129,010,035 (GRCm39) missense probably damaging 1.00
R7454:Or6c203 UTSW 10 129,010,324 (GRCm39) missense probably damaging 1.00
R7669:Or6c203 UTSW 10 129,010,128 (GRCm39) missense probably damaging 1.00
R8307:Or6c203 UTSW 10 129,010,101 (GRCm39) missense probably benign 0.00
R8830:Or6c203 UTSW 10 129,010,715 (GRCm39) nonsense probably null
R9405:Or6c203 UTSW 10 129,010,165 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- CAGGAAAGTCAGTCGACCAC -3'
(R):5'- CACTCATTATAACGCTGGTGTGTG -3'

Sequencing Primer
(F):5'- TCGACCACAAAGAGAAAGAGTGTTC -3'
(R):5'- ATCATCAAGACAGTTCTTAGATTCCC -3'
Posted On 2019-12-20